-
1
-
-
0032505870
-
NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint
-
Miagkov, A. V., Kovalenko, D. V., Brown, C. E., Didsbury, J. R., Cogswell, J. P., Stimpson, S. A., Baldwin, A. S., and Makarov, S. S. (1998) NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc. Natl. Acad. Sci. U. S. A. 95, 13859-13864
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 13859-13864
-
-
Miagkov, A.V.1
Kovalenko, D.V.2
Brown, C.E.3
Didsbury, J.R.4
Cogswell, J.P.5
Stimpson, S.A.6
Baldwin, A.S.7
Makarov, S.S.8
-
2
-
-
0034049908
-
Gene therapy that inhibits nuclear translocation of nuclear factor kappaB results in tumor necrosis factor alpha-induced apoptosis of human synovial fibroblasts
-
Zhang, H. G., Huang, N., Liu, D., Bilbao, L., Zhang, X., Yang, P., Zhou, T., Curiel, D. T., and Mountz, J. D. (2000) Gene therapy that inhibits nuclear translocation of nuclear factor kappaB results in tumor necrosis factor alpha-induced apoptosis of human synovial fibroblasts. Arthritis Rheum. 43, 1094-1105
-
(2000)
Arthritis Rheum.
, vol.43
, pp. 1094-1105
-
-
Zhang, H.G.1
Huang, N.2
Liu, D.3
Bilbao, L.4
Zhang, X.5
Yang, P.6
Zhou, T.7
Curiel, D.T.8
Mountz, J.D.9
-
3
-
-
0033506335
-
Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy
-
Tomita, T., Takeuchi, E., Tomita, N., Morishita, R., Kaneko, M., Yamamoto, K., Nakase, T., Seki, H., Kato, K., Kaneda, Y., and Ochi, T. (1999) Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy. Arthritis Rheum. 42, 2532-2542
-
(1999)
Arthritis Rheum.
, vol.42
, pp. 2532-2542
-
-
Tomita, T.1
Takeuchi, E.2
Tomita, N.3
Morishita, R.4
Kaneko, M.5
Yamamoto, K.6
Nakase, T.7
Seki, H.8
Kato, K.9
Kaneda, Y.10
Ochi, T.11
-
4
-
-
0036721844
-
Inhibition of NF-kappa B activity by a membrane-transducing mutant of i kappa B alpha
-
Kabouridis, P. S., Hasan, M., Newson, J., Gilroy, D. W., and Lawrence, T. (2002) Inhibition of NF-kappa B activity by a membrane-transducing mutant of I kappa B alpha. J. Immunol. 169, 2587-2593
-
(2002)
J. Immunol.
, vol.169
, pp. 2587-2593
-
-
Kabouridis, P.S.1
Hasan, M.2
Newson, J.3
Gilroy, D.W.4
Lawrence, T.5
-
5
-
-
4043056611
-
Reduced infiltration and increased apoptosis of leukocytes at sites of inflammation by systemic administration of a membrane-permeable IkappaBalpha repressor
-
Blackwell, N. M., Sembi, P., Newson, J. S., Lawrence, T., Gilroy, D. W., and Kabouridis, P. S. (2004) Reduced infiltration and increased apoptosis of leukocytes at sites of inflammation by systemic administration of a membrane-permeable IkappaBalpha repressor. Arthritis Rheum. 50, 2675-2684
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 2675-2684
-
-
Blackwell, N.M.1
Sembi, P.2
Newson, J.S.3
Lawrence, T.4
Gilroy, D.W.5
Kabouridis, P.S.6
-
6
-
-
0034284715
-
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex
-
May, M. J., D'Acquisto, F., Madge, L. A., Glockner, J., Pober, J. S., and Ghosh, S. (2000) Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science 289, 1550-1554
-
(2000)
Science
, vol.289
, pp. 1550-1554
-
-
May, M.J.1
D'acquisto, F.2
Madge, L.A.3
Glockner, J.4
Pober, J.S.5
Ghosh, S.6
-
7
-
-
14944353807
-
Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation
-
Di Meglio, P., Ianaro, A., and Ghosh, S. (2005) Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation. Arthritis Rheum. 52, 951-958
-
(2005)
Arthritis Rheum.
, vol.52
, pp. 951-958
-
-
Di Meglio, P.1
Ianaro, A.2
Ghosh, S.3
-
8
-
-
70350545937
-
Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation
-
Tas, S. W., Vervoordeldonk, M. J., Hajji, N., May, M. J., Ghosh, S., and Tak, P. P. (2006) Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation. Arthritis Res. Ther. 8, R86
-
(2006)
Arthritis Res. Ther.
, vol.8
-
-
Tas, S.W.1
Vervoordeldonk, M.J.2
Hajji, N.3
May, M.J.4
Ghosh, S.5
Tak, P.P.6
-
9
-
-
0033605424
-
Nuclear retention of IkappaBalpha protects it from signal-induced degradation and inhibits nuclear factor kappaB transcriptional activation
-
Rodriguez, M. S., Thompson, J., Hay, R. T., and Dargemont, C. (1999) Nuclear retention of IkappaBalpha protects it from signal-induced degradation and inhibits nuclear factor kappaB transcriptional activation. J. Biol. Chem. 274, 9108-9115
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 9108-9115
-
-
Rodriguez, M.S.1
Thompson, J.2
Hay, R.T.3
Dargemont, C.4
-
10
-
-
0031934634
-
Cloning and expression of murine IFN beta and a TNF antagonist for gene therapy of experimental allergic encephalomyelitis
-
Triantaphyllopoulos, K., Croxford, J., Baker, D., and Chernajovsky, Y. (1998) Cloning and expression of murine IFN beta and a TNF antagonist for gene therapy of experimental allergic encephalomyelitis. Gene Ther. 5, 253-263
-
(1998)
Gene Ther.
, vol.5
, pp. 253-263
-
-
Triantaphyllopoulos, K.1
Croxford, J.2
Baker, D.3
Chernajovsky, Y.4
-
11
-
-
15344344686
-
Latent cytokines: Development of novel cleavage sites and kinetic analysis of their differential sensitivity to MMP-1 and MMP-3
-
Vessillier, S., Adams, G., and Chernajovsky, Y. (2004) Latent cytokines: development of novel cleavage sites and kinetic analysis of their differential sensitivity to MMP-1 and MMP-3. Protein Eng. Des. Sel. 17, 829-835
-
(2004)
Protein Eng. Des. Sel.
, vol.17
, pp. 829-835
-
-
Vessillier, S.1
Adams, G.2
Chernajovsky, Y.3
-
12
-
-
0031055415
-
Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras
-
de Rooij, J., and Bos, J. L. (1997) Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene 14, 623-625
-
(1997)
Oncogene
, vol.14
, pp. 623-625
-
-
De Rooij, J.1
Bos, J.L.2
-
13
-
-
0031759170
-
Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration
-
Nagahara, H., Vocero-Akbani, A. M., Snyder, E. L., Ho, A., Latham, D. G., Lissy, N. A., Becker-Hapak, M., Ezhevsky, S. A., and Dowdy, S. F. (1998) Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat. Med. 4, 1449-1452
-
(1998)
Nat. Med.
, vol.4
, pp. 1449-1452
-
-
Nagahara, H.1
Vocero-Akbani, A.M.2
Snyder, E.L.3
Ho, A.4
Latham, D.G.5
Lissy, N.A.6
Becker-Hapak, M.7
Ezhevsky, S.A.8
Dowdy, S.F.9
-
14
-
-
0003903343
-
-
Cold Spring Harbor Laboratory Press, New York
-
Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, New York
-
(1989)
Molecular Cloning: A Laboratory Manual
-
-
Sambrook, J.1
Fritsch, E.F.2
Maniatis, T.3
-
15
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
16
-
-
0029996147
-
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
-
Naldini, L., Blomer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., and Trono, D. (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272, 263-267
-
(1996)
Science
, vol.272
, pp. 263-267
-
-
Naldini, L.1
Blomer, U.2
Gallay, P.3
Ory, D.4
Mulligan, R.5
Gage, F.H.6
Verma, I.M.7
Trono, D.8
-
17
-
-
33846682591
-
The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells
-
Kulbe, H., Thompson, R., Wilson, J. L., Robinson, S., Hagemann, T., Fatah, R., Gould, D., Ayhan, A., and Balkwill, F. (2007) The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells. Cancer Res. 67, 585-592
-
(2007)
Cancer Res.
, vol.67
, pp. 585-592
-
-
Kulbe, H.1
Thompson, R.2
Wilson, J.L.3
Robinson, S.4
Hagemann, T.5
Fatah, R.6
Gould, D.7
Ayhan, A.8
Balkwill, F.9
-
18
-
-
0242353920
-
Targeting cytokines to inflammation sites
-
Adams, G., Vessillier, S., Dreja, H., and Chernajovsky, Y. (2003) Targeting cytokines to inflammation sites. Nat. Biotechnol. 21, 1314-1320
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 1314-1320
-
-
Adams, G.1
Vessillier, S.2
Dreja, H.3
Chernajovsky, Y.4
-
19
-
-
82955163194
-
Molecular engineering of short half-life small peptides (VIP, alphaMSH and gamma3MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics
-
Vessillier, S., Adams, G., Montero-Melendez, T., Jones, R., Seed, M., Perretti, M., and Chernajovsky, Y. (2012) Molecular engineering of short half-life small peptides (VIP, alphaMSH and gamma3MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics. Ann. Rheum. Dis. 71, 143-149
-
(2012)
Ann. Rheum. Dis.
, vol.71
, pp. 143-149
-
-
Vessillier, S.1
Adams, G.2
Montero-Melendez, T.3
Jones, R.4
Seed, M.5
Perretti, M.6
Chernajovsky, Y.7
-
20
-
-
84890613685
-
A comparative study of matrix metalloproteinase and aggrecanase mediated release of latent cytokines at arthritic joints. [E-pub ahead of print
-
PMID: 23813971
-
Mullen, L., Adams, G., Foster, J., Vessillier, S., Koster, M., Hauser, H., Layward, L., Gould, D., and Chernajovsky, Y. (2013) A comparative study of matrix metalloproteinase and aggrecanase mediated release of latent cytokines at arthritic joints. [E-pub ahead of print] Ann. Rheum Dis. PMID: 23813971
-
(2013)
Ann. Rheum Dis
-
-
Mullen, L.1
Adams, G.2
Foster, J.3
Vessillier, S.4
Koster, M.5
Hauser, H.6
Layward, L.7
Gould, D.8
Chernajovsky, Y.9
-
21
-
-
84890611751
-
Latency can be conferred to a variety of cytokines by fusion with latency associated peptide from TGF
-
In press
-
Mullen, L., Rigby, A., Sclanders, M., Adams, G., Mittal, G., Colston, J., Fatah, R., Subang, C., Foster, J., Francis-West, P., Koster, M., Hauser, H., Layward, L., Vessillier, S., Annenkov, A., Al-Izki, S., Pryce, G., Bolton, C., Baker, D., Gould, D., and Chernajovsky, Y. (2013) Latency can be conferred to a variety of cytokines by fusion with latency associated peptide from TGF. Expert Opin. Drug Deliv. In press
-
(2013)
Expert Opin. Drug Deliv
-
-
Mullen, L.1
Rigby, A.2
Sclanders, M.3
Adams, G.4
Mittal, G.5
Colston, J.6
Fatah, R.7
Subang, C.8
Foster, J.9
Francis-West, P.10
Koster, M.11
Hauser, H.12
Layward, L.13
Vessillier, S.14
Annenkov, A.15
Al-Izki, S.16
Pryce, G.17
Bolton, C.18
Baker, D.19
Gould, D.20
Chernajovsky, Y.21
more..
-
22
-
-
77349102209
-
In vitro modulation of MMP-2 and MMP-9 in human cervical and ovarian cancer cell lines by cytokines, inducers and inhibitors
-
Roomi, M. W., Monterrey, J. C., Kalinovsky, T., Rath, M., and Niedzwiecki, A. (2010) In vitro modulation of MMP-2 and MMP-9 in human cervical and ovarian cancer cell lines by cytokines, inducers and inhibitors. Oncol. Rep. 23, 605-614
-
(2010)
Oncol. Rep.
, vol.23
, pp. 605-614
-
-
Roomi, M.W.1
Monterrey, J.C.2
Kalinovsky, T.3
Rath, M.4
Niedzwiecki, A.5
-
23
-
-
1842534969
-
Production of cell lines secreting TAT fusion proteins
-
Barka, T., Gresik, E. S., and Henderson, S. C. (2004) Production of cell lines secreting TAT fusion proteins. J. Histochem. Cytochem. 52, 469-477
-
(2004)
J. Histochem. Cytochem.
, vol.52
, pp. 469-477
-
-
Barka, T.1
Gresik, E.S.2
Henderson, S.C.3
-
24
-
-
38549110556
-
Comparison of protein transduction domains in mediating cell delivery of a secreted CRE protein
-
Shaw, P. A., Catchpole, I. R., Goddard, C. A., and Colledge, W. H. (2008) Comparison of protein transduction domains in mediating cell delivery of a secreted CRE protein. Biochemistry 47, 1157-1166
-
(2008)
Biochemistry
, vol.47
, pp. 1157-1166
-
-
Shaw, P.A.1
Catchpole, I.R.2
Goddard, C.A.3
Colledge, W.H.4
-
25
-
-
63649084523
-
Delivery of therapeutic proteins as secretable TAT fusion products
-
Flinterman, M., Farzaneh, F., Habib, N., Malik, F., Gaken, J., and Tavassoli, M. (2009) Delivery of therapeutic proteins as secretable TAT fusion products. Mol. Ther. 17, 334-342
-
(2009)
Mol. Ther.
, vol.17
, pp. 334-342
-
-
Flinterman, M.1
Farzaneh, F.2
Habib, N.3
Malik, F.4
Gaken, J.5
Tavassoli, M.6
-
26
-
-
58149187809
-
Secretion and uptake of TAT-fusion proteins produced by engineered mammalian cells
-
Koutsokeras, A., and Kabouridis, P. S. (2009) Secretion and uptake of TAT-fusion proteins produced by engineered mammalian cells. Biochim. Biophys. Acta 1790, 147-153
-
(2009)
Biochim. Biophys. Acta
, vol.1790
, pp. 147-153
-
-
Koutsokeras, A.1
Kabouridis, P.S.2
-
27
-
-
79955623951
-
Expressed cell-penetrating peptides can induce a bystander effect, but passage through the secretory pathway reduces protein transduction activity
-
Shen, Y., Yu, W., Hay, J. G., and Sauthoff, H. (2011) Expressed cell-penetrating peptides can induce a bystander effect, but passage through the secretory pathway reduces protein transduction activity. Mol. Ther. 19, 903-912
-
(2011)
Mol. Ther.
, vol.19
, pp. 903-912
-
-
Shen, Y.1
Yu, W.2
Hay, J.G.3
Sauthoff, H.4
-
28
-
-
0035863391
-
Synthetic protein transduction domains: Enhanced transduction potential in vitro and in vivo
-
Ho, A., Schwarze, S. R., Mermelstein, S. J., Waksman, G., and Dowdy, S. F. (2001) Synthetic protein transduction domains: enhanced transduction potential in vitro and in vivo. Cancer Res. 61, 474-477
-
(2001)
Cancer Res.
, vol.61
, pp. 474-477
-
-
Ho, A.1
Schwarze, S.R.2
Mermelstein, S.J.3
Waksman, G.4
Dowdy, S.F.5
-
29
-
-
0032812877
-
Immune response to green fluorescent protein: Implications for gene therapy
-
Stripecke, R., Carmen Villacres, M., Skelton, D., Satake, N., Halene, S., and Kohn, D. (1999) Immune response to green fluorescent protein: implications for gene therapy. Gene Ther. 6, 1305-1312
-
(1999)
Gene Ther.
, vol.6
, pp. 1305-1312
-
-
Stripecke, R.1
Carmen Villacres, M.2
Skelton, D.3
Satake, N.4
Halene, S.5
Kohn, D.6
-
30
-
-
0031596724
-
Nuclear localization of IkappaB alpha is mediated by the second ankyrin repeat: The IkappaB alpha ankyrin repeats define a novel class of cis-acting nuclear import sequences
-
Sachdev, S., Hoffmann, A., and Hannink, M. (1998) Nuclear localization of IkappaB alpha is mediated by the second ankyrin repeat: the IkappaB alpha ankyrin repeats define a novel class of cis-acting nuclear import sequences. Mol. Cell. Biol. 18, 2524-2534
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 2524-2534
-
-
Sachdev, S.1
Hoffmann, A.2
Hannink, M.3
-
31
-
-
0033525233
-
Characterization of IkappaBalpha nuclear import pathway
-
Turpin, P., Hay, R. T., and Dargemont, C. (1999) Characterization of IkappaBalpha nuclear import pathway. J. Biol. Chem. 274, 6804-6812
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 6804-6812
-
-
Turpin, P.1
Hay, R.T.2
Dargemont, C.3
-
32
-
-
77957730859
-
Expression pattern of matrix metalloproteinases in human gynecological cancer cell lines
-
Schropfer, A., Kammerer, U., Kapp, M., Dietl, J., Feix, S., and Anacker, J. (2010) Expression pattern of matrix metalloproteinases in human gynecological cancer cell lines. BMC Cancer 10, 553
-
(2010)
BMC Cancer
, vol.10
, pp. 553
-
-
Schropfer, A.1
Kammerer, U.2
Kapp, M.3
Dietl, J.4
Feix, S.5
Anacker, J.6
-
33
-
-
33750358664
-
Use of cell permeable NBD peptides for suppression of inflammation
-
Strickland, I., and Ghosh, S. (2006) Use of cell permeable NBD peptides for suppression of inflammation. Ann. Rheum Dis. 65(Suppl. 3), iii75-iii82
-
(2006)
Ann. Rheum Dis.
, vol.65
, Issue.SUPPL. 3
-
-
Strickland, I.1
Ghosh, S.2
-
34
-
-
15944410614
-
PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation
-
Lee, K. Y., D'Acquisto, F., Hayden, M. S., Shim, J. H., and Ghosh, S. (2005) PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Science 308, 114-118
-
(2005)
Science
, vol.308
, pp. 114-118
-
-
Lee, K.Y.1
D'acquisto, F.2
Hayden, M.S.3
Shim, J.H.4
Ghosh, S.5
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