Transcriptomic evaluation of the nicotinic acetylcholine receptor pathway in levamisole-resistant and -sensitive Oesophagostomum dentatum

Molecular and Biochemical Parasitology

Volumn 193, Issue 1, 2014, Pages 66-70

  Romine, Nathan M ^a   Martin, Richard J ^a   Beetham, Jeffrey K ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

Levamisole; nAChR; Nodular worm; Resistance

Indexed keywords

LEVAMISOLE; NICOTINIC RECEPTOR; ANTHELMINTIC AGENT; PROTEIN SUBUNIT;

ACR 16 GENE; ACR 21 GENE; ACR 25 GENE; ANTHELMINTIC RESISTANCE; ANTHELMINTIC SENSITIVITY; ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; DRUG SENSITIVITY; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; HAEMONCHUS CONTORTUS; LEV 1 GENE; MALE; MICROBIAL GENE; NONHUMAN; NRA 2 GENE; OESOPHAGOSTOMUM; OESOPHAGOSTOMUM DENTATUM; PARASITE ISOLATION; PRIORITY JOURNAL; RIC 3 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTOMICS; UNC 22 GENE; UNC 38 GENE; UNC 50 GENE; UNC 63 GENE; UNC 74 GENE; ANIMAL; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROTEIN SUBUNIT;

NEMATODA; OESOPHAGOSTOMUM DENTATUM;

ANIMALS; ANTHELMINTICS; DRUG RESISTANCE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LEVAMISOLE; OESOPHAGOSTOMUM; PROTEIN SUBUNITS; RECEPTORS, NICOTINIC;

EID: 84894767482     PISSN: 01666851     EISSN: 18729428     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2014.02.002     Document Type: Article

References (24)

1. A.P. Robertson, S.K. Buxton, S. Puttachary, S.M. Williamson, A.J. Wolstenholme, and C. Neveu et al. Antinematodal drugs- modes of action and resistance: and worms will not come to thee E.R. Caffrey, Parasitic helminths, targets, screens, drugs and vaccines 2012 Wiley-Blackwell 233 249
2. R.M. Kaplan Drug resistance in nematodes of veterinary importance: a status report Trends Parasitol 20 2004 477 481 (Pubitemid 39195057)
3. C.E. James, A.L. Hudson, and M.W. Davey Drug resistance mechanisms in helminths: is it survival of the fittest? Trends Parasitol 25 2009 328 335
4. A.K. Jones, and D.B. Sattelle The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans Invert Neurosci 8 2008 41 47
5. WHO Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions: a manual for health professionals and programme managers 2006
6. A.P. Robertson, H.E. Bjorn, and R.J. Martin Resistance to levamisole resolved at the single-channel level FASEB J 13 1999 749 760 (Pubitemid 29156406)
7. R.N. Beech, R.K. Prichard, and M.E. Scott Genetic variability of the beta-tubulin genes in benzimidazole-susceptible and -resistant strains of Haemonchus contortus Genetics 138 1994 103 110
8. R.J. Martin, A.P. Robertson, S.K. Buxton, R.N. Beech, C.L. Charvet, and C. Neveu Levamisole receptors: a second awakening Trends Parasitol 28 2012 289 296
9. N.M. Romine, R.J. Martin, and J.K. Beetham Computational cloning of drug target genes of a parasitic nematode, Oesophagostomum dentatum BMC Genet 14 2013 55
10. M.L. Blaxter, P. De Ley, J.R. Garey, L.X. Liu, P. Scheldeman, and A. Vierstraete et al. A molecular evolutionary framework for the phylum Nematoda Nature 392 1998 71 75 (Pubitemid 28150590)
11. M.A. Dillies, A. Rau, J. Aubert, C. Hennequet-Antier, M. Jeanmougin, and N. Servant et al. A comprehensive evaluation of normalization methods for Illumina high-throughput RNA sequencing data analysis Brief Bioinform 2012
12. T. Koepke, S. Schaeffer, V. Krishnan, D. Jiwan, A. Harper, and M. Whiting et al. Rapid gene-based SNP and haplotype marker development in non-model eukaryotes using 3'UTR sequencing BMC Genomics 13 2012 18
13. C. Neveu, C.L. Charvet, A. Fauvin, J. Cortet, R.N. Beech, and J. Cabaret Genetic diversity of levamisole receptor subunits in parasitic nematode species and abbreviated transcripts associated with resistance Pharmacogenet Genom 20 2010 414 425
14. S.R. Kopp, G.T. Coleman, R.J. Traub, J.S. McCarthy, and A.C. Kotze Acetylcholine receptor subunit genes from Ancylostoma caninum: altered transcription patterns associated with pyrantel resistance Int J Parasitol 39 2009 435 441
15. C. Vogel, and E.M. Marcotte Insights into the regulation of protein abundance from proteomic and transcriptomic analyses Nat Rev Genet 13 2012 227 232
16. S.M. Williamson, A.P. Robertson, L. Brown, T. Williams, D.J. Woods, and R.J. Martin et al. The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits PLoS Pathog 5 2009 e1000517
17. T. Boulin, A. Fauvin, C.L. Charvet, J. Cortet, J. Cabaret, and J.L. Bessereau et al. Functional reconstitution of Haemonchus contortus acetylcholine receptors in Xenopus oocytes provides mechanistic insights into levamisole resistance Br J Pharmacol 164 2011 1421 1432
18. G. Hernando, I. Berge, D. Rayes, and C. Bouzat Contribution of subunits to Caenorhabditis elegans levamisole-sensitive nicotinic receptor function Mol Pharmacol 82 2012 550 560
19. J.I. Lee, S. Mukherjee, K.H. Yoon, M. Dwivedi, and J. Bandyopadhyay The multiple faces of calcineurin signaling in Caenorhabditis elegans: development, behaviour and aging J Biosci 38 2013 417 431
20. S. Wu, Z. Zhu, L. Fu, B. Niu, and W. Li WebMGA: a customizable web server for fast metagenomic sequence analysis BMC Genomics 12 2011 444
21. H. Li, B. Handsaker, A. Wysoker, T. Fennell, J. Ruan, and N. Homer et al. The sequence alignment/map format and SAMtools Bioinformatics (Oxford, England) 25 2009 2078 2079
22. J.H. Bullard, E. Purdom, K.D. Hansen, and S. Dudoit Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments BMC Bioinformatics 11 2010 94
23. S. Anders, and W. Huber Differential expression analysis for sequence count data Genome Biol 11 2010 R106
24. H. Li, and R. Durbin Fast and accurate short read alignment with Burrows-Wheeler transform Bioinformatics (Oxford, England) 25 2009 1754 1760