A novel method for determining articular cartilage chondrocyte mechanics in vivo

Journal of Biomechanics

Volumn 44, Issue 5, 2011, Pages 930-934

  Abusara, Z ^a   Seerattan, R ^a   Leumann, A ^b   Thompson, R ^a   Herzog, W ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Articular cartilage; Chondrocytes; In vivo cell mechanics; Live cell imaging; Osteoarthritis; Two photon microscopy

Indexed keywords

ARTICULAR CARTILAGES; CHONDROCYTES; IN-VIVO; LIVE-CELL IMAGING; OSTEOARTHRITIS; TWO PHOTON MICROSCOPY;

ANIMALS; BODY FLUIDS; CARTILAGE; LASER EXCITATION; LIGAMENTS; LOADING; MECHANICS; MUSCLE; ORGANIC POLYMERS; PHOTONS; PHYSIOLOGICAL MODELS; PHYSIOLOGY;

JOINTS (ANATOMY);

ACCURACY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTICULAR CARTILAGE; BIOMECHANICS; CARTILAGE CELL; CELL SIZE; CELL VOLUME; CONTROLLED STUDY; ELECTRIC ACTIVITY; IN VIVO STUDY; KNEE; KNEE OSTEOARTHRITIS; LASER MICROSCOPY; LOADING TEST; MOUSE; MULTIPHOTON MICROSCOPY; MUSCLE CONTRACTION; MUSCLE FORCE; NONHUMAN; PRIORITY JOURNAL; RELIABILITY;

ANIMALS; BIOMECHANICS; CARTILAGE, ARTICULAR; CHONDROCYTES; EQUIPMENT DESIGN; HINDLIMB; JOINTS; LASERS; MICE; MICROSCOPY; MUSCLE CONTRACTION; MUSCLES; OSTEOARTHRITIS; PRESSURE; REPRODUCIBILITY OF RESULTS; STRESS, MECHANICAL;

EID: 79952037888     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2010.11.031     Document Type: Article

References (24)

1. Buschmann M.D., Gluzband Y.A., Grodzinsky A.J., Hunziker E. Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture. J. Cell Sci. 1995, 108:1497-1508.
2. Buschmann M.D., Soulhat J., Shirazi-Adl A., Jurvelin J.S., Hunziker E.B. Confined compression of articular cartilage: linearity in ramp and sinusoidal tests and the importance of interdigitation and incomplete confinement. J. Biomech. 1998, 31:171-178.
3. Choi J.B., Youn I., Cao L., Leddy H.A., Gilchrist C.L., Setton L.A., Guilak F. Zonal changes in the three-dimensional morphology of the chondron under compression: the relationship among cellular, pericellular, and extracellular deformation in articular cartilage. J. Biomech. 2007, 40:2596-2603.
4. Clark A.L., Votta B.J., Kumar S., Liedtke W., Guilak F. Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice. Arthritis Rheum. 2010, 62:2973-2983.
5. Freeman P.M., Natarajan R.N., Kimura J.H., Andriacchi T.P. Chondrocyte cells respond mechanically to compressive loads. J. Orthop. Res. 1994, 12:311-320.
6. Garcia M., Knight M.M. Cyclic loading opens hemichannels to release ATP as part of a chondrocyte mechanotransduction pathway. J. Orthop. Res. 2010, 28:510-515.
7. Guilak F. Compression-induced changes in the shape and volume of the chondrocyte nucleus. J. Biomech. 1995, 28:1529-1541.
8. Guilak F., Donahue H.J., Zell R.A., Grande D., McLeod K.J., Rubin C.T. Deformation-induced calcium signaling in articular chondrocytes. Cell Mechanics and Cellular Engineering 1994, 380-397. Springer-Verlag, New York. V.C. Mow, F. Guilak, R. Tran-Son-Tray, R.M. Hochmuth (Eds.).
9. Guilak F., Ratcliffe A., Mow V.C. Chondrocyte deformation and local tissue strain in articular cartilage: a confocal microscopy study. J. Orthop. Res. 1995, 13:410-421.
10. Guilak F., Sah R.L., Setton L.A. Physical regulation of cartilage metabolism. Basic Orthopaedics Biomechanics 1997, 179-207. Lippincott-Raven Publishers, Philadelphia. V.C. Mow, W.C. Hayes (Eds.).
11. Guilak F., Zell R.A., Erickson G.R., Grande D.A., Rubin C.T., McLeod K.J., Donahue H.J. Mechanically induced calcium waves in articular chondrocytes are inhibited by gadolinium and amiloride. J. Orthop. Res. 1999, 17:421-429.
12. Han S.K., Colarusso G., Herzog W. Confocal microscopy indentation system for studying in situ chondrocyte mechanics and biology. Med. Eng. Phys. 2009, 31:1038-1042.
13. Han S.K., Federico S., Grillo A., Giaquinta G., Herzog W. The mechanical behaviour of chondrocytes predicted with a micro-structural model of articular cartilage. Biomech. Model. Mechanobiol. 2007, 6:139-150.
14. Hasler E.M., Herzog W., Ronsky J. Experimental evaluation of theoretical contact forces in the cat patellofemoral joint. J. Biomech. 1996, 29:1201-1205.
15. Hasler E.M., Herzog W., Wu J.Z., Muller W., Wyss U. Articular cartilage biomechanics: theoretical models, material properties, and biosynthetic response. Crit. Rev. Biomed. Eng. 1999, 27(6):415-488.
16. Herzog W., Leonard T.R. Depression of cat soleus forces following isokinetic shortening. J. Biomech. 1997, 30(9):865-872.
17. Langevin H.M., Bouffard N.A., Badger G.J., Iatridis J.C., Howe A.K. Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo. Am. J. Physiol. Cell Physiol. 2005, 288:C747-C756.
18. Lee D.A., Knight M.M., Bolton J.F., Idowu B.D., Kayser M.V., Bader D.L. Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels. J. Biomech. 2000, 33:81-95.
19. Millward-Sadler S.J., Wright M.O., Lee H., Caldwell H., Nuki G., Salter D.M. Altered electrophysiological responses to mechanical stimulation and abnormal signaling through alpha5beta1 integrin in chondrocytes from osteoarthritic cartilage. Osteoarthritis Cartilage 2000, 8:272-278.
20. Mobasheri A., Carter S.D., Martin-Vasallo P., Shakibaei M. Integrins and stretch activated ion channels; putative components of functional cell surface mechanoreceptors in articular chondrocytes. Cell Biol. Int. 2002, 26:1-18.
21. Piston D.W. Imaging living cells and tissues by two-photon excitation microscopy. Trends Cell Biol. 1999, 9:66-69.
22. Poole C.A., Gilbert R.T., Herbage D., Hartmann D.J. Immunolocalization of type IX collagen in normal and spontaneously osteoarthritic canine tibial cartilage and isolated chondrons. Osteoarthritis Cartilage 1997, 5:191-204.
23. Sah R.L., Grodzinsky A.J., Plaas A.H.K., Sandy J.D. Effects of static and dynamic compression on matrix metabolism in cartilage explants. Articular Cartilage and Osteoarthritis 1992, 373-392. Raven Press, New York. K. Kuettner, J.G. Peyron, R. Schleyerbach, V.C. Hascall (Eds.).
24. Wilkins R.J., Browning J.A., Urban J.P. Chondrocyte regulation by mechanical load. Biorheology 2000, 37:67-74.