Toxic metals contained in cosmetics: A status report

Regulatory Toxicology and Pharmacology

Volumn 68, Issue 3, 2014, Pages 447-467

  Bocca, Beatrice ^a   Pino, Anna ^a   Alimonti, Alessandro ^a   Forte, Giovanni ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Cosmetics; Dermal exposure; Metals; Systemic effects

Indexed keywords

ANTIMONY; ARSENIC; CADMIUM; CHROMIUM; COBALT; COSMETIC; LEAD; MERCURY; NICKEL; HEAVY METAL;

AGE; ARTICLE; CONCENTRATION (PARAMETERS); COSMETIC INDUSTRY; DISEASE ASSOCIATION; HEALTH HAZARD; HUMAN; LIMIT OF DETECTION; NONHUMAN; PRIORITY JOURNAL; PRODUCT DEVELOPMENT; PRODUCT SAFETY; RISK ASSESSMENT; RISK FACTOR; SEX RATIO; SKIN ABSORPTION; SKIN TOXICITY; SYSTEMIC TOXICITY; TOXICITY AND INTOXICATION; ANIMAL; TOXICITY;

ANIMALS; ARSENIC; CONSUMER PRODUCT SAFETY; COSMETICS; HUMANS; METALS, HEAVY;

EID: 84894752914     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2014.02.003     Document Type: Article

References (170)

1. Adepoju-Bello A.A., Oguntibeju O.O., Adebisi R.A., Okpala N., Coker H.A.B. Evaluation of the concentration of toxic metals in cosmetic products in Nigeria. Afr. J. Biotechnol. 2012, 11:16360-16364.
2. Aguilar-Bernier M., Bernal-Ruiz A.I., Rivas-Ruiz F., Fernández-Morano M.T., de Troya-Martín M. Contact sensitization to allergens in the Spanish standard series at Hospital Costa del Sol in Marbella, Spain: a retrospective study (2005-2010). Actas Dermosifiliogr. 2012, 103:223-228.
3. Akyol A., Boyvat A., Peksari Y., Gürgey E. Contact sensitivity to standard series allergens in 1038 patients with contact dermatitis in Turkey. Contact dermatitis 2005, 52:333-337.
4. Al-Ashban R.M., Aslam M., Shah A.H. Kohl (surma): a toxic traditional eye cosmetic study in Saudi Arabia. Public Health 2004, 118:292-298.
5. Allenby C.F., Basketter D.A. Minimum eliciting patch test concentrations of cobalt. Contact Dermatitis 1989, 20:185-190.
6. Allenby C.F., Goodwin B.F. Influence of detergent washing powders on minimal eliciting patch test concentrations of nickel and chromium. Contact Dermatitis 1983, 9:491-499.
7. Alqadami A.A., Abdalla M.A., Alothman Z.A., Omer K. Application of solid phase extraction on multiwalled carbon nanotubes of some heavy metal ions to analysis of skin whitening cosmetics using ICP-AES. Int. J. Environ. Res. Public Health 2013, 10:361-374.
8. Al-Saleh I., Al-Doush I. Mercury content in skin lightening creams and potential health hazards to the health of Saudi women. J. Toxicol. Environ. Health 1997, 51:123-130.
9. Al-Saleh I., Al-Enazi S. Trace metals in lipsticks. Toxicol. Environ. Chem. 2011, 93:1149-1165.
10. Al-Saleh I., Al-Enazi S., Shinwari N. Assessment of lead in cosmetic products. Regul. Toxicol. Pharm. 2009, 54:105-113.
11. Amartey E.O., Asumadu-Sakyi A.B., Adjei C.A., Quashie F.K., Duodu G.O., Bentil N.O. Determination of heavy metals concentration in hair pomades on the Ghanaian market using Atomic Absorption Spectrometry Technique. Br. J. Pharmacol. Toxicol. 2011, 2:192-198.
12. ANVISA, Agência Nacional de Vigilância Sanitária, Brazil. Decree 79.094 of January 5th, 1977.
13. ASEAN, Association of Southeast Asian Nations. 2003. Available at: <>. Accessed 03 September 2013. http://aseancosmetics.org/default/asean-cosmetics-directive/foreword.
14. ATSDR Agency for Toxic Substances and Disease Registry. Toxicological Profile for Chromium 2008, U.S. Department of Health and Human Services, Public Health Service, Atlanta, USA.
15. ATSDR Agency for Toxic Substances and Disease Registry. Toxicological Profile for Antimony 1992, U.S. Department of Health and Human Services, Public Health Service, Atlanta, USA.
16. ATSDR Agency for Toxic Substances and Disease Registry. Toxicological Profile for Mercury 1999, U.S. Department of Health and Human Services, Public Health Service, Atlanta, USA.
17. ATSDR Agency for Toxic Substances and Disease Registry. Toxicological Profile for Cobalt 2004, U.S. Department of Health and Human Services, Public Health Service, Atlanta, USA.
18. ATSDR Agency for Toxic Substances and Disease Registry. Toxicological Profile for Nickel 2005, U.S. Department of Health and Human Services, Public Health Service, Atlanta, USA.
19. ATSDR Agency for Toxic Substances and Disease Registry. Toxicological Profile for Arsenic 2007, U.S. Department of Health and Human Services, Public Health Service, Atlanta, USA.
20. ATSDR Agency for Toxic Substances and Disease Registry. Toxicological Profile for Lead 2007, U.S. Department of Health and Human Services, Public Health Service, Atlanta, USA.
21. ATSDR Agency for Toxic Substances and Disease Registry. Toxicological Profile for Cadmium 2012, U.S. Department of Health and Human Services, Public Health Service, Atlanta, USA.
22. Ayenimo J.G., Yusuf A.M., Adekunle A.S., Makinde O.W. Heavy metal exposure from personal care products. Bull. Environ. Contam. Toxicol. 2010, 84:8-14.
23. Bajaj A.K., Saraswat A., Mukhija G., Rastogi S., Yadav S. Patch testing experience with 1000 patients. Indian J. Dermatol. Venereol. Leprol. 2007, 73:313-318.
24. Basketter D.A., Angelini G., Ingber A., Kern P.S., Menné T. Nickel, chromium and cobalt in consumer products: revisiting safe levels in the new millennium. Contact Dermatitis 2003, 49:1-7.
25. Bellinger D.C. Very low lead exposure and children's neurodevelopment. Curr. Opin. Pediatr. 2008, 20:172-177.
26. BfR, Bundesinstitut für Risikobewertung. Kosmetische Mittel: BfR empfiehlt Schwermetallgehalte über Reinheitsanforderungen der Ausgangsstoffe zu regeln, Stellungnahme Nr. 025/2006 des BfR vom 05. April 2006. Available at: <>. [Accessed 03 September 2013]. http://www.bfr.bund.de/cm/343/kosmetische_mittel_bfr_empfiehlt_schwermetallgehalte_ueber.pdf.
27. Bocca B., Forte G., Petrucci F., Cristaudo A. Levels of nickel and other potentially allergenic metals in Ni-tested commercial body creams. J. Pharmaceut. Biomed. 2007, 44:1197-1202.
28. Bress W.C., Bidanset J.H. Percutaneous in vivo and in vitro absorption of lead. Vet. Hum. Toxicol. 1991, 33:212-214.
29. CA, Comunidad Andina. Decision 516. 2002. Available at: <>. [Accessed 03 September 2013]. http://intranet.comunidadandina.org/Documentos/decisiones/DEC516.doc.
30. CDC, Centers for Disease Control and Prevention. Preventing Lead Poisoning in Young Children. Atlanta, CDC, 2005.
31. CDC, Center for Disease Control and Prevention Childhood Lead Poisoning webpage. 2013. Available at: <>. [Accessed 03 September 2013]. http://www.cdc.gov/nceh/lead/.
32. Chauhan A.S., Bhadauria R., Singh A.K., Lodhi S.S., Chaturvedi D.K., Tomar V.S. Determination of Lead and cadmium in cosmetic products. J. Chem. Pharm. Res. 2010, 2:92-97.
33. Chave T.A., Warin A.P. Allergic contact dermatitis from cobalt in a beauty product. Contact Dermatitis 1991, 41:236.
34. CIR, Cosmetics Ingredient Review. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. CIR, Washington DC; 2003.
35. CNS, Canwest News Service. Tories won't list leaded lipsticks. 2008. Available at: <>. [Accessed 14 October 2013]. http://www.canada.com/topics/news/national/story.html?id=4b8f58b0-c225-4925-8e6e-3b41a3687626.
36. COLIPA, The European Cosmetic Toiletry and Perfumery Association. European Cosmetic, Toiletry & Perfumery. Market Overview: 2005.
37. Contado C., Pagnoni A. A new strategy for pressed powder eye shadow analysis: allergenic metal ion content and particle size distribution. Sci. Total Environ. 2012, 432:173-179.
38. Corazza M., Baldo F., Pagnoni A., Miscioscia R., Virgili A. Measurement of nickel, cobalt and chromium in toy make-up by atomic absorption spectroscopy. Acta Derm. Venereol. 2009, 89:130-133.
39. CPHR, Centre for Public Health Research, 2011. Report for a survey of low cost cosmetics (lipstick) for the Ministry of Health. Massey University, Wellington, New Zealand.
40. CSC, Campaign for Safe Cosmetics. A poison kiss: the problem of lead in lipstick. 2007. Available at www.safecosmetics.org. Accessed 14 October 2013.
41. CSC, Campaign for Safe Cosmetics. No more toxic tub: getting contaminants out of children's bath & personal care products. 2009. Available at: <>. [Accessed 14 October 2013]. http://www.safecosmetics.org/article.php?id=223.
42. CSF, Campaign for Safe Cosmetics. A report on heavy metals in face paints. Campaign for Safe Cosmetics. 2009. Available at: <>. [Accessed 11 October 2013]. http://www.safecosmetics.org/downloads/PrettyScary_Oct2709.pdf.
43. Dotterud L.K., Smith-Sivertsen T. Allergic contact sensitization in the general adult population: a population-based study from Northern Norway. Contact Dermatitis 2007, 56:10-15.
44. EARAE, Environmental Assessment and Risk Analysis Element, 2003. White Paper Summary. FDA.
45. EC, European Commission, 2004. DG Enterprise. Report on the comparative study on cosmetics legislation in the EU and other principal markets with special attention to so-called borderline products. Risk & Policy Analysts Limited, Loddon, UK.
46. ED, Environmental Defence Canada, 2011. Heavy metal hazard. The health risks of hidden heavy metals in face makeup. Environmental Defence, Toronto, Canada. Available at: <>. [Accessed 10 October 2013]. http://environmentaldefence.ca/sites/default/files/report_files/HeavyMetalHazard%20FINAL.pdf.
47. El-Shazly E.A.A., Abo Zahra Sh.F., El-Sweify F.H., Kanias G.D. Simultaneous multi-element determination in some cosmetic samples of different origins using neutron activation analysis. Radiochim. Acta 2004, 92:111-117.
48. Engler D.E. Mercury "bleaching" creams. J. Am. Acad. Dermatol. 2005, 52:1113-1114.
49. EPA, Environmental Protection Agency, 2004a. Risk Assessment Guidance for Superfund. Volume I: Human Health Evaluation Manual, Part E, Supplemental Guidance for Dermal Risk Assessment, Final. EPA/540/R/005. EPA, Office of Solid Waste and Emergency Response, Washington, DC.
50. EPA, Environmental Protection Agency. IRIS data base. 2004b. Available at: <>. [Accessed 03 September 2013]. http://www.epa.gov/iris/subst/0277.html.
51. EU, European Union. Council Directive 76/768/EEC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products. Official Journal L 262, 27/09/1976, p. 169.
52. EU, European Union. Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products. Official Journal L342, 22/12/2009, p. 59.
53. EWG, Environmental Working Group. Exposures Add Up - Survey Results. 2004. Available at: <>. [Accessed 03 September 2013]. http://www.ewg.org/skindeep/2004/06/15/exposures-add-up-survey-results/.
54. EWG, Environmental Working Group. Impurities of Concern in Personal Care Products. 2007. Available at: <>. [Accessed 03 September 2013]. http://www.ewg.org/skindeep/2007/02/04/impurities-of-concern-in-personal-care-products/.
55. Fasanya-Odewumi C., Latinwo L.M., Ikediobi C.O., Gilliard L., Sponholtz G., Nwoga J., Stino F., Hamilton N., Erdos G.W. The genotoxicity and cytotoxicity of dermally-administered cadmium: effects of dermal cadmium administration. Int. J. Mol. Med. 1998, 1:1001-1006.
56. FDA, Food and Drug Administration, 2000. Cosmetics: ingredients prohibited & restricted by FDA regulations. Available at: <>. [Accessed 14 October 2013]. http://www.fda.gov/Cosmetics/ProductandIngredientSafety/SelectedCosmeticIngredients/ucm127406.html.
57. FDA, Food and Drug Administration, 2006a. Federal Food, Drug, and Cosmetic Act (FD&C Act). Available at: <>. [Accessed 03 September 2013]. http://www.fda.gov/RegulatoryInformation/Legislation/FederalFoodDrugandCosmeticActFDCAct/default.html.
58. FDA, Food and Drug Administration, 2006b. Kohl, Kajal, Al-Kahal, or Surma: by any name, a source of lead poisoning. Available at: <>. [Accessed 14 October 2013]. http://www.fda.gov/Cosmetics/ProductandIngredientSafety/ProductInformation/ucm137250.html.
59. FDA, Food and Drug Administration, 2009. Lipstick and lead: questions and answers. Available at: <>. [Accessed 14 October 2013]. http://www.fda.gov/Cosmetics/ProductandIngredientSafety/ProductInformation/ucm137224.html.
60. FDA, Food and Drug Administration, 2012. Color Additives and Cosmetics. Available at: <>. [Accessed 27 January 2014]. http://www.fda.gov/ForIndustry/ColorAdditives/ColorAdditivesinSpecificProducts/InCosmetics/ucm110032.html.
61. FDA, Food and Drug Administration, 2013. Title 21-Food and Drugs. Chapter I - Food and Drug Administration, Department of Health and Human Services. Part 74 - Listing of Color Additives Subject to Certification. Sec. 74.1306 D&C Red No. 6. Available at: <>. [Accessed 14 October 2013]. http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=74.1306.
62. Fischer T. Cobalt chloride. Management of Positive Patch Test Reactions 2003, 3-6. Springer, Heidelberg. J.E. Wahlberg, P. Elsner, L. Kanerva, H.I. Maibach (Eds.).
63. Fischer T., Rystedt I. Cobalt allergy in hard metal workers. Contact Dermatitis 1983, 9:115-121.
64. Fischer L.A., Mennè T., Johansen J.D. Experimental nickel elicitation thresholds - a review focusing on occluded nickel exposure. Contact Dermatitis 2005, 52:57-64.
65. Forte G., Petrucci F., Bocca B. Metal allergens of growing significance: epidemiology, immunotoxicology, strategies for testing and prevention. Inflammation Allergy Drug Targets 2008, 7:145-162.
66. Foulds, I.S., 2006. Facial eczema due to color pigments in foundation makeup in nickel-sensitive patients. Contact Dermatitis 55(S 1):11.
67. Freireich-Astman M., David M., Trattner A. Standard patch test results in patients with contact dermatitis in Israel: age and sex differences. Contact Dermatitis 2007, 56:103-107.
68. Gammelgaard B., Fullerton A., Avnstorp C., Menné T. Permeation of chromium salts through human skin in vitro. Contact Dermatitis 1992, 27:302-310.
69. Godt J., Scheidig F., Grosse-Siestrup C., Esche V., Brandenburg P., Reich A., Gronenberg D.A. The toxicity of cadmium and resulting hazards for human health. J. Occup. Med. Toxicol. 2006, 1:1-6.
70. Goh C.L., Ng S.K., Kwok S.F. Allergic contact dermatitis from nickel in eyeshadows. Contact Dermatitis 1989, 20:380-381.
71. Gondal M.A., Seddigi Z.S., Nasr M.M., Gondal B. Spectroscopic detection of health hazardous contaminants in lipstick using Laser Induced Breakdown Spectroscopy. J. Hazard Mater. 2010, 175:726-732.
72. Graeme K.A., Pollack C.V. Heavy metal toxicity, part I: arsenic and mercury. J. Emerg. Med. 1998, 16:45-56.
73. Grosser Z., Davidowski L., Thompson L. The determination of metals in cosmetics. PerkinElmer Appl. Note 2011, 1-6.
74. Guarneri F., Guarneri C., Cannavò S.P. Nail-art and cobalt allergy. Contact Dermatitis 2010, 62:320-321.
75. Gunduz S., Akman S. Investigation of lead contents in lipsticks by solid sampling high resolution continuum source electrothermal atomic absorption spectromentry. Regul. Toxicol. Pharm. 2013, 65:34-37.
76. Guy R., Hostynek J.J., Hinz R.S., Lorence C.R. Metals and the Skin: Topical Effects and Systemic Absorption 1999, CRC Press, New York. third ed.
77. Hall B., Tozer S., Safford B., Coroama M., Steiling W., Leneveu-Duchemin M.C., McNamara C., Gibney M. European consumer exposure to cosmetic products, a framework for conducting population exposure assessments. Food Chem. Toxicol. 2007, 45:2097-2108.
78. Hansen M.B., Rydin S., Menné T., Duus J.J. Quantitative aspects of contact allergy to chromium and exposure to chrome-tanned leather. Contact Dermatitis 2002, 47:127-134.
79. HC-SC, Health Canada-Santé Canada, 1993. Arsenic and its compounds. Available at: <>. [Accessed 14 October 2013]. http://www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/psl1-lsp1/arsenic_comp/index-eng.php.
80. HC-SC, Health Canada-Santé Canada, 1994. Cadmium and its compounds. Available at: <>. [Accessed 14 October 2013]. http://www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/psl1-lsp1/cadmium_comp/index-eng.php.
81. HC-SC, Health Canada-Santé Canada, 2011. Cosmetic Ingredient Hotlist. Available at: <>. [Accessed 03 September 2013]. http://www.hc-sc.gc.ca/cps-spc/alt_formats/hecs-sesc/pdf/cosmet-person/indust/hot-list-critique/hotlist-liste_2011-eng.pdf.
82. HC-SC, Health Canada-Santé Canada, 2012. Guidance on Heavy Metal Impurities in Cosmetics. Available at: <>. [Accessed 03 September 2013]. http://www.hc-sc.gc.ca/cps-spc/pubs/indust/heavy_metals-metaux_lourds/index-eng.php.
83. Hepp N. Determination of total lead in 400 lipsticks on the U.S. market using a validated microwave-assisted digestion, inductively coupled plasma-mass spectrometry method. J. Cosmet. Sci. 2012, 63:159-176.
84. Hepp N.M., Mindak W.R., Cheng J. Determination of total lead in lipstick: development and validation of a microwave-assisted digestion, inductively coupled plasma-mass spectrometric method. J. Cosmet. Sci. 2009, 60:405-414.
85. Hostynek J.J. Factors determining percutaneous metal absorption. Food Chem. Toxicol. 2003, 41:327-345.
86. Hostynek J.J., Dreher F., Nakada T., Schwindt D., Anigbogu A., Maibach H.I. Human stratum corneum adsorption of nickel salts. Acta Derm. Veneorol. 2001, S212:11-18.
87. HSNO, Hazardous Substances and New Organisms Act 1996. Cosmetic Products Group Standard 2006 (amended 2012) of New Zealand. Available at: <>. [Accessed 03 September 2013]. http://www.epa.govt.nz/Publications/Cosmetic%20Products%20Group%20Standard.pdf.
88. Hughes M.F., Mitchell C.T., Edwards B.C., Rahman M.S. In vitro percutaneous absorption of dimethylarsinic acid in mice. J. Toxicol. Environ. Health 1995, 45:279-290.
89. Hwang M., Yoon E.K., Kim J.Y., Son B.K., Yang S.J., Yun M.O., Choi S.S., Jang D.D., Yoo T.M. Safety assessment of chromium by exposure from cosmetic products. Arch. Pharm. Res. 2009, 32:235-241.
90. IARC, International Agency for Research on Cancer, 1989. Some organic solvents, resin monomers and related compounds, pigments and occupational exposures in paint manufacture and painting. Vol. 47. IARC, Lyon, France.
91. IARC, International Agency for Research on Cancer, 1990. Chromium, Nickel and welding. Vol. 49. IARC, Lyon, France.
92. IARC, International Agency for Research on Cancer, 1991. Chlorinated Drinking-Water; Chlorination By-Products; Some Other Halogenated Compounds; Cobalt and Cobalt Compounds. Vol. 52. IARC, Lyon, France.
93. IARC, International Agency for Research on Cancer, 1993. Beryllium, Cadmium, Mercury, and Exposures in the Glass Manufacturing Industry. Vol. 58. IARC, Lyon, France.
94. IARC, International Agency for Research on Cancer, 2006. Inorganic and organic lead compounds. Vol. 87, IARC, Lyon, France.
95. IARC, International Agency for Research on Cancer, 2012. Arsenic, metals, fibres, and dusts. Vol. 100 C, IARC, Lyon, France.
96. Iavicoli I., Caroli S., Alimonti A., Petrucci F., Carelli G. Biomonitoring of workers exposed to low antimony trioxide levels. J. Trace Elem. Med. Biol. 2002, 16:33-39.
97. Iyer V.J., Banerjee G., Govindram C.B., Kamath V., Shinde S., Gaikwad A., Jeraiani H.R., Raman G., Cherian K.M. Role of different valence states of chromium in the elicitation of allergic contact dermatitis. Contact Dermatitis 2002, 47:357-360.
98. Jäger C., Jappe U. Contact dermatitis to permanent make up: manifestation of a pre-existing nickel allergy. JDDG 2005, 3:527-529.
99. Jallad K.N., Espada-Jallad C. Lead exposure from the use of Lawsonia inermis (Henna) in emporary paint-on-tattoing and hair dying. Sci. Total Environ. 2008, 397:244-250.
100. Jomova K., Jenisova Z., Feszterova M., Baros S., Liska J., Hudecova D., Rhodes C.J., Valko M. Arsenic: toxicity, oxidative stress and human disease. J. Appl. Toxicol. 2011, 31:95-107.
101. Kang I.J., Lee M.H. Quantification of para-phenylenediamine and heavy metals in henna dye. Contact Dermatitis 2006, 55:26-29.
102. Kang E.K., Lee S., Park J.H., Joo K.M., Jeong H.J., Chang I.S. Determination of hexavalent chromium in cosmetic products by ion chromatography and postcolumn derivatization. Contact Dermatitis 2006, 54:244-248.
103. Karlberg A.T., Lidén C., Ehrin E. Colophony in mascara as a cause of eyelid dermatitis. Chemical analyses and patch testing. Acta Derm. Venereol. 1991, 71:445-447.
104. KFDA, Korean Food and Drug Administration. Notification No. 2003-23. Regulation on ingredient designation, specification and test methods of cosmetics of 19 2003.
105. Kosann M.K., Brancaccio R.R., Shupack J.L., Franks A.G., Cohen D.E. Six-hour versus 48-h patch testing with varying concentrations of potassium dichromate. Am. J. Contact Dermatitis 1998, 9:92-95.
106. Lacy S.A., Merritt K., Brown S.A., Puryear A. Distribution of nickel and cobalt following dermal and systematic administration with in vitro and in vivo studies. J. Biomed. Mater. Res. 1996, 32:279-283.
107. Lansdown A.B., Sampson B. Dermal toxicity and percutaneous absorption of cadmium in rats and mice. Lab. Anim. Sci. 1996, 46:549-554.
108. Larese F., Gianpietro A., Venier M., Maina G., Renzi N. In vitro percutaneous absorption of metal compounds. Toxicol. Lett. 2007, 170:49-56.
109. Larese Filon F., Maina G., Adami G., Venier M., Coceani N., Bussani R., Massiccio M., Barbieri P., Spinelli P. In vitro percutaneous absorption of cobalt. Int. Arch. Occup. Environ. Health 2004, 77:85-89.
110. Larese Filon F., Boeniger M., Maina G., Adami G., Spinelli P., Damian A. Skin absorption of inorganic lead (PbO) and the effect of skin cleansers. J. Occup. Environ. Med. 2006, 48:692-699.
111. Larese Filon F., D'Agostin F., Crosera M., Adami G., Bovenzi M., Maina G. In vitro percutaneous absorption of chromium powder and the effect of skin cleanser. Toxicol. In Vitro 2008, 22:1562-1567.
112. Larese Filon F., D'Agostin F., Crosera M., Adami G., Bovenzi M., Maina G. In vitro absorption of metal powders through intact and damaged human skin. Toxicol. In Vitro 2009, 23:574-579.
113. Lavilla I., Cabaleiro N., Costas M., de la Calle I., Bendicho C. Ultrasound-assisted emulsification of cosmetic samples prior to elemental analysis by different atomic spectrometric techniques. Talanta 2009, 80:109-116.
114. Lekouch N., Sedki A., Nejmeddine A., Gamon S. Lead and traditional Moroccan pharmacopoeia. Sci. Total Environ. 2001, 280:39-43.
115. Liu S., Hammond K., Rojas-Cheatham A. Concentrations and potential health risks of metals in lip products. Environ. Health Persp. 2013, 121:705-710.
116. Loretz L.J., Api A.M., Barraj L.M., Burdick J., Dressler W.E., Gettings S.D., Han Hsu H., Pan Y.H.L., Re T.A., Renskers K.J., Rothenstein A., Scrafford C.G., Sewall C. Exposure data for cosmetic products: lipstick, body lotion, and face cream. Food Chem. Toxicol. 2005, 43:279-291.
117. Loretz L.J., Api A.M., Barraj L.M., Burdick J., Davis D.A., Dressler W., Gilberti E., Jarret G., Mann S., Pan L., Re T., Renskers K., Scrafford C., Vater S. Exposure data for personal care products: Hairspray, spray perfume, liquid foundation, shampoo, body wash, and solid antiperspirant. Food Chem. Toxicol. 2006, 44:2008-2018.
118. Lowney Y.W., Ruby M.V., Wester R.C., Schoof R.A., Holm S.E., Hui X.Y., Barbadillo S., Maibach H.I. Percutaneous absorption of arsenic from environmental media. Toxicol. Ind. Health 2005, 21:1-14.
119. Machovcova A., Dastychiva E., Kostalova D., Vojtechivska A., Reslova J., Smejkalova D., Vaneckova J., Vocilkova A. Common contact sensitizers in the Czech Republic. Patch test results in 12,058 patients with suspected contact dermatitis. Contact Dermatitis 2005, 53:162-166.
120. Marzulli F.N., Watlington P.M., Maibach H.I. Exploratory skin penetration findings relating to the use of lead acetate hair dyes. Hair as a test tissue for monitoring uptake of systemic lead. Curr. Probl. Dermatol. 1978, 7:196-204.
121. McKelvey W., Jeffery N., Clark N., Kass D., Parsons P.J. Population-based inorganic mercury biomonitoring and the identification of skin care products as a source of exposure in New York City. Environ. Health Perspect. 2011, 119:203-209.
122. Mennè T., Christopherson J. A Green. Epidemiology of Nickel Dermatitis. Nickel and the Skin: Immunology and Toxicology 1989, 109-115. CRC Press, Boca Raton. H.I. Maibach, T. Mennè (Eds.).
123. MHLW, Ministry of Health Labor and Welfare Notification no. 331 of 2000. Japan. Available at: <>. [Accessed 03 September 2013]. http://www.mhlw.go.jp/english/dl/cosmetics.pdf.
124. Murphy T., Slotton D.G., Irvine K., Sukontason K., Goldman C.R. Mercury contamination of skin whiteners in Cambodia. Hum. Ecol. Risk Assess. 2009, 15:1286-12303.
125. Nico P.S., Ruby M.V., Lowney Y.W., Holm S.E. Chemical speciation and bioaccessibility of arsenic and chromium in chromated copper arsenate-treated wood and soils. Environ. Sci. Technol. 2006, 40:402-408.
126. Nnorom I.C., Igwe J.C., Oji-Nnorom C.G. Trace metal contents of facial (make-up) cosmetics commonly used in Nigeria. Afr. J. Biotechnol. 2005, 4:1133-1138.
127. Nohynek G.J., Antignac E., Re T., Toutain H. Safety assessment of personal care products/cosmetics and their ingredients. Toxicol. Appl. Pharm. 2010, 243:239-259.
128. Omolaoye J.A., Uzairu A., Gimba C.E. Heavy metal assessment of some eye shadow products imported into Nigeria from China. Arch. Appl. Sci. Res. 2010, 2:76-84.
129. Onwordi C.T., Orizu C.O., Wusu A.D., Ogunwande I.A. Potentially toxic metals exposure from body creams sold in Lagos. Nigeria Res. 2011, 3(1):30-37.
130. Oyedeji F.O., Hassan G.O., Adeleke B.B. Hydroquinone and heavy metals levels in cosmetics marketed in Nigeria. Trends App. Sci. Res. 2011, 6:622-639.
131. Özkaya E., Mirzoyeva L., Ötkür B. Mercury-induced systemic allergic dermatitis caused by 'white precipitate' in a skin lightening cream. Contact Dermatitis 2009, 60:61-63.
132. Palmer R.B., Godwin D.A., McKinney P.E. Transdermal kinetics of a mercurous chloride beauty cream: an in-vitro human skin analysis. Clin. Toxicol. 2000, 38:701-707.
133. Peregrino C.P., Moreno M.V., Miranda S., Rubio A.D., Leal L.O. Mercury levels in locally manufactured mexican skin-lightening creams. Int. J. Environ. Res. Public Health 2011, 8:2516-2523.
134. Piccinini P., Piecha M., Fortaner Torrent S. European survey on the content of lead in lip products. J. Pharm. Biomed. Anal. 2013, 76:225-233.
135. Piela Z., Kiec-Swierczynska M. Skin reactivity in subjects sensitive to different concentrations of nickel, chromium and cobalt. Med. Pr. 1998, 49:457-463.
136. 1 mice. Toxicol. In Vitro 1994, 8:441-448.
137. Rodrigues Soares A., Nascentes C.C. Development of a simple method for the determination of lead in lipstick using alkaline solubilization and graphite furnace atomic absorption spectrometry. Talanta 2013, 105:272-277.
138. Roper, S.C., Stupart, L., 2006. The in vitro percutaneous absorption of antimony trioxide through human skin. Charles River Laboratories Report No. 25985. Edinburgh (UK).
139. Ruengsitagoon, W., Thanasakulpasert, S., Ngiamsombat, K., Boonmalert, J., Sachdev, C., Waiprom, N., Yingkondee, S., 2011. Determination of lead in lipsticks using atomic absorption spectrophotometric method. The 3rd International Conference on Science and Technology for Sustainable Development of the Greater Mekong Sub-region (STGMS) Souphanouvong University, Luang Prabang, Lao PDR. 24-25 March, 2011. pp. 580-584.
140. Sainio E.L., Jolanki R., Hakala E., Kanerva L. Metals and arsenic in eye shadows. Contact Dermatitis 2000, 42:5-10.
141. Sanders T., Liu Y., Buchner V., Tchounwou P.B. Neurotoxic effects and biomarkers of lead exposure: a review. Rev. Environ. Health 2009, 24:15-45.
142. Scansetti G., Botta G.C., Spinelli P., Reviglione L., Ponzetti C. Absorption and excretion of cobalt in the hard metal industry. Sci. Total Environ. 1994, 150:141-144.
143. SCCNFP, Scientific Committee on Cosmetic Products and Non-Food Products intended for Consumers. Chemical ingredients in cosmetic products classified as carcinogenic, mutagenic or toxic to reproduction according to the chemicals Directive 67/548/EEC adopted by the SCCNFP during the 18th Plenary meeting of 25 September 2001. SCCNFP/0474/01.
144. SCCS, Scientific Committee on Consumers Products. The SCCS'S Notes of guidance for the testing of cosmetic substances and their safety evaluation, 8th revision. SCCS/1501/12.
145. Sharma V.K., Chakrabarti A. Common contact sensitizers in Chandigarh, India. A study of 200 patients with the European standard series. Contact Dermatitis 1998, 38:127-131.
146. Simonsen A.B., Deleuran M., Johansen J.D., Sommerlund M. Contact allergy and allergic contact dermatitis in children - a review of current data. Contact Dermatitis 2011, 65:254-265.
147. Sin K.W., Tsang H.F. Large-scale mercury exposure due to s cream cosmetic: community-wide case series. Hong Kong Med. J. 2003, 9:29-34.
148. 0-instrumental neutron activation analysis. J. Radioanal. Nucl. Chem. 2009, 281:259-263.
149. Sprinkle R.V. Leaded eye cosmetics: a cultural cause of elevated lead levels in children. J. Fam. Practice 1995, 40:358-362.
150. Stauber J., Florence T., Gulson B., Dale L. Percutaneous absorption of inorganic lead compounds. Sci. Tot. Environ. 1994, 145:55-70.
151. Stigter J.B., De Haan H.P.M., Guicherit R., Dekkers C.P.A., Daane M.L. Determination of cadmium, zinc, copper, chromium and arsenic in crude oil cargoes. Environ. Pollut. 2000, 107:451-464.
152. Sun C.C., Wong T.T., Hwang T.W., Chao K.Y., Jee S.H., Wang J.D. Percutaneous absorption of inorganic lead compounds. AIHAJ 2002, 63:641-646.
153. Tanojo H., Hostynek J.J., Mountford H.S., Maibach H.I. In vitro permeation of nickel salts through human stratum corneum. Acta Derm. Veneorol. 2001, S212:19-23.
154. Thyssen J.P., Menné T. Metal allergy - a review on exposures, penetration, genetics, prevalence, and clinical implications. Chem. Res. Toxicol. 2010, 23:309-318.
155. Thyssen J.P., Johansen J.D., Menné T. Contact allergy epidemics and their controls. Contact Dermatitis 2007, 56:185-195.
156. Travassos A.R., Bruze M., Dahlin J., Goossens A. Allergic contact dermatitis caused by nickel in a green eye pencil. Contact Dermatitis 2011, 65:302-309.
157. Uram E., Bischofer B.P., Hagermann S. Market analysis of some mercury-containing products and their mercury-free alternatives in selected regions 2010, Gesellschaft für Anlagenund Reaktorsicherheit, Brunswick, Germany, pp. 1-140.
158. Uter W., Aberer W., Armario-Hita J.C., Fernandez-Vozmediano J.M., Ayala F., Balato A., Bauer A., et al. Current patch test results with the European baseline series and extensions to it from the 'European Surveillance System on Contact Allergy' network, 2007-2008. Contact Dermatitis 2012, 67:9-19.
159. van der Krogt, P., 2003. Triumph-Wagen des Antimonij (Triumphal Chariot of Antimony). A monograph on Antimony 1604 Basilius Valentinus (1565-1624). Elementymology & Elements Multidict-Stibium: Antimony. Available at: <>. [Accessed 03 September 2013]. http://www.vanderkrogt.net/elements/element.php?sym=Sb.
160. Van Lierde V., Chéry C.C., Roche N., Monstrey S., Moens L., Vanhaecke F. In vitro permeation of chromium species through porcine and human skin as determined by capillary electrophoresis-inductively coupled plasma-sector field mass spectrometry. Anal. Bioanal. Chem. 2006, 384:378-384.
161. Vilaplana J., Grimalt F., Romaguera C., Mascaro J.M. Cobalt content of household cleaning products. Contact Dermatitis 1987, 16:139-141.
162. Volpe M.G., Nazzaro M., Coppola R., Rapuano F., Aquino R.P. Determination and assessments of selected heavy metals in eye shadow cosmetics from China, Italy, and USA. Microchem. J. 2012, 101:65-69.
163. de Waard-van der Spek, F.B., Oranje, A.P., 2009. Patch tests in children with suspected allergic contact dermatitis: a prospective study and review of the literature. Dermatology 218, 119-259.
164. Weldon M.M., Smolinski M.S., Maroufi A., Hasty B.W., Gilliss D.L., Boulanger L.L., Ballaz L.S., Dutton R.J. Mercury poisoning associated with a Mexican beauty cream. West. J. Med. 2000, 173:15-18.
165. Wester R.C., Maibach H.I., Sedik L., Melendres J., DiZio S., Wade M. In vitro percutaneous absorption of cadmium from water and soil into human skin. Fundam. Appl. Toxicol. 1992, 19:1-5.
166. Wester R.C., Maibach H.I., Sedik L., Melendres J., Wade M. In vivo and in vitro percutaneous absorption and skin decontamination of arsenic from water and soil. Fund. Appl. Toxicol. 1993, 20:336-340.
167. Wester R.C., Hui X.Y., Barbadillo S., Maibach H.I., Lowney Y.W., Schoof R.A., Holm S.E., Ruby M.V. In vivo percutaneous absorption of arsenic from water and CCA-treated wood residue. Toxicol. Sci. 2004, 79:287-295.
168. White G.P., Mathias C.G., Davin J.S. Dermatitis in workers exposed to antimony in a melting process. J. Occup. Med. 1993, 35:392-395.
169. WHO, World Health Organization, 2011. Mercury in skin lightening products. Public Health and Environment, World Health Organization, Geneva, Switzerland.
170. Zhang C., Guo S., Huang C. Determination of compositions in cosmetics by multiple-instrument. Am. J. Anal. Chem. 2011, 2:857-862.