Citrate versus heparin lock for hemodialysis catheters: A systematic review and meta-analysis of randomized controlled trials

American Journal of Kidney Diseases

Volumn 63, Issue 3, 2014, Pages 479-490

  Zhao, Yuliang ^a   Li, Zheng ^b   Zhang, Ling ^a   Yang, Jiqiao ^a   Yang, Yingying ^a   Tang, Yi ^a   Fu, Ping ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

antimicrobial solution; catheter lock; catheter related bacteremia; citrate; exit site infection; Hemodialysis; heparin; lock solution; renal replacement therapy; vascular access

Indexed keywords

ANTIMICROBIAL SOLUTION; CATHETER LOCK; CATHETER-RELATED BACTEREMIA; CITRATE; EXIT-SITE INFECTION; HEMODIALYSIS; HEPARIN; LOCK SOLUTION; RENAL REPLACEMENT THERAPY; VASCULAR ACCESS;

ANTICOAGULANTS; CATHETER-RELATED INFECTIONS; CENTRAL VENOUS CATHETERS; CITRIC ACID; HEPARIN; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RENAL DIALYSIS; THROMBOSIS;

EID: 84894457558     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2013.08.016     Document Type: Article

References (26)

1. S.J. Schwab, and G. Beathard The hemodialysis catheter conundrum: hate living with them, but can't live without them Kidney Int 56 1 1999 1 17
2. A. Power, N. Duncan, and S.K. Singh et al. Sodium citrate versus heparin catheter locks for cuffed central venous catheters: A single-center randomized controlled trial Am J Kidney Dis 53 6 2009 1034 1041
3. J. Moran, S. Sun, and I. Khababa et al. A randomized trial comparing gentamicin/citrate and heparin locks for central venous catheters in maintenance hemodialysis patients Am J Kidney Dis 59 1 2012 102 107
4. R.M. Shanks, J.L. Sargent, R.M. Martinez, M.L. Graber, and G.A. O'Toole Catheter lock solutions influence staphylococcal biofilm formation on abiotic surfaces Nephrol Dial Transplant 21 8 2006 2247 2255
5. J.M. MacRae, I. Dojcinovic, and O. Djurdjev et al. Citrate 4% Versus Heparin and the Reduction of Thrombosis Study (CHARTS) Clin J Am Soc Nephrol 3 2 2008 369 374
6. M.C. Weijmer, M.A. van den Dorpel, and P.J. Van de Ven et al. Randomized, clinical trial comparison of trisodium citrate 30% and heparin as catheter-locking solution in hemodialysis patients J Am Soc Nephrol 16 9 2005 2769 2777
7. J. Buturovic, R. Ponikvar, and A. Kandus et al. Filling hemodialysis catheters in the interdialytic period: heparin versus citrate versus polygeline: A prospective randomized study Artif Organs 22 11 1998 945 947
8. L. Hendrickx, D. Kuypers, and P. Evenepoel et al. A comparative prospective study on the use of low concentrate citrate lock versus heparin lock in permanent dialysis catheters Int J Artif Organs 24 4 2001 208 211
9. G.K. Dogra, H. Herson, and B. Hutchison et al. Prevention of tunneled hemodialysis catheter-related infections using catheter-restricted filling with gentamicin and citrate: A randomized controlled study J Am Soc Nephrol 13 8 2002 2133 2139
10. A. Pervez, M. Ahmed, and S. Ram et al. Antibiotic lock technique for prevention of cuffed tunnel catheter associated bacteremia J Vasc Access 3 3 2002 108 113
11. M.G. Betjes, and M. van Agteren Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution Nephrol Dial Transplant 19 6 2004 1546 1551
12. U.S. Nori, A. Manoharan, J. Yee, and A. Besarab Comparison of low-dose gentamicin with minocycline as catheter lock solutions in the prevention of catheter-related bacteremia Am J Kidney Dis 48 4 2006 596 605
13. L.R. Solomon, J.S. Cheesbrough, and L. Ebah et al. A randomized double-blind controlled trial of taurolidine-citrate catheter locks for the prevention of bacteremia in patients treated with hemodialysis Am J Kidney Dis 55 6 2010 1060 1068
14. V. Filiopoulos, D. Hadjiyannakos, and I. Koutis et al. Approaches to prolong the use of uncuffed hemodialysis catheters: results of a randomized trial Am J Nephrol 33 3 2011 260 268
15. D.G. Maki, S.R. Ash, R.K. Winger, and P. Lavin A novel antimicrobial and antithrombotic lock solution for hemodialysis catheters: A multi-center, controlled, randomized trial Crit Care Med 39 4 2011 613 620
16. M. Allon Current management of vascular access Clin J Am Soc Nephrol 2 2007 786 800
17. A.S. Yevzlin, R.J. Sanchez, and J.G. Hiatt et al. Concentrated heparin lock is associated with major bleeding complications after tunneled hemodialysis catheter placement Semin Dial 20 4 2007 351 354
18. Y. Jaffer, N.M. Selby, M.W. Taal, R.J. Fluck, and C.W. McIntyre A meta-analysis of hemodialysis catheter locking solutions in the prevention of catheter-related infection Am J Kidney Dis 51 2 2008 233 241
19. L. Labriola, R. Crott, and M. Jadoul Preventing haemodialysis catheter-related bacteraemia with an antimicrobial lock solution: A meta-analysis of prospective randomized trials Nephrol Dial Transplant 23 5 2008 1666 1672
20. D. Yahav, B. Rozen-Zvi, and A. Gafter-Gvili et al. Antimicrobial lock solutions for the prevention of infections associated with intravascular catheters in patients undergoing hemodialysis: systematic review and meta-analysis of randomized, controlled trials Clin Infect Dis 47 1 2008 83 93
21. J.W. Bosma, C.E. Siegert, P.G. Peerbooms, and M.C. Weijmer Reduction of biofilm formation with trisodium citrate in haemodialysis catheters: A randomized controlled trial Nephrol Dial Transplant 25 4 2010 1213 1217
22. L. Grudzinski, P. Quinan, S. Kwok, and A. Pierratos Sodium citrate 4% locking solution for central venous dialysis catheters - an effective, more cost-efficient alternative to heparin Nephrol Dial Transplant 22 2 2007 471 476
23. J.E. Moran, and S.R. Ash Locking solutions for hemodialysis catheters; heparin and citrate - a position paper by ASDIN Semin Dial 21 5 2008 490 492
24. R. Vanholder, B. Canaud, and R. Fluck et al. Catheter-related blood stream infections (CRBSI): A European view Nephrol Dial Transplant 25 6 2010 1753 1756
25. C.K. Yon, and C.L. Low Sodium citrate 4% versus heparin as a lock solution in hemodialysis patients with central venous catheters Am J Health Syst Pharm 70 2 2013 131 136
26. D.A. Pierce, and M.V. Rocco Trisodium citrate: An alternative to unfractionated heparin for hemodialysis catheter dwells Pharmacotherapy 30 11 2010 1150 1158