Antidepressant effects of crocin and its effects on transcript and protein levels of CREB, BDNF, and VGF in rat hippocampus

DARU, Journal of Pharmaceutical Sciences

Volumn 22, Issue 1, 2014, Pages

  Vahdati Hassani, Faezeh ^a   Naseri, Vahideh ^a   Razavi, Bibi Marjan ^a   Mehri, Soghra ^a   Abnous, Khalil ^a   Hosseinzadeh, Hossein ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antidepressant; Crocin; Forced swimming test; qRT PCR; Western blot

Indexed keywords

EID: 84894416012     PISSN: 15608115     EISSN: 20082231     Source Type: Journal    
DOI: 10.1186/2008-2231-22-16     Document Type: Article

References (61)

1. Alternative projections of mortality and disability by cause 1990-2020: global burden of disease study. Murray CJ, Lopez AD, Lancet 1997 349 1498 1504 10.1016/S0140-6736(96)07492-2 9167458 (Pubitemid 27216360)
2. Compliance during treatment with antidepressants. Demyttenaere K, J Affect Disord 1997 43 27 39 10.1016/S0165-0327(96)00095-X 9127828 (Pubitemid 27146246)
3. Antidepressant drugs: side effects and compliance. Blackwell B, J Clin Psychiatry 1982 43 14 21 7174629 (Pubitemid 13208344)
4. Safety of St John's Wort extract compared to synthetic antidepressants. Schulz V, Phytomedicine 2006 13 199 204 10.1016/j.phymed.2005.07.005 16428030 (Pubitemid 43120322)
5. Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. Modaghegh MH, Shahabian M, Esmaeili HA, Rajbai O, Hosseinzadeh H, Phytomedicine 2008 15 1032 1037 10.1016/j.phymed.2008.06.003 18693099
6. Innovative approaches for the development of antidepressant drugs: current and future strategies. Schechter LE, Ring RH, Beyer CE, Hughes ZA, Khawaja X, Malberg JE, Rosenzweig-Lipson S, NeuroRx 2005 2 590 611 10.1602/neurorx.2.4.590 16489368 (Pubitemid 41393268)
7. Neuropeptides in depression: role of VGF. Thakker-Varia S, Alder J, Behav Brain Res 2009 197 262 278 10.1016/j.bbr.2008.10.006 18983874
8. Hippocampal neurogenesis: regulation by stress and antidepressants. Dranovsky A, Hen R, Biol Psychiatry 2006 59 1136 1143 10.1016/j.biopsych.2006. 03.082 16797263
9. Is mood chemistry? Castren E, Nat Rev Neurosci 2005 6 241 246 15738959 (Pubitemid 40342418)
10. Strategies for producing faster acting antidepressants. Adell A, Castro E, Celada P, Bortolozzi A, Pazos A, Artigas F, Drug Discov Today 2005 10 578 585 10.1016/S1359-6446(05)03398-2 15837601 (Pubitemid 40552825)
11. The role of CREB in depression and antidepressant treatment. Blendy JA, Biol Psychiatry 2006 59 1144 1150 10.1016/j.biopsych.2005.11.003 16457782
12. The role of BDNF in depression on the basis of its location in the neural circuitry. Yu H, Chen ZY, Acta Pharmacol Sin 2011 32 3 11 10.1038/aps.2010.184 21131999
13. Avicenna's (Ibn Sina) the Canon of Medicine and Saffron (Crocus sativus): a review. Hosseinzadeh H, Nassiri-Asl M, Phytother Res 2013 27 475 483 10.1002/ptr.4784 22815242
14. Safranal: from an aromatic natural product to a rewarding pharmacological agent. Rezaee R, Hosseinzadeh H, Iran J Basic Med Sci 2013 16 12 26 23638289
15. Evaluation of the cytotoxic activity of crocin and safranal using potato disc and brine shrimp assays. Behravan J, Hosseinzadeh H, Rastgoo A, Hessani M, Physiol Pharmacol 2010 13 397 403
16. Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): an experimental study in the rat. Garcia-Olmo DC, Riese HH, Escribano J, Ontanon J, Fernandez JA, Atienzar M, Garcia-Olmo D, Nutr Cancer 1999 35 120 126 10.1207/S15327914NC352-4 10693164 (Pubitemid 30115121)
17. Anti-tumor and cytotoxic evaluation of Crocus sativus L. Stigma and petal extracts using brine shrimp and potato disc assays. Hosseinzadeh H, Behravan J, Ramezani M, Ajgan K, J Med Plants 2005 4 59 65 (Pubitemid 41752362)
18. Antitumor Activity of PEGylated Nanoliposomes Containing Crocin in Mice Bearing C26 Colon Carcinoma. Rastgoo M, Hosseinzadeh H, Alavizadeh H, Abbasi A, Ayati Z, Jaafari MR, Planta medica 2013 79 447 451 23539350
19. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Salomi MJ, Nair SC, Panikkar KR, Nutr Cancer 1991 16 67 72 10.1080/01635589109514142 1923908
20. Antioxidant activity of aqueous and ethanolic extracts of Crocus sativus L. stigma and its bioactive constituents, crocin and safranal. Hosseinzadeh H, Shamsaie F, Mehri S, Pharmacogn Mag 2009 5 419 424
21. Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. Amin B, Hosseinzadeh H, Fitoterapia 2012 83 888 895 10.1016/j.fitote.2012.03.022 22484092
22. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. Hosseinzadeh H, Younesi HM, BMC Pharmacol 2002 2 7 11914135
23. The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats. Hosseinzadeh H, Ziaee T, Sadeghi A, Phytomedicine 2008 15 491 495 10.1016/j.phymed.2007.09.020 17962007 (Pubitemid 351783383)
24. Evaluation of the antitussive effect of stigma and petals of saffron (Crocus sativus) and its components, safranal and crocin in guinea pigs. Hosseinzadeh H, Ghenaati J, Fitoterapia 2006 77 446 448 10.1016/j.fitote.2006. 04.012 16814486 (Pubitemid 44308375)
25. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Imenshahidi M, Hosseinzadeh H, Javadpour Y, Phytother Res 2010 24 990 994 20013822
26. Cardioprotective Effect of Saffron Extract and Safranal in Isoproterenol-Induced Myocardial Infarction in Wistar Rats. Mehdizadeh R, Parizadeh MR, Khooei A-R, Mehri S, Hosseinzadeh H, Iran J Basic Med Sci 2013 16 56 63 23638293
27. Sadat Motamedahariaty V, Imenshahidi M: Crocin Restores Hypotensive Effect of Subchronic Administration of Diazinon in Rats. Razavi M, Hosseinzadeh H, Abnous K, Iran J Basic Med Sci 2012 16 64 72
28. Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. Hosseinzadeh H, Sadeghnia HR, Ghaeni FA, Motamedshariaty VS, Mohajeri SA, Phytother Res 2012 26 381 386 21774008
29. Effects of Crocus sativus stigma extract and its constituents, crocin and safranal, on intact memory and scopolamine-induced learning deficits in rats performing the Morris water maze task. Hosseinzadeh H, Ziaei T, J Med Plants 2006 5 40 50
30. Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice. Hosseinzadeh H, Noraei NB, Phytother Res 2009 23 768 774 10.1002/ptr.2597 19142981
31. Effect of Crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice. Hosseinzadeh H, Jahanian Z, Phytother Res 2010 24 726 730 19827024
32. Effects of crocin on the acquisition and reinstatement of morphine-induced conditioned place preference in mice. Imenshahidi M, Zafari H, Hosseinzadeh H, Pharmacologyonline 2011 1 1007 1013
33. Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice. Hosseinzadeh H, Talebzadeh F, Fitoterapia 2005 76 722 724 10.1016/j.fitote.2005.07.008 16253437 (Pubitemid 41688398)
34. Antidepressant effects of Crocus sativus stigma extracts and its constituents, crocin and safranal, in mice. Hosseinzadeh H, Karimi G, Niapoor M, J Med Plants 2004 3 48 58
35. Antidepressant effect of kaempferol, a constituent of saffron (Crocus sativus) petal, in mice and rats. Hosseinzadeh H, Motamedshariaty V, Hadizadeh F, Pharmacologyonline 2007 2 367 370 (Pubitemid 47408666)
36. Study of antidepressant effect of aqueous and ethanolic extract of Crocus sativus in mice. Karimi GR, Hosseinzadeh H, Khaleghpanah P, Iran J Basic Med Sci 2001 4 11 15
37. Antidepressant properties of bioactive fractions from the extract of Crocus sativus L. Wang Y, Han T, Zhu Y, Zheng CJ, Ming QL, Rahman K, Qin LP, J Nat Med 2010 64 24 30 10.1007/s11418-009-0360-6 19787421
38. Extraction and purification of crocin from saffron stigmas employing a simple and efficient crystallization method. Hadizadeh F, Mohajeri SA, Seifi M, Pak J Biol Sci 2010 13 691 698 21848061
39. Crocus sativus L. extracts antagonize memory impairments in different behavioural tasks in the rat. Pitsikas N, Sakellaridis N, Behav Brain Res 2006 173 112 115 10.1016/j.bbr.2006.06.005 16860406 (Pubitemid 44572020)
40. Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus. Fortunato JJ, Reus GZ, Kirsch TR, Stringari RB, Fries GR, Kapczinski F, Hallak JE, Zuardi AW, Crippa JA, Quevedo J, J Neural Transm 2010 117 1131 1137 10.1007/s00702-010-0451-2 20686906
41. Antidepressant-like effects of aniracetam in aged rats and its mode of action. Nakamura K, Tanaka Y, Psychopharmacology (Berl) 2001 158 205 212 10.1007/s002130100849 11702095 (Pubitemid 33020840)
42. Depression: A new animal model sensitive to antidepressant treatments. Porsolt RD, Le Pichon M, Jalfre M, Nature 1977 266 730 732 10.1038/266730a0 559941 (Pubitemid 8073804)
43. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Detke MJ: Rickels M, Lucki I, Psychopharmacology (Berl) 1995 121 66 72 10.1007/BF02245592 8539342
44. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Livak KJ, Schmittgen TD, Methods 2001 25 402 408 10.1006/meth.2001.1262 11846609 (Pubitemid 34164012)
45. Levels of neurotrophic factors in the hippocampus and amygdala correlate with anxiety- and fear-related behaviour in C57BL6 mice. Yee BK, Zhu SW, Mohammed AH, Feldon J, J Neural Transm 2007 114 431 444 10.1007/s00702-006-0548- 9 16897598 (Pubitemid 46474856)
46. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. Smith MA, Makino S, Kvetnansky R, Post RM, J Neurosci 1995 15 1768 1777 7891134
47. Hippocampal volume and depression: a meta-analysis of MRI studies. Videbech P, Ravnkilde B, Am J Psychiatry 2004 161 1957 1966 10.1176/appi.ajp. 161.11.1957 15514393 (Pubitemid 39441394)
48. Hippocampal atrophy in recurrent major depression. Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW, Proc Natl Acad Sci U S A 1996 93 3908 3913 10.1073/pnas.93.9.3908 8632988 (Pubitemid 26144221)
49. Hippocampal volume reduction in major depression. Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, Charney DS, Am J Psychiatry 2000 157 115 118 10618023
50. Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades. Tiraboschi E, Tardito D, Kasahara J, Moraschi S, Pruneri P, Gennarelli M, Racagni G, Popoli M, Neuropsychopharmacology 2004 29 1831 1840 10.1038/sj.npp.1300488 15138445 (Pubitemid 39336795)
51. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. Nibuya M, Nestler EJ, Duman RS, J Neurosci 1996 16 2365 2372 8601816 (Pubitemid 26154346)
52. Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain. Reus GZ, Stringari RB, Ribeiro KF, Ferraro AK, Vitto MF, Cesconetto P, Souza CT, Quevedo J, Behav Brain Res 2011 221 166 171 10.1016/j.bbr.2011.02. 024 21397634
53. Altered regulation of CREB by chronic antidepressant administration in the brain of transgenic mice with impaired glucocorticoid receptor function. Blom JM, Tascedda F, Carra S, Ferraguti C, Barden N, Brunello N, Neuropsychopharmacology 2002 26 605 614 10.1016/S0893-133X(01)00401-8 11927185 (Pubitemid 34260979)
54. The role of neurotrophins in the developing nervous system. Davies AM, J Neurobiol 1994 25 1334 1348 10.1002/neu.480251103 7852989 (Pubitemid 24325060)
55. The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study. Aydemir O, Deveci A, Taneli F, Prog Neuropsychopharmacol Biol Psychiatry 2005 29 261 265 10.1016/j.pnpbp.2004.11.009 15694233 (Pubitemid 40202912)
56. Partial normalization of serum brain-derived neurotrophic factor in remitted patients after a major depressive episode. Gervasoni N, Aubry JM, Bondolfi G, Osiek C, Schwald M, Bertschy G, Karege F, Neuropsychobiology 2005 51 234 238 10.1159/000085725 15897674 (Pubitemid 40976406)
57. Hippocampal brain-derived neurotrophic factor expression following treatment with reboxetine, citalopram, and physical exercise. Russo-Neustadt AA, Alejandre H, Garcia C, Ivy AS, Chen MJ, Neuropsychopharmacology 2004 29 2189 2199 10.1038/sj.npp.1300514 15199375 (Pubitemid 39578909)
58. Bi-phasic change in BDNF gene expression following antidepressant drug treatment. Coppell AL, Pei Q, Zetterstrom TS, Neuropharmacology 2003 44 903 910 10.1016/S0028-3908(03)00077-7 12726822 (Pubitemid 36515026)
59. VGF, a new player in antidepressant action? Malberg JE, Monteggia LM, Sci Signal 2008 1 e19 18460680
60. Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes. Allaman I, Fiumelli H, Magistretti PJ, Martin JL, Psychopharmacology (Berl) 2011 216 75 84 10.1007/s00213-011-2190-y 21301813
61. Antidepressant actions of the exercise-regulated gene VGF. Hunsberger JG, Newton SS, Bennett AH, Duman CH, Russell DS, Salton SR, Duman RS, Nat Med 2007 13 1476 1482 10.1038/nm1669 18059283 (Pubitemid 350224242)