Mechanical behaviour of in-situ chondrocytes subjected to different loading rates: A finite element study

Biomechanics and Modeling in Mechanobiology

Volumn 11, Issue 7, 2012, Pages 983-993

  Moo, E K ^a   Herzog, W ^b   Han, S K ^b   Abu Osman, N A ^a   Pingguan Murphy, B ^a   Federico, S ^b  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Cartilage mechano biology; Cell membrane damage; Chondrocyte mechanics; Finite element modelling; Impact loading; Osteoarthritis

Indexed keywords

BODY FLUIDS; CELL DEATH; FINITE ELEMENT METHOD; FLOW VELOCITY; MEMBRANES;

CARTILAGE MECHANO-BIOLOGY; CELL MEMBRANE DAMAGES; CHONDROCYTE MECHANIC; CHONDROCYTES; ELEMENT MODELS; FINITE ELEMENT MODELING; IMPACT LOADINGS; MECHANO-BIOLOGY; OSTEOARTHRITIS; STRAIN-RATES;

CARTILAGE;

ALGORITHM; ARTICLE; BIOLOGICAL MODEL; BIOMECHANICS; CARTILAGE; CARTILAGE CELL; CELL MEMBRANE; COMPUTER PROGRAM; COMPUTER SIMULATION; CYTOLOGY; ELASTICITY; FINITE ELEMENT ANALYSIS; HUMAN; MECHANICAL STRESS; METABOLISM; OSTEOARTHRITIS; PATHOLOGY; PRESSURE; STATISTICAL MODEL; TENSILE STRENGTH; THEORETICAL MODEL; TIME;

ALGORITHMS; BIOMECHANICS; CARTILAGE; CELL MEMBRANE; CHONDROCYTES; COMPUTER SIMULATION; ELASTICITY; FINITE ELEMENT ANALYSIS; HUMANS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; MODELS, THEORETICAL; OSTEOARTHRITIS; PRESSURE; SOFTWARE; STRESS, MECHANICAL; TENSILE STRENGTH; TIME FACTORS;

EID: 84865662108     PISSN: 16177959     EISSN: 16177940     Source Type: Journal    
DOI: 10.1007/s10237-011-0367-2     Document Type: Article

References (55)

1. Z Abusara R Seerattan A Leumann R Thompson W Herzog 2011 A novel method for determining articular cartilage chondrocyte mechanics in vivo J Biomech 44 5 930 934 10.1016/j.jbiomech.2010.11.031
2. LG Alexopoulos LA Setton F Guilak 2005 The biomechanical role of the chondrocyte pericellular matrix in articular cartilage Acta Biomater 1 3 317 325 10.1016/j.actbio.2005.02.001
3. LG Alexopoulos GM Williams ML Upton LA Setton F Guilak 2005 Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage J Biomech 38 3 509 517 10.1016/j.jbiomech.2004.04.012
4. GA Ateshian KD Costa CT Hung 2007 A theoretical analysis of water transport through chondrocytes Biomech Model Mechanobiol 6 1-2 91 101 10.1007/s10237-006-0039-9
5. MO Bevensee CJ Schwiening WF Boron 1995 Use of bcecf and propidium iodide to assess membrane integrity of acutely isolated ca1 neurons from rat hippocampus J Neurosci Methods 58 1-2 61 75 10.1016/0165-0270(94)00159-E
6. FJ Blanco R Guitian E Vázquez-Martul FJ de Toro F Galdo 1998 Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology Arthr Rheum 41 2 284 289 10.1002/1529-0131(199802)41: 2<284::AID-ART12>3.0.CO;2-T
7. K Brandt H Mankin L Shulman 1986 Workshop on etiopathogenesis of osteoarthritis J Rheumatol 13 1126 1160
8. NO Chahine GA Ateshian CT Hung 2007 The effect of finite compressive strain on chondrocyte viability in statically loaded bovine articular cartilage Biomech Model Mechanobiol 6 1-2 103 111 10.1007/s10237-006-0041-2
9. GN Duda M Eilers L Loh JE Hoffman M Kääb K Schaser 2001 Chondrocyte death precedes structural damage in blunt impact trauma Clin Orthop Relat Res 393 302 309 10.1097/00003086-200112000-00035
10. G Escolar E Leistikow JG White 1989 The fate of the open canalicular system in surface and suspension-activated platelets Blood 74 6 1983 1988
11. EA Evans R Skalak 1979 Mechanics and thermodynamics of biomembranes: part 1 CRC Crit Rev Bioeng 3 3 181 330
12. BJ Ewers D Dvoracek-Driksna MW Orth RC Haut 2001 The extent of matrix damage and chondrocyte death in mechanically traumatized articular cartilage explants depends on rate of loading J Orthop Res Off Publ Orthop Res Soc 19 5 779 784
13. S Federico A Grillo W Herzog 2004 A transversely isotropic composite with a statistical distribution of spheroidal inclusions: a geometrical approach to overall properties J Mech Phys Solids 52 10 2309 2327 2092645 1115.74358 10.1016/j.jmps.2004.03.010
14. S Federico A Grillo G Larosa G Giaquinta W Herzog 2005 A transversely isotropic, transversely homogeneous microstructural-statistical model of articular cartilage Jv Biomech 38 10 2008 2018 10.1016/j.jbiomech.2004.09.020
15. DM Geddes RS Cargill MC LaPlaca 2003 Mechanical stretch to neurons results in a strain rate and magnitude-dependent increase in plasma membrane permeability J Neurotrauma 20 10 1039 1049 10.1089/089771503770195885
16. A Grillo G Wittum G Giaquinta MV Micunovic 2009 A multiscale analysis of growth and diffusion dynamics in biological materials Int J Eng Sci 47 2 261 283 2498975 1213.74226 10.1016/j.ijengsci.2008.08.010
17. F Guilak VC Mow 1992 Determination of the mechanical response of the chondrocyte in situ using finite element modeling and confocal microscopy ASME Adv Bioeng BED 20 21 23
18. F Guilak VC Mow 2000 The mechanical environment of the chondrocyte: a biphasic finite element model of cell-matrix interactions in articular cartilage J Biomech 33 12 1663 1673 10.1016/S0021-9290(00)00105-6
19. F Guilak A Ratcliffe VC Mow 1995 Chondrocyte deformation and local tissue strain in articular cartilage: a confocal microscopy study J Orthop Res Off Publ Orthop Res Soc 13 3 410 421
20. SK Han S Federico A Grillo G Giaquinta W Herzog 2007 The mechanical behaviour of chondrocytes predicted with a micro-structural model of articular cartilage Biomech Model Mechanobiol 6 3 139 150 10.1007/s10237-006-0016-3
21. SK Han S Federico W Herzog 2011 A depth-dependent model of the pericellular microenvironment of chondrocytes in articular cartilage Comput Methods Biomech Biomed Eng 14 7 657 664 10.1080/10255842.2010.493512
22. SM Hassanizadeh 1986 Derivation of basic equations of mass transport in porous media, part 1. Macroscopic balance laws Adv Water Resour 9 4 196 206 10.1016/0309-1708(86)90024-2
23. H Hedlund S Mengarelli-Widholm FP Reinholt O Svensson 1993 Stereologic studies on collagen in bovine articular cartilage APMIS 101 1-6 133 140 10.1111/j.1699-0463.1993.tb00092.x
24. MH Holmes VC Mow 1990 The nonlinear characteristics of soft gels and hydrated connective tissues in ultrafiltration J Biomech 23 11 1145 1156 10.1016/0021-9290(90)90007-P
25. RO Hynes 1992 Integrins: versatility, modulation, and signaling in cell adhesion Cell 69 1 11 25 10.1016/0092-8674(92)90115-S
26. DI Isaac EG Meyer RC Haut 2008 Chondrocyte damage and contact pressures following impact on the rabbit tibiofemoral joint J Biomech Eng 130 4 041,018 041,018 10.1115/1.2948403
27. N Islam TM Haqqi KJ Jepsen M Kraay JF Welter VM Goldberg CJ Malemud 2002 Hydrostatic pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor necrosis factor-alpha, inducible nitric oxide synthase, p53, c-myc, and bax-alpha, and suppression of bcl-2 J Cell Biochem 87 3 266 278 10.1002/jcb.10317
28. AW Jay PB Canham 1977 Viscoelastic properties of the human red blood cell membrane. ii. area and volume of individual red cells entering a micropipette Biophys J 17 2 169 178 10.1016/S0006-3495(77)85634-8
29. B Kurz M Jin P Patwari DM Cheng MW Lark AJ Grodzinsky 2001 Biosynthetic response and mechanical properties of articular cartilage after injurious compression J Orthop Res 19 6 1140 1146 10.1016/S0736-0266(01)00033-X
30. L Li W Herzog R Korhonen J Jurvelin 2005 The role of viscoelasticity of collagen fibers in articular cartilage: axial tension versus compression Med Eng Phys 27 1 51 57 10.1016/j.medengphy.2004.08.009
31. HJ Mankin 1963 Localization of tritiated thymidine in articular cartilage of rabbits: Iii. Mature articular cartilage J Bone Jt Surg Am 45 3 529 540
32. A Maroudas P Bullough 1968 Permeability of articular cartilage Nature 219 5160 1260 1261 10.1038/2191260a0
33. PL McNeil RA Steinhardt 2003 Plasma membrane disruption: repair, prevention, adaptation Annu Rev Cell Dev Biol 19 697 731 10.1146/annurev. cellbio.19.111301.140101
34. D Milentijevic PA Torzilli 2005 Influence of stress rate on water loss, matrix deformation and chondrocyte viability in impacted articular cartilage J Biomech 38 3 493 502 10.1016/j.jbiomech.2004.04.016
35. D Milentijevic DL Helfet PA Torzilli 2003 Influence of stress magnitude on water loss and chondrocyte viability in impacted articular cartilage J Biomech Eng 125 5 594 601 10.1115/1.1610021
36. Mow VC, Guilak F (1993) Deformation of chondrocytes within the extracellular matrix of articular cartilage. Birkhäuser, Boston, pp 128-145
37. VC Mow SC Kuei WM Lai CG Armstrong 1980 Biphasic creep and stress relaxation of articular cartilage in compression: theory and experiments J Biomech Eng 102 1 73 84 10.1115/1.3138202
38. S Nakamura Y Arai KA Takahashi R Terauchi S Ohashi O Mazda J Imanishi A Inoue H Tonomura T Kubo 2006 Hydrostatic pressure induces apoptosis of chondrocytes cultured in alginate beads J Orthop Res Off Publ Orthop Res Soc 24 4 733 739
39. BV Nguyen Q Wang NJ Kuiper AJ El Haj CR Thomas Z Zhang 2009 Strain-dependent viscoelastic behaviour and rupture force of single chondrocytes and chondrons under compression Biotechnol Lett 31 6 803 809 10.1007/s10529-009-9939-y
40. S Nielsen SR DiGiovanni EI Christensen MA Knepper HW Harris 1993 Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney Proc Natl Acad Sci USA 90 24 11,663 11,667 10.1073/pnas.90.24.11663
41. CA Poole MH Flint BW Beaumont 1987 Chondrons in cartilage: ultrastructural analysis of the pericellular microenvironment in adult human articular cartilages J Orthop Res Off Publ Orthop Res Soc 5 4 509 522
42. TM Quinn RG Allen BJ Schalet P Perumbuli EB Hunziker 2001 Matrix and cell injury due to sub-impact loading of adult bovine articular cartilage explants: effects of strain rate and peak stress J Orthop Res Off Publ Orthop Res Soc 19 2 242 249
43. D Raucher MP Sheetz 1999 Characteristics of a membrane reservoir buffering membrane tension Biophys J 77 4 1992 2002 10.1016/S0006-3495(99)77040- 2
44. RU Repo JB Finlay 1977 Survival of articular cartilage after controlled impact J Bone Jt Surg A 59 8 1068 1076
45. RM Schinagl D Gurskis AC Chen RL Sah 1997 Depth-dependent confined compression modulus of full-thickness bovine articular cartilage J Orthop Res Off Publ Orthop Res Soc 15 4 499 506
46. MP Sheetz J Dai 1996 Modulation of membrane dynamics and cell motility by membrane tension Trends Cell Biol 6 3 85 89 10.1016/0962-8924(96)80993-7
47. R Shi J Whitebone 2006 Conduction deficits and membrane disruption of spinal cord axons as a function of magnitude and rate of strain J Neurophysiol 95 6 3384 3390 10.1152/jn.00350.2005
48. AC Shieh KA Athanasiou 2006 Biomechanics of single zonal chondrocytes J Biomech 39 9 1595 1602 10.1016/j.jbiomech.2005.05.002
49. WH Simon S Richardson W Herman JR Parsons J Lane 1976 Long-term effects of chondrocyte death on rabbit articular cartilage in vivo J Bone Jt Surg Am 58 4 517 526
50. RW Stroetz NE Vlahakis BJ Walters MA Schroeder RD Hubmayr 2001 Validation of a new live cell strain system: characterization of plasma membrane stress failure J Appl Physiol 90 6 2361 2370
51. WR Trickey GM Lee F Guilak 2000 Viscoelastic properties of chondrocytes from normal and osteoarthritic human cartilage J Orthop Res Off Publ Orthop Res Soc 18 6 891 898
52. CCB Wang NO Chahine CT Hung GA Ateshian 2003 Optical determination of anisotropic material properties of bovine articular cartilage in compression J Biomech 36 3 339 353 10.1016/S0021-9290(02)00417-7
53. MD Ward DA Hammer 1993 A theoretical analysis for the effect of focal contact formation on cell-substrate attachment strength Biophys J 64 3 936 959 10.1016/S0006-3495(93)81456-5
54. RE Waugh 1983 Effects of abnormal cytoskeletal structure on erythrocyte membrane mechanical properties Cell Motil 3 5-6 609 622
55. JZ Wu W Herzog 2000 Finite element simulation of location- and time-dependent mechanical behavior of chondrocytes in unconfined compression tests Ann Biomed Eng 28 3 318 330 10.1114/1.271