Cutaneous richter's syndrome, prognosis, and clinical, histological and immunohistological patterns: Report of four cases and review of the literature

Dermatology

Volumn 220, Issue 3, 2010, Pages 226-233

  Duong, T ^a,d   Grange, F ^e   Auffret, N ^b   Aractingi, S ^c   Bodemer, C ^a   Brousse, N ^a   Hermine, O ^a   Fraitag, S ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^c HÔPITAL TENON   (France)

^d HENRI MONDOR HOSPITAL   (France)

^e UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

Chronic lymphocytic leukemia; Cutaneous B cell lymphoma; Cutaneous Richter's syndrome; Leukemia cutis; Transformation

Indexed keywords

CD20 ANTIGEN; CD3 ANTIGEN; CD30 ANTIGEN; CD5 ANTIGEN; CHLORAMBUCIL; CHLORMETHINE; CYCLOPHOSPHAMIDE; DOXORUBICIN; PREDNISONE; RITUXIMAB; STEROID; VINCRISTINE SULFATE; VIRUS RNA;

ADULT; ARTICLE; BRAIN LYMPHOMA; CANCER COMBINATION CHEMOTHERAPY; CASE REPORT; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL FEATURE; CUTANEOUS RICHTER SYNDROME; EPSTEIN BARR VIRUS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOLOGY; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION; MALE; MALIGNANT TRANSFORMATION; MAXILLA SINUS TUMOR; MOLECULAR BIOLOGY; MULTIPLE CYCLE TREATMENT; PRIORITY JOURNAL; PROGNOSIS; SEPSIS; SKIN BIOPSY;

ANTIGENS, CD20; ANTIGENS, CD3; ANTIGENS, CD30; ANTIGENS, CD5; ANTIGENS, NEOPLASM; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL TRANSFORMATION, VIRAL; EPSTEIN-BARR VIRUS INFECTIONS; FATAL OUTCOME; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; PROGNOSIS; SKIN NEOPLASMS; VIDARABINE;

EID: 77951880235     PISSN: 10188665     EISSN: None     Source Type: Journal    
DOI: 10.1159/000269737     Document Type: Article

References (29)

1. Senff NJ, Noordijk EM, Kim YH, Bagot M, Berti E, Cerroni L, Dummer R, Duvic M, Hoppe RT, Pimpinelli N, Rosen ST, Vermeer MH, Whittaker S, Willemze R, European Organization for Research and Treatment of Cancer, International Society for Cutaneous Lymphoma: European Organization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas. Blood 2008; 112: 1600-1609.
2. Richter MN: Generalized reticular cell sarcoma of lymph nodes associated with lymphatic leukaemia. Am J Pathol 1928; 6: 285-292.
3. Trump DL, Mann RB, Phelps R, Roberts H, Conley CL: Richter's syndrome: diffuse histiocytic lymphoma in patients with chronic lymphocytic leukemia: a report of five cases and review of the literature. Am J Med 1980; 68: 539-548. (Pubitemid 10141819)
4. Tsimberidou AM, Keating MJ: Richter syndrome: biology, incidence, and therapeutic strategies. Cancer 2005; 103: 216-228.
5. Cheson BD, Bennett JM, Grever M, Kay N, Keating MJ, O'Brien S, Rai KR: National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996; 87: 4990-4997. (Pubitemid 26189840)
6. Brumpt C, Delabesse E, Beldjord K, et al: The incidence of clonal T-cell receptor rearrangements in B-cell precursor acute lymphoblastic leukaemia varies with age and genotype. Blood 2000; 96: 2254-2261.
7. Landman-Parker J, Aubin J, Delabesse E, et al: Simplified strategies for minimal residual disease detection in B-cell precursor acute lymphoblastic leukaemia. Br J Haematol 1996; 95: 281-290. (Pubitemid 26360216)
8. Rossi D, Cerri M, Capello D, et al: Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndrome. Br J Haematol 2008; 142: 202-215. (Pubitemid 351987315)
9. Reiniger L, Bödör C, Bognár A, Balogh Z, Csomor J, Szepesi A, Kopper L, Matolcsy A: Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation. Leukemia 2006; 20: 1089-1095. (Pubitemid 43797302)
10. Cuneo A, de Angeli C, Roberti MG, Piva N, Bigoni R, Gandini D, Rigolin GM, Moretti S, Cavazzini P, del Senno L, Castoldi G: Richter's syndrome in a case of atypical chronic lymphocytic leukaemia with the t(11; 14) (q13;q32): role for a p53 exon 7 gene mutation. Br J Haematol 1996; 92: 375-381. (Pubitemid 26046511)
11. Matolcsy A, Inghirami G, Knowles DM: Molecular genetic demonstration of the diverse evolution of Richter's syndrome (chronic lymphocytic leukemia and subsequent large cell lymphoma). Blood 1994; 83: 1363-1372. (Pubitemid 24062860)
12. Robak T: Second malignancies and Richter's syndrome in patients with chronic lymphocytic leukemia. Hematology 2004; 9: 387-400. (Pubitemid 40123589)
13. Robak E, Gora-Tybor J, Kordek R, Wawrzyniak E, Bartkowiak J, Bednarek A, Constantinou M, Kaluzewski B, Robak T: Richter syndrome first manifesting as cutaneous B-cell lymphoma clonally distinct from primary B-cell chronic lymphocytic leukaemia. Br J Dermatol 2005; 153: 833-837. (Pubitemid 41415916)
14. Ratnavel RC, Dunn-Walters DK, Boursier L, et al: B-cell lymphoma associated with chronic lymphatic leukaemia: two cases with contrasting aggressive and indolent behaviour. Br J Dermatol 1999; 140: 708-714. (Pubitemid 29191395)
15. Brynes RK, McCourty A, Sun NC, Koo CH: Trisomy 12 in Richter's transformation of chronic lymphocytic leukemia. Am J Clin Pathol 1995; 104: 199-203.
16. Zhu Y, Monni O, Franssila K, Elonen E, Vilpo J, Joensuu H, Knuutila S: Deletions at 11q23 in different lymphoma subtypes. Haematologica 2000; 85: 908-912.
17. Lazzarino M, Orlandi E, Baldanti F, Furione M, Pagnucco G, Astori C, Arcaini L, Viglio A, Paulli M, Gerna G, Bernasconi C: The immunosuppression and potential for EBV reactivation of fludarabine combined with cyclophosphamide and dexamethasone in patients with lymphoproliferative disorders. Br J Haematol 1999; 107: 877-882. (Pubitemid 30020163)
18. Harousseau JL, Flandrin G, Tricot G, Brouet JC, Seligmann M, Bernard J: Malignant lymphoma supervening in chronic lymphocytic leukemia and related disorders: Richter's syndrome -a study of 25 cases. Cancer 1981; 48: 1302-1308. (Pubitemid 11042579)
19. Tsimberidou AM, O'Brien S, Khouri I, et al: Clinical outcomes and prognostic factors in patients with Richter's syndrome treated with chemotherapy or chemoimmunotherapy with or without stem-cell transplantation. J Clin Oncol 2006; 24: 2343-2351. (Pubitemid 46655600)
20. Novice FM, Mikhail GR, Maeda K, Hawley RG: Richter's syndrome presenting as a solitary cutaneous nodule. Int J Dermatol 1989; 28: 36-37. (Pubitemid 19064478)
21. Zarco C, Lahuerta-Palacios JJ, Borrego L, Toscano R, Gil R, Iglesias L: Centroblastic transformation of chronic lymphocytic leukaemia with primary skin involvement: cutaneous presentation of Richter's syndrome. Clin Exp Dermatol 1993; 18: 263-267. (Pubitemid 23171149)
22. Yamazaki ML, Lum CA, Izumi AK: Primary cutaneous Richter syndrome: prognostic implications and review of the literature. J Am Acad Dermatol 2009; 60: 157-161.
23. Cerroni L, Zenahlik P, Höfler G, Kaddu S, Smolle J, Kerl H: Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia: a clinicopathologic and prognostic study of 42 patients. Am J Surg Pathol 1996; 20: 1000-1010. (Pubitemid 26250640)
24. Robertson LE, Pugh W, O'Brien S, Kantarjian H, Hirsch-Ginsberg C, Cork A, McLaughlin P, Cabanillas F, Keating MJ: Richter's syndrome: a report on 39 patients. J Clin Oncol 1993; 11: 1985-1989. (Pubitemid 23304625)
25. Dierlamm J, Michaux L, Criel A, Wlodarska I, van den Berghe H, Hossfeld DK: Genetic abnormalities in chronic lymphocytic leukemia and their clinical and prognostic implications. Cancer Genet Cytogenet 1997; 94: 27-35. (Pubitemid 27133498)
26. Maeshima AM, Taniguchi H, Nomoto J, et al: Secondary CD5+ diffuse large B-cell lymphoma not associated with transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma (Richter syndrome). Am J Clin Pathol 2009; 131: 339-346.
27. Hans CP, Weisenburger DD, Greiner TC, et al: Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood 2004; 103: 275-282.
28. Gibbs SD, Westerman DA, Lade S, McCormack C, Seymour JF, Prince HM: Early Bcell chronic lymphocytic leukemia presenting as cutaneous lesions with a normal peripheral blood lymphocyte count. J Am Acad Dermatol 2005; 53: 535-536. (Pubitemid 41196000)
29. Thornton PD, Bellas C, Santon A, Shah G, Pocock C, Wotherspoon AC, Matutes E, Catovsky D: Richter's transformation of chronic lymphocytic leukemia: the possible role of fludarabine and the Epstein-Barr virus in its pathogenesis. Leuk Res 2005; 29: 389-395. (Pubitemid 40255812)