Merkel cell carcinoma: Clinical characteristics, markers, staging and treatment

Journal of Drugs in Dermatology

Volumn 9, Issue 7, 2010, Pages 779-784

  Lien, Mary H ^a   Baldwin, Brooke T ^a   Thareja, Sumeet K ^a   Fenske, Neil Alan ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; BMI1 PROTEIN; CARBOPLATIN; CHROMOGRANIN A; CISPLATIN; CK 20; CK 7; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ETOPOSIDE; IMP 3 PROTEIN; L523S PROTEIN; MONOCLONAL ANTIBODY; NEURON SPECIFIC ENOLASE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN; PROTEIN MCL 1; PSORALEN; SOMATOMEDIN B; STEM CELL FACTOR RECEPTOR; SYNAPTOPHYSIN; THYROID TRANSCRIPTION FACTOR 1; TOPOTECAN; TUMOR MARKER; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN A; VASCULOTROPIN C; VASCULOTROPIN RECEPTOR 2;

ARM; AUTOCRINE EFFECT; BASAL CELL CARCINOMA; BENIGN TUMOR; BUTTOCK; CANCER ADJUVANT THERAPY; CANCER DIAGNOSIS; CANCER RADIOTHERAPY; CANCER RISK; CANCER STAGING; CANCER SURGERY; CANCER THERAPY; CARCINOGENESIS; CARCINOID; CAUCASIAN; CELL PROLIFERATION; CHEMOSURGERY; CHRONIC LYMPHATIC LEUKEMIA; CLIMATE; CLINICAL ASSESSMENT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CYST; DERMATOFIBROMA; DIFFERENTIAL DIAGNOSIS; DISEASE SURVEILLANCE; DNA SYNTHESIS; EARLY DIAGNOSIS; FIBROMA; FOLLOW UP; GENE OVEREXPRESSION; GEOGRAPHY; GERIATRIC PATIENT; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; INCIDENCE; LEG; LIPOMA; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MALIGNANT NEOPLASTIC DISEASE; MERKEL CELL TUMOR; METASTASIS; MICROARRAY ANALYSIS; MOLECULARLY TARGETED THERAPY; MULTIMODALITY CANCER THERAPY; NEUROBLASTOMA; NEUROENDOCRINE TUMOR; NONMELANOMA SKIN CARCINOMA; ORGAN TRANSPLANTATION; PRACTICE GUIDELINE; PROGNOSIS; PROTEIN EXPRESSION; PUVA; PYOGENIC GRANULOMA; RECEPTOR UPREGULATION; RETINOBLASTOMA; REVIEW; SENTINEL LYMPH NODE BIOPSY; SKIN CARCINOMA; SKIN LEUKEMIA; SQUAMOUS CELL CARCINOMA; SUN EXPOSURE; THORAX RADIOGRAPHY; TRUNK; TUMOR LOCALIZATION; TUMOR VOLUME; ULTRAVIOLET B RADIATION; UTERINE ADNEXA TUMOR; VASCULAR LESION; VULVA; MORTALITY; PATHOLOGY; SKIN TUMOR;

CARCINOMA, MERKEL CELL; HUMANS; NEOPLASM STAGING; PROGNOSIS; SKIN NEOPLASMS;

EID: 77955881570     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (52)

1. Toker C. Trabecular carcinoma of the skin. Arch Dermatol. 1972;105:107-110.
2. Allen PJ, Bowne WB, Jaques DP, et al. Merkel cell carcinoma: Prognosis and treatment of patients from a single institution. J Clin Oncol. 2005;23:2300-2309. (Pubitemid 46218722)
3. Hodgson NC. Merkel cell carcinoma: Changing incidence trends. J Surg Oncol. 2005;89:1-4. (Pubitemid 40075960)
4. Liao PB. Merkel cell carcinoma. Dermatolog Ther. 2008; 21:447- 451.
5. Heath M, Jaimes N, Lemos B, et al. Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: The AEIOU features. J Am Acad Dermatol. 2008;58:375-381. (Pubitemid 351226308)
6. Shaw JH, Rumball E. Merkel cell tumor: Clinical behavior and treatment. Br J Surg. 1991;78:138.
7. Hitchcock CL, Bland KI, Laney RG 3d, et al. Neuroendocrine (Merkel cell) carcinoma of the skin. Its natural history, diagnosis, and treatment. Ann Surg. 1988;207:201.
8. Tai PT, Yu E, Tonita J, Gilchrist J. Merkel cell carcinoma of the skin. J Cutan Med Surg. 2000;4:186.
9. Penn I, First MR. Merkel's cell carcinoma in organ recipients: report of 41 cases. Transplant. 1999;68:1717.
10. Ratner D, Nelson BR, Brown MD, et al. Merkel cell carcinoma. J Am Acad Dermatol. 1993;29:143.
11. Medina-Franco H, Urist MM, Fiveash J, et al. Multimodality treatment of Merkel cell carcinoma: Case series and literature review of 1024 cases. Ann Surg Oncol. 2001;8:204.
12. Savage P, Constenia K, Fisher C, et al. The natural history and management of Merkel cell carcinoma of the skin: A review of 22 patients treated at the Royal Marxden Hospital. Clin Oncol (R Coll Radiol). 1997;9:164.
13. Morrison, WH, Peters LJ, Silva EG, et al. The essential role of radiation therapy in securing locoregional control of Merkel cell carcinoma. Int J Radiat Oncol Biol Phys. 1990;19:583.
14. Tai PT, Yu E, Winquist E, et al. Chemotherapy in neuroendocrine/ Merkel cell carcinoma of the skin: Case series and review of 204 cases. J Clin Oncol. 2000;18:2493.
15. Miller RW, Rabkin CS. Merkel cell carcinoma and melanoma: Etiological similarities and differences. Cancer Epidermiol Biomarkers Prev. 1999;8:153-158. (Pubitemid 29085382)
16. Engels EA, Frisch M, Goedert JJ, et al. Merkel cell carcinoma and HIV infection. Lancet. 2002;359:497-498. (Pubitemid 34164301)
17. Friedlaender MM, Rubinger D, Rosenbaum E, et al. Temporary regression of Merkel cell carcinoma metastases after cessation of cyclosporine. Transplant. 2002;73:1849-1850. (Pubitemid 34655267)
18. Agelli M, Clegg LX. Epidemiology of primary Merkel cell carcinoma in the United States. J Am Acad Dermatol. 2003;49:832-841. (Pubitemid 37314870)
19. Lunder EJ, Stern RS. Merkel-cell carcinomas in patients treated with methoxsalen and ultraviolet A radiation. N Engl J Med. 1998;339:1247-1248. (Pubitemid 28482140)
20. Argenyi ZB. Neural and neuroendocrine neoplasms (other than neurofibromatosis). In: Bolognia JL, Jorizzo JL, Rapini RP, eds. Dermatology. Edinburgh, MO: Mosby. 2003:1854-1855.
21. Kolijonen V. Merkel cell carcinoma. World J Surg Onc. 2006:4:7.
22. Bichakjian CK, Lowe L, Lao CD, et al. Merkel cell carcinoma: Critical review with guidelines for multidisciplinary management. Cancer. 2007:110:1-12. (Pubitemid 46986412)
23. Kerl H, Hofmann-Wellenhof R. Cutaneous neuroendocrine carcinoma: Merkel cell carcinoma. In: Freedberg IM, Eisen AZ, Wolff K, et al, eds. Fitzpatrick's Dermatology in General Medicine. New York: McGraw-Hill, 2003:808-813.
24. Reed RJ, Argenyi Z. Tumors of neural tissue. In: Elder D, Elenitsas R, Jaworsky C, Johnson B Jr, eds. Lever's Histopathology of the Skin. Philadelphia, PA: Lippincott Williams & Wilkins. 1997:1000- 1002.
25. Szeder V, Grim M, Halata Z, Sieber-Blum M. Neural crest origin of mammalian Merkel cells. Dev Biol. 2003:253:258-263. (Pubitemid 36259886)
26. Veness MJ, Palme CE, Morgan GJ. Merkel cell carcinoma. A review of management. Curr Opin Oto Head Neck Surg. 2008:16:170- 174.
27. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: Merkel cell carcinoma.V.1.2008.www.nccn. org.
28. Eng TY, Boersma MG, Fuller CD, et al. A comprehensive review of the treatment of Merkel cell carcinoma. Am J Clin Onc. 2007:30:624-636. (Pubitemid 350307189)
29. Ngheim P. Merkel cell carcinoma: Diagnosis, management and controversies. Forum 542, American Academy of Dermatology Annual Meeting 2008, San Antonio, TX.
30. Warner RE, Quinn MJ, Hruby G, et al. Management of Merkel cell carcinoma: The roles of lymphoscintigraphy, sentinel lymph node biopsy and adjuvant radiotherapy. Ann Surg Onc. 2008:15:2509- 2518.
31. Gupta SG, Want LC, Penas PF, et al. Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma. Arch Derm. 2006:142:685-690.
32. Duker I, Starz H, Bachter D, Balda BR. Prognostic and therapeutic implications of sentinel lymphonodectomy and S-staging in Merkel cell carcinoma. Dermatology. 2001;202:225-229. (Pubitemid 32506970)
33. Mehrany K, Otley CC, Weening RH, et al. A meta-analysis of the prognostic significance of sentinel lymph node status in Merkelcell carcinoma. Dermatolog Surg. 2002:28:113-117. (Pubitemid 34177347)
34. Saito A, Tsutsumida A, Furukawa H, et al. Merkel cell carcinoma of the face: An analysis of 16 cases in the Japanese. J Plast Reconstr Aesthet Surg. 2008; doi:10.1016/j.bjps.2008.03.027.
35. Dancey Al, Rayatt SS, Soon C, et al. Merkel cell carcinoma: A report of 34 cases and literature review. J Plast Reconst Aesthet Surg. 2006:59:1294-1299.
36. Boyer JD, Zitelli JA, Brodland DG, D'Angelo G. Local control of primary Merkel cell carcinoma. Review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiation. J Am Acad Dermatol. 2002:47:885-892. (Pubitemid 35403048)
37. Mortier L, Mirabel X, Fournier C, et al. Radiotherapy alone for primary Merkel cell carcinoma. Arch Derm. 2003:139:1587-1590. (Pubitemid 37523077)
38. Pryor, JG, Simon RA, Bourne PA, et al. Merkel cell carcinoma expresses K homology domain-containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomas. Hum Pathol. 2009:40:238-243.
39. Krasagakis K, Kruger-Krasagakis S, Eberle J, et al. Co-expression of KIT receptor and its ligand stem cell factor in Merkel cell carcinoma. Dermatology. 2009:218:37-43.
40. Bowers JW, Schlauder SM, Calder KB, Morgan MB. Acetylcholine receptor expression in Merkel cell carcinoma. Am J Dermatopathol. 2008:30:340-343.
41. Brunner M, Thurnher D, Pammer J, et al. Expression of VEGF-A/C, VEGF-R2, PDGF-alpha/beta, c-kit, EGFR, Her-2/Neu, Mcl-1 and Bmi- 1 in Merkel cell carcinoma. Mod Pathol. 2008:21:876-884. (Pubitemid 351896662)
42. Krasagakis K, Krüger-Krasagakis S, Tzanakakis GN. Interferon-alpha inhibits proliferation and induces apoptosis of merkel cell carcinoma in vitro. Cancer Invest. 2008:26:562-568. (Pubitemid 351918576)
43. Dinh VD, Feun L, Elgart G, Savaraj N. Merkel cell carcinomas. Hematol Oncol Clin N Am. 2007:21:527-544. (Pubitemid 46850793)
44. Lemos B, Nghiem P. Merkel cell carcinoma: More deaths but still no pathway to blame. J Invest Dermatol. 2007:127:2100-2103. (Pubitemid 47258499)
45. Ho SY, Tsai YC, Lee MC, Guo HR. Merkel cell carcinoma in patients with long term ingestion of arsenic. J Occup Health. 2005:47:188- 192.
46. Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008:318:1096- 1100.
47. Kassan A, Schopflin A, Diaz C, et al. Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. Cancer Res. 2008:68:5009-5013.
48. Garneski KM, Warcola AH, Feng Q, et al. Merkel cell polyomavirus if more frequently present in north American than Australian Merkel cell carcinoma tumors. J Invest Dermatol. 2008:doi:10.1038/ jid.2008.229.
49. Becker JC, Houben R, Ugurel S, et al. MC polyomavirus is frequently present in Merkel cell carcinoma of european patients. J Invest Dermatol. 2008;doi:10.1038/jid.2008.198.
50. Papamichail M, Nikolaidis I, Nidolaidis N, et al. Merkel cell carcinoma of the upper extremity: Case report and an update. World J Surg Onc. 2008;6:32.
51. Swann MH, Yoon J. Merkel cell carcinoma. Sem Onc. 2007:34:51- 56.
52. Mojica P, Smith D, Elenhorn JDI. Adjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skin. J Clin Onc. 2007;25:1043-1047. (Pubitemid 46596754)