Poly(ADP-ribose) polymerase inhibition with HYDAMTIQ reduces allergen-induced asthma-like reaction, bronchial hyper-reactivity and airway remodelling

Journal of Cellular and Molecular Medicine

Volumn 18, Issue 3, 2014, Pages 468-479

  Lucarini, Laura ^a   Pini, Alessandro ^b   Gerace, Elisabetta ^a   Pellicciari, Roberto ^c   Masini, Emanuela ^a   Moroni, Flavio ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Airway inflammation and remodelling; Asthma like reaction; Histamine release; Hydroxyl dimethylaminomethyl thieno 2,3 c isoquinolin 5(4H) one (HYDAMTIQ); Poly (ADP ribose) polymerase (PARP)

Indexed keywords

2-((DIMETHYLAMINO)METHYL)-9-HYDROXYTHIENO(2,3-C)ISOQUINOLIN-5(4H)-ONE; ALLERGEN; CYTOKINE; ENZYME INHIBITOR; ISOQUINOLINE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; OVALBUMIN; POLY(ADENOSINE DIPHOSPHATE RIBOSE); THIOPHENE DERIVATIVE;

AIRWAY REMODELING; ANIMAL; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; DRUG EFFECTS; GUINEA PIG; HISTAMINE RELEASE; IMMUNOLOGY; INFLAMMATION; LEUKOCYTE; LUNG; MAST CELL; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY;

AIRWAY REMODELING; ALLERGENS; ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; ENZYME INHIBITORS; GUINEA PIGS; HISTAMINE RELEASE; INFLAMMATION; ISOQUINOLINES; LEUKOCYTES; LUNG; MAST CELLS; OVALBUMIN; OXIDATIVE STRESS; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASE INHIBITORS; POLY(ADP-RIBOSE) POLYMERASES; THIOPHENES;

EID: 84894567125     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12197     Document Type: Article

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