Pax-5 expression in nonhematopoietic tissues

American Journal of Clinical Pathology

Volumn 126, Issue 5, 2006, Pages 798-804

  Torlakovic, Emina ^a   Slipicevic, Ana ^b   Robinson, Chris ^a   DeCoteau, John F ^a   Alfsen, G Cecilie ^b   Vyberg, Mogens ^c   Chibbar, Richa ^d   Flørenes, Vivi Ann ^b  

^a ROYAL UNIVERSITY HOSPITAL   (Canada)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c AALBORG UNIVERSITY HOSPITAL   (Denmark)

^d UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Expression; Immunohistochemistry; Nonhematopoietic tissues; Pax 5

Indexed keywords

FORMALDEHYDE; MONOCLONAL ANTIBODY; PARAFFIN; POLYMER; TRANSCRIPTION FACTOR PAX5;

ARTICLE; BRAIN TISSUE; CANCER CELL CULTURE; CONTROLLED STUDY; DAUDI CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOMA CELL; MEDULLA OBLONGATA; MESONEPHROS; MUELLERIAN DUCT; NEUROENDOCRINE TUMOR; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TRIGEMINAL NUCLEUS; WESTERN BLOTTING;

EID: 33750697290     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/XEC7-JMW9-YRM7-4RNO     Document Type: Article

References (30)

1. Heller N, Brandli AW. Xenopus Pax-2/5/8 orthologues: novel insights into Pax gene evolution and identification of Pax-8 as the earliest marker for otic and pronephric cell lineages. Dev Genet. 1999;24:208-219.
2. Adams B, Dorfler P, Aguzzi A, et al. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev. 1992;6:1589-1607.
3. Smith E, Sigvardsson M. The roles of transcription factors in B lymphocyte commitment, development, and transformation. J Leukoc Biol. 2004;75:973-981.
4. Singh H, Medina KL, Pongubala JMR. Contingent gene regulatory networks and B cell fate specification. Proc Natl Acad Sci USA. 2005;102:4949-4953.
5. Rolink AG, Schaniel C, Busslinger M, et al. Fidelity and infidelity in commitment to B-lymphocyte lineage development. Immunol Rev. 2000;175:104-111.
6. Rolink AG, Nutt SL, Melchers F, et al. Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors. Nature. 1999;401:603-606.
7. Robichaud GA, Nardini M, Laflamme M, et al. Human Pax-5 C-terminal isoforms possess distinct transactivation properties and are differentially modulated in normal and malignant B cells. J Biol Chem. 2004;279:49956-49963.
8. Torlakovic E, Torlakovic G, Nguyen PL, et al. The value of anti-pax-5 immunostaining in routinely fixed and paraffin-embedded sections: a novel pan pre-B and B-cell marker. Am J Surg Pathol. 2002;26:1343-1350.
9. Tiacci E, Pileri S, Orleth A, et al. PAX5 expression in acute leukemias: higher B-lineage specificity than CD79a and selective association with t(8;21)-acute myelogenous leukemia. Cancer Res. 2004;64:7399-7404.
10. Zhang X, Lin Z, Kim I. Pax5 expression in non-Hodgkin's lymphomas and acute leukemias. J Korean Med Sci. 2003;18:804-808.
11. Dong HY, Liu W, Cohen P, et al. B-cell specific activation protein encoded by the PAX-5 gene is commonly expressed in Merkel cell carcinoma and small cell carcinomas. Am J Surg Pathol. 2005;29:687-692.
12. Babjuk M, Soukup V, Mares J, et al. The expression of PAX5, p53 immunohistochemistry and p53 mutation analysis in superficial bladder carcinoma tissue: correlation with pathological findings and clinical outcome. Int Urol Nephrol. 2002-2003;34:495-501.
13. Klein E, Klein G, Nadkarni JS, et al. Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines. Cancer Res. 1968;28:1300-1310.
14. Gazdar AF, Carney DN, Russell EK, et al. Establishment of continuous, clonable cultures of small-cell carcinoma of lung which have amine precursor uptake and decarboxylation cell properties. Cancer Res. 1980;40:3502-3507.
15. Simon HH, Bhatt L, Gherbassi D, et al. Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors. Ann N Y Acad Sci. 2003;991:36-47.
16. Krelova J, Holland LZ, Schubert M, et al. Functional equivalency of amphioxus and vertebrate Pax258 transcription factors suggests that the activation of mid-hindbrain specific genes in vertebrates occurs via the recruitment of Pax regulatory elements. Gene. 2002;282:143-150.
17. Nakamura H. Regionalization of the optic tectum: combinations of gene expression that define the tectum. Trends Neurosci. 2001;24:32-39.
18. Baumann Kubetzko FB, Di Paolo C, Maag C, et al. The PAX5 oncogene is expressed in N-type neuroblastoma cells and increases tumorigenicity of a S-type cell line. Carcinogenesis. 2004;25:1839-1846.
19. Schafer BW. Emerging roles for PAX transcription factors in cancer biology. Gen Physiol Biophys. 1998;17:211-224.
20. Stuart ET, Kioussi C, Aguzzi A, et al. PAX5 expression correlates with increasing malignancy in human astrocytomas. Clin Cancer Res. 1995;1:207-214.
21. Stuart ET, Haffner R, Oren M, et al. Loss of p53 function through PAX-mediated transcriptiorial repression. EMBO J. 1995;14:5638-5645.
22. Nutt SL, Morrison AM, Dörfler P, et al. Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments. EMBO J. 1998;17:2319-2333.
23. Kozmik Z, Sure U, Ruedi D, et al. Deregulated expression of PAX5 in medulloblastoma. Proc Natl Acad Sci U S A. 1995;92:5709-5713.
24. Krenacs L, Himmelmann AW, Quintanilla-Martinez L, et al. Transcription factor B-cell-specific activator protein (BSAP) is differentially expressed in B cells and in subsets of B-cell lymphomas. Blood. 1998;92:1308-1316.
25. Scholl FA, Kamarashev J, Murmann OV, et al. PAX3 is expressed in human melanomas and contributes to tumor cell survival. Cancer Res. 2001;61:823-826.
26. Hashi A, Yuminamochi T, Murata S, et al. Wilms tumor gene immunoreactivity in primary serous carcinomas of the fallopian tube, ovary, endometrium, and peritoneum. Int J Gynecol Pathol. 2003;22:374-377.
27. Adams B, Dorfler P, Aguzzi A, et al. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev. 1992;6:1589-1607.
28. Torres M, Gomez-Pardo E, Dressler GR, et al. Pax-2 controls multiple steps of urogenital development. Development. 1995;121:4057-4065.
29. Urbanek P, Fetka I, Meisler MH, et al. Cooperation of Pax2 and Pax5 in midbrain and cerebellum development. Proc Natl Acad Sci U S A. 1997;94:5703-5708.
30. Lagergren A, Manetopoulos C, Axelson H, et al. Neuroblastoma and pre-B lymphoma cells share expression of key transcription factors but display tissue restricted target gene expression. BMC Cancer. 2004;4:80.