Merkel cell carcinoma with partial b-cell blastic immunophenotype: A potential mimic of cutaneous richter transformation in a patient with chronic lymphocytic lymphoma

American Journal of Dermatopathology

Volumn 36, Issue 2, 2014, Pages 148-152

  Papalas, John A ^a,b   Mckinney, Matthew S ^a   Kulbacki, Evan ^a   Dave, Sandeep S ^a   Wang, Endi ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Eastern Dermatology and Pathology   (United States)

Author keywords

Chronic lymphocytic lymphoma; Merkel cell carcinoma; Merkel cell polyomavirus; Richter transformation

Indexed keywords

AGED; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; B-LYMPHOCYTES; CARCINOMA, MERKEL CELL; CYCLOPHOSPHAMIDE; DIAGNOSIS, DIFFERENTIAL; FATAL OUTCOME; HUMANS; IMMUNOPHENOTYPING; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MERKEL CELL POLYOMAVIRUS; NEOPLASMS, MULTIPLE PRIMARY; POLYOMAVIRUS INFECTIONS; SKIN NEOPLASMS; TUMOR VIRUS INFECTIONS; VIDARABINE;

EID: 84894522178     PISSN: 01931091     EISSN: 15330311     Source Type: Journal    
DOI: 10.1097/DAD.0b013e31829ed784     Document Type: Article

References (62)

1. Kuwamoto S. Recent advances in the biology of Merkel cell carcinoma. Hum Pathol. 2011;42:1063-1077
2. Feng H, Shuda M, Chang Y, et al. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008;319:1096-1100
3. Foulongne V, Kluger N, Dereure O, et al. Merkel cell polyomavirus and Merkel cell carcinoma, France. Emerg Infect Dis. 2008;14:1491-1493
4. Kassem A, Schopflin A, Diaz C, et al. Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. Cancer Res. 2008;68:5009-5013
5. Becker JC, Houben R, Ugurel S, et al. MC polyomavirus is frequently present in Merkel cell carcinoma of European patients. J Invest Dermatol. 2009;129:248-250
6. Garneski KM, Warcola AH, Feng Q, et al. Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors. J Invest Dermatol. 2009;129:246-248
7. Sihto H, Kukko H, Koljonen V, et al. Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma. J Natl Cancer Inst. 2009;101:938-945
8. Quaglino D, Di Leonardo G, Lalli G, et al. Association between chronic lymphocytic leukaemia and secondary tumours: Unusual occurrence of a neuroendocrine (Merkell cell) carcinoma. Eur Rev Med Pharmacol Sci. 1997;1:11-16
9. Vlad R, Woodlock TJ. Merkel cell carcinoma after chronic lymphocytic leukemia: Case report and literature review. Am J Clin Oncol. 2003;26: 531-534
10. Kaae J, Hansen AV, Biggar RJ, et al. Merkel cell carcinoma: Incidence, mortality, and risk of other cancers. J Natl Cancer Inst. 2010;102:793-801
11. Koljonen V, Kukko H, Tukiainen E, et al. Second cancers following the diagnosis of Merkel cell carcinoma: A nationwide cohort study. Cancer Epidemiol. 2010;34:62-65
12. Koljonen V, Kukko H, Pukkala E, et al. Chronic lymphocytic leukaemia patients have a high risk of Merkel-cell polyomavirus DNA-positive Merkel-cell carcinoma. Br J Cancer. 2009;101:1444-1447
13. Pandey U, Naraynan M, Karnik U, et al. Carcinoma metastasis to unexpected synchronous lymphoproliferative disorder: Report of three cases and review of literature. J Clin Pathol. 2003;56:970-971
14. Sinclair N, Mireskandari K, Forbes J, et al. Merkel cell carcinoma of the eyelid in association with chronic lymphocytic leukaemia. Br J Ophthalmol. 2003;87:240
15. Agnew KL, Ruchlemer R, Catovsky D, et al. Cutaneous findings in chronic lymphocytic leukaemia. Br J Dermatol. 2004;150:1129-1135
16. Robak E, Biernat W, Krykowski E, et al. Merkel cell carcinoma in a patient with B-cell chronic lymphocytic leukemia treated with cladribine and rituximab. Leuk Lymphoma. 2005;46:909-914
17. Papageorgiou KI, Kaniorou-Larai MG. A case report of Merkel cell carcinoma on chronic lymphocytic leukemia: Differential diagnosis of coexisting lymphadenopathy and indications for early aggressive treatment. BMC Cancer. 2005;5:106
18. Ben-David A, Lazarov A, Lev S, et al. Merkel cell tumor and chronic lymphocytic leukemia-coincidence or a possible association? Dermatol Online J. 2005;11:16
19. Barroeta JE, Farkas T. Merkel cell carcinoma and chronic lymphocytic leukemia (collision tumor) of the arm: A diagnosis by fine-needle aspiration biopsy. Diagn Cytopathol. 2007;35:293-295
20. Zhang H, Gupta G, Yang XY, et al. A unique case of merkel cell carcinoma and chronic lymphocytic leukaemia presenting in a single cutaneous lesion (collision tumour). BMJ Case Rep. 2009;2009:bcr09. 2008.1016
21. Craig PJ, Calonje JE, Harries M, et al. Incidental chronic lymphocytic leukaemia in a biopsy of Merkel cell carcinoma. J Cutan Pathol. 2009; 36:706-710
22. Turk T, Orlic ZC, Smoljan I, et al. Spontaneous regression of Merkel cell carcinoma in a patient with chronic lymphocytic leukemia: A case report. J Med Case Rep. 2009;3:7270
23. Hartley MA, Tao J, Baz R. Merkel cell carcinoma in the peripheral blood of a patient with concomitant chronic lymphocytic leukemia and multiple myeloma. J Clin Oncol. 2010;28:e113-e114
24. Tolstov YL, Arora R, Scudiere SC, et al. Lack of evidence for direct involvement of Merkel cell polyomavirus (MCV) in chronic lymphocytic leukemia (CLL). Blood. 2010;115:4973-4974
25. Khezri F, Brewer JD, Weaver AL. Merkel cell carcinoma in the setting of chronic lymphocytic leukemia. Dermatol Surg. 2011;37:1100-1105
26. Cottoni F, Montesu MA, Lissia A, et al. Merkel cell carcinoma, Kaposi's sarcoma, basal cell carcinoma and keratoacanthoma: Multiple association in a patient with chronic lymphatic leukaemia. Br J Dermatol. 2002;147: 1029-1031
27. Kuhajda FP, Olson JL, Mann RB. Merkel cell (small cell) carcinoma of the skin: Immunohistochemical and ultrastructural demonstration of distinctive perinuclear cytokeratin aggregates and a possible association with B cell neoplasms. Histochem J. 1986;18:239-244
28. Silva EG, Mackay B, Goepfert H, et al. Endocrine carcinoma of the skin (Merkel cell carcinoma). Pathol Annu. 1984;19(pt 2):1-30
29. Brenner B, Sulkes A, Rakowsky E, et al. Second neoplasms in patients with Merkel cell carcinoma. Cancer. 2001;91:1358-1362
30. Heath M, Jaimes N, Lemos B, et al. Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: The AEIOU features. J Am Acad Dermatol. 2008;58:375-381
31. Howard RA, Dores GM, Curtis RE, et al. Merkel cell carcinoma and multiple primary cancers. Cancer Epidemiol Biomarkers Prev. 2006;15: 1545-1549
32. Shuda M, Feng H, Kwun HJ, et al. T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci U S A. 2008;105:16272-16277
33. Teman CJ, Tripp SR, Perkins SL, et al. Merkel cell polyomavirus (MCPyV) in chronic lymphocytic leukemia/small lymphocytic lymphoma. Leuk Res. 2011;35:689-692
34. Pantulu ND, Pallasch CP, Kurz AK, et al. Detection of a novel truncating Merkel cell polyomavirus large T antigen deletion in chronic lymphocytic leukemia cells. Blood. 2010;116:5280-5284
35. Kassem A, Technau K, Kurz AK, et al. Merkel cell polyomavirus sequences are frequently detected in nonmelanoma skin cancer of immunosuppressed patients. Int J Cancer. 2009;125:356-361
36. Torlakovic E, Torlakovic G, Nguyen PL, et al. The value of anti-pax-5 immunostaining in routinely fixed and paraffin-embedded sections: A novel pan pre-B and B-cell marker. Am J Surg Pathol. 2002;26: 1343-1350
37. Dong HY, Liu W, Cohen P, et al. B-cell specific activation protein encoded by the PAX-5 gene is commonly expressed in merkel cell carcinoma and small cell carcinomas. Am J Surg Pathol. 2005;29:687-692
38. Torlakovic E, Slipicevic A, Robinson C, et al. Pax-5 expression in nonhematopoietic tissues. Am J Clin Pathol. 2006;126:798-804
39. Buresh CJ, Oliai BR, Miller RT. Reactivity with TdT in Merkel cell carcinoma: A potential diagnostic pitfall. Am J Clin Pathol. 2008;129: 894-898
40. Jaeger T, Ring J, Andres C. Histological, immunohistological, and clinical features of merkel cell carcinoma in correlation to merkel cell polyomavirus status. J Skin Cancer. 2012;2012:983421
41. Lien MH, Baldwin BT, Thareja SK, et al. Merkel cell carcinoma: Clinical characteristics, markers, staging and treatment. J Drugs Dermatol. 2010; 9:779-784
42. Ball NJ, Tanhuanco-Kho G. Merkel cell carcinoma frequently shows histologic features of basal cell carcinoma: A study of 30 cases. J Cutan Pathol. 2007;34:612-619
43. Lee WJ, Kim CH, Chang SE, et al. Cutaneous metastasis from large-cell neuroendocrine carcinoma of the urinary bladder expressing CK20 and TTF-1. Am J Dermatopathol. 2009;31:166-169
44. Boyd AS, Hayes BB. Metastatic small cell neuroendocrine carcinoma of the breast. J Cutan Pathol. 2012;39:1042-1046
45. Li N, Wolgamot G, Argenyi Z. Primary cutaneous neuroendocrine cell carcinoma (Merkel cell carcinoma) with prominent microcystic features, mimicking eccrine carcinoma. J Cutan Pathol. 2007;34:410-414
46. Hwang JH, Alanen K, Dabbs KD, et al. Merkel cell carcinoma with squamous and sarcomatous differentiation. J Cutan Pathol. 2008;35: 955-959
47. Covello R, Licci S, Ferrari A, et al. Merkel cell carcinoma of the thumb with squamous and leiomyosarcomatous differentiation. Eur J Dermatol. 2010;20:529-530
48. Cho-Vega JH, Medeiros LJ, Prieto VG, et al. Leukemia cutis. Am J Clin Pathol. 2008;129:130-142
49. Cerroni L, Zenahlik P, Hofler G, et al. Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia: A clinicopathologic and prognostic study of 42 patients. Am J Surg Pathol. 1996;20:1000-1010
50. Swerdlow SH; International Agency for Research on Cancer, World Health Organization. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon, France: International Agency for Research on Cancer; 2008:439
51. Duong T, Grange F, Auffret N, et al. Cutaneous Richter's syndrome, prognosis, and clinical, histological and immunohistological patterns: Report of four cases and review of the literature. Dermatology. 2010; 220:226-233
52. Robak E, Gora-Tybor J, Kordek R, et al. Richter syndrome first manifesting as cutaneous B-cell lymphoma clonally distinct from primary B-cell chronic lymphocytic leukaemia. Br J Dermatol. 2005;153: 833-837
53. Ratnavel RC, Dunn-Walters DK, Boursier L, et al. B-cell lymphoma associated with chronic lymphatic leukaemia: Two cases with contrasting aggressive and indolent behaviour. Br J Dermatol. 1999;140:708-714
54. Novice FM, Mikhail GR, Maeda K, et al. Richter's syndrome presenting as a solitary cutaneous nodule. Int J Dermatol. 1989;28:36-37
55. Zarco C, Lahuerta-Palacios JJ, Borrego L, et al. Centroblastic transformation of chronic lymphocytic leukaemia with primary skin involvement-cutaneous presentation of Richter's syndrome. Clin Exp Dermatol. 1993; 18:263-267
56. Yamazaki ML, Lum CA, Izumi AK. Primary cutaneous Richter syndrome: Prognostic implications and review of the literature. J Am Acad Dermatol. 2009;60:157-161
57. Harousseau JL, Flandrin G, Tricot G, et al. Malignant lymphoma supervening in chronic lymphocytic leukemia and related disorders. Richter's syndrome: A study of 25 cases. Cancer. 1981;48:1302-1308
58. Tsimberidou AM, O'Brien S, Khouri I, et al. Clinical outcomes and prognostic factors in patients with Richter's syndrome treated with chemotherapy or chemoimmunotherapy with or without stem-cell transplantation. J Clin Oncol. 2006;24:2343-2351
59. Bruzzi JF, Macapinlac H, Tsimberidou AM, et al. Detection of Richter's transformation of chronic lymphocytic leukemia by PET/CT. J Nucl Med. 2006;47:1267-1273
60. Pectasides D, Pectasides M, Economopoulos T. Merkel cell cancer of the skin. Ann Oncol. 2006;17:1489-1495
61. Lemos BD, Storer BE, Iyer JG, et al. Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: Analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol. 2010;63:751-761
62. Allen PJ, Bowne WB, Jaques DP, et al. Merkel cell carcinoma: Prognosis and treatment of patients from a single institution. J Clin Oncol. 2005;23: 2300-2309