메뉴 건너뛰기




Volumn 32, Issue 1, 2014, Pages 1-8

Recently abused synthetic cathinones, α-pyrrolidinophenone derivatives: A review of their pharmacology, acute toxicity, and metabolism

Author keywords

PVP; Pyrrolidinophenone derivatives; Cathinones; Metabolism; Pharmacology; Toxicity

Indexed keywords


EID: 84895120226     PISSN: 18608965     EISSN: 18608973     Source Type: Journal    
DOI: 10.1007/s11419-013-0218-1     Document Type: Review
Times cited : (49)

References (62)
  • 1
    • 0026601939 scopus 로고
    • Cathinone, a natural amphetamine
    • 1:CAS:528:DyaK38XhvVOgtL8%3D 1508843 10.1111/j.1600-0773.1992.tb00434.x
    • Kalix P (1992) Cathinone, a natural amphetamine. Pharmacol Toxicol 70:77-86
    • (1992) Pharmacol Toxicol , vol.70 , pp. 77-86
    • Kalix, P.1
  • 2
    • 79960609138 scopus 로고    scopus 로고
    • Recently abused β-keto derivatives of 3,4- methylenedioxyphenylalkylamines: A review of their metabolisms and toxicological analysis
    • 1:CAS:528:DC%2BC3MXosVWhurk%3D 10.1007/s11419-011-0111-8
    • Zaitsu K, Katagi M, Tatsuno M, Sato T, Tsuchihashi H, Suzuki K (2011) Recently abused β-keto derivatives of 3,4-methylenedioxyphenylalkylamines: a review of their metabolisms and toxicological analysis. Forensic Toxicol 29:73-84
    • (2011) Forensic Toxicol , vol.29 , pp. 73-84
    • Zaitsu, K.1    Katagi, M.2    Tatsuno, M.3    Sato, T.4    Tsuchihashi, H.5    Suzuki, K.6
  • 3
    • 79960634938 scopus 로고    scopus 로고
    • Cathinone derivatives: A review of their chemistry, pharmacology and toxicology
    • 1:CAS:528:DC%2BC3MXptVOiur4%3D 21755607 10.1002/dta.313
    • Kelly JP (2011) Cathinone derivatives: a review of their chemistry, pharmacology and toxicology. Drug Test Anal 3:439-453
    • (2011) Drug Test Anal , vol.3 , pp. 439-453
    • Kelly, J.P.1
  • 4
    • 84878890238 scopus 로고    scopus 로고
    • Designer cathinones - An emerging class of novel recreational drugs
    • 1:CAS:528:DC%2BC3sXhtF2hsr3N 23890615 10.1016/j.forsciint.2013.04.015
    • Zawilska JB, Wojcieszak J (2013) Designer cathinones - an emerging class of novel recreational drugs. Forensic Sci Int 231:42-53
    • (2013) Forensic Sci Int , vol.231 , pp. 42-53
    • Zawilska, J.B.1    Wojcieszak, J.2
  • 5
    • 84866776116 scopus 로고    scopus 로고
    • Detection and quantification of new designer drugs in human blood: Part 2 - Designer cathinones
    • 1:CAS:528:DC%2BC38XotVShurc%3D 22593565 10.1093/jat/bks049
    • Ammann D, McLaren JM, Gerostamoulos D, Beyer J (2012) Detection and quantification of new designer drugs in human blood: part 2 - designer cathinones. J Anal Toxicol 36:381-389
    • (2012) J Anal Toxicol , vol.36 , pp. 381-389
    • Ammann, D.1    McLaren, J.M.2    Gerostamoulos, D.3    Beyer, J.4
  • 6
    • 84872675032 scopus 로고    scopus 로고
    • Changes in the prevalence of synthetic cannabinoids and cathinone derivatives in Japan until early 2012
    • 10.1007/s11419-012-0165-2
    • Kikura-Hanajiri R, Uchiyama N, Kawamura M, Goda Y (2013) Changes in the prevalence of synthetic cannabinoids and cathinone derivatives in Japan until early 2012. Forensic Toxicol 31:44-53
    • (2013) Forensic Toxicol , vol.31 , pp. 44-53
    • Kikura-Hanajiri, R.1    Uchiyama, N.2    Kawamura, M.3    Goda, Y.4
  • 7
    • 84895185030 scopus 로고    scopus 로고
    • Synthetic cannabinoids abused in South Korea: Drug identifications by the National Forensic Service from 2009 to June 2013
    • 10.1007/s11419-013-0213-6
    • Chung H, Choi H, Heo S, Kim E, Lee J (2013) Synthetic cannabinoids abused in South Korea: drug identifications by the National Forensic Service from 2009 to June 2013. Forensic Toxicol. doi: 10.1007/s11419-013-0213-6
    • (2013) Forensic Toxicol
    • Chung, H.1    Choi, H.2    Heo, S.3    Kim, E.4    Lee, J.5
  • 8
    • 79957604914 scopus 로고    scopus 로고
    • Spectroscopic characterization of 3,4- methylenedioxypyrrolidinobutyrophenone: A new designer drug with α-pyrrolidinophenone structure
    • 1:CAS:528:DC%2BC3MXmslygtL0%3D 21316166 10.1016/j.forsciint.2011.01.016
    • Westphal F, Junge T, Klein B, Fritschi G, Girreser U (2011) Spectroscopic characterization of 3,4-methylenedioxypyrrolidinobutyrophenone: a new designer drug with α-pyrrolidinophenone structure. Forensic Sci Int 209:126-132
    • (2011) Forensic Sci Int , vol.209 , pp. 126-132
    • Westphal, F.1    Junge, T.2    Klein, B.3    Fritschi, G.4    Girreser, U.5
  • 9
    • 77956642096 scopus 로고    scopus 로고
    • Analyses of second-generation 'legal highs' in the UK: Initial findings
    • 1:CAS:528:DC%2BC3cXhtFKlt7jO 20687197 10.1002/dta.155
    • Brandt SD, Sumnall HR, Measham F, Cole J (2010) Analyses of second-generation 'legal highs' in the UK: initial findings. Drug Test Anal 2:377-382
    • (2010) Drug Test Anal , vol.2 , pp. 377-382
    • Brandt, S.D.1    Sumnall, H.R.2    Measham, F.3    Cole, J.4
  • 10
    • 79951517620 scopus 로고    scopus 로고
    • Naphyrone: Analytical profile of the new "legal high" substitute for mephedrone
    • 10.1016/j.jflm.2010.12.001
    • De Paoli G, Maskell PD, Pounder DJ (2011) Naphyrone: analytical profile of the new "legal high" substitute for mephedrone. J Forensic Legal Med 18:93
    • (2011) J Forensic Legal Med , vol.18 , pp. 93
    • De Paoli, G.1    Maskell, P.D.2    Pounder, D.J.3
  • 11
    • 84879793220 scopus 로고    scopus 로고
    • Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products
    • 1:CAS:528:DC%2BC3sXhtVGlu77L 10.1007/s11419-013-0182-9
    • Uchiyama N, Matsuda S, Kawamura M, Kikura-Hanajiri R, Goda Y (2013) Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products. Forensic Toxicol 31:223-240
    • (2013) Forensic Toxicol , vol.31 , pp. 223-240
    • Uchiyama, N.1    Matsuda, S.2    Kawamura, M.3    Kikura-Hanajiri, R.4    Goda, Y.5
  • 12
    • 0024508366 scopus 로고
    • Khat consumption: A pharmacological review
    • 1:STN:280:DyaL1M7lt1ymsg%3D%3D 2537717 10.1016/0376-8716(89)90029-X
    • Nencini P, Ahmed AM (1989) Khat consumption: a pharmacological review. Drug Alcohol Depend 23:19-29
    • (1989) Drug Alcohol Depend , vol.23 , pp. 19-29
    • Nencini, P.1    Ahmed, A.M.2
  • 13
    • 0014752906 scopus 로고
    • A new stimulant, prolintane hydrochloride, compared with dextroamphetamine in fatigued volunteers
    • 1:STN:280:DyaE3c7islOisA%3D%3D 4392006 10.1177/009127007001000205
    • Hollister LE, Gillespie HK (1970) A new stimulant, prolintane hydrochloride, compared with dextroamphetamine in fatigued volunteers. J Clin Pharmacol J New Drugs 10:103-109
    • (1970) J Clin Pharmacol J New Drugs , vol.10 , pp. 103-109
    • Hollister, L.E.1    Gillespie, H.K.2
  • 14
    • 0015139655 scopus 로고
    • Evaluation of pyrovalerone in chronically fatigued volunteers
    • 1:CAS:528:DyaE38XotFegsw%3D%3D 4402508
    • Gardos G, Cole JO (1971) Evaluation of pyrovalerone in chronically fatigued volunteers. Curr Ther Res Clin Exp 13:631-635
    • (1971) Curr Ther Res Clin Exp , vol.13 , pp. 631-635
    • Gardos, G.1    Cole, J.O.2
  • 16
    • 80054792045 scopus 로고    scopus 로고
    • Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats
    • 1:CAS:528:DC%2BC3MXhsFyqsL3P 21615721 10.1111/j.1476-5381.2011.01499.x
    • Kehr J, Ichinose F, Yoshitake S, Goiny M, Sievertsson T, Nyberg F, Yoshitake T (2011) Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats. Br J Pharmacol 164:1949-1958
    • (2011) Br J Pharmacol , vol.164 , pp. 1949-1958
    • Kehr, J.1    Ichinose, F.2    Yoshitake, S.3    Goiny, M.4    Sievertsson, T.5    Nyberg, F.6    Yoshitake, T.7
  • 20
    • 84865424242 scopus 로고    scopus 로고
    • Comparative neuropharmacology of three psychostimulant cathinone derivatives: Butylone, mephedrone and methylone
    • 22509960 10.1111/j.1476-5381.2012.01998.x
    • López-Arnau R, Martínez-Clemente J, Pubill D, Escubedo E, Camarasa J (2012) Comparative neuropharmacology of three psychostimulant cathinone derivatives: butylone, mephedrone and methylone. Br J Pharmacol 167:407-420
    • (2012) Br J Pharmacol , vol.167 , pp. 407-420
    • López-Arnau, R.1    Martínez-Clemente, J.2    Pubill, D.3    Escubedo, E.4    Camarasa, J.5
  • 21
    • 84856538825 scopus 로고    scopus 로고
    • Interaction of mephedrone with dopamine and serotonin targets in rats
    • 21824752 10.1016/j.euroneuro.2011.07.009
    • Martínez-Clemente J, Escubedo E, Pubill D, Camarasa J (2012) Interaction of mephedrone with dopamine and serotonin targets in rats. Eur Neuropsychopharmacol 22:231-236
    • (2012) Eur Neuropsychopharmacol , vol.22 , pp. 231-236
    • Martínez-Clemente, J.1    Escubedo, E.2    Pubill, D.3    Camarasa, J.4
  • 22
    • 80054872333 scopus 로고    scopus 로고
    • 3,4-Methylenedioxypyrovalerone (MDPV): Chemistry, pharmacology and toxicology of a new designer drug of abuse marketed online
    • 1:CAS:528:DC%2BC3MXhsV2rtrnF 22008731 10.1016/j.toxlet.2011.10.002
    • Coppola M, Mondola R (2012) 3,4-Methylenedioxypyrovalerone (MDPV): chemistry, pharmacology and toxicology of a new designer drug of abuse marketed online. Toxicol Lett 208:12-15
    • (2012) Toxicol Lett , vol.208 , pp. 12-15
    • Coppola, M.1    Mondola, R.2
  • 23
    • 79960626573 scopus 로고    scopus 로고
    • The pharmacology and toxicology of the synthetic cathinone mephedrone (4-methylmethcathinone)
    • 1:CAS:528:DC%2BC3MXptVOitLw%3D 21755604 10.1002/dta.312
    • Dargan PI, Sedefov R, Gallegos A, Wood DM (2011) The pharmacology and toxicology of the synthetic cathinone mephedrone (4-methylmethcathinone). Drug Test Anal 3:454-463
    • (2011) Drug Test Anal , vol.3 , pp. 454-463
    • Dargan, P.I.1    Sedefov, R.2    Gallegos, A.3    Wood, D.M.4
  • 24
    • 70350311005 scopus 로고    scopus 로고
    • Mephedrone-Internet drug which seems to have come and stay. Fatal cases in Sweden have drawn attention to previously unknown substance. (in Swedish and English abstract)
    • 19960905
    • Gustavsson D, Escher C (2009) Mephedrone-Internet drug which seems to have come and stay. Fatal cases in Sweden have drawn attention to previously unknown substance. (in Swedish and English abstract). Lakartidningen 106:2769-2771
    • (2009) Lakartidningen , vol.106 , pp. 2769-2771
    • Gustavsson, D.1    Escher, C.2
  • 25
    • 78650726892 scopus 로고    scopus 로고
    • Clinical pattern of toxicity associated with the novel synthetic cathinone mephedrone
    • 1:STN:280:DC%2BC3M3ptlahsw%3D%3D 20581379 10.1136/emj.2010.092288
    • Wood DM, Greene SL, Dargan PI (2011) Clinical pattern of toxicity associated with the novel synthetic cathinone mephedrone. Emerg Med J 28:280-282
    • (2011) Emerg Med J , vol.28 , pp. 280-282
    • Wood, D.M.1    Greene, S.L.2    Dargan, P.I.3
  • 26
    • 84860488942 scopus 로고    scopus 로고
    • Hyperthermia and multiorgan failure after abuse of "bath salts" containing 3,4-methylenedioxypyrovalerone
    • 22387085 10.1016/j.annemergmed.2012.01.005
    • Borek HA, Holstege CP (2012) Hyperthermia and multiorgan failure after abuse of "bath salts" containing 3,4-methylenedioxypyrovalerone. Ann Emerg Med 60:103-105
    • (2012) Ann Emerg Med , vol.60 , pp. 103-105
    • Borek, H.A.1    Holstege, C.P.2
  • 27
    • 80052556761 scopus 로고    scopus 로고
    • Bath salts" intoxication
    • 1:CAS:528:DC%2BC3MXhtFGktLvK 21899474 10.1056/NEJMc1107097
    • Ross EA, Watson M, Goldberger B (2011) "Bath salts" intoxication. N Engl J Med 365:967-968
    • (2011) N Engl J Med , vol.365 , pp. 967-968
    • Ross, E.A.1    Watson, M.2    Goldberger, B.3
  • 28
    • 84857748270 scopus 로고    scopus 로고
    • Death following recreational use of designer drug "bath salts" containing 3,4-methylenedioxypyrovalerone (MDPV)
    • 3550226 22271565 10.1007/s13181-011-0196-9
    • Murray B, Murphy C, Beuhler M (2012) Death following recreational use of designer drug "bath salts" containing 3,4-methylenedioxypyrovalerone (MDPV). J Med Toxicol 8:69-75
    • (2012) J Med Toxicol , vol.8 , pp. 69-75
    • Murray, B.1    Murphy, C.2    Beuhler, M.3
  • 29
    • 0029549951 scopus 로고
    • Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: Pharmacological profile of protective and nonprotective agents
    • 1:CAS:528:DyaK28XhvVymsQ%3D%3D 8531070
    • Albers DS, Sonsalla PK (1995) Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: pharmacological profile of protective and nonprotective agents. J Pharmacol Exp Ther 275:1104-1114
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 1104-1114
    • Albers, D.S.1    Sonsalla, P.K.2
  • 30
    • 33646871323 scopus 로고    scopus 로고
    • Acute toxic effects of 'Ecstasy' (MDMA) and related compounds: Overview of pathophysiology and clinical management
    • 1:CAS:528:DC%2BD28Xks1Slurc%3D 16595612 10.1093/bja/ael078
    • Hall AP, Henry JA (2006) Acute toxic effects of 'Ecstasy' (MDMA) and related compounds: overview of pathophysiology and clinical management. Br J Anaesth 96:678-685
    • (2006) Br J Anaesth , vol.96 , pp. 678-685
    • Hall, A.P.1    Henry, J.A.2
  • 31
    • 71749104455 scopus 로고    scopus 로고
    • Chapter 10 - Neural and cardiac toxicities associated with 3,4-methylenedioxymethamphetamine (MDMA)
    • S. Hari Shanker (eds) Academic Press New York
    • Baumann MH, Rothman RB (2009) Chapter 10 - Neural and cardiac toxicities associated with 3,4-methylenedioxymethamphetamine (MDMA). In: Hari Shanker S (ed) International review of neurobiology, vol. 88. Academic Press, New York, pp 257-296
    • (2009) International Review of Neurobiology, Vol. 88 , pp. 257-296
    • Baumann, M.H.1    Rothman, R.B.2
  • 32
    • 84878135503 scopus 로고    scopus 로고
    • The novel recreational drug 3,4-methylenedioxypyrovalerone (MDPV) is a potent psychomotor stimulant: Self-administration and locomotor activity in rats
    • 1:CAS:528:DC%2BC3sXoslWnsbo%3D 23597511 10.1016/j.neuropharm.2013.04.003
    • Aarde SM, Huang PK, Creehan KM, Dickerson TJ, Taffe MA (2013) The novel recreational drug 3,4-methylenedioxypyrovalerone (MDPV) is a potent psychomotor stimulant: self-administration and locomotor activity in rats. Neuropharmacology 71:130-140
    • (2013) Neuropharmacology , vol.71 , pp. 130-140
    • Aarde, S.M.1    Huang, P.K.2    Creehan, K.M.3    Dickerson, T.J.4    Taffe, M.A.5
  • 33
    • 84860488943 scopus 로고    scopus 로고
    • Serotonin syndrome associated with MDPV use: A case report
    • 22237165 10.1016/j.annemergmed.2011.11.033
    • Mugele J, Nañagas KA, Tormoehlen LM (2012) Serotonin syndrome associated with MDPV use: a case report. Ann Emerg Med 60:100-102
    • (2012) Ann Emerg Med , vol.60 , pp. 100-102
    • Mugele, J.1    Nañagas, K.A.2    Tormoehlen, L.M.3
  • 34
    • 84855858697 scopus 로고    scopus 로고
    • Recurrent acute kidney injury following bath salts intoxication
    • 22119408 10.1053/j.ajkd.2011.10.012
    • Adebamiro A, Perazella MA (2012) Recurrent acute kidney injury following bath salts intoxication. Am J Kidney Dis 59:273-275
    • (2012) Am J Kidney Dis , vol.59 , pp. 273-275
    • Adebamiro, A.1    Perazella, M.A.2
  • 35
    • 79955466828 scopus 로고    scopus 로고
    • Acute poisoning involving the pyrrolidinophenone-type designer drug 4′-methyl-alpha-pyrrolidinohexanophenone (MPHP)
    • 1:CAS:528:DC%2BC3MXlsVCisbo%3D 21444164 10.1016/j.forsciint.2011.02.026
    • Sauer C, Hoffmann K, Schimmel U, Peters FT (2011) Acute poisoning involving the pyrrolidinophenone-type designer drug 4′-methyl-alpha- pyrrolidinohexanophenone (MPHP). Forensic Sci Int 208:e20-e25
    • (2011) Forensic Sci Int , vol.208
    • Sauer, C.1    Hoffmann, K.2    Schimmel, U.3    Peters, F.T.4
  • 36
    • 84879795357 scopus 로고    scopus 로고
    • SPME-GC-MS analysis of α-pyrrolidinovaleorophenone in blood in a fatal poisoning case
    • 10.1007/s11419-013-0183-8
    • Saito T, Namera A, Osawa M, Aoki H, Inokuchi S (2013) SPME-GC-MS analysis of α-pyrrolidinovaleorophenone in blood in a fatal poisoning case. Forensic Toxicol 31:328-332
    • (2013) Forensic Toxicol , vol.31 , pp. 328-332
    • Saito, T.1    Namera, A.2    Osawa, M.3    Aoki, H.4    Inokuchi, S.5
  • 38
    • 0014792608 scopus 로고
    • Metabolism of pyrovalerone hydrochloride
    • 1:CAS:528:DyaE3cXktlemtbY%3D 5441133 10.1021/jm00297a036
    • Michaelis W, Russel JH, Schindler O (1970) Metabolism of pyrovalerone hydrochloride. J Med Chem 13:497-503
    • (1970) J Med Chem , vol.13 , pp. 497-503
    • Michaelis, W.1    Russel, J.H.2    Schindler, O.3
  • 39
    • 0029837492 scopus 로고    scopus 로고
    • Detection and identification of pyrovalerone and its hydroxylated metabolite in the rat
    • 1:CAS:528:DyaK28XntV2mtLg%3D 8934308 10.1093/jat/20.7.568
    • Shin H-S, Shin Y-SO, Lee S, Park B-B (1996) Detection and identification of pyrovalerone and its hydroxylated metabolite in the rat. J Anal Toxicol 20:568-572
    • (1996) J Anal Toxicol , vol.20 , pp. 568-572
    • Shin, H.-S.1    Shin, Y.-S.2    Lee, S.3    Park, B.-B.4
  • 40
    • 0030572975 scopus 로고    scopus 로고
    • Identification of a pyrovalerone metabolite in the rat by gas chromatography-mass spectrometry and determination of pyrovalerone by gas chromatography-nitrogen-phosphorus detection
    • 1:CAS:528:DyaK2sXntFWktQ%3D%3D 10.1016/S0378-4347(96)00183-1
    • Lho D-S, Lee J, Kim S, Park J, Shin H-S (1996) Identification of a pyrovalerone metabolite in the rat by gas chromatography-mass spectrometry and determination of pyrovalerone by gas chromatography-nitrogen-phosphorus detection. J Chromatogr B 687:253-259
    • (1996) J Chromatogr B , vol.687 , pp. 253-259
    • Lho, D.-S.1    Lee, J.2    Kim, S.3    Park, J.4    Shin, H.-S.5
  • 41
    • 0037097028 scopus 로고    scopus 로고
    • Studies on the metabolism and toxicological detection of the new designer drug 4′-methyl-α-pyrrolidinopropiophenone in urine using gas chromatography-mass spectrometry
    • 1:CAS:528:DC%2BD38XltVGltLY%3D 10.1016/S1570-0232(01)00578-5
    • Springer D, Peters FT, Fritschi G, Maurer HH (2002) Studies on the metabolism and toxicological detection of the new designer drug 4′-methyl-α-pyrrolidinopropiophenone in urine using gas chromatography-mass spectrometry. J Chromatogr B 773:25-33
    • (2002) J Chromatogr B , vol.773 , pp. 25-33
    • Springer, D.1    Peters, F.T.2    Fritschi, G.3    Maurer, H.H.4
  • 42
    • 0037420911 scopus 로고    scopus 로고
    • New designer drug 4′-methyl-α-pyrrolidinohexanophenone: Studies on its metabolism and toxicological detection in urine using gas chromatography-mass spectrometry
    • 1:CAS:528:DC%2BD3sXjt1Grt7k%3D 10.1016/S1570-0232(03)00043-6
    • Springer D, Peters FT, Fritschi G, Maurer HH (2003) New designer drug 4′-methyl-α-pyrrolidinohexanophenone: studies on its metabolism and toxicological detection in urine using gas chromatography-mass spectrometry. J Chromatogr B 789:79-91
    • (2003) J Chromatogr B , vol.789 , pp. 79-91
    • Springer, D.1    Peters, F.T.2    Fritschi, G.3    Maurer, H.H.4
  • 43
    • 0142165136 scopus 로고    scopus 로고
    • Metabolism of the new designer drug α-pyrrolidinopropiophenone (PPP) and the toxicological detection of PPP and 4′-methyl-α- pyrrolidinopropiophenone (MPPP) studied in rat urine using gas chromatography-mass spectrometry
    • 1:CAS:528:DC%2BD3sXosVyisbo%3D 10.1016/j.jchromb.2003.07.008
    • Springer D, Fritschi G, Maurer HH (2003) Metabolism of the new designer drug α-pyrrolidinopropiophenone (PPP) and the toxicological detection of PPP and 4′-methyl-α-pyrrolidinopropiophenone (MPPP) studied in rat urine using gas chromatography-mass spectrometry. J Chromatogr B 796:253-266
    • (2003) J Chromatogr B , vol.796 , pp. 253-266
    • Springer, D.1    Fritschi, G.2    Maurer, H.H.3
  • 44
    • 0142091104 scopus 로고    scopus 로고
    • Metabolism and toxicological detection of the new designer drug 4′-methoxy-α-pyrrolidinopropiophenone studied in rat urine using gas chromatography-mass spectrometry
    • 1:CAS:528:DC%2BD3sXlvFGiu7Y%3D 10.1016/S1570-0232(03)00334-9
    • Springer D, Fritschi G, Maurer HH (2003) Metabolism and toxicological detection of the new designer drug 4′-methoxy-α- pyrrolidinopropiophenone studied in rat urine using gas chromatography-mass spectrometry. J Chromatogr B 793:331-342
    • (2003) J Chromatogr B , vol.793 , pp. 331-342
    • Springer, D.1    Fritschi, G.2    Maurer, H.H.3
  • 45
    • 0142122818 scopus 로고    scopus 로고
    • Metabolism and toxicological detection of the new designer drug 3′,4′-methylenedioxy-α-pyrrolidinopropiophenone studied in urine using gas chromatography-mass spectrometry
    • 1:CAS:528:DC%2BD3sXlvFGhsr0%3D 10.1016/S1570-0232(03)00350-7
    • Springer D, Fritschi G, Maurer HH (2003) Metabolism and toxicological detection of the new designer drug 3′,4′-methylenedioxy-α- pyrrolidinopropiophenone studied in urine using gas chromatography-mass spectrometry. J Chromatogr B 793:377-388
    • (2003) J Chromatogr B , vol.793 , pp. 377-388
    • Springer, D.1    Fritschi, G.2    Maurer, H.H.3
  • 46
    • 24044529175 scopus 로고    scopus 로고
    • Studies on the metabolism and toxicological detection of the new designer drug 4′-methyl-α-pyrrolidinobutyrophenone (MPBP) in rat urine using gas chromatography-mass spectrometry
    • 1:CAS:528:DC%2BD2MXpslyntbs%3D 10.1016/j.jchromb.2005.07.003
    • Peters FT, Meyer MR, Fritschi G, Maurer HH (2005) Studies on the metabolism and toxicological detection of the new designer drug 4′-methyl-α-pyrrolidinobutyrophenone (MPBP) in rat urine using gas chromatography-mass spectrometry. J Chromatogr B 824:81-91
    • (2005) J Chromatogr B , vol.824 , pp. 81-91
    • Peters, F.T.1    Meyer, M.R.2    Fritschi, G.3    Maurer, H.H.4
  • 47
    • 67649201776 scopus 로고    scopus 로고
    • New designer drug α-pyrrolidinovalerophenone (PVP): Studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques
    • 1:CAS:528:DC%2BD1MXosVCmtrs%3D 19241365 10.1002/jms.1571
    • Sauer C, Peters FT, Haas C, Meyer MR, Fritschi G, Maurer HH (2009) New designer drug α-pyrrolidinovalerophenone (PVP): studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques. J Mass Spectrom 44:952-964
    • (2009) J Mass Spectrom , vol.44 , pp. 952-964
    • Sauer, C.1    Peters, F.T.2    Haas, C.3    Meyer, M.R.4    Fritschi, G.5    Maurer, H.H.6
  • 48
    • 77955858928 scopus 로고    scopus 로고
    • Toxicological determination and in vitro metabolism of the designer drug methylenedioxypyrovalerone (MPDV) by gas chromatography/mass spectrometry and liquid chromatography/quadrupole time-of-flight mass spectrometry
    • 1:CAS:528:DC%2BC3cXhtFWhu7rO 10.1002/rcm.4692
    • Strano-Rossi S, Cadwallader AB, de la Torre X, Botrè F (2010) Toxicological determination and in vitro metabolism of the designer drug methylenedioxypyrovalerone (MPDV) by gas chromatography/mass spectrometry and liquid chromatography/quadrupole time-of-flight mass spectrometry. Rapid Comm Mass Spectrom 24:2706-2714
    • (2010) Rapid Comm Mass Spectrom , vol.24 , pp. 2706-2714
    • Strano-Rossi, S.1    Cadwallader, A.B.2    De La Torre, X.3    Botrè, F.4
  • 49
    • 78650716854 scopus 로고    scopus 로고
    • Studies on the metabolism of the α-pyrrolidinophenone designer drug methylenedioxy-pyrovalerone (MDPV) in rat and human urine and human liver microsomes using GC-MS and LC-high-resolution MS and its detectability in urine by GC-MS
    • 1:CAS:528:DC%2BC3cXhs1Wntr3F 21053377 10.1002/jms.1859
    • Meyer MR, Du P, Schuster F, Maurer HH (2010) Studies on the metabolism of the α-pyrrolidinophenone designer drug methylenedioxy-pyrovalerone (MDPV) in rat and human urine and human liver microsomes using GC-MS and LC-high-resolution MS and its detectability in urine by GC-MS. J Mass Spectrom 45:1426-1442
    • (2010) J Mass Spectrom , vol.45 , pp. 1426-1442
    • Meyer, M.R.1    Du, P.2    Schuster, F.3    Maurer, H.H.4
  • 50
    • 84881366722 scopus 로고    scopus 로고
    • In silico and in vitro metabolism studies support identification of designer drugs in human urine by liquid chromatography/quadrupole-time-of-flight mass spectrometry
    • 23797910 10.1007/s00216-013-7137-1
    • Tyrkkö E, Pelander A, Ketola R, Ojanperä I (2013) In silico and in vitro metabolism studies support identification of designer drugs in human urine by liquid chromatography/quadrupole-time-of-flight mass spectrometry. Anal Bioanal Chem 405:6697-6709
    • (2013) Anal Bioanal Chem , vol.405 , pp. 6697-6709
    • Tyrkkö, E.1    Pelander, A.2    Ketola, R.3    Ojanperä, I.4
  • 51
    • 84895144130 scopus 로고    scopus 로고
    • Time-course profile of urinary excretion of intravenously administered α-pyrrolidinovalerophenone and α-pyrrolidinobutiophenone in a human
    • 10.1007/s11419-013-0203-8
    • Namera A, Konuma K, Kawamura M, Saito T, Nakamoto A, Yahata M, Ohta S, Miyazaki S, Shiraishi H, Nagao M (2013) Time-course profile of urinary excretion of intravenously administered α-pyrrolidinovalerophenone and α-pyrrolidinobutiophenone in a human. Forensic Toxicol. doi: 10.1007/s11419-013-0203-8
    • (2013) Forensic Toxicol
    • Namera, A.1    Konuma, K.2    Kawamura, M.3    Saito, T.4    Nakamoto, A.5    Yahata, M.6    Ohta, S.7    Miyazaki, S.8    Shiraishi, H.9    Nagao, M.10
  • 53
    • 0016139001 scopus 로고
    • The identification of four metabolic products after incubation of p-methoxyamphetamine with liver preparations of various species
    • 1:CAS:528:DyaE2MXhtV2rug%3D%3D 4407064 10.3109/00498257409052058
    • Beckett AH, Midha KK (1974) The identification of four metabolic products after incubation of p-methoxyamphetamine with liver preparations of various species. Xenobiotica 4:297-311
    • (1974) Xenobiotica , vol.4 , pp. 297-311
    • Beckett, A.H.1    Midha, K.K.2
  • 54
    • 0017572111 scopus 로고
    • The metabolism of p-methoxyamphetamine in dog and monkey. O-Demethylation as a major route
    • 1:CAS:528:DyaE2sXlsVGmsrs%3D 19212
    • Hubbard JW, Midha KK, Cooper JK (1977) The metabolism of p-methoxyamphetamine in dog and monkey. O-Demethylation as a major route. Drug Metab Dispos 5:329-334
    • (1977) Drug Metab Dispos , vol.5 , pp. 329-334
    • Hubbard, J.W.1    Midha, K.K.2    Cooper, J.K.3
  • 55
    • 0018674294 scopus 로고
    • Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine
    • 1:CAS:528:DyaL3cXht1WntLk%3D 582863 10.3109/00498257909038744
    • Kitchen I, Tremblay J, André J, Dring LG, Idle JR, Smith RL, Williams RT (1979) Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine. Xenobiotica 9:397-404
    • (1979) Xenobiotica , vol.9 , pp. 397-404
    • Kitchen, I.1    Tremblay, J.2    André, J.3    Dring, L.G.4    Idle, J.R.5    Smith, R.L.6    Williams, R.T.7
  • 56
    • 0242585357 scopus 로고    scopus 로고
    • New designer drug p-methoxymethamphetamine: Studies on its metabolism and toxicological detection in urine using gas chromatography-mass spectrometry
    • 1:CAS:528:DC%2BD3sXjt1Grt7w%3D 10.1016/S1570-0232(02)01018-8
    • Staack RF, Fehn J, Maurer HH (2003) New designer drug p-methoxymethamphetamine: studies on its metabolism and toxicological detection in urine using gas chromatography-mass spectrometry. J Chromatogr B 789:27-41
    • (2003) J Chromatogr B , vol.789 , pp. 27-41
    • Staack, R.F.1    Fehn, J.2    Maurer, H.H.3
  • 57
    • 19944368433 scopus 로고    scopus 로고
    • Metabolism of designer drugs of abuse
    • 1:CAS:528:DC%2BD2MXkvF2isL4%3D 15975043 10.2174/1389200054021825
    • Staack RF, Maurer HH (2005) Metabolism of designer drugs of abuse. Curr Drug Metab 6:259-274
    • (2005) Curr Drug Metab , vol.6 , pp. 259-274
    • Staack, R.F.1    Maurer, H.H.2
  • 58
    • 41049107611 scopus 로고    scopus 로고
    • Determination of a newly encountered designer drug "p- methoxyethylamphetamine" and its metabolites in human urine and blood
    • 1:CAS:528:DC%2BD1cXktV2jsb8%3D 18155375 10.1016/j.forsciint.2007.11.001
    • Zaitsu K, Katagi M, Kamata T, Kamata H, Shima N, Tsuchihashi H, Hayashi T, Kuroki H, Matoba R (2008) Determination of a newly encountered designer drug "p-methoxyethylamphetamine" and its metabolites in human urine and blood. Forensic Sci Int 177:77-84
    • (2008) Forensic Sci Int , vol.177 , pp. 77-84
    • Zaitsu, K.1    Katagi, M.2    Kamata, T.3    Kamata, H.4    Shima, N.5    Tsuchihashi, H.6    Hayashi, T.7    Kuroki, H.8    Matoba, R.9
  • 60
    • 33746882802 scopus 로고    scopus 로고
    • Metabolism of the recently encountered designer drug, methylone, in humans and rats
    • 1:CAS:528:DC%2BD28XpsFentbs%3D 16891251 10.1080/00498250600780191
    • Kamata HT, Shima N, Zaitsu K, Kamata T, Miki A, Nishikawa M, Katagi M, Tsuchihashi H (2006) Metabolism of the recently encountered designer drug, methylone, in humans and rats. Xenobiotica 36:709-723
    • (2006) Xenobiotica , vol.36 , pp. 709-723
    • Kamata, H.T.1    Shima, N.2    Zaitsu, K.3    Kamata, T.4    Miki, A.5    Nishikawa, M.6    Katagi, M.7    Tsuchihashi, H.8
  • 61
    • 39349110177 scopus 로고    scopus 로고
    • Urinary excretion of the main metabolites of 3,4- methylenedioxymethamphetamine (MDMA), including the sulfate and glucuronide of 4-hydroxy-3-methoxymethamphetamine (HMMA), in humans and rats
    • 1:CAS:528:DC%2BD1cXhvVeqtL8%3D 18274959 10.1080/00498250701802506
    • Shima N, Katagi M, Kamata H, Zaitsu K, Kamata T, Nishikawa M, Miki A, Tsuchihashi H, Sakuma T, Nemoto N (2008) Urinary excretion of the main metabolites of 3,4-methylenedioxymethamphetamine (MDMA), including the sulfate and glucuronide of 4-hydroxy-3-methoxymethamphetamine (HMMA), in humans and rats. Xenobiotica 38:314-324
    • (2008) Xenobiotica , vol.38 , pp. 314-324
    • Shima, N.1    Katagi, M.2    Kamata, H.3    Zaitsu, K.4    Kamata, T.5    Nishikawa, M.6    Miki, A.7    Tsuchihashi, H.8    Sakuma, T.9    Nemoto, N.10
  • 62
    • 67349215762 scopus 로고    scopus 로고
    • Determination of the metabolites of the new designer drugs bk-MBDB and bk-MDEA in human urine
    • 1:CAS:528:DC%2BD1MXmtlKgsL8%3D 19406592 10.1016/j.forsciint.2009.04.001
    • Zaitsu K, Katagi M, Kamata HT, Kamata T, Shima N, Miki A, Tsuchihashi H, Mori Y (2009) Determination of the metabolites of the new designer drugs bk-MBDB and bk-MDEA in human urine. Forensic Sci Int 188:131-139
    • (2009) Forensic Sci Int , vol.188 , pp. 131-139
    • Zaitsu, K.1    Katagi, M.2    Kamata, H.T.3    Kamata, T.4    Shima, N.5    Miki, A.6    Tsuchihashi, H.7    Mori, Y.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.