Association of the HTR2A gene with alcohol and heroin abuse

Human Genetics

Volumn 133, Issue 3, 2014, Pages 357-365

  Cao, Jian ^a   Liu, Xiangtao ^b   Han, Shizhong ^c   Zhang, Clarence K ^a   Liu, Zongzhi ^a   Li, Dawei ^d,e,f  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^e University of Vermont   (United States)

^f UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLISM; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEROIN DEPENDENCE; HUMANS; LINEAR MODELS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, SEROTONIN, 5-HT2A; SENSITIVITY AND SPECIFICITY;

EID: 84894475027     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/s00439-013-1388-y     Document Type: Article

References (55)

1. Arranz MJ, Munro J, Owen MJ, Spurlock G, Sham PC, Zhao J, Kirov G, Collier DA, Kerwin RW (1998) Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine. Mol Psychiatry 3:61-66
2. Bierut LJ, Dinwiddie SH, Begleiter H, Crowe RR, Hesselbrock V, Nurnberger JI Jr, Porjesz B, Schuckit MA, Reich T (1998) Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism. Arch Gen Psychiatry 55:982-988
3. Cadoret RJ, Yates WR, Troughton E, Woodworth G, Stewart MA (1995) Adoption study demonstrating two genetic pathways to drug abuse. Arch Gen Psychiatry 52:42-52
4. Califano JA (2007) High Society: How Substance Abuse Ravages America and What to Do About It. Public Affairs
5. Cao L, Li T, Xu K, Liu X (2002) Association study of heroin dependence and 5-HT2A gene polymorphism -1438A/G. Chin J Drug Depend 11:266-268
6. Chen YF (2002) Chinese classification of mental disorders (CCMD-3): towards integration in international classification. Psychopathology 35:171-175
7. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177-188
8. Duval S, Tweedie R (2000) Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56:455-463
9. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629-634
10. Fehr C, Schleicher A, Szegedi A, Anghelescu I, Klawe C, Hiemke C, Dahmen N (2001) Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy. Prog Neuropsychopharmacol Biol Psychiatry 25:965-982
11. Frazer A, Hensler JG (1998) Serotonin, basic neurochemistry, molecular, cellular and medical aspects. Lippincott-Raven Publishers, Philadephia
12. Fu Q, Heath AC, Bucholz KK, Nelson E, Goldberg J, Lyons MJ, True WR, Jacob T, Tsuang MT, Eisen SA (2002) Shared genetic risk of major depression, alcohol dependence, and marijuana dependence: contribution of antisocial personality disorder in men. Arch Gen Psychiatry 59:1125-1132
13. Gao F, Zhu YS, Wei SG, Li SB, Lai JH (2011) Polymorphism G861C of 5-HT receptor subtype 1B is associated with heroin dependence in Han Chinese. Biochem Biophys Res Commun 412:450-453
14. Gelernter J, Kranzler HR (2009) Genetics of alcohol dependence. Hum Genet 126:91-99
15. Gelernter J, Panhuysen C, Wilcox M, Hesselbrock V, Rounsaville B, Poling J, Weiss R, Sonne S, Zhao H, Farrer L, Kranzler HR (2006) Genomewide linkage scan for opioid dependence and related traits. Am J Hum Genet 78:759-769
16. Glatt SJ, Su JA, Zhu SC, Zhang R, Zhang B, Li J, Yuan X, Lyons MJ, Faraone SV, Tsuang MT (2006) Genome-wide linkage analysis of heroin dependence in Han Chinese: results from wave one of a multi-stage study. Am J Med Genet B Neuropsychiatr Genet 141B:648-652
17. Hill EM, Stoltenberg SF, Bullard KH, Li S, Zucker RA, Burmeister M (2002) Antisocial alcoholism and serotonin-related polymorphisms: association tests. Psychiatr Genet 12:143-153
18. Himei A, Kono Y, Yoneda H, Sakai T, Koh J, Sakai J, Inada Y, Imamichi H (2000) An association study between alcoholism and the serotonergic receptor genes. Alcohol Clin Exp Res 24:341-342
19. Hwu HG, Chen CH (2000) Association of 5HT2A receptor gene polymorphism and alcohol abuse with behavior problems. Am J Med Genet 96:797-800
20. Jakubczyk A, Wrzosek M, Lukaszkiewicz J, Sadowska-Mazuryk J, Matsumoto H, Sliwerska E, Glass J, Burmeister M, Brower KJ, Wojnar M (2011) The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients. J Psychiatr Res 46:44-49
21. Kendler KS, Jacobson KC, Prescott CA, Neale MC (2003) Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. Am J Psychiatry 160:687-695
22. Kendler KS, Myers J, Prescott CA (2007) Specificity of genetic and environmental risk factors for symptoms of cannabis, cocaine, alcohol, caffeine, and nicotine dependence. Arch Gen Psychiatry 64:1313-1320
23. Kreek MJ, Nielsen DA, Butelman ER, LaForge KS (2005) Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nat Neurosci 8:1450-1457
24. Lee YS, Choi SW, Han DH, Kim DJ, Joe KH (2009) Clinical manifestation of alcohol withdrawal symptoms related to genetic polymorphisms of two serotonin receptors and serotonin transporter. Eur Addict Res 15:39-46
25. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531
26. Li T, Liu X, Zhao J, Hu X, Ball DM, el Loh W, Sham PC, Collier DA (2002) Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABA(A)gamma2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects. Am J Med Genet 114:329-335
27. Li D, Collier DA, He L (2006a) Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia. Hum Mol Genet 15:1995-2002
28. Li D, Duan Y, He L (2006b) Association study of serotonin 2A receptor (5-HT2A) gene with schizophrenia and suicidal behavior using systematic meta-analysis. Biochem Biophys Res Commun 340:1006-1015
29. Li D, Zhao H, Gelernter J (2011) Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases. Biol Psychiatry 70:504-512
30. Marek GJ, Aghajanian GK (1996) LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex. J Pharmacol Exp Ther 278:1373-1382
31. Maurel S, De Vry J, De Beun R, Schreiber R (1999) 5-HT2A and 5-HT2C/5-HT1B receptors are differentially involved in alcohol preference and consummatory behavior in cAA rats. Pharmacol Biochem Behav 62:89-96
32. Myers RL, Airey DC, Manier DH, Shelton RC, Sanders-Bush E (2007) Polymorphisms in the regulatory region of the human serotonin 5-HT2A receptor gene (HTR2A) influence gene expression. Biol Psychiatry 61:167-173
33. Nakamura T, Matsushita S, Nishiguchi N, Kimura M, Yoshino A, Higuchi S (1999) Association of a polymorphism of the 5HT2A receptor gene promoter region with alcohol dependence. Mol Psychiatry 4:85-88
34. Pandey SC, Davis JM, Pandey GN (1995) Phosphoinositide system-linked serotonin receptor subtypes and their pharmacological properties and clinical correlates. J Psychiatry Neurosci 20:215-225
35. Parsian A, Cloninger CR (2001) Serotonergic pathway genes and subtypes of alcoholism: association studies. Psychiatr Genet 11:89-94
36. Polina ER, Contini V, Hutz MH, Bau CH (2009) The serotonin 2A receptor gene in alcohol dependence and tobacco smoking. Drug Alcohol Depend 101:128-131
37. Rosenthal R (1979) The file drawer problem and tolerance for null results. Psychol Bull 86:638-641
38. Roth BL, Berry SA, Kroeze WK, Willins DL, Kristiansen K (1998) Serotonin 5-HT2A receptors: molecular biology and mechanisms of regulation. Crit Rev Neurobiol 12:319-338
39. Saiz PA, Garcia-Portilla MP, Arango C, Morales B, Martinez-Barrondo S, Alvarez C, San Narciso G, Carreno E, Alvarez V, Coto E, Bobes J (2008) Association between heroin dependence and 5-HT2A receptor gene polymorphisms. Eur Addict Res 14:47-52
40. Saxon AJ, Oreskovich MR, Brkanac Z (2005) Genetic determinants of addiction to opioids and cocaine. Harv Rev Psychiatry 13:218-232
41. Schmidt CJ, Sorensen SM, Kehne JH, Carr AA, Palfreyman MG (1995) The role of 5-HT2A receptors in antipsychotic activity. Life Sci 56:2209-2222
42. Shao C, Jiang K, Li Y, Zhao M, Song L, Xu Y, Lin L, Wang Q, Zhu M, Zhou W (2005) Association study between 5-HT2A receptor gene polymorphism and heroin dependence and cue-elicited heroin craving. Chin J Nerv Ment Dis 31:321-325
43. Terayama H, Takimoto T, Fukunishi I, Itoh M, Iwahashi K (2003) The serotonin-2A receptor polymorphism and clinical symptoms in mood disorders, schizophrenia and alcohol dependence in Japan. Acta Neuropsychiatrica 15:129-132
44. True WR, Xian H, Scherrer JF, Madden PA, Bucholz KK, Heath AC, Eisen SA, Lyons MJ, Goldberg J, Tsuang M (1999) Common genetic vulnerability for nicotine and alcohol dependence in men. Arch Gen Psychiatry 56:655-661
45. Tsuang MT, Lyons MJ, Meyer JM, Doyle T, Eisen SA, Goldberg J, True W, Lin N, Toomey R, Eaves L (1998) Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. Arch Gen Psychiatry 55:967-972
46. Tsunoka T, Kishi T, Kitajima T, Okochi T, Okumura T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Inada T, Ujike H, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N (2010) Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population. Prog Neuropsychopharmacol Biol Psychiatry 34:639-644
47. Uhl GR, Drgon T, Johnson C, Li CY, Contoreggi C, Hess J, Naiman D, Liu QR (2008) Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects. Ann N Y Acad Sci 1141:318-381
48. van den Bree MB, Johnson EO, Neale MC, Pickens RW (1998) Genetic and environmental influences on drug use and abuse/dependence in male and female twins. Drug Alcohol Depend 52:231-241
49. Wang G, Zhang L, Zhong A, Li N, Yu H, Sun F, Hu C, Wang Y (2001) Association study between 5-HT2A receptor gene polymorphism and heroin-dependent patients. Sichuan Mental Health 14:101-102
50. Woolf B (1955) On estimating the relation between blood group and disease. Ann Hum Genet 19:251-253
51. Wrzosek M, Lukaszkiewicz J, Serafin P, Jakubczyk A, Klimkiewicz A, Matsumoto H, Brower KJ, Wojnar M (2011) Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report. Psychiatry Res 190:149-151
52. Wrzosek M, Jakubczyk A, Matsumoto H, Lukaszkiewicz J, Brower KJ, Wojnar M (2012) Serotonin 2A receptor gene (HTR2A) polymorphism in alcohol-dependent patients. Pharmacol Rep 64:449-453
53. Xian H, Scherrer JF, Grant JD, Eisen SA, True WR, Jacob T, Bucholz KK (2008) Genetic and environmental contributions to nicotine, alcohol and cannabis dependence in male twins. Addiction 103:1391-1398
54. Yang M, Hao W, Wu Z, Wang W, Zhou X, Jiang G, Tang M, Huang J (2010) Association Study of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR Polymorphisms with Cooccurrence Heroin Dependence and Antisocial Personality Disorders in Males. Chin J Drug Dependence 19:349-363
55. Yang M, Kavi V, Wang W, Wu Z, Hao W (2012) The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and antisocial personality disorder in male heroin-dependent Chinese subjects. Prog Neuropsychopharmacol Biol Psychiatry 36:282-289