A selective antagonist of histamine H4 receptors prevents antigen-induced airway inflammation and bronchoconstriction in guinea pigs: Involvement of lipocortin-1

British Journal of Pharmacology

Volumn 170, Issue 1, 2013, Pages 200-213

  Somma, T ^a   Cinci, L ^a   Formicola, G ^a   Pini, A ^a   Thurmond, R ^b   Ennis, M ^c   Bani, D ^a   Masini, E ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

airway inflammation; apoptosis; asthma like reaction; cytokines; histamine H4 receptors; JNJ 7777120; lipocortin 1; oxidative stress; prostaglandins

Indexed keywords

1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; 8 HYDROXYDEOXYGUANOSINE; CASPASE 3; ICOSANOID; INTERLEUKIN 4; LEUKOTRIENE B4; LIPOCORTIN 1; MAJOR BASIC PROTEIN; MALONALDEHYDE; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; MYELOPEROXIDASE; PROSTAGLANDIN D2; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRONCHOSPASM; CELL GRANULE; CONTROLLED STUDY; COUGHING; DRUG EFFECT; DYSPNEA; ENZYME ACTIVITY; EXPERIMENTAL GUINEA PIG; GENE EXPRESSION; ICOSANOID METABOLISM; IL 4 GENE; LIPOCORTIN 1 GENE; LUNG ALVEOLUS EPITHELIUM; LUNG LAVAGE; MALE; MAST CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RESPIRATORY TRACT INFLAMMATION; TNF ALPHA GENE; TREATMENT DURATION; UPREGULATION;

AIRWAY INFLAMMATION; APOPTOSIS; ASTHMA-LIKE REACTION; CYTOKINES; HISTAMINE H4 RECEPTORS; JNJ 7777120; LIPOCORTIN-1; OXIDATIVE STRESS; PROSTAGLANDINS;

ANIMALS; ANNEXIN A1; ANTIGENS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOCONSTRICTION; COUGH; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HISTAMINE ANTAGONISTS; INDOLES; INFLAMMATION; LUNG; MALE; OVALBUMIN; PIPERAZINES; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84881655607     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12264     Document Type: Article

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