Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin αIIbβ3 in activated platelets

Thrombosis Research

Volumn 125, Issue 2, 2010, Pages 152-158

  Israels, Sara J ^a,b   McMillan Ward, Eileen M ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

blood platelets; CD63; CD9; palmitoylation; platelet activation; tetraspanin

Indexed keywords

2 BROMOPALMITIC ACID; ALPHAIIB BETA3 INTEGRIN; BETA3 INTEGRIN; CD63 ANTIGEN; CD9 ANTIGEN; CELL PROTEIN; FIBRINOGEN; PALMITIC ACID; TETRASPANIN; THROMBIN; TYLOXAPOL; UNCLASSIFIED DRUG;

ARTICLE; CELL SPREADING; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; DENSITY GRADIENT CENTRIFUGATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INHIBITION KINETICS; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

ANTIGENS, CD; BLOOD PLATELETS; HUMANS; LIPOYLATION; MEMBRANE GLYCOPROTEINS; PLATELET ACTIVATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PLATELET MEMBRANE GLYCOPROTEINS;

EID: 76449106747     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2009.07.005     Document Type: Article

References (45)

1. Boucheix C., and Rubenstein E. Tetraspanins. Cell Mol Life Sci 58 (2001) 1189-1205
2. Hemler M.E. Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu Rev Cell Dev Biol 19 (2003) 397-422
3. Levy S., and Shosham T. The tetraspanin web modulates immune-signalling complexes. Nat Rev Immunol 5 (2005) 136-148
4. Berditchevski F., and Odintsova E. Tetraspanins as regulators of protein trafficking. Traffic 8 (2007) 89-96
5. Stipp C.S., Kolesnikova T.V., and Hemler M.E. Functional domains in tetraspanin proteins. Trends Biochem Sci 28 (2003) 106-112
6. Boucheix C., Huynh G., Duc T., Jasmin C., and Rubinstein E. Tetraspanins and malignancy. Exp Rev Mol Med 3 (2001) 1-17
7. Yunta M., and Lazo P.A. Tetraspanin proteins as organizers of membrane microdomains and signalling complexes. Cell Signal 15 (2003) 559-564
8. Tarrant J.M., Robb L., van Spriel A.B., and Wright M.D. Tetraspanins: molecular organisers of the leukocyte surface. Trends Immunol 24 (2003) 610-617
9. Goschnick M., and Jackson D.E. Tetraspanins -- structural and signaling scaffolds that regulate platelet function. Min-Rev Med Chem 7 (2007) 1248-1254
10. Israels S.J., McMillan-Ward E.M., Easton J., Roberston C., and McNicol A. CD63 associates with the αIIbβ3 integrin-CD9 complex on the surface of activated platelets. Thromb Haemost 85 (2001) 134-141
11. Protty M.B., Watkins N.A., Colombo D., Thomas S.G., Heath V.L., Herbert J.M.J., et al. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. Biochem J 417 (2009) 391-400
12. Israels S.J., and McMillan-Ward E.M. Platelet tetraspanin complexes and their association with lipid rafts. Thromb Haemost 98 (2007) 1081-1087
13. Hemler M.E. Tetraspanin functions and associated microdomains. Nat Rev Mol Cell Biol 6 (2005) 801-811
14. Kropshofer H., Spindeldreher S., Röhn T.A., Platania N., Grygar C., Daniel N., et al. Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes. Nat Immunol 3 (2002) 61-68
15. Foster L.J., De Hoog C.L., and Mann M. Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors. Proc Natl Acad Sci U S A 100 (2003) 5813-5818
16. Yang X., Kovalinko O.V., Tang W., Claas C., Stipp S., and Hemler M.E. Palmitoylation supports assembly and function of integrin-tetraspanin complexes. J Biol Chem 167 (2004) 1231-1240
17. Resh M.D. Palmitoylation of ligands, receptors, and intracellular signaling molecules. Sci STKE 359 (2006) re14
18. Flaumenhaft R., and Sim D.S. Protein palmitoylation in signal transduction of hematopoietic cells. Hematology 10 (2005) 511-519
19. Charrin S., Manie S., Oualid M., Oualid M., Billard M., Boucheix C., et al. Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation. FEBS Lett 516 (2002) 139-144
20. Berditchevski F., Odintsova E., Sawada S., and Gilbert E. Expression of the palmitoylation-deficient CD151 weakens the association of α3β1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling. J Biol Chem 277 (2002) 36991-37000
21. Yang X., Claas C., Kraeft S.K., Chen L.B., Wang Z., Kreidberg J.A., et al. Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology. Mol Biol Cell 13 (2002) 767-781
22. Sim D.S., Dilks J.R., and Flaumenhaft R. Platelets possess and require and active protein palmitoylation pathway for agonist-mediated activation and in vivo thrombus formation. Arterioscler Thromb Vasc Biol 27 (2007) 1478-1485
23. Webb Y., Hermida-Matsumoto L., and Resh M.D. Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acid. J Biol Chem 275 (2000) 261-270
24. Gerrard J.M., Lint D., Sims P.J., Wiedmer T., Fugate R.D., McMillan E., et al. Identification of a platelet dense granule membrane protein which is deficient in a patient with the Hermansky-Pudlak syndrome. Blood 77 (1991) 101-112
25. Nishibori M., Cham B., McNicol A., Shalev A., Jain N., and Gerrard J.M. The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin. J Clin Invest 91 (1993) 1775-1782
26. McNicol A. Platelet preparation and estimation of functional responses. In: Watson S.P., and Authi K.S. (Eds). Platelets: A Practical Approach (1996), Oxford University Press, Oxford 1-26
27. Indig F.E., Diaz-Gonzalez F., and Ginsberg M.H. Analysis of the tetraspanin CD9-integrin αIIbβ3 (GPIIb-IIIa) complex in platelet membranes and transfected cells. Biochem J 327 (1997) 291-298
28. Huang M.E. Agonist-enhanced palmitoylation of platelet proteins. Biochim Biophys Acta 1011 (1989) 134-139
29. Cierniewski C.S., Krzeslowska J., Pawlowska Z., Witas H., and Meyer M. Palmitylation of the glycoprotein IIb-IIIa complex in human blood platelets. J Biol Chem 264 (1989) 12158-12164
30. Claas C., Stipp C.S., and Hemler M.E. Evaluation of prototype TM4SF protein complexes and their relation to lipid rafts. J Biol Chem 276 (2001) 7974-7984
31. Goussett K., Wolkers W.F., Tsvetkova N.M., Oliver A.E., Field C.L., Walker N.J., et al. Evidence for a physiological role for membrane rafts in human platelets. J Cell Physiol 190 (2002) 117-128
32. Fox J.E.B. Study of proteins associated with the platelet cytoskeleton. In: Watson S.P., and Authi K.S. (Eds). Platelets: A Practical Approach (1996), Oxford University Press, Oxford 217-233
33. McNicol A., Robertson C., and Gerrard J.M. Vanadate activates platelets by enhancing arachidonic acid release. Blood 81 (1993) 2329-2338
34. McNicol A., Shibou T.S., Pampolina C., and Israels S.J. Incorporation of MAP kinases into the platelet cytoskeleton. Thromb Res 103 (2001) 25-34
35. Derrick J.M., Shattil S.J., Poncz M., Gruppo R.A., and Gartner T.K. Distinct domains of αIIbβ3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF, an αIIbβ3 interacting peptide. Thromb Haemost 86 (2001) 894-901
36. La Naour F., Andre M., Boucheix C., and Rubinstein E. Membrane microdomains and proteomics: lessons from tetraspanin microdomains and comparison with lipid rafts. Proteomics 6 (2006) 6447-6454
37. Rubinstein E., Le Naour F., Lagaudriere-Gesbert C., Billard M., Conjeaud H., and Boucheix C. CD9, CD63, CD81, and CD82 are components of a surface tetraspan network connected to HLA-DR and VLA integrins. Eur J Immunol 26 (1996) 2657-2665
38. Shrimpton C.N., Borthakur G., Larrucea S., Cruz M.A., Dong J.-F., and Lopez J.A. Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation. J Exp Med 196 (2002) 1057-1066
39. Hallak H., Muszbek L., Laposata M., Belmonte E., Brass L.F., and Manning D.R. Covalent binding of arachidonate to G protein alpha subunits of human platelets. J Biol Chem 269 (1994) 713-716
40. Vogel K., and Roche P.A. SNAP-23 and SNAP-25 are palmitoylated in vivo. Biochem Biophys Res Commun 258 (1999) 407-410
41. Mollner S., Beck K., and Pfeuffer T. Acylation of adenylyl cyclase catalyst is important for enzymatic function. FEBS Lett 371 (1995) 241-244
42. Sincock P.M., Fitter S., Parton R.G., Berndt M.C., Gamble J.R., and Ashman L.K. PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function. J Cell Sci 112 (1999) 833-844
43. Goshnick M.W., Lau L.-M., Wee J.L., Liu Y.S., Hogarth P.M., Robb L.M., et al. Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice. Blood 108 (2006) 1911-1918
44. Bjilmakers M.J., and Marsh M. The on-off story of protein palmitoylation. Trends Cell Biol 13 (2003) 32-42
45. Sharma C., Yang X.H., and Hemler M.E. DHHC2 affects palmitoylation and stability of tetraspanins CD9 and CD151. Mol Biol Cell 19 (2008) 3415-3425