Functional reconstitution of Haemonchus contortus acetylcholine receptors in Xenopus oocytes provides mechanistic insights into levamisole resistance

British Journal of Pharmacology

Volumn 164, Issue 5, 2011, Pages 1421-1432

  Boulin, T ^a,b,c   Fauvin, A ^d   Charvet, C L ^d   Cortet, J ^d   Cabaret, J ^d   Bessereau, J L ^a,b,c   Neveu, C ^d  

^a ECOLE NORMALE SUPÉRIEURE   (France)

^b INSERM   (France)

^c CNRS   (France)

^d UR1282   (France)

Author keywords

acetylcholine receptor; anthelminthic drug; drug resistance; Haemonchus contortus; levamisole; nematode; recombinant receptor expression

Indexed keywords

1,1 DIMETHYL 4 PHENYLPIPERAZINIUM; CHOLINERGIC RECEPTOR; LEVAMISOLE; NICOTINE; PROTEIN SUBUNIT; PYRANTEL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG RESISTANCE; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG TARGETING; GENE EXPRESSION SYSTEM; GENETIC CONSERVATION; GENETIC POLYMORPHISM; HAEMONCHUS CONTORTUS; HETEROLOGOUS EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PARASITE ISOLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN SYNTHESIS; XENOPUS;

ABOMASUM; ANIMALS; ANTINEMATODAL AGENTS; CAENORHABDITIS ELEGANS PROTEINS; CLONING, MOLECULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; FEMALE; GASTRIC MUCOSA; GENES, HELMINTH; HAEMONCHIASIS; HAEMONCHUS; HELMINTH PROTEINS; LEVAMISOLE; MALE; OOCYTES; PROTEIN SUBUNITS; RECEPTORS, CHOLINERGIC; SHEEP; SHEEP DISEASES; XENOPUS LAEVIS;

EID: 80054036923     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01420.x     Document Type: Article

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