Triennial growth symposium-vitamin D: Bones and beyond

Journal of Animal Science

Volumn 92, Issue 3, 2014, Pages 917-929

  DeLuca, H F ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Calcium; Osteomalacia; Phosphorus; Rickets; Vitamin D

Indexed keywords

DRUG ADMINISTRATION; PHARMACOLOGY; VITAMIN D;

ANIMAL; BONE DEVELOPMENT; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM;

ADMINISTRATION AND DOSAGE; ANIMALS; BONE DEVELOPMENT; CHEMISTRY; DRUG EFFECTS; HUMANS; METABOLISM; MOLECULAR STRUCTURE; PHARMACOLOGY; VITAMIN D;

EID: 84895114560     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2013-7237     Document Type: Article

References (121)

1. 3. Proc. Natl. Acad. Sci. USA 78:4990-4994.
2. 2+ absorption in small intestine. Arch. Biochem. Biophys. 460:227-232.
3. Askew, F. A., R. B. Bourdillon, H. M. Bruce, R. G. C. Jenkins, and T. A. Webster. 1930. The distillation of vitamin D. Proc. R. Soc. Lond., B 107:76-90.
4. Baker, A. R., D. P. McDonnell, M. Hughes, T. M. Crisp, D. J. Mangelsdorf, M. R. Haussler, J. W. Pike, J. Shine, and B. W. O'Malley. 1988. Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc. Natl. Acad. Sci. USA 85:3294-3298.
5. Balsan, S., M. Garabedian, U. A. Liberman, C. Eil, A. Bourdeau, H. Guillozo, R. Grimberg, M. J. Le Deunff, M. Lieberherr, P. Guimbaud, M. Broyer, and S. J. Marx. 1983. Rickets and alopecia with resistance to 1,25-dihydroxyvitamin D: Two different clinical courses with two different cellular defects. J. Clin. Endocrinol. Metab. 57:803-811.
6. Bauer, G. C. H., A. Carlsson, and B. Lindquist. 1955. Evaluation of accretion, resorption and exchange reactions in the skeleton. Kungl. Fysiograf. Sallskapets I. Lund Forhandlingar 25:3-18.
7. Becklund, B. R., K. S. Severson, S. V. Vang, and H. F. DeLuca. 2010. UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production. Proc. Natl. Acad. Sci. USA 107:6418-6423.
8. 3-24-hydroxylase, a multicatalytic enzyme. Biochemistry 35:8465-8472.
9. Bills, C. E. 1954. The vitamins. In: W. H. Sebrell Jr. and R. S. Harris, editors, The vitamins II. Academic Press, New York. p. 210-214.
10. Binderup, L., E. Binderup, and W. O. Godtfredsen. 1997. Development of new vitamin D analogs. In: D. Feldman, F. H. Glorieux, and J. W. Pike, editors, Vitamin D. Academic Press, San Diego, CA. p. 1027-1043.
11. Boyle, I. T., R. W. Gray, and H. F. DeLuca. 1971. Regulation by calcium of in vivo synthesis of 1,25-dihydroxycholecalciferol and 21,25-dihydroxycholecalciferol. Proc. Natl. Acad. Sci. USA 68:2131-2134.
12. 3: Nicolaysen's endogenous factor. In: S. Taylor, editor, Endocrinology 1972, Proceedings of the Third International Symposium. Wm. Heinemann Medical Books Ltd., London, UK. p. 468-476.
13. Boyle, I. T., L. Miravet, R. W. Gray, M. F. Holick, and H. F. DeLuca. 1972b. The response of intestinal calcium transport to 25-hydroxy and 1,25-dihydroxy vitamin D in nephrectomized rats. Endocrinology 90:605-608.
14. 3. Biochemistry 8:671-676.
15. 3. Biochemistry 7:3317-3322.
16. 3. Proc. Natl. Acad. Sci. USA 61:1503-1506.
17. Brooks, M. H., N. H. Bell, L. Love, P. H. Stern, E. Orfei, S. F. Queener, A. J. Hamstra, and H. F. DeLuca. 1978. Vitamin D-dependent rickets type II. Resistance of target organs to 1,25-dihydroxyvitamin D. N. Engl. J. Med. 198:966-999.
18. Brown, E. M. 2005. Calcium-sensing receptor. In: D. Feldman, J. W. Pike, and F. H. Glorieux, editors, Vitamin D. Vol. I, 2nd ed. Elsevier Academic Press, Burlington, MA. p. 551-562.
19. Brumbaugh, P. F., and M. R. Haussler. 1975. Specific binding of 1α,25-dihydroxycholecalciferol to nuclear components of chick intestine. J. Biol. Chem. 250:1588-1594.
20. 3 synthesis in the kidney. Nature 276:287-289.
21. 3 receptor cDNA. Proc. Natl. Acad. Sci. USA 85:1005-1009.
22. Cai, Q., J. S. Chandler, R. H. Wasserman, R. Kumar, and J. T. Penniston. 1993. Vitamin D and adaptation to dietary calcium and phosphate deficiencies increase intestinal plasma membrane calcium pump gene expression. Proc. Natl. Acad. Sci. USA 90:1345-1349.
23. 3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc. Natl. Acad. Sci. USA 93:7861-7864.
24. Carlsson, A. 1952. Tracer experiment on the effect of vitamin D on the skeletal metabolism of calcium and phosphorus. Acta Physiol. Scand. 26:212-220.
25. Chen, T. C., L. Castillo, M. Korycka-Dahl, and H. F. DeLuca. 1974. Role of vitamin D metabolites in phosphate transport of rat intestine. J. Nutr. 104:1056-1060.
26. Cheng, J. B., D. L. Motola, D. J. Mangelsdorf, and D. W. Russell. 2003. De-orphanization of cytochrome P450 2R1: A microsomal vitamin D 25-hydroxylase. J. Biol. Chem. 278:38084-38093.
27. Chick, H., E. J. Palzell, and E. M. Humme. 1923. Studies of rickets in Vienna 1919-1922. Medical Research Council, Special Report. No. 77. Her Majesty's Stationery Office, London, UK.
28. Deftos, L. J. 1981. Regulation of calcitonin secretion: Effects of species, age, and sex. In: D. V. Cohn, R. V. Talmage, and J. L. Matthews, editors, Hormonal control of calcium metabolism. Proceedings of the Seventh International Conference on Calcium Regulating Hormones. Excerpta Medica, New York. p. 266-280.
29. DeLuca, H. F. 1967. Mechanism of action and metabolic fate of vitamin D. Vitam. Horm. 25:315-367.
30. DeLuca, H. F. 1974. Vitamin D: The vitamin and the hormone. Fed. Proc. 33:2211-2219.
31. DeLuca, H. F., W. Bedale, N. Binkley, J. C. Gallagher, M. Bolognese, M. Peacock, J. Aloia, M. Clagett-Dame, and L. Plum. 2011. The vitamin D analogue 2MD increases bone turnover but not BMD in postmenopausal women with osteopenia: Results of a 1-year phase 2 double-blind, placebo-controlled, randomized clinical trial. J. Bone Miner. Res. 26:538-545.
32. DeLuca, H. F., Holick, M. F., H. K. Schnoes, T. Suda, and R. J. Cousins. 1971. Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine. Biochemistry 10:2799-2804.
33. DeLuca, H. F., and L. A. Plum. 2011. Vitamin D deficiency diminishes the severity and delays onset of experimental autoimmune encephalomyelitis. Arch. Biochem. Biophys. 513:140-143.
34. 3. Proc. Natl. Acad. Sci. USA 89:8097-8101.
35. Dowdle, E. B., D. Schachter, and H. Schenker. 1960. Requirement for vitamin D for the active transport of calcium by the intestine. Am. J. Physiol. 198:269-275.
36. 3. Biochemistry 18:3977-3983.
37. Fernandes de Abreu, D. A., E. C. Ibrahim, J. Boucraut, M. Khrestchatisky, and F. Féron. 2010. Severity of experimental autoimmune encephalomyelitis is unexpectedly reduced in mice born to vitamin D-deficient mothers. J. Steroid Biochem. Mol. Biol. 121:250-253.
38. Fraser, D. R., and E. Kodicek. 1970. Unique biosynthesis by kidney of a biologically active vitamin D metabolite. Nature 228:764-766.
39. Fraser, D., S. W. Kooh, H. P. Kind, M. F. Holick, Y. Tanaka, and H. F. DeLuca. 1973. Pathogenesis of hereditary vitamin D-dependent rickets. An inborn error of vitamin D metabolism involving defective conversion of 25-hydroxyvitamin D to 1α,25-dihydroxyvitamin D. N. Engl. J. Med. 289:817-822.
40. Frost, H. M. 1966. Bone dynamics in osteoporosis and osteomalacia. Henry Ford Hospital Surgical Monograph Series, Charles A. Thomas Co., Springfield, IL.
41. 3: Short-and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis. Proc. Natl. Acad. Sci. USA 79:3325-3329.
42. Garabedian, M., M. F. Holick, H. F. DeLuca, and I. T. Boyle. 1972. Control of 25-hydroxycholecalciferol metabolism by parathyroid glands. Proc. Natl. Acad. Sci. USA 69:1673-1676.
43. 3 in thyroparathyroidectomized rats. Endocrinology 94:1022-1027.
44. Glorieux, F. H., and R. St-Arnaud. 2005. Vitamin D pseudodeficiency. In: D. Feldman, J. W. Pike, and F. H. Glorieux, editors, Vitamin D. 2nd ed. Elsevier Academic Press, Burlington, MA. p. 1197-1205.
45. Goldberg, P. 1974. Multiple sclerosis: Vitamin D and calcium as environmental determinants of prevalence (a viewpoint). Part 1: Biochemical and genetic factors. Int. J. Environ. Stud. 6:19-27.
46. Gray, R., I. Boyle, and H. F. DeLuca. 1971. Vitamin D metabolism: The role of kidney tissue. Science 172:1232-1234.
47. Havinga, E. 1973. Vitamin D, example and challenge. Experientia 29:1181-1193.
48. Heersche, J. N. M., C. G. Bellow, and J. E. Aubin. 1994. Cellular actions of parathyroid hormone on osteoblast and osteoclast differentiation. In: J. P. Bilezikian, R. Marcus, and M. A. Levine, editors, The parathyroids: Basic and clinical concepts. Raven Press, New York. p. 83-91.
49. 3 active on bone in anephric rats. Science 176:1146-1147.
50. 3 metabolically active in the intestine. Proc. Natl. Acad. Sci. USA 68:803-804.
51. 3 receptors in parathyroid glands. Preliminary characterization of cytoplasmic and nuclear binding components. J. Biol. Chem. 253:1065-1073.
52. Huldshinsky, K. 1919. Heilung von rachitis durch kunstilch hohen-sonne. Deut. Med. Wochenscher. 45:712-713. Z. Orthopad. Chir. 1920, 39:426 (as described in Bills, C. E. 1954. II. Chemistry. In: W. H. Sebrell Jr. and R. S. Harris, editors, The vitamins chemistry, physiology, pathology, vol. 2, Academic Press, New York, NY. p.162).
53. Institute of Medicine. 2011. Institute of Medicine committee to review dietary reference intakes for vitamin D and calcium. Food and Nutrition Board, National Academies. A. C. Ross, C. L. Taylor, A. L. Yaktine, and H. B. Del Valle, editors. The National Academies Press, Washington, DC. p. 135-147.
54. Irving, A. A., R. B. Halberg, D. M. Albrecht, L. A. Plum, K. J. Krentz, L. Clipson, N. Drinkwater, J. M. Amos-Landgraf, W. F. Dove, and H. F. DeLuca. 2011. Supplementation by vitamin D compounds does not affect colonic tumor development in vitamin D sufficient murine models. Arch. Biochem. Biophys. 515:64-71.
55. Jenkins, J. W. 1991. A centennial history: A history of the College of Agricultural and Life Sciences at the University of Wisconsin-Madison. College of Agricultural and Life Sciences, University of Wisconsin, Madison. p. 81-84.
56. Jones, G., S. A. Strugnell, and H. F. DeLuca. 1998. Current understanding of the molecular actions of vitamin D. Physiol. Rev. 78:1193-1231.
57. Kallfelz, F. A., A. N. Taylor, and R. H. Wasserman. 1967. Vitamin D-induced calcium-binding factor in rat intestinal mucosa. Proc. Soc. Exp. Biol. Med. 125:54-58.
58. Ke, H. Z., H. Qi, D. T. Crawford, H. A. Simmons, G. Xu, M. Li, L. Plum, M. Clagett-Dame, H. F. DeLuca, D. D. Thompson, and T. A. Brown. 2005. A new vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia. J. Bone Miner. Res. 20:1742-1755.
59. Kodicek, E. 1956. Metabolic studies on vitamin D. In: G. W. E. Wolstenholme and C. M. O'Connor, editors, Ciba Foundation symposium on bone structure and metabolism. Little, Brown and Co., Boston, MA. p. 161-174.
60. Kragballe, K., B. T. Gjertsen, D. de Hoop, T. Karlsmark, P. C. M. van de Kerhof, O. Larko, C. Nieboer, J. Roed-Petersn, A. Strand, and B. Tikjob. 1991. Double-blind right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris. Lancet 337:193-196.
61. 3. Arch. Biochem. Biophys. 176:779-787.
62. Kumar, R. 1995. Calcium transport in epithelial cells of the intestine and kidney. 1995. J. Cell. Biochem. 57:392-398.
63. Kutuzova, G. D., F. Sundersingh, J. Vaughan, B. P. Tadi, S. E. Ansay, S. Christakos, and H. F. DeLuca. 2008. TRPV6 is not required for 1α,25-dihydroxyvitamin D3-induced intestinal calcium absorption in vivo. Proc. Natl. Acad. Sci. USA 105:19655-19659.
64. Lamm, M., and W. F. Neuman. 1958. On the role of vitamin D in calcification. Arch. Pathol. 66:204-209.
65. 3. Am. J. Physiol. 251:G90-G95.
66. Li, Y. C., A. E. Pirro, M. Amling, G. Delling, R. Baron, R. Bronson, and M. B. Demay. 1997. Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type II with alopecia. Proc. Natl. Acad. Sci. USA 94:9831-9835.
67. 2. Am. J. Kidney Dis. 32:S48-S54.
68. 3 from bone, liver, and blood serum. J. Lipid Res. 7:739-744.
69. Malloy, P. J., J. W. Pike, and D. Feldman. 2005. Hereditary 1,25-dihydroxyvitamin D resistant rickets. In: D. Feldman, J. W. Pike, and F. H. Glorieux, editors, Vitamin D. Vol. 2, 2nd ed., chapter 72. Elsevier Academic Press, Burlington, MA. p. 1207-1237.
70. McCollum, E. V., and M. Davis. 1913. The necessity of certain lipins in the diet during growth. J. Biol. Chem. 25:167-175.
71. McCollum, E. V., N. Simmonds, J. E. Becker, and P. G. Shipley. 1922. An experimental demonstration of the existence of a vitamin which promotes calcium deposition. J. Biol. Chem. 53:293-298.
72. McCollum, E. V., N. Simmons, and W. Pitz. 1916. The relation of the unidentified dietary factors, the fat-soluble A and water-soluble B of the diet to the growth promoting properties of milk. J. Biol. Chem. 27:33-38.
73. Meehan, T. F., J. Vanhooke, J. Prahl, and H. F. DeLuca. 2005. Hypercalcemia produced by parathyroid hormone suppresses experimental autoimmune encephalomyelitis in female but not male mice. Arch. Biochem. Biophys. 442:214-221.
74. Mellanby, E. 1919. An experimental investigation on rickets. Lancet 1:407-412.
75. 3 receptors on osteoclasts of calciumdeficient chicken despite demonstrable receptors on circulating monocytes. J. Clin. Invest. 77:312-314.
76. Morii, H., J. Lund, P. F. Neville, and H. F. DeLuca. 1967. Biological activity of a vitamin D metabolite. Arch. Biochem. Biophys. 120:508-512.
77. 3 and the tissue localization of a 0.25 μg (10 IU) dose per rat. Biochemistry 5:2201-2207.
78. Nicolaysen, R. 1937. Studies upon the mode of action of vitamin D. III. The influence of vitamin D on the absorption of calcium and phosphorus in the rat. Biochem. J. 31:122-129.
79. Nicolaysen, R., N. Eeg-Larsen, and O. J. Malm. 1953. Physiology of calcium metabolism. Physiol. Rev. 33:424-444.
80. 3 mediated rapid and genomic responses are dependent upon critical structure-function relationships for both the ligand and receptor(s). In: D. Feldman, J. W. Pike, and F. H. Glorieux, editors, Vitamins. Vol. II, 2nd ed. Elsevier Academic Press, Burlington, MA. p. 381-410.
81. 3 and their localization in the rat. Biochemistry 2:1160-1168.
82. Omdahl, J. L., and B. May. 2005. The 25-hydroxyvitamin D 24-hydroxylase. In: D. Feldman, J. W. Pike, and F. H. Glorieux, editors, Vitamin D. Vol. I, 2nd ed. Elsevier Academic Press, Burlington, MA. p. 85-104.
83. Osborne, T. B., and L. B. Mendel. 1917. The role of vitamins in the diet. J. Biol. Chem. 31:149-163.
84. 3) for the treatment of psoriasis. Br. J. Dermatol. 134:238-246.
85. Pike, J. W. 2011. Genome-wide principles of gene regulation by the vitamin D receptor and its activating ligand. Mol. Cell. Endocrinol. 347:3-10.
86. Plum, L. A., L. A. Fitzpatrick, X. Ma, N. C. Binkley, J. B. Zella, M. Clagett-Dame, and H. F. DeLuca. 2006. 2MD, a new anabolic agent for osteoporosis treatment. Osteoporos. Int. 17:704-715.
87. Rasmussen, H., H. DeLuca, C. Arnaud, C. Hawker, and M. von Stedingk. 1963. The relationship between vitamin D and parathyroid hormone. J. Clin. Invest. 42:1940-1946.
88. Rochel, N., J. M. Wurtz, A. Mitschler, B. Klaholz, and D. Moras. 2000. The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. Mol. Cell 5:173-179.
89. 3 receptor in the male rat. Biochem. Biophys. Res. Commun. 181:611-616.
90. Schlingmann, K. P., M. Kaufmann, S. Weber, A. Irwin, C. Goos, U. John, J. Misselwitz, G. Klaus, E. Kuwertz-Bröking, H. Fehrenbach, A. M. Wingen, T. Güran, J. G. Hoenderop, R. J. Bindels, D. E. Prosser, G. Jones, and M. Konrad. 2011. Mutations in CYP24A1 and idiopathic infantile hypercalcemia. N. Engl. J. Med. 365:410-421.
91. 3. Tetrahedron Lett. 13:4147-4150.
92. 3 selectively induces bone formation. Proc. Natl. Acad. Sci. USA 99:13487-13491.
93. Singarapu, K. K., J. Zhu, M. Tonelli, H. Rao, F. M. Assadi-Porter, W. M. Westler, H. F. DeLuca, and J. L. Markley. 2011. Ligandspecific structural changes in the vitamin D receptor in solution. Biochemistry 50:11025-11033.
94. 3-1α-hydroxylase cDNA. Proc. Natl. Acad. Sci. USA 94:12920-12925.
95. 3-1α-hydroxylase gene in normocalcemic rats. Proc. Natl. Acad. Sci. USA 96:8253-8258.
96. Silver, J., and T. Naveh-Many. 2005. Vitamin D and the parathyroids. In: D. Feldman, J. W. Pike, and F. H. Glorieux, editors, Vitamin D. Vol. 1, 2nd ed. Elsevier Academic Press, Burlington, MA. p. 537-549.
97. Slatopolsky, E. A. B., and A. Dusso. 2005. Calcium, phosphorus and vitamin D disorders in uremia. Contrib. Nephrol. 149:262-271.
98. Slatopolsky, E., J. L. Finch, A. J. Brown, C. S. Ritter, M. Mizobuchi, L. A. Plum, M. Clagett-Dame, R. R. Sicinski, and H. F. DeLuca. 2007. Effect of 2-methylene-19-nor-(20S)-1α-hydroxybishomopregnacalciferol (2MbisP), an analog of vitamin D, on secondary hyperparathyroidism. J. Bone Miner. Res. 22:686-694.
99. 3 in the intestine and kidney of mice. Endocrinology 144:3885-3894.
100. St. Arnaud, R., S. Messerlian, J. M. Moir, J. L. Omdahl, and F. H. Glorieux. 1997. The 25-hydroxyvitamin D 1α-hydroxylase gene maps to the pseudovitamin D deficiency rickets (PDDR) disease locus. J. Bone Miner. Res. 12:1552-1558.
101. Steenbock, H. 1924. The induction of growth promoting and calcifying properties in a ration by exposure to light. Science 60:224-225.
102. Steenbock, H., and A. Black. 1924. Fat-soluble vitamins. XVII. The induction of growth-promoting and calcifying properties in a ration by exposure to ultraviolet light. J. Biol. Chem. 61:405-422.
103. Steenbock, H., and A. Black. 1925. Fat-soluble vitamins. XXIII. The induction of growth-promoting and calcifying properties in rats and their unsaponifiable constituents by exposure to light. J. Biol. Chem. 64:263-298.
104. 3 identified by thaw-munt autoradiography. In: D. V. Cohn, R. V. Talmage, and J. L. Matthews, editors, Hormonal control of calcium metabolism, Proceedings of Seventh International Conference on Calcium Regulating Hormones. Excerpta Medica, Amsterdam-Oxford-Princeton. p. 222-229.
105. 3 in intestinal tract, stomach, kidney, skin, pituitary and parathyroid. Science 206:1188-1190.
106. Suda, T., H. F. DeLuca, and R. B. Hallick. 1971. Synthesis of [26,27-3H]-25-hydroxycholecaliferol. Anal. Biochem. 43:139-146.
107. 3-1α-hydroxylase and vitamin D synthesis. Science 277:1827-1830.
108. 3 receptors. Cell 65:1255-1266.
109. 3 hormone analogues and a LXXLL-containing coactivator peptide. Biochemistry 43:4101-4110.
110. Velluz, L., G. Amiard, and A. Petit. 1949. Le precalciferol-ses relations d'equilibre avc le calciferol. (In French.) Bull. Soc. Chim. Fr. 16:501-508.
111. Walling, M. W., and S. S. Rothman. 1969. Phosphate-independent, carrier-mediated active transport of calcium by rat intestine. Am. J. Physiol. 217:1144-1148.
112. Wang, Y., S. J. Marling, S. M. McKnight, A. L. Danielson, K. S. Severson, and H. F. DeLuca. 2013. Suppression of experimental autoimmune encephalomyelitis by 300-315 nm ultraviolet light. Arch. Biochem. Biophys. 536:81-86.
113. Wang, Y., S. J. Marling, J. G. Zhu, K. S. Severson, and H. F. DeLuca. 2012a. Development of experimental autoimmune encephalomyelitis (EAE) in mice requires vitamin D and the vitamin D receptor. Proc. Natl. Acad. Sci. USA 109:8501-8504.
114. Wang, Y., J. Zhu, and H. F. DeLuca. 2012b. Where is the vitamin D receptor? Arch. Biochem. Biophys. 523:123-133.
115. Windaus, A. A., and F. Schenck. 1937. Antirachitic vitamin (to Winthrop Chem. Co., Inc.). U.S. Patent #2,099,550.
116. 3 exerts a skeletal anabolic effect and improves mineral ion homeostasis in mice that are homozygous for both the 1α-hydroxylase and parathyroid hormone null alleles. Endocrinology 147:4801-4810.
117. Yamamoto, M., Y. Kawanobe, H. Takahashi, E. Shimazawa, S. Kimura, and E. Ogata. 1984. Vitamin D deficiency and renal calcium transport in the rat. J. Clin. Invest. 74:507-512.
118. Yasuda, H., K. Higashio, and T. Suda. 2005. Vitamin D and osteoclastogenesis. In: D. Feldman, J. W. Pike, and F. H. Glorieux, editors, Vitamin D. Vol. I, 2nd ed. Elsevier Academic Press, Burlington, MA. p. 665-685.
119. Yoshizawa, T., Y. Handa, Y. Uematsu, S. Takeda, K. Sekine, Y. Yoshihara, T. Kawakami, K. Arioka, H. Sato, Y. Uchiyama, S. Masushige, A. Fukamizu, T. Matsumoto, and S. Kato. 1997. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat. Genet. 16:391-396.
120. Zella, J. B., and H. F. DeLuca. 2003. Vitamin D and autoimmune diabetes. J. Cell. Biochem. 88:216-222.
121. Zhu, J. G., J. T. Ochalek, M. Kaufmann, G. Jones, and H. F. DeLuca. 2013. CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo. Proc. Natl. Acad. Sci. USA 110:15650-15655.