Location of modulatory β subunits in BK potassium channels

Journal of General Physiology

Volumn 135, Issue 5, 2010, Pages 449-459

  Liu, Guoxia ^a   Niu, Xiaowei ^a,b   Wu, Roland S ^a   Chudasama, Neelesh ^a   Yao, Yongneng ^b   Jin, Xin ^b   Weinberg, Richard ^a   Zakharov, Sergey I ^a   Motoike, Howard ^a   Marx, Steven O ^a,b   Karlin, Arthur ^b  

^a University of New York   (United States)

^b Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; DISULFIDE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; PROTEIN SUBUNIT;

ANIMAL; ARTICLE; CELL CULTURE; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; GENETIC TRANSFECTION; GENETICS; HUMAN; KIDNEY; METABOLISM; MOUSE; PROTEIN TERTIARY STRUCTURE;

ANIMALS; CELL MEMBRANE; CELLS, CULTURED; CYSTEINE; DISULFIDES; HUMANS; KIDNEY; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MICE; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; TRANSFECTION;

EID: 77951728181     PISSN: 00221295     EISSN: 15407748     Source Type: Journal    
DOI: 10.1085/jgp.201010417     Document Type: Article

References (37)

1. Arnold, K., L. Bordoli, J. Kopp, and T. Schwede. 2006. The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Bioinformaties. 22:195-201. doi:10.1093/bioinformatics/bti770 (Pubitemid 43205406)
2. 2+ sensitivity is enhanced by its β1 subunit. J. Gm. Physiol, 126:393-412. doi:10.1085/jgp.200509346
3. Becker, L., M.E. Nesheim, and M.L. Koschinsky. 2006. Catalysis of covalent Lp(a) assembly: evidence for an extracellular enzyme activity that enhances disulfide bond formation. Biochemistry. 45:9919-9928. doi:10.1021/bi060283t (Pubitemid 44257437)
4. Brenner, R., T.J. Jegla, A. Wickenden, Y. Liu, and R.W. Aldrich. 2000. Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4, J. Biol. Chem. 275:6453-6461. doi:10.1074/jbc.275.9.6453 (Pubitemid 30129943)
5. Butler, A., S. Tsunoda, D.P. McCobb, A. Wei, and L. Salkoff. 1993. mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels. Science. 261:221-224. doi: 10.1126/science.7687074
6. + channel. J. Gen. Physiol 110:257-281. doi:10.1085/jgp.110.3.257
7. DeLano, W.L. 2002. PyMOL Molecular Viewer, org (accessed March 31, 2010).
8. Emsley, P., and K. Cowtan. 2004. Coot: model-building tools for molecular graphics. Acta Crystallogr. D.Biol Crystallogr. 60:2126-2132. doi:10.1107/S0907444904019158 (Pubitemid 41742764)
9. Fernández-Fernández, J.M., M. Tomás, E. Vázquez, P. Orio, R. Latorre, M. Sentí, J. Marrugat, and M.A. Valverde. 2004. Gain-offunction mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension. J. Clin. Invest. 113:1032-1039. (Pubitemid 38544125)
10. Hanner, M., W.A. Schmalhofer, P. Munujos, H.G. Knaus, G.J. Kaczorowski, and M.L. Garcia. 1997. The beta subunit of the high-conductance calcium-activated potassium channel contributes to the high-affinity receptor for charybdotoxin. Proc. Natl. Acad. Sci USA. 94:2853-2858. doi: 10.1073/pnas.94.7.2853
11. 2+. J. Gen, Physiol. 114:305-336. doi:10.1085/jgp.114.2.305
12. 2+ binding and channel opening in large conductance (BK) potassium channels. J. Gen, Physiol. 120:267-305. doi:10.1085/jgp.20028605
13. Horrigan, F.T., and T. Hoshi. 2008. Integration of an electric-metal sensory experience in the Slo 1 BK channel. Nat. Struct. Mol Biol. 15:1130-1132. doi:10.1038/nsmb1108-1130
14. 2+ J. Gen. Physiol. 114:277-304. doi:10.1085/jgp.114.2.277
15. Jiang, X.M., M. Fitzgerald, C.M. Grant, and P.J. Hogg. 1999. Redox control of exofacial protein thiols/disulfides by protein disulfide isomerase. J. Biol. Chem, 274:2416-2423. doi:10.1074/jbc.274.4.2416 (Pubitemid 29061403)
16. Kiefer, F., K. Arnold, M. Künzli, L. Bordoli, and T. Schwede. 2009. The SWISS-MODEL repository and associated resources. Nucleic Acids Res. 37:D387-D392. doi:10.1093/nar/gkn750
17. Knaus, H.G., A. Eberhart, G.J. Kaczorowski, and M.L. Garcia. 1994a. Covalent attachment of charybdotoxin to the beta-subunit of the high conductance Ca(2+)-activated K+ channel. Identification of the site of incorporation and implications for channel topology. J. Biol Chem. 269:23336-23341. (Pubitemid 24283326)
18. Knaus, H.G., K Folander, M. Garcia-Calvo, M.L. Garcia, G.J. Kaczorowski, M. Smith, and R. Swanson. 1994b. Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth, muscle. J. Biol. Chem. 269:17274-17278. (Pubitemid 24978724)
19. Lippiat, J.D., N.B. Standen, I.D. Harrow, S.C. Phillips, and N.W. Davies. 2003. Properties of BK(Ca) channels formed by bicistronic expression of hSloalpha and be ta 1-4 subunits in HEK293 cells. J. Membr. Biol, 192:141-148. doi:10.1007/s00232-002-1070-0
20. Liu, G., S.I. Zakharov, L. Yang, S.X. Deng, D.W. Landry, A. Karlin, and S.O. Marx. 2008a. Position and role of the BK channel α subunit; S0 helix inferred from disulfide crosslinking. J. Gen, Physiol, 131:537-548. doi:10.1085/jgp.200809968
21. Liu, G., S.I. Zakharov, L. Yang, R.S. Wu, S.X. Deng, D.W. Landry, A. Karlin, and S.O. Marx. 2008b. Locations of the betal transmembrane helices in the BK potassium channel. Proc. Natl. Acad. Sci USA, 105:10727-10732. doi:10.1073/pnas.0805212105
22. Long, S.B., E.B. Campbell, and R. Mackinnon. 2005. Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science. 309:897-903. doi:10.1126/science.11.16269
23. Meera, P., M. Wallner, and L. Toro. 2000. A neuronal beta subunit; (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. Proc. Natl. Acad. Sci, USA. 97:5562-5567. doi:10.1073/pnas.100118597 (Pubitemid 30313758)
24. Niu, X., X. Qian, and K.L. Magleby. 2004. Linker-gating ring complex as passive spring and Ca(2+)-dependent; machine for a voltage- and Ca(2+)-activated potassium channel. Neuron, 42:745-756. doi:10.1016/j.neuron.2004.05.001 (Pubitemid 38748789)
25. Peitsch, M.C. 1995. Protein modeling by email. Nat. Biotechnol 13:658-660. doi:10.1038/nbt0795-658
26. Seibold, M.A., B. Wang, C. Eng, G. Kumar, KB. Beckman, S. Sen, S. Choudhry, K. Meade, M. Lenoir, H.G. Watson, et al. 2008. An african-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity. Hum, Mol, Genet. 17:2681-2690. doi:10.1093/hmg/ddn168
27. Stefani, E., M. Ottolia, F. Noceti, R. Olcese, M. Wallner, R. Latorre, and L. Toro. 1997. Voltage-controlled gating in a large conductance Ca2+-sensit;ive K+channel (hslo). Proc. Natl. Acad. Sci. USA. 94:5427-5431. doi: 10.1073/pnas.94.10.5427
28. Uebele, V.N., A. Lagrutta, T. Wade, D.J. Figueroa, Y. Liu, E. McKenna, C.P. Austin, P.B. Bennett, and R. Swanson. 2000. Cloning and functional expression of two families of beta-subunits of the large conductance calcium-activated K+ channel. J. Biol, Chem. 275:23211-23218. doi:10.1074/jbc.M910187199 (Pubitemid 30646218)
29. Wallner, M., P. Meera, and L. Toro. 1996. Determinant for betasubunit regulation in high-conductance voltage-activated and Ca(2+)-sensitive K+ channels: an additional transmembrane region at the N terminus. Proc Natl, Acad. Sci. USA. 93:14922-14927. doi: 10.1073/pnas.93.25.14922 (Pubitemid 26419071)
30. Wallner, M., P. Meera, and L. Toro. 1999. Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog. Proc. Natl. Acad, Sci. USA. 96:4137-4142. doi:10.1()73/pnas.96.7.4137 (Pubitemid 29169049)
31. Wang, B., B.S. Rothberg, and R. Brenner. 2006. Mechanism of (β4 subunit modulation of BK channels. J. Gen. Physiol. 127:449-465. doi:10.1085/jgp.200509436
32. Wang, L., and F.J. Sigworth. 2009. Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy. Nature. 461:292-295. doi:10.1038/nature08291
33. Wang, Y.W., J.P. Ding, X.M. Xia, and C.J. Lingle. 2002. Consequences of the stoichiometry of Slol alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels. J. Neurosd. 22:1550-1561.
34. Wilkinson, B., and H.F. Gilbert. 2004. Protein disulfide isomerase. Biochim. Biophys. Acta. 1699:35-44.
35. Wu, R.S., N. Chudasama, S.I. Zakharov, D. Doshi, H. Motoike, G. Liu, Y. Yao, X. Niu, S.X. Deng, D.W. Landry, et al. 2009. Location of the beta 4 transmembrane helices in the BK potassium channel. J. Neuroci. 29:8321-8328. doi:10.1523/JNEUROSCI.6191-08.2009
36. Xia, X.M., J.P. Ding, X.H. Zeng, K.L. Duan, and C.J. Lingle. 2000. Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit. J. Neuroci, 20:4890-4903.
37. Yarov-Yarovoy, V., D. Baker, and W.A. Catterall. 2006. Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels. Proc. Natl. Acad. Sci. USA. 103:7292-7297. doi:10.1073/pnas. 0602350103 (Pubitemid 43727826)