Conopeptide Vt3.1 preferentially inhibits BK potassium channels containing β4 subunits via electrostatic interactions

Journal of Biological Chemistry

Volumn 289, Issue 8, 2014, Pages 4735-4742

  Li, Min ^a,b   Chang, Shan ^c   Yang, Longjin ^a   Shi, Jingyi ^b   McFarland, Kelli ^b   Yang, Xiao ^b   Moller, Alyssa ^b   Wang, Chunguang ^a   Zou, Xiaoqin ^c   Chi, Chengwu ^a,d   Cui, Jianmin ^b,e  

^a TONGJI UNIVERSITY   (China)

^b WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

^d INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^e MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

BK-CHANNEL; CONOPEPTIDES; EXTRACELLULAR LOOPS; POTASSIUM CHANNELS; TISSUE SPECIFICS;

ELECTROSTATICS;

CONOPEPTIDE VT3.1; CONOTOXIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA 1 SUBUNIT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA 2 SUBUNIT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA 3 SUBUNIT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA 4 SUBUNIT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; NEUROPHYSIOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SINGLE CHANNEL PATCH CLAMP; STATIC ELECTRICITY; XENOPUS LAEVIS;

ACTIVATION; BK CHANNEL; CONOPEPTIDE; ELECTROPHYSIOLOGY; ELECTROSTATIC INTERACTION; MOLECULAR MODELING; PEPTIDE INTERACTIONS; POTASSIUM CHANNELS; TOXINS; Β4 SUBUNIT;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; CONOTOXINS; FEMALE; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; PROTEIN SUBUNITS; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 84894426204     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.535898     Document Type: Article

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