Extracellular matrix integrity affects the mechanical behaviour of in-situ chondrocytes under compression

Journal of Biomechanics

Volumn 47, Issue 5, 2014, Pages 1004-1013

  Moo, Eng Kuan ^a,b   Han, Sang Kuy ^c   Federico, Salvatore ^b   Sibole, Scott C ^b   Jinha, Azim ^b   Abu Osman, Noor Azuan ^a   Pingguan Murphy, Belinda ^a   Herzog, Walter ^b  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF MARYLAND   (United States)

Author keywords

Chondrocyte mechanics; Multi scale finite element modelling; Osteoarthritis; Tensile strain; Tissue lesions; Transient response

Indexed keywords

CARTILAGE; CYTOLOGY; ENZYMES; FINITE ELEMENT METHOD; GENE EXPRESSION; MAMMALS; NUMERICAL METHODS; TENSILE STRAIN; TRANSIENT ANALYSIS;

CHONDROCYTES; COMPRESSION SYSTEM; EXPERIMENTAL AND NUMERICAL METHODS; EXTRACELLULAR MATRICES; FINITE ELEMENT MODELLING; GREEN LAGRANGE STRAINS; MECHANICAL BEHAVIOUR; OSTEOARTHRITIS;

TISSUE;

ARTICLE; ARTICULAR CARTILAGE; BIOMECHANICS; CARTILAGE CELL; CARTILAGE DEGENERATION; CATABOLISM; CELL STRUCTURE; CHONDROPATHY; COMPRESSION; EXTRACELLULAR MATRIX; FINITE ELEMENT ANALYSIS; GENE EXPRESSION; MULTIPHOTON MICROSCOPY; NONLINEAR SYSTEM; PRIORITY JOURNAL; STEADY STATE; TARGET CELL; UPREGULATION;

CHONDROCYTE MECHANICS; MULTI-SCALE FINITE ELEMENT MODELLING; OSTEOARTHRITIS; TENSILE STRAIN; TISSUE LESIONS; TRANSIENT RESPONSE;

ANIMALS; CARTILAGE, ARTICULAR; CATTLE; CHONDROCYTES; EXTRACELLULAR MATRIX; FINITE ELEMENT ANALYSIS; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; PRESSURE; STRESS, MECHANICAL; UP-REGULATION;

EID: 84894875987     PISSN: 00219290     EISSN: 18732380     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2014.01.003     Document Type: Article

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