Reduction of biofilm formation with trisodium citrate in haemodialysis catheters: A randomized controlled trial

Nephrology Dialysis Transplantation

Volumn 25, Issue 4, 2010, Pages 1213-1217

  Bosma, Jacob W ^a   Siegert, Carl E H ^a   Peerbooms, Paul G H ^a   Weijmer, Marcel C ^a  

^a ONZE LIEVE VROUWE GASTHUIS   (Netherlands)

Author keywords

Biofilm; Catheter locking solutions; Catheter related infections; Dialysis; Electron microscopy; Vascular access

Indexed keywords

CITRATE TRISODIUM; HEPARIN;

ADULT; AGED; ARTICLE; BACTERIAL COLONIZATION; BIOFILM; CATHETER INFECTION; CATHETER REMOVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIALYSIS CATHETER; DISEASE ASSOCIATION; ELECTIVE SURGERY; HEMODIALYSIS; HUMAN; IN VIVO STUDY; MALE; MICROORGANISM; PATIENT SELECTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; SCANNING ELECTRON MICROSCOPY; TREATMENT DURATION;

ADULT; AGED; AGED, 80 AND OVER; ANTICOAGULANTS; BACTERIAL ADHESION; BIOFILMS; CATHETER-RELATED INFECTIONS; CATHETERS, INDWELLING; CITRATES; EQUIPMENT CONTAMINATION; FEMALE; HEPARIN; HUMANS; KIDNEY DISEASES; MALE; MIDDLE AGED; RENAL DIALYSIS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 77950207610     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfp651     Document Type: Article

References (23)

1. Labriola L, Crott R, Jadoul M. Preventing haemodialysis catheter-related bacteraemia with an antimicrobial lock solution: a meta-analysis of prospective randomized trials. Nephrol Dial Transplant 2008; 231666-231672
2. Weijmer MC, van den Dorpel MA, Van d V, et al. Randomized, clinical trial comparison of trisodium citrate 30% and heparin as catheter-locking solution in hemodialysis patients. J Am Soc Nephrol 2005; 162769-162777
3. Costerton JW, Cheng KJ, Geesey GG, et al. Bacterial biofilms in nature and disease. Annu Rev Microbiol 1987; 41: 435-464
4. Diskin CJ, Stokes TJ, Dansby LM, et al. Is systemic heparin a risk factor for catheter-related sepsis in dialysis patients? An evaluation of various biofilm and traditional risk factors. Nephron Clin Pract 2007; 107: c128-c132
5. Hoyle BD, Costerton JW. Bacterial resistance to antibiotics: the role of biofilms. Prog Drug Res 1991; 37: 91-105
6. Passerini L, Lam K, Costerton JW, et al. Biofilms on indwelling vascular catheters. Crit Care Med 1992; 20: 665-673
7. Tenney JH, Moody MR, Newman KA, et al. Adherent microorganisms on lumenal surfaces of long-term intravenous catheters. Importance of Staphylococcus epidermidis in patients with cancer. Arch Intern Med 1986; 146: 1949-1954
8. Weijmer MC, bets-Ossenkopp YJ, Van d V, et al. Superior antimicrobial activity of trisodium citrate over heparin for catheter locking. Ne-phrol Dial Transplant 2002; 17: 2189-2195
9. Raad II, Fang X, Keutgen XM, et al. The role of chelators in preventing biofilm formation and catheter-related bloodstream infections. Curr Opin Infect Dis 2008; 21: 385-392
10. Root JL, McIntyre OR, Jacobs NJ, et al. Inhibitory effect of disodium EDTA upon the growth of Staphylococcus epidermidis in vitro: relation to infection prophylaxis of Hickman catheters. Antimicrob Agents Chemother 1988; 32: 1627-1631
11. Winnett G, Nolan J, Miller M, et al. Trisodium citrate 46.7% selectively and safely reduces staphylococcal catheter-related bacteraemia. Nephrol Dial Transplant 2008; 23: 3592-3598
12. Karaaslan H, Peyronnet P, Benevent D, et al. Risk of heparin lock-related bleeding when using indwelling venous catheter in haemodia-lysis. Nephrol Dial Transplant 2001; 16: 2072-2074
13. Moritz ML, Vats A, Ellis D. Systemic anticoagulation and bleeding in children with hemodialysis catheters. Pediatr Nephrol 2003; 18: 68-70
14. FDA. FDA issues warning on TriCitrasol dialysis catheter anticoa-gulation April 2000
15. Marrie TJ, Costerton JW. Scanning and transmission electron microscopy of in situ bacterial colonization of intravenous and intraarterial catheters. J Clin Microbiol 1984; 19: 687-693
16. Raad I, Costerton W, Sabharwal U, et al. Ultrastructural analysis of indwelling vascular catheters: a quantitative relationship between lu-minal colonization and duration of placement. J Infect Dis 1993; 168: 400-407
17. Maki DG, Weise CE, Sarafin HW. A semiquantitative culture method for identifying intravenous-catheter-related infection. N Engl J Med 1977; 296: 1305-1309
18. Shah CB, Mittelman MW, Costerton JW, et al. Antimicrobial activity of a novel catheter lock solution. Antimicrob Agents Chemother 2002; 46: 1674-1679
19. Shanks RM, Sargent JL, Martinez RM, et al. Catheter lock solutions influence staphylococcal biofilm formation on abiotic surfaces. Ne-phrol Dial Transplant 2006; 21: 2247-2255
20. Steczko J, Ash SR, Nivens DE, et al. Microbial inactivation properties of a new antimicrobial/antithrombotic catheter lock solution (citrate/methylene blue/parabens). Nephrol Dial Transplant 2009; 24: 1937-1945
21. Bach A, Bohrer H, Motsch J, et al. Prevention of catheter-related infections by antiseptic bonding. J Surg Res 1993; 55: 640-646
22. Raad I, Buzaid A, Rhyne J, et al. Minocycline and ethylenediamine- tetraacetate for the prevention of recurrent vascular catheter infections. Clin Infect Dis 1997; 25: 149-151
23. Cooper GL, Schiller AL, Hopkins CC. Possible role of capillary action in pathogenesis of experimental catheter-associated dermal tunnel infections. J Clin Microbiol 1988; 26: 8-12