ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats

World Journal of Gastroenterology

Volumn 20, Issue 8, 2014, Pages 2091-2097

  Chen, Yu ^a   Lin, Chun ^a   Tang, Ying ^a   Chen, Ai Qin ^a   Liu, Cui Ying ^a   Lu, Da Li ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Abdominal withdrawal reflex; Electromyography; Hyperpolarization activated cyclic nucleotidegated channel; Irritable bowel syndrome; Visceral hypersensitivity; ZD 7288

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1, 2 DIMETHYL 6 (METHYLAMINO) PYRIMIDINIUM CHLORIDE; UNCLASSIFIED DRUG; ANALGESIC AGENT; CARDIOTONIC AGENT; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; ICI D2788; PYRIMIDINE DERIVATIVE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTROMYOGRAPHY; FEMALE; IRRITABLE COLON; MALE; NEWBORN; NONHUMAN; RAT; SCORING SYSTEM; VISCERAL PAIN; ANIMAL; ANTAGONISTS AND INHIBITORS; CHRONIC PAIN; COLON; DISEASE MODEL; DRUG EFFECTS; HYPERALGESIA; IRRITABLE BOWEL SYNDROME; PAIN; PAIN THRESHOLD; PATHOLOGY; SKELETAL MUSCLE; SPRAGUE DAWLEY RAT;

ANALGESICS; ANIMALS; CARDIOTONIC AGENTS; CHRONIC PAIN; COLON; DISEASE MODELS, ANIMAL; ELECTROMYOGRAPHY; HYPERALGESIA; HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS; IRRITABLE BOWEL SYNDROME; MALE; MUSCLE, SKELETAL; PAIN; PAIN THRESHOLD; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; VISCERAL PAIN;

EID: 84894590993     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i8.2091     Document Type: Article

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