메뉴 건너뛰기




Volumn 19, Issue 5, 2011, Pages 903-912

Expressed cell-penetrating peptides can induce a bystander effect, but passage through the secretory pathway reduces protein transduction activity

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CELL PENETRATING PEPTIDE; FURIN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; RED FLUORESCENT PROTEIN; SECRETORY PROTEIN; TRANSACTIVATOR PROTEIN;

EID: 79955623951     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2010.283     Document Type: Article
Times cited : (7)

References (34)
  • 1
    • 0024262589 scopus 로고
    • Cellular uptake of the tat protein from human immunodeficiency virus
    • DOI 10.1016/0092-8674(88)90263-2
    • Frankel, AD and Pabo, CO (1988). Cellular uptake of the tat protein from human immunodeficiency virus. Cell 55: 1189-1193. (Pubitemid 19020071)
    • (1988) Cell , vol.55 , Issue.6 , pp. 1189-1193
    • Frankel, A.D.1    Pabo, C.O.2
  • 2
    • 0030904245 scopus 로고    scopus 로고
    • A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
    • DOI 10.1074/jbc.272.25.16010
    • Vivès, E, Brodin, P and Lebleu, B (1997). A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem 272: 16010-16017. (Pubitemid 27265584)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.25 , pp. 16010-16017
    • Vives, E.1    Brodin, P.2    Lebleu, B.3
  • 3
    • 68549110328 scopus 로고    scopus 로고
    • Twenty years of cell-penetrating peptides: From molecular mechanisms to therapeutics
    • Heitz, F, Morris, MC and Divita, G (2009). Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics. Br J Pharmacol 157: 195-206.
    • (2009) Br J Pharmacol , vol.157 , pp. 195-206
    • Heitz, F.1    Morris, M.C.2    Divita, G.3
  • 4
    • 0025344596 scopus 로고
    • Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients
    • Ensoli, B, Barillari, G, Salahuddin, SZ, Gallo, RC and Wong-Staal, F (1990). Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients. Nature 345: 84-86.
    • (1990) Nature , vol.345 , pp. 84-86
    • Ensoli, B.1    Barillari, G.2    Salahuddin, S.Z.3    Gallo, R.C.4    Wong-Staal, F.5
  • 5
    • 0030862924 scopus 로고    scopus 로고
    • HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region
    • Chang, HC, Samaniego, F, Nair, BC, Buonaguro, L and Ensoli, B (1997). HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region. AIDS 11: 1421-1431. (Pubitemid 27421173)
    • (1997) AIDS , vol.11 , Issue.12 , pp. 1421-1431
    • Chang, H.C.1    Samaniego, F.2    Nair, B.C.3    Buonaguro, L.4    Ensoli, B.5
  • 6
    • 0027458469 scopus 로고
    • Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation
    • Ensoli, B, Buonaguro, L, Barillari, G, Fiorelli, V, Gendelman, R, Morgan, RA et al. (1993). Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation. J Virol 67: 277-287. (Pubitemid 23002988)
    • (1993) Journal of Virology , vol.67 , Issue.1 , pp. 277-287
    • Ensoli, B.1    Buonaguro, L.2    Barillari, G.3    Fiorelli, V.4    Gendelman, R.5    Morgan, R.A.6    Wingfield, P.7    Gallo, R.C.8
  • 8
    • 77953934642 scopus 로고    scopus 로고
    • HIV-1 Tat is unconventionally secreted through the plasma membrane
    • Rayne, F, Debaisieux, S, Bonhoure, A and Beaumelle, B (2010). HIV-1 Tat is unconventionally secreted through the plasma membrane. Cell Biol Int 34: 409-413.
    • (2010) Cell Biol Int , vol.34 , pp. 409-413
    • Rayne, F.1    Debaisieux, S.2    Bonhoure, A.3    Beaumelle, B.4
  • 9
    • 77951498245 scopus 로고    scopus 로고
    • Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells
    • Rayne, F, Debaisieux, S, Yezid, H, Lin, YL, Mettling, C, Konate, K et al. (2010). Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells. EMBO J 29: 1348-1362.
    • (2010) EMBO J , vol.29 , pp. 1348-1362
    • Rayne, F.1    Debaisieux, S.2    Yezid, H.3    Lin, Y.L.4    Mettling, C.5    Konate, K.6
  • 10
    • 0034633618 scopus 로고    scopus 로고
    • Selective CXCR4 antagonism by Tat: Implications for in vivo expansion of coreceptor use by HIV-1
    • Xiao, H, Neuveut, C, Tiffany, HL, Benkirane, M, Rich, EA, Murphy, PM et al. (2000). Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1. Proc Natl Acad Sci USA 97: 11466-11471.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11466-11471
    • Xiao, H.1    Neuveut, C.2    Tiffany, H.L.3    Benkirane, M.4    Rich, E.A.5    Murphy, P.M.6
  • 11
    • 0035793619 scopus 로고    scopus 로고
    • Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans
    • Tyagi, M, Rusnati, M, Presta, M and Giacca, M (2001). Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans. J Biol Chem 276: 3254-3261.
    • (2001) J Biol Chem , vol.276 , pp. 3254-3261
    • Tyagi, M.1    Rusnati, M.2    Presta, M.3    Giacca, M.4
  • 12
    • 0043201343 scopus 로고    scopus 로고
    • Evidence of protein transduction but not intercellular transport by proteins fused to HIV Tat in retinal cell culture and in vivo
    • DOI 10.1016/S1525-0016(03)00131-X
    • Cashman, SM, Morris, DJ and Kumar-Singh, R (2003). Evidence of protein transduction but not intercellular transport by proteins fused to HIV tat in retinal cell culture and in vivo. Mol Ther 8: 130-142. (Pubitemid 36939304)
    • (2003) Molecular Therapy , vol.8 , Issue.1 , pp. 130-142
    • Cashman, S.M.1    Morris, D.J.2    Kumar-Singh, R.3
  • 13
    • 29244469125 scopus 로고    scopus 로고
    • Fusion of the human immunodeficiency virus type 1 Tat protein transduction domain to thymidine kinase increases bystander effect and induces enhanced tumor killing in vivo
    • DOI 10.1089/hum.2005.16.1389
    • Tasciotti, E and Giacca, M (2005). Fusion of the human immunodeficiency virus type 1 tat protein transduction domain to thymidine kinase increases bystander effect and induces enhanced tumor killing in vivo. Hum Gene Ther 16: 1389-1403. (Pubitemid 41829014)
    • (2005) Human Gene Therapy , vol.16 , Issue.12 , pp. 1389-1403
    • Tasciotti, E.1    Giacca, M.2
  • 14
    • 29244451451 scopus 로고    scopus 로고
    • Tat8-TK/GCV suicide gene therapy induces pancreatic tumor regression in vivo
    • DOI 10.1089/hum.2005.16.1377
    • Cascante, A, Huch, M, Rodríguez, LG, González, JR, Costantini, L and Fillat, C (2005). Tat8-TK/GCV suicide gene therapy induces pancreatic tumor regression in vivo. Hum Gene Ther 16: 1377-1388. (Pubitemid 41829013)
    • (2005) Human Gene Therapy , vol.16 , Issue.12 , pp. 1377-1388
    • Cascante, A.1    Huch, M.2    Rodriguez, L.G.3    Gonzalez, J.R.4    Costantini, L.5    Fillat, C.6
  • 15
    • 0034941801 scopus 로고    scopus 로고
    • The HIV Tat protein transduction domain improves the biodistribution of β-glucuronidase expressed from recombinant viral vectors
    • DOI 10.1038/90242
    • Xia, H, Mao, Q and Davidson, BL (2001). The HIV Tat protein transduction domain improves the biodistribution of α-glucuronidase expressed from recombinant viral vectors. Nat Biotechnol 19: 640-644. (Pubitemid 32625434)
    • (2001) Nature Biotechnology , vol.19 , Issue.7 , pp. 640-644
    • Xia, H.1    Mao, Q.2    Davidson, B.L.3
  • 17
    • 58149187809 scopus 로고    scopus 로고
    • Secretion and uptake of TAT-fusion proteins produced by engineered mammalian cells
    • Koutsokeras, A and Kabouridis, PS (2009). Secretion and uptake of TAT-fusion proteins produced by engineered mammalian cells. Biochim Biophys Acta 1790: 147-153.
    • (2009) Biochim Biophys Acta , vol.1790 , pp. 147-153
    • Koutsokeras, A.1    Kabouridis, P.S.2
  • 18
    • 38549110556 scopus 로고    scopus 로고
    • Comparison of protein transduction domains in mediating cell delivery of a secreted CRE protein
    • DOI 10.1021/bi701542p
    • Shaw, PA, Catchpole, IR, Goddard, CA and Colledge, WH (2008). Comparison of protein transduction domains in mediating cell delivery of a secreted CRE protein. Biochemistry 47: 1157-1166. (Pubitemid 351161872)
    • (2008) Biochemistry , vol.47 , Issue.4 , pp. 1157-1166
    • Shaw, P.A.1    Catchpole, I.R.2    Goddard, C.A.3    Colledge, W.H.4
  • 20
    • 56149126835 scopus 로고    scopus 로고
    • Development of a bidirectional caspase-3 expression system for the induction of apoptosis
    • White, MK, Amini, S, Khalili, K, Kogan, M, Donaldson, K and Darbinian, N (2008). Development of a bidirectional caspase-3 expression system for the induction of apoptosis. Cancer Biol Ther 7: 945-954.
    • (2008) Cancer Biol Ther , vol.7 , pp. 945-954
    • White, M.K.1    Amini, S.2    Khalili, K.3    Kogan, M.4    Donaldson, K.5    Darbinian, N.6
  • 21
    • 0036294517 scopus 로고    scopus 로고
    • Human secretory signal peptide description by hidden Markov model and generation of a strong artificial signal peptide for secreted protein expression
    • DOI 10.1016/S0006-291X(02)00566-1, PII S0006291X02005661
    • Barash, S, Wang, W and Shi, Y (2002). Human secretory signal peptide description by hidden Markov model and generation of a strong artificial signal peptide for secreted protein expression. Biochem Biophys Res Commun 294: 835-842. (Pubitemid 34687192)
    • (2002) Biochemical and Biophysical Research Communications , vol.294 , Issue.4 , pp. 835-842
    • Barash, S.1    Wang, W.2    Shi, Y.3
  • 22
    • 2342663134 scopus 로고    scopus 로고
    • Furin cleavage of the HIV-1 Tat protein
    • DOI 10.1016/j.febslet.2004.03.079, PII S0014579304003886
    • Tikhonov, I, Ruckwardt, TJ, Berg, S, Hatfield, GS and David Pauza, C (2004). Furin cleavage of the HIV-1 Tat protein. FEBS Lett 565: 89-92. (Pubitemid 38595325)
    • (2004) FEBS Letters , vol.565 , Issue.1-3 , pp. 89-92
    • Tikhonov, I.1    Ruckwardt, T.J.2    Berg, S.3    Hatfield, G.S.4    Pauza, C.D.5
  • 23
    • 0035863391 scopus 로고    scopus 로고
    • Synthetic protein transduction domains: Enhanced transduction potential in vitro and in vivo
    • Ho, A, Schwarze, SR, Mermelstein, SJ, Waksman, G and Dowdy, SF (2001). Synthetic protein transduction domains: enhanced transduction potential in vitro and in vivo. Cancer Res 61: 474-477. (Pubitemid 32128600)
    • (2001) Cancer Research , vol.61 , Issue.2 , pp. 474-477
    • Ho, A.1    Schwarze, S.R.2    Mermelstein, S.J.3    Waksman, G.4    Dowdy, S.F.5
  • 24
    • 0026561901 scopus 로고
    • Brefeldin A: Insights into the control of membrane traffic and organelle structure
    • Klausner, RD, Donaldson, JG and Lippincott-Schwartz, J (1992). Brefeldin A: insights into the control of membrane traffic and organelle structure. J Cell Biol 116: 1071-1080.
    • (1992) J Cell Biol , vol.116 , pp. 1071-1080
    • Klausner, R.D.1    Donaldson, J.G.2    Lippincott-Schwartz, J.3
  • 26
    • 0037021410 scopus 로고    scopus 로고
    • HIV-1 TAT-mediated protein transduction and subcellular localization using novel expression vectors
    • DOI 10.1016/S0014-5793(02)03624-4, PII S0014579302036244
    • Yang, Y, Ma, J, Song, Z and Wu, M (2002). HIV-1 TAT-mediated protein transduction and subcellular localization using novel expression vectors. FEBS Lett 532: 36-44. (Pubitemid 35375863)
    • (2002) FEBS Letters , vol.532 , Issue.1-2 , pp. 36-44
    • Yang, Y.1    Ma, J.2    Song, Z.3    Wu, M.4
  • 28
    • 0036846565 scopus 로고    scopus 로고
    • Full-length proteins attached to the HIV tat protein transduction domain are neither transduced between cells, nor exhibit enhanced immunogenicity
    • DOI 10.1038/sj.gt.3301819
    • Leifert, JA, Harkins, S and Whitton, JL (2002). Full-length proteins attached to the HIV tat protein transduction domain are neither transduced between cells, nor exhibit enhanced immunogenicity. Gene Ther 9: 1422-1428. (Pubitemid 35345570)
    • (2002) Gene Therapy , vol.9 , Issue.21 , pp. 1422-1428
    • Leifert, J.A.1    Harkins, S.2    Whitton, J.L.3
  • 29
    • 0041698459 scopus 로고    scopus 로고
    • "Translocatory proteins" and "protein transduction domains": A critical analysis of their biological effects and the underlying mechanisms
    • DOI 10.1016/S1525-0016(03)00151-5
    • Leifert, JA and Whitton, JL (2003). "Translocatory proteins" and "protein transduction domains": a critical analysis of their biological effects and the underlying mechanisms. Mol Ther 8: 13-20. (Pubitemid 36939292)
    • (2003) Molecular Therapy , vol.8 , Issue.1 , pp. 13-20
    • Leifert, J.A.1    Whitton, J.L.2
  • 30
    • 0036430472 scopus 로고    scopus 로고
    • Correlation between hydrophobic properties and efficiency of carrier-mediated membrane transduction and apoptosis of a p53 C-terminal peptide
    • DOI 10.1016/S0006-291X(02)02470-1, PII S0006291X02024701
    • Li, Y, Rosal, RV, Brandt-Rauf, PW and Fine, RL (2002). Correlation between hydrophobic properties and efficiency of carrier-mediated membrane transduction and apoptosis of a p53 C-terminal peptide. Biochem Biophys Res Commun 298: 439-449. (Pubitemid 35333726)
    • (2002) Biochemical and Biophysical Research Communications , vol.298 , Issue.3 , pp. 439-449
    • Li, Y.1    Rosal, R.V.2    Brandt-Rauf, P.W.3    Fine, R.L.4
  • 31
    • 2342595835 scopus 로고    scopus 로고
    • Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis
    • DOI 10.1038/nm996
    • Wadia, JS, Stan, RV and Dowdy, SF (2004). Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat Med 10: 310-315. (Pubitemid 38667624)
    • (2004) Nature Medicine , vol.10 , Issue.3 , pp. 310-315
    • Wadia, J.S.1    Stan, R.V.2    Dowdy, S.F.3
  • 32
    • 34250835903 scopus 로고    scopus 로고
    • A comprehensive model for the cellular uptake of cationic cell-penetrating peptides
    • DOI 10.1111/j.1600-0854.2007.00572.x
    • Duchardt, F, Fotin-Mleczek, M, Schwarz, H, Fischer, R and Brock, R (2007). A comprehensive model for the cellular uptake of cationic cell-penetrating peptides. Traffic 8: 848-866. (Pubitemid 46971632)
    • (2007) Traffic , vol.8 , Issue.7 , pp. 848-866
    • Duchardt, F.1    Fotin-Mleczek, M.2    Schwarz, H.3    Fischer, R.4    Brock, R.5
  • 34
    • 0029315806 scopus 로고
    • Methods for construction of adenovirus vectors
    • Graham, FL and Prevec, L (1995). Methods for construction of adenovirus vectors. Mol Biotechnol 3: 207-220.
    • (1995) Mol Biotechnol , vol.3 , pp. 207-220
    • Graham, F.L.1    Prevec, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.