Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 9, 2003, Pages 2725-2731

  Hill, Philip ^a   Kessl, Jacques ^b   Fisher, Nicholas ^a   Meshnick, Steven ^c   Trumpower, Bernard L ^b   Meunier, Brigitte ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ATOVAQUONE; CYTOCHROME B;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL PNEUMONIA; GENE MUTATION; GENETIC LINKAGE; IMMUNE DEFICIENCY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OPPORTUNISTIC INFECTION; PATHOGENESIS; PNEUMOCYSTIS; PNEUMOCYSTIS CARINII; PNEUMOCYSTIS JIROVECI; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

AMINO ACID SEQUENCE; ANTIFUNGAL AGENTS; ATOVAQUONE; CYTOCHROME B GROUP; DRUG RESISTANCE, FUNGAL; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NAPHTHOQUINONES; OXYGEN CONSUMPTION; PNEUMOCYSTIS; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE;

EID: 0041422277     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.9.2725-2731.2003     Document Type: Article

References (16)

1. Bonnefoy, N., and T. D. Fox. 2001. Genetic transformation of Saccharomyces cerevisiae mitochondria. Methods Cell. Biol. 65:381-396.
2. Brown, S., A. M. Colson, B. Meunier, and P. R. Rich. 1993. Rapid screening of cytochromes of respiratory mutants of Saccharomyces cerevisiae - application to the selection of strains containing novel forms of cytochrome c oxidase. Eur. J. Biochem. 213:137-145.
3. Conde, J., and G. R. Fink. 1976. A mutant of Saccharomyces cerevisae defective for nuclear fusion. Proc. Natl. Acad. Sci. USA 73:3651-3655.
4. Decottignies, A., A. M. Grant, J. W. Nichols, de Wet, H., D. B. McIntosh, and A. Goffeau. 1998. ATPAse and multidrug transporter activities of the overexpressed yeast ABC protein Yor1p. J. Biol. Chem. 273:12612-12622.
5. diRago, J. P., J. Y. Coppé, and A. M. Colson. 1989. Molecular basis for resistance to myxothiazol, mucidin (strobilurin A) and stigmatellin. J. Biol. Chem. 264:14543-14548.
6. 1 complex from the yeast Saccharomyces cerevisiae cocrystallized with an antibody Fv fragment. Structure Fold. Des. 8:669-684.
7. Kazanjian, P., W. Armstrong, P. A. Hossler, L. Huang, C. B. Beard, J. Carter, L. Crane, J. Duchin, W. Burman, J. Richardson, and S. R. Meshnick. 2001. Pneumocystis carinii cytochrome b mutations are associated with atovaquone exposure in patients with AIDS. J. Infect. Dis. 183:819-822.
8. Korsinczky, M., N. Chen, B. Kotecka, A. Saul, K. Rieckmann, and Q. Cheng. 2000. Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drung-binding site. Antimicrob. Agents Chemother. 44:2100-2108.
9. Mahe, Y., Y. Lemoine, and K. Kuchler. 1996. The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisae can meditate transport of steroids in vivo. J. Biol. Chem. 271:25167-25172.
10. o domain mutations as a mechanism of atovaquone-resistance. Mol. Biochem. Parasitol. 108:1-12.
11. Sanglard, D., F. Ischer, and J. Bille. 2001. Role of ATP-Binding-Cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata. Antimicrob. Agents Chemother. 45:1174-1183.
12. 1 complex and can be suppressed by overexpression of subunit 9. J. Biol. Chem. 266:14958-14963.
13. Srivastava, I. K., J. M. Morrisey, E. Darrouzet, F. Daldal, and A. B. Vaidya. 1999. Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites. Mol. Microbiol. 33:704-711.
14. Syafruddin, D., J. E. Siregar, and S. Marzuki. 1999. Mutations in cytochrome b gene of Plasmodium berghei conferring resistance to atovaquone. Mol. Biochem. Parasitol. 104:185-195.
15. Vanden Bossche, H., F. Dromer, I. Improvisi, Lozano-Chiu, M., J. H Rex, and D. Sanglard. 1998. D. Antifungal drug resistance in pathogenic fungi. Med. Mycol. 36:116-128.
16. Wolfger, H., Y. Mamnun, and K. Kuchler. 2001. Fungal ABC proteins: pleitropic drug resistance, stress response and cellular detoxification. Res. Microbiol. 152:375-389.