The novel recreational drug 3,4-methylenedioxypyrovalerone (MDPV) is a potent psychomotor stimulant: Self-administration and locomotor activity in rats

Neuropharmacology

Volumn 71, Issue , 2013, Pages 130-140

  Aarde, S M ^a   Huang, P K ^a   Creehan, K M ^a   Dickerson, T J ^a   Taffe, M A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Bath salts; Locomotor; Self administration; Thermoregulation

Indexed keywords

3,4 METHYLENEDIOXYPYROVALERONE; METHAMPHETAMINE; RECREATIONAL DRUG; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG SELF ADMINISTRATION; IMPLANT; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOTYPY; TELEMETRY; THERMOREGULATION;

ANIMALS; BEHAVIOR, ANIMAL; BENZODIOXOLES; BODY TEMPERATURE REGULATION; DESIGNER DRUGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERKINESIS; INFUSIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; MALE; METHAMPHETAMINE; MOTOR ACTIVITY; PSYCHOMOTOR AGITATION; PSYCHOTROPIC DRUGS; PYRROLIDINES; RANDOM ALLOCATION; RATS; RATS, WISTAR; SELF ADMINISTRATION; STEREOTYPIC MOVEMENT DISORDER; SUBSTANCE-RELATED DISORDERS;

EID: 84878135503     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.04.003     Document Type: Article

References (40)

1. S.M. Aarde, D. Angrish, D.J. Barlow, M.J. Wright Jr., S.A. Vandewater, K.M. Creehan, K.L. Houseknecht, T.J. Dickerson, and M.A. Taffe Mephedrone (4-methylmethcathinone) supports intravenous self-administration in Sprague-Dawley and Wistar rats Addiction Biology 2013 10.1111/adb.12038
2. S.M. Aarde, P.-K. Huang, K.M. Creehan, B.D. Vaillancourt, S.A. Vandewater, M.J. Wright, M.L. Miller, and M.A. Taffe Methylenedioxypyrovalerone (MDPV): self-administration and acute drug challenges in rats The FASEB Journal 26 2012 1040 1045
3. S.M. Aarde, J.M.J. Wright, M.W. Buczynski, D. Angrish, L.H. Parsons, K.L. Houseknecht, T.J. Dickerson, and M.A. Taffe Behavioral and thermoregulatory effects of novel cathinone derivative drugs 4-MMC and MDPV Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 36 2011 S441
4. C.T. Bauer, M.L. Banks, B.E. Blough, and S.S. Negus Use of intracranial self-stimulation to evaluate abuse-related and abuse-limiting effects of monoamine releasers in rats British Journal of Pharmacology 168 2013 850 862
5. M.H. Baumann, J.S. Partilla, K.R. Lehner, E.B. Thorndike, A.F. Hoffman, M. Holy, R.B. Rothman, S.R. Goldberg, C.R. Lupica, H.H. Sitte, S.D. Brandt, S.R. Tella, N.V. Cozzi, and C.W. Schindler Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 38 2013 552 562
6. F. Benzie, K. Hekman, L. Cameron, D.R. Wade, and S. Smolinske Emergency department visits after use of a drug sold as "bath salts" - Michigan, November 13, 2010-March 31, 2011 Morbidity and Mortality Weekly Report 60 2011 624 627
7. S.B. Caine, R. Lintz, and G.F. Koob Intravenous drug self-administration techniques in animals A. Sahgal, Behavioral Neuroscience: a Practical Approach 1993 Oxford University Press New York, NY 117 143
8. J.D. Clark, R.L. Baldwin, K.A. Bayne, M.J. Brown, G.F. Gebhart, J.C. Gonder, J.K. Gwathmey, M.E. Keeling, D.F. Kohn, J.W. Robb, O.A. Smith, J.-A.D. Steggarda, J.G. Vandenbergh, W.J. White, S. Williams-Blangero, and J.L. VandeBerg Guide for the Care and Use of Laboratory Animals 1996 Institute of Laboratory Animal Resources, National Research Council Washington D.C. 125
9. M.W. Emmett-Oglesby, and J.D. Lane Tolerance to the reinforcing effects of cocaine Behavioural Pharmacology 3 1992 193 200
10. W.E. Fantegrossi, B.M. Gannon, S.M. Zimmerman, and K.C. Rice In vivo effects of abused 'bath salt' constituent 3,4-methylenedioxypyrovalerone (MDPV) in mice: drug discrimination, thermoregulation, and locomotor activity Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 38 2013 563 573
11. R. Fog, and A. Randrup Commentary on: "Stereotyped activities produced by amphetamine in several animal species and man." Psychopharmacologia (1967) 11: 300-310. A landmark publication from the early days of the dopamine hypothesis Psychopharmacology 162 2002 349 350
12. T. Fuwa, T. Kodama, Y. Honda, T. Tanaka, Y. Kubo, N. Ohashi, D. Nakae, and A. Ogata Influence of methylenedioxypyrovalerone on central nervous system using microdialysis method ChemoBio Integrated Management 5 2009 62 72
13. B.A. Gosnell, J.M. Yracheta, S.M. Bell, and K.E. Lane Intravenous self-administration of cathinone by rats Behavioural Pharmacology 7 1996 526 531
14. G.C. Hadlock, K.M. Webb, L.M. McFadden, P.W. Chu, J.D. Ellis, S.C. Allen, D.M. Andrenyak, P.L. Vieira-Brock, C.L. German, K.M. Conrad, A.J. Hoonakker, J.W. Gibb, D.G. Wilkins, G.R. Hanson, and A.E. Fleckenstein 4- Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse The Journal of Pharmacology and Experimental Therapeutics 339 2011 530 536
15. W. Hodos Progressive ratio as a measure of reward strength Science (New York, NY) 134 1961 943 944
16. P.K. Huang, S.M. Aarde, D. Angrish, K.L. Houseknecht, T.J. Dickerson, and M.A. Taffe Contrasting effects of d-methamphetamine, 3,4- methylenedioxymethamphetamine, 3,4-methylenedioxypyrovalerone, and 4-methylmethcathinone on wheel activity in rats Drug and Alcohol Dependence 126 2012 168 175
17. C.E. Johanson, and C.R. Schuster A comparison of the behavioral effects of l- and dl-cathinone and d-amphetamine The Journal of Pharmacology and Experimental Therapeutics 219 1981 355 362
18. B.J. Kaminski, and R.R. Griffiths Intravenous self-injection of methcathinone in the baboon Pharmacology Biochemistry and Behavior 47 1994 981 983
19. P.R. Killeen, D. Posadas-Sanchez, E.B. Johansen, and E.A. Thrailkill Progressive ratio schedules of reinforcement Journal of Experimental Psychology Animal Behavior Processes 35 2009 35 50
20. C. Kincaid Guidelines for Selecting the Covariance Structure in Mixed Model Analysis 2005 SAS Institute Inc Philadelphia, Pennsylvania
21. O. Kitamura, S. Wee, S.E. Specio, G.F. Koob, and L. Pulvirenti Escalation of methamphetamine self-administration in rats: a dose-effect function Psychopharmacology 186 2006 48 53
22. J.A. Marusich, K.R. Grant, B.E. Blough, and J.L. Wiley Effects of synthetic cathinones contained in "bath salts" on motor behavior and a functional observational battery in mice Neurotoxicology 33 2012 1305 1313
23. M.L. Miller, K.M. Creehan, D. Angrish, D.J. Barlow, K.L. Houseknecht, T.J. Dickerson, and M.A. Taffe Changes in ambient temperature differentially alter the thermoregulatory, cardiac and locomotor stimulant effects of 4-methylmethcathinone (mephedrone) Drug and Alcohol Dependence 127 2013 248 253
24. M.L. Miller, A.Y. Moreno, S.M. Aarde, K.M. Creehan, S.A. Vandewater, B.D. Vaillancourt, M.J. Wright Jr., K.D. Janda, and M.A. Taffe A methamphetamine vaccine attenuates methamphetamine-induced disruptions in thermoregulation and activity in rats Biological Psychiatry 2012 10.1016/j.biopsych.2012.09.010
25. B.J. Myles, L.A. Jarrett, S.L. Broom, H.A. Speaker, and K.E. Sabol The effects of methamphetamine on core body temperature in the rat - part 1: chronic treatment and ambient temperature Psychopharmacology 198 2008 301 311
26. T.M. Penders, and R. Gestring Hallucinatory delirium following use of MDPV: "bath salts" General Hospital Psychiatry 33 2011 525 526
27. G. Phelps, H.A. Speaker, and K.E. Sabol Relationship between methamphetamine-induced behavioral activation and hyperthermia Brain Research 1357 2010 41 52
28. N.R. Richardson, and D.C. Roberts Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy Journal of Neuroscience Methods 66 1996 1 11
29. B.L. Roth, E. Lopez, S. Patel, and W.K. Kroeze The multiplicity of serotonin receptors: uselessly diverse molecules or an embarrasment of riches? The Neuroscientist 6 2000 252 262
30. R.B. Rothman, M.H. Baumann, C.M. Dersch, D.V. Romero, K.C. Rice, F.I. Carroll, and J.S. Partilla Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin Synapse 39 2001 32 41
31. R.B. Rothman, N. Vu, J.S. Partilla, B.L. Roth, S.J. Hufeisen, B.A. Compton-Toth, J. Birkes, R. Young, and R.A. Glennon In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates The Journal of Pharmacology and Experimental Therapeutics 307 2003 138 145
32. C.R. Schuster, and C.E. Johanson Behavioral studies on cathinone in monkeys and rats NIDA Research Monographs 27 1979 324 325
33. D.S. Segal, and A.J. Mandell Long-term administration of d-amphetamine: progressive augmentation of motor activity and stereotypy Pharmacology Biochemistry and Behavior 2 1974 249 255
34. L. Simmler, T. Buser, M. Donzelli, Y. Schramm, L.H. Dieu, J. Huwyler, S. Chaboz, M. Hoener, and M. Liechti Pharmacological characterization of designer cathinones in vitro British Journal of Pharmacology 168 2013 458 470
35. H.A. Spiller, M.L. Ryan, R.G. Weston, and J. Jansen Clinical experience with and analytical confirmation of "bath salts" and "legal highs" (synthetic cathinones) in the United States Clinical Toxicology (Philadelphia) 49 2011 499 505
36. Z. Wang, and L.A. Goonewardene The use of MIXED models in the analysis of animal experiments with repeated measures data Canadian Journal of Animal Science 84 2004 1 11
37. L.R. Watterson, P.R. Kufahl, N.E. Nemirovsky, K. Sewalia, M. Grabenauer, B.F. Thomas, J.A. Marusich, S. Wegner, and M.F. Olive Potent rewarding and reinforcing effects of the synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV) Addiction Biology 2012 10.1111/j.1369-1600.2012.00474.x
38. S. Wee, Z. Wang, W.L. Woolverton, L. Pulvirenti, and G.F. Koob Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 32 2007 2238 2247
39. W.L. Woolverton, and C.E. Johanson Preference in rhesus monkeys given a choice between cocaine and d, l-cathinone Journal of the Experimental Analysis of Behavior 41 1984 35 43
40. M.J. Wright Jr., D. Angrish, S.M. Aarde, D.J. Barlow, M.W. Buczynski, K.M. Creehan, S.A. Vandewater, L.H. Parsons, K.L. Houseknecht, T.J. Dickerson, and M.A. Taffe Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone in Wistar and Sprague-Dawley rats PloS One 7 2012 e44652