Regulation of FOXO3 by phosphorylation and methylation in hepatitis C virus infection and alcohol exposure

Hepatology

Volumn 59, Issue 1, 2014, Pages 58-70

  Tikhanovich, Irina ^a   Kuravi, Sudhakiranmayi ^a   Campbell, Roosevelt V ^a   Kharbanda, Kusum K ^b   Artigues, Antonio ^a   Villar, Maria T ^a   Weinman, Steven A ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; ALCOHOL; ARGININE; TRANSCRIPTION FACTOR FKHRL1; UBIQUITIN; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; SOLVENT; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CAPILLARY ISOELECTRIC FOCUSING; COMPLEX FORMATION; CONTROLLED STUDY; HEPATITIS C; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER BIOPSY; NONALCOHOLIC FATTY LIVER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METHYLATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; AMINO ACID SUBSTITUTION; COMPARATIVE STUDY; DRINKING BEHAVIOR; DRUG EFFECT; ISOELECTRIC FOCUSING; METABOLISM; METHYLATION; PHOSPHORYLATION; PROTEIN PROCESSING; TUMOR CELL LINE; DRUG EFFECTS;

ALCOHOL DRINKING; AMINO ACID SUBSTITUTION; CELL LINE, TUMOR; ETHANOL; FORKHEAD TRANSCRIPTION FACTORS; HEPATITIS C; HUMANS; ISOELECTRIC FOCUSING; JNK MITOGEN-ACTIVATED PROTEIN KINASES; METHYLATION; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SOLVENTS;

EID: 84894798787     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26618     Document Type: Article

References (31)

1. Safdar K, Schiff ER. Alcohol and hepatitis C. Semin Liver Dis 2004;24:305-315.
2. Choi J. Oxidative stress, endogenous antioxidants, alcohol, and hepatitis C: pathogenic interactions and therapeutic considerations. Free Radic Biol Med 2012;52:1135-1150.
3. Tikhanovich I, Cox J, Weinman S. FOXO transcription factors in liver function and disease. J Gastroenterol Hepatol 2013;28(Suppl 1):125-131.
4. Calnan DR, Brunet A. The FoxO code. Oncogene 2008;27:2276-2288.
5. Burgering BM. A brief introduction to FOXOlogy. Oncogene 2008;27:2258-2262.
6. van der Horst A, Burgering BM. Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 2007;8:440-450.
7. Zhao Y, Wang Y, Zhu WG. Applications of post-translational modifications of FoxO family proteins in biological functions. J Mol Cell Biol 2011;3:276-282.
8. Tikhanovich I, Zhao J, Kuravi S, Weinman S. FOXO3 is a novel cytoprotection factor for alcoholic liver injury that is disrupted by HCV-specific posttranslational modifications. Hepatology 2012;56:293A.
9. Ren JY, Zeng Z, Tumurbaatar B, Campbell RV, Chaturvedi G, Zhao J, et al. HCV induces FOXO3a translocation to cytosol during alcohol-associated inflammation and hepatocellular carcinoma. Hepatology 2011;54:1312A-1312A.
10. Jones CT, Catanese MT, Law LM, Khetani SR, Syder AJ, Ploss A, et al. Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system. Nat Biotechnol 2010;28:167-171.
11. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999;96:857-868.
12. Lei K, Nimnual A, Zong WX, Kennedy NJ, Flavell RA, Thompson CB, et al. The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol 2002;22:4929-4942.
13. Kato T, Date T, Murayama A, Morikawa K, Akazawa D, Wakita T. Cell culture and infection system for hepatitis C virus. Nat Protoc 2006;1:2334-2339.
14. Fan AC, Deb-Basu D, Orban MW, Gotlib JR, Natkunam Y, O'Neill R, et al. Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens. Nat Med 2009;15:566-571.
15. O'Neill RA, Bhamidipati A, Bi X, Deb-Basu D, Cahill L, Ferrante J, et al. Isoelectric focusing technology quantifies protein signaling in 25 cells. Proc Natl Acad Sci U S A 2006;103:16153-16158.
16. Qadri I, Iwahashi M, Capasso JM, Hopken MW, Flores S, Schaack J, et al. Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1. Biochem J 2004;378:919-928.
17. Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, et al. Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Mol Cell 2008;32:221-231.
18. Kharbanda KK. Alcoholic liver disease and methionine metabolism. Semin Liver Dis 2009;29:155-165.
19. Fowler B. Homocysteine: overview of biochemistry, molecular biology, and role in disease processes. Semin Vasc Med 2005;5:77-86.
20. Haeusler RA, Kaestner KH, Accili D. FoxOs function synergistically to promote glucose production. J Biol Chem 2010;285:35245-35248.
21. Leyendecker M, Korsten P, Reinehr R, Speckmann B, Schmoll D, Scherbaum WA, et al. Ceruloplasmin expression in rat liver cells is attenuated by insulin: role of FoxO transcription factors. Horm Metab Res 2011;43:268-274.
22. Tao R, Wei D, Gao H, Liu Y, DePinho RA, Dong XC. Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene. J Biol Chem 2011;286:14681-14690.
23. Banerjee A, Meyer K, Mazumdar B, Ray RB, Ray R. Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression. J Virol 2010;84:5936-5946.
24. Deng L, Shoji I, Ogawa W, Kaneda S, Soga T, Jiang DP, et al. Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway. J Virol 2011;85:8556-8568.
25. Honda M, Takehana K, Sakai A, Tagata Y, Shirasaki T, Nishitani S, et al. Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C. Gastroenterology 2011;141:128-140, 140 e121-122.
26. Essers MA, Weijzen S, de Vries-Smits AM, Saarloos I, de Ruiter ND, Bos JL, et al. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J 2004;23:4802-4812.
27. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004;303:2011-2015.
28. Wang F, Nguyen M, Qin FX, Tong Q. SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 2007;6:505-514.
29. Parvaiz F, Manzoor S, Tariq H, Javed F, Fatima K, Qadri I. Hepatitis C virus infection: molecular pathways to insulin resistance. Virol J 2011;8:474.
30. Wang F, Chan CH, Chen K, Guan X, Lin HK, Tong Q. Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. Oncogene 2012;31:1546-1557.
31. Duong FH, Christen V, Berke JM, Penna SH, Moradpour D, Heim MH. Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1. J Virol 2005;79:15342-15350.