T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 42, 2008, Pages 16272-16277

  Shuda, Masahiro ^a   Feng, Huichen ^a   Kwun, H J ^a   Rosen, Steven T ^b   Gjoerup, Ole ^a   Moore, Patrick S ^a   Chang, Yuan ^a,b  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Helicase; Merkel cell carcinoma; pRB interaction; Viral integration; Virus replication

Indexed keywords

HELICASE; TUMOR ANTIGEN; VIRUS DNA; VIRUS LARGE T ANTIGEN; VIRUS T ANTIGEN;

ARTICLE; CELL SURVIVAL; EMBRYO; EPISOME; GENE SEQUENCE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MERKEL CELL; MERKEL CELL POLYOMAVIRUS; MERKEL CELL TUMOR; MUTATION; NUCLEOTIDE SEQUENCE; POLYOMA VIRUS; PRIORITY JOURNAL; VIRUS MUTATION; VIRUS REPLICATION; WILD TYPE;

POLYOMAVIRUS;

EID: 55849098118     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806526105     Document Type: Article

References (36)

1. Popp S, et al. (2002) UV-B-type mutations and chromosomal imbalances indicate common pathways for the development of Merkel and skin squamous cell carcinomas. Int J Cancer 99:352-360.
2. Engels EA, et al. (2002) Merkel cell carcinoma and HIV infection. Lancet 359:497-498.
3. Feng H, Shuda M, Chang Y, Moore PS (2008) Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319:1096-1100.
4. Feng H, et al. (2007) Human transcriptome subtraction by using short sequence tags to search for tumor viruses in conjunctival carcinoma. J Virol 81:11332-11340.
5. Kassem A, et al. (2008) Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. Cancer Res 68:5009-5013.
6. DeCaprio JA, et al. (1988) SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54:275-283.
7. Lane DP, Crawford LV (1979) T antigen is bound to a host protein in SV40-transformed cells. Nature 278:261-263.
8. Linzer DI, Levine AJ (1979) Characterization of a 54-kDa cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17:43-52.
9. Pallas DC, et al. (1990) Polyoma small and middle T antigens and SV40 small T antigen form stable complexes with protein phosphatase 2A. Cell 60:167-176.
10. Cotsiki M, et al. (2004) Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1. Proc Natl Acad Sci USA 101:947-952.
11. Kaplan DR, et al. (1989) Mechanisms of transformation by polyoma virus middle T antigen. Biochim Biophys Acta 948:345-364.
12. Dilworth SM (2002) Polyoma virus middle T antigen and its role in identifying cancer-related molecules. Nat Rev Cancer 2:951-956.
13. Ahuja D, Saenz-Robles MT, Pipas JM (2005) SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation. Oncogene 24:7729-7745.
14. Zerrahn J, Knippschild U, Winkler T, Deppert W (1993) Independent expression of the transforming amino-terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA. EMBO J 12:4739-4746.
15. Pipas JM (1992) Common and unique features of T antigens encoded by the polyomavirus group. J Virol 66:3979-3985.
16. Moran E (1993) DNA tumor virus transforming proteins and the cell cycle. Curr Opin Genet Dev 3:63-70.
17. Wang TL, et al. (2002) Prevalence of somatic alterations in the colorectal cancer cell genome. Proc Natl Acad Sci USA 99:3076-3080.
18. Leonard JH, Bell JR, Kearsley JH (1993) Characterization of cell lines established from Merkel cell ("small cell") carcinoma of the skin. Int J Cancer 55:803-810.
19. Van Gele M, et al. (2004) Gene-expression profiling reveals distinct expression patterns for classic versus variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small-cell lung carcinoma. Oncogene 23:2732-2742.
20. Rosen ST, et al. (1987) Establishment and characterization of a neuroendocrine skin carcinoma cell line. Lab Invest 56:302-312.
21. Van Gele M, et al. (2002) Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma. Int J Cancer 101:137-145.
22. Ronan SG, et al. (1993) Merkel cell carcinoma: In vitro and in vivo characteristics of a new cell line. J Am Acad Dermatol 29:715-722.
23. Leonard JH, et al. (1995) Characterization of four Merkel cell carcinoma adherent cell lines. Int J Cancer 60:100-107.
24. Lynch KJ, Frisque RJ (1990) Identification of critical elements within the JC virus DNA replication origin. J Virol 64:5812-5822.
25. Small MB, Gluzman Y, Ozer HL (1982) Enhanced transformation of human fibroblasts by origin-defective simian virus 40. Nature 296:671-672.
26. Prives C, Covey L, Scheller A, Gluzman Y (1983) DNA-binding properties of simian virus 40 T-antigen mutants defective in viral DNA replication. Mol Cell Biol 3:1958-1966.
27. Manos MM, Gluzman Y (1984) Simian virus 40 large T-antigen point mutants that are defective in viral DNA replication but competent in oncogenic transformation. Mol Cell Biol 4:1125-1133.
28. Lania L, Hayday A, Fried M (1981) Loss of functional large T-antigen and free viral genomes from cells transformed in vitro by polyoma virus after passage in vivo as tumor cells. J Virol 39:422-431.
29. Israel MA, Vanderryn DF, Meltzer ML, Martin MA (1980) Characterization of polyoma viral DNA sequences in polyoma-induced hamster tumor cell lines. J Biol Chem 255:3798-3805.
30. Gish WR, Botchan MR (1987) Simian virus 40-transformed human cells that express large T antigens defective for viral DNA replication. J Virol 61:2864-2876.
31. Lunder EJ, Stern RS (1998) Merkel cell carcinomas in patients treated with methoxsalen and ultraviolet A radiation. N Engl J Med 339:1247-1248.
32. Busse PM, Clark JR, Muse VV, Liu V (2008) Case records of the Massachusetts General Hospital: Case 19-2008, A 63-year-old HIV-positive man with cutaneous Merkel cell carcinoma. N Engl J Med 358:2717-2723.
33. Kadaja M, et al. (2007) Genomic instability of the host cell induced by the human papillomavirus replication machinery. EMBO J 26:2180-2191.
34. Tian D, et al. (2008) Single-nucleotide mutation rate increases close to insertions/deletions in eukaryotes. Nature 455:105-108.
35. Lukas J, et al. (1997) Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes Dev 11:1479-1492.
36. Campbell KS, et al. (1997) DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. Genes Dev 11:1098-1110.