Serotonin 2A receptor gene (HTR2A) polymorphism in alcohol-dependent patients

Pharmacological Reports

Volumn 64, Issue 2, 2012, Pages 449-453

  Wrzosek, Małgorzata ^a   Jakubczyk, Andrzej ^a   Wrzosek, Michał ^a   Matsumoto, Halina ^a   Łukaszkiewicz, Jacek ^a   Brower, Kirk J ^b   Wojnar, Marcin ^a,b  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Alcohol dependence; Genetic polymorphism; HTR2A

Indexed keywords

SEROTONIN 2A RECEPTOR;

ADULT; ALCOHOLISM; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE FUNCTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENETIC VARIABILITY; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; ONSET AGE; RECEPTOR GENE; SEROTONIN 2A RECEPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84862185891     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/s1734-1140(12)70787-9     Document Type: Article

References (22)

1. American Psychiatric Association: Diagnostic and statistical manual of mental disorders, 4th edn. - Text Revision (DSM IV-TR), Washington, D.C., 2000.
2. 2A receptor gene 102T/C polymorphism is associated with suicidal behavior in depressed patients. Am J Med Genet, 2001, 105, 801-804.
3. Crawford LK, Craige CP, Beck SG: Increased intrinsic excitability of lateral wing serotonin neurons of the dorsal raphe: a mechanism for selective activation in stress circuits. J Neurophysiol, 2010, 103, 2652-2663.
4. Dick DM, Foroud T: Candidate genes for alcohol dependence: a review of genetic evidence from human studies. Alcohol Clin Exp Res, 2003, 27, 868-879. (Pubitemid 36583371)
5. Du L, Bakish D, Lapierre YD, Ravindran AV, Hrdina PD: Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. Am J Med Genet, 2000, 96, 56-60. (Pubitemid 30077651)
6. Fehr C, Schleicher A, Szegedi A, Anghelescu I, Klawe C, Hiemke C, Dahmen N: Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy. Prog Neuropsychopharmacol Biol Psychiatry, 2001, 25, 965-982. (Pubitemid 32769992)
7. Haleem DJ: Behavioral deficits and exaggerated feedback control over raphe-hippocampal serotonin neurotransmission in restrained rats. Pharmacol Rep, 2011, 63, 888-897.
8. Huang CL: The role of serotonin and possible interaction of serotonin-related genes with alcohol dehydrogenase and aldehyde dehydrogenase genes in alcohol dependence - a review. Am J Transl Res, 2010, 2, 190-199.
9. Hwu HG, Chen CH: Association of 5HT2A receptor gene polymorphism and alcohol abuse with behavior problems. Am J Med Genet, 2000, 96, 797-800.
10. Jakubczyk A, Wrzosek M, Łukaszkiewicz J, Sadowska-Mazuryk J, Matsumoto H, OEliwerska E, Glass J et al.: The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients. J Psychiatr Res, 2012, 46, 44-49.
11. Lanzenberger R,WadsakW, Spindelegger C, Mitterhauser M, Akimova E, Mien LK, Fink M et al.: Cortisol plasma levels in social anxiety disorder patients correlate with serotonin-1A receptor binding in limbic brain regions. Int J Neuropsychopharmacol, 2010, 13, 1129-1143.
12. Lanzenberger RR, Mitterhauser M, Spindelegger C, Wadsak W, Klein N, Mien LK, Holik A et al.: Reduced serotonin-1A receptor binding in social anxiety disorder. Biol Psychiatry, 2007, 61, 1081-1089. (Pubitemid 46551966)
13. Lee YS, Choi SW, Han DH, Kim DJ, Joe KH: Clinical manifestation of alcohol withdrawal symptoms related to genetic polymorphisms of two serotonin receptors and serotonin transporter. Eur Addict Res, 2009, 15, 39-46.
14. Lesch KP: Alcohol dependence and gene x environment interaction in emotion regulation: Is serotonin the link? Eur J Pharmacol, 2005, 526, 113-124. (Pubitemid 41744110)
15. Li D, Duan Y, He L: Association study of serotonin 2A receptor (5-HT2A) gene with schizophrenia and suicidal behavior using systematic meta-analysis, Biochem Biophys Res Commun, 2006, 340, 1006-1015. (Pubitemid 43053926)
16. Nakamura T, Matsushita S, Nishiguchi N, Kimura M, Yoshino A, Higuchi S: Association of a polymorphism of the 5-HT2A receptor gene promoter region with alcohol dependence. Mol Psychiatry, 1999, 4, 85-88. (Pubitemid 29050207)
17. Polesskaya OO, Sokolov BP: Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. J Neurosci Res, 2002, 67, 812-822. (Pubitemid 34226294)
18. Selzer ML: The Michigan alcoholism screening test: the quest for a new diagnostic instrument. Am J Psychiatry, 1971, 127, 1653-1658.
19. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T et al.: The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry, 1998, 59, Suppl 20, 22-33. (Pubitemid 29001829)
20. Stokes PE: The potential role of excessive cortisol induced by HPA hyperfunction in the pathogenesis of depression. Eur Neuropsychopharmacol, 1995, 5, Suppl 1, 77-82.
21. Underwood MD, Mann JJ, Huang YY, Arango V: Family history of alcoholism is associated with lower 5-HT2A receptor binding in the prefrontal cortex. Alcohol Clin Exp Res, 2008, 32, 593-599. (Pubitemid 351430422)
22. Wrzosek M, Łukaszkiewicz J, Wrzosek M, Serafin P, Jakubczyk A, Klimkiewicz A, Matsumoto H et al.: Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: A preliminary report. Psychiatry Res, 2011, 190, 149-151.