Synthesis of unsymmetrical biphenyls as potent cytotoxic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 19, 2008, Pages 5272-5276

  Wu, Gang ^a,c   Guo, Huan Fang ^a   Gao, Kun ^c   Liu, Yi Nan ^b   Bastow, Kenneth F ^b   Morris Natschke, Susan L ^b   Lee, Kuo Hsiung ^b   Xie, Lan ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c LANZHOU UNIVERSITY   (China)

Author keywords

Anticancer agents; Suzuki coupling reaction; Unsymmetrical biphenyls

Indexed keywords

4',5' METHYLENEDIOXY (4,5,6 TRIMETHOXYBIPHENYL 2,2' DIYL)BIS (METHYLENE)DIBENZOATE; BICYCLOL; BIPHENYL DERIVATIVE; CYTOTOXIC AGENT; ETOPOSIDE; HOMOHARRINGTONINE; METHYL 2' FORMYL 4,5,6 TRIMETHOXYBIPHENYL 2 CARBOXYLATE; METHYL 4,4' DIMETHOXY 5,6,5',6' DIMETHYLENEDIOXYBIPHENYL 2,2 DICARBOXYLATE; UNCLASSIFIED DRUG; WUWEIZI B; WUWEIZI C;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BIPHENYL COMPOUNDS; CELL LINE, TUMOR; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MALE;

EID: 52349094101     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.050     Document Type: Article

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20. +).Compound 38: Yield 80%; white solid, mp 106-107 °C