Cerebral protection of purified Herba Leonuri extract on middle cerebral artery occluded rats

Journal of Ethnopharmacology

Volumn 125, Issue 2, 2009, Pages 337-343

  Loh, Kok Poh ^a   Huang, Shan Hong ^a   Tan, Benny Kwong Huat ^a   Zhu, Yi Zhun ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b Institutes of Brain Science   (China)

Author keywords

Antioxidant; MCAO; Oxidative stress; Purified Herba Leonuri; Stroke

Indexed keywords

FAS ANTIGEN; LEONURUS EXTRACT; NEUROPROTECTIVE AGENT; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN INFARCTION SIZE; BRAIN PROTECTION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; LEONURUS; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NONHUMAN; RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BRAIN; DISEASE MODELS, ANIMAL; DNA DAMAGE; DRUGS, CHINESE HERBAL; INFARCTION, MIDDLE CEREBRAL ARTERY; LEONURUS; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; PHYTOTHERAPY; RATS; RATS, WISTAR; STROKE;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 68849093636     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.05.025     Document Type: Article

References (25)

1. Antonio C., Maria C.P., Mario B., Salvatore P., Roberta C., Tiziana T., and Angelo D.I. Antioxidant profile and early outcome in stroke patients. Stroke 31 (2000) 2295-2300
2. Ashe P.C., and Berry M.D. Apoptotic signalling cascades. Progress in Neuro-Psychopharmacology & Biological Psychiatry 27 (2003) 199-214
3. Chandra J., Samali A., and Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radical Biology and Medicine 29 (2000) 323-333
4. Chen C.X., and Kwan C.Y. Endothelium-independent vasorelaxation by leonurine, a plant alkaloid purified from Chinese motherwort. Life Sciences 68 (2001) 953-960
5. Dan B. Chinese Herbal Medicine: Material Medica. Revised Version (1993), Eastland Press, Seattle, Washington pp. 273-274
6. Halliwell B., and Gutteridge J.M.C. Free Radicals in Biology and Medicine. fourth edition (2007) pp. 220-236
7. Kevin J.B., Colin L.M., and Ashley I.B. Neurodegenerative diseases and oxidative stress. Nature Reviews (Drug Discovery) 3 (2004) 205-214
8. Liu W.W., Ogata T., Sato S., Unoura K., and Onodera J.I. Superoxide scavenging activities of sixty Chinese medicines determined by an ESR spin-trapping method using electrogenerated superoxide. Yakugaku Zasshi 121 (2001) 265-270
9. Loh K.P., Huang S.H., De Silva R., Tan B.K., and Zhu Y.Z. Oxidative stress: apoptosis in neuronal injury. Current Alzheimer Research 3 (2006) 327-337
10. Loh K.P., Low L.S., Wong W.H., Zhou S., Huang S.H., De Silva R., et al. A comparison study of cerebral protection using Ginkgo biloba extract and Losartan on stroked rats. Neuroscience Letters 398 (2006) 28-33
11. Love S. Apoptosis and brain ischemia. Progress in Neuropsychopharmacology & Biological Psychiatry 27 (2003) 267-282
12. Lu Q., Zhu Y.Z., and Wong P.T. Angiotensin receptor gene expression in candesartan mediated neuroprotection. Neuroreport 15 (2004) 2643-2646
13. Lu Q., Zhu Y.Z., and Wong P.T. Neuroprotective effects of candesartan against cerebral ischemia in spontaneously hypertensive rats. Neuroreport 16 (2005) 1963-1967
14. In: Miller L.P. (Ed). Stroke Therapy: Basic, Preclinical and Clinical Directions (1999), Wiley-Liss, New York pp. 3-56
15. Nicholas J.M., Catherine R.E., Michael J.D., Vimala G., and Anthony M. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clinical Science 84 (1993) 407-412
16. 2O-extract from an oriental medicinal plant Leonuri Herba. Japan Journal of Pharmacology 86 (2001) 215-222
17. Stocks J., Gutteridge M.C., Sharp R.J., and Dormandy L. Assay using brain homogenate for measuring the antioxidant activity of biological fluids. Clinical Science and Molecular Medicine 47 (1974) 215-222
18. Sun J., Huang S.H., Zhu Y.C., Whiteman M., Wang M.J., Tan B.K.H., et al. Anti-oxidative stress effects of Herba Leonuri on ischemic rat hearts. Life Sciences 76 (2005) 3043-3056
19. Suresh L.M., Namratta M., Ram, and Raghubir. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Research Reviews 54 (2007) 34-66
20. Whiteman M., Huang S.H., Jennifer A., and Halliwell B. Loss of oxidized and chlorinated bases in DNA treated with reactive oxygen species: implications for assessment of oxidative damage in vivo. Biochemical and Biophysical Research Communications 296 (2002) 883-889
21. Zemke D., Smith J., Reeves M.J., and Majid A. Ischemia and ischemic tolerance in the brain: an overview. Neurotoxicology 25 (2004) 895-904
22. Zhu Y.Z., Huang S.H., Tan B.K.H., Sun J., Whiteman M., and Zhu Y.C. Antioxidants in Chinese herbal medicine: a biochemical perspective. Natural Product Reports 21 (2004) 478-489
23. Zhu Y.Z., Zhu Y.C., Gohlke P., and Unger Th.. Overview on pharmacological properties of angiotensin converting enzyme inhibitors. In: Hall, and Unger (Eds). ACE Inhibition and Target Organ Protection (1998), Euromed Communications Ltd., Oxford p1-p20 (UK)
24. Zhu Y.Z., and Zhu Y.C. Rediscovering remedies. Science Online 297 (2002) 1231
25. Zou Q.Z., Bi R.G., Li J.M., Feng J.B., Yu A.M., Chan H.P., et al. Effect of motherwort on blood hyperviscosity. American Journal of Chinese Medicines 17 (1989) 65-70