Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain

Behavioural Brain Research

Volumn 221, Issue 1, 2011, Pages 166-171

  Réus, Gislaine Z ^a   Stringari, Roberto B ^a   Ribeiro, Karine F ^a   Ferraro, Ana K ^a   Vitto, Marcelo F ^a   Cesconetto, Patrícia ^a   Souza, Claúdio T ^a   Quevedo, João ^a  

^a UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

Author keywords

Brain derived neurotrophic factor; CAMP response element bindig; Depression; NMDA receptor; Protein kinase A; Protein kinase C

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; IMIPRAMINE; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN KINASE C;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG DOSE COMPARISON; FORCED SWIMMING TEST; HIPPOCAMPUS; LOCOMOTION; MALE; NONHUMAN; OPEN FIELD TEST; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; ANTIDEPRESSIVE AGENTS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DEPRESSION; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; IMIPRAMINE; IMMOBILITY RESPONSE, TONIC; KETAMINE; MOTOR ACTIVITY; PHOSPHORYLATION; PROTEIN KINASE C; RATS; RATS, WISTAR;

EID: 79953070155     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.02.024     Document Type: Article

References (57)

1. Souery D., Amsterdam J., de Montigny C., Lecrubier Y., Montgomery S., Lipp O., et al. Treatment resistant depression: metodological overview and operational criteria. Eur Neuropsychopharmacol 1999, 9:83-91.
2. Kos T., Popik P., Pietraszek M., Schafer D., Danysz W., Dravolina O., et al. Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice. Eur Neuropsychopharmacol 2006, 16:297-310.
3. Garcia L.B., Comim C.M., Valvassori S.S., Réus G.Z., Barbosa L.M., Andreazza A.C., et al. Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry 2008, 32:140-144.
4. Garcia L.B., Comim C.M., Valvassori S.S., Réus G.Z., Andreazza A.C., Stertz L., et al. Chronic administration of ketamine elicits antidepressant-like effects in rats without affecting hippocampal brain-derived neurotrophic factor protein levels. Basic Clin Pharmacol Toxicol 2008, 103:502-506.
5. Réus G.Z., Stringari R.B., Kirsch T.R., Fries G.R., Kapczinski F., Roesler R., et al. Neurochemical and behavioural effects of acute and chronic memantine administration in rats: further support for NMDA as a new pharmacological target for the treatment of depression?. Brain Res Bull 2010, 81:585-589.
6. Rogóz Z., Skuza G., Maj J., Danysz W. Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats. Neuropharmacology 2002, 42:1024-1030.
7. Zarate C.A., Singh J.B., Carson P.J., Brutshe N.E., Ameli R., Luckenbaugh D.A., et al. A randomized trial of N-methyl-d-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 2006, 63:856-864.
8. Law A.J., Deakin J.F. Asymmetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses. Neuroreport 2001, 12:2971-2974.
9. Beneyto M., Kristiansen L.V., Oni-Orisan A., McCullumsmith R.E., Meador Woodruff J.H. Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders. Neuropsychopharmacology 2007, 32:1888-1902.
10. Feyissa A.M., Chandran A., Stockmeier C.A., Karolewicz B. Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33:70-75.
11. Garcia L.S., Comim C.M., Valvassori S.S., Réus G.Z., Stertz L., Kapczinski F., et al. Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33:450-455.
12. Berman R.B., Cappielo A., Anand A., Oren D.A., George R.H., Charney D.S., et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 2000, 47:351-354.
13. Gould E., McEwen B.S., Tanapat P., Galea L.A., Fuchs E. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci 1997, 17:2492-2498.
14. Sapolsky R.M. Why stress is bad for your brain. Science 1996, 273:749-750.
15. Cook S.C., Wellman C.L. Chronic stress alters dendritic morphology in rat medial prefrontal cortex. J Neurobiol 2004, 60:236-248.
16. Rajkowska G., Miguel-Hidalgo J.J., Wei J., Dilley G., Pittman S.D., Meltzer H.Y., et al. Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biol Psychiatry 1999, 45:1085-1098.
17. Drevets W.C., Videen T.O., Price J.L., Preskorn S.H., Carmichael S.T., Raichle M.E. A functional anatomical study of unipolar depression. J Neurosci 1992, 12:3628-3641.
18. Lange C., Irle E. Enlarged amygdala volume and reduced hippocampal volume in young women with major depression. Psychol Med 2004, 34:1059-1064.
19. Bremner J.D., Narayan M., Anderson E.R., Staib L.H., Miller H.L., Charney D.S. Hippocampal volume reductions in major depression. Am J Psychiatry 2000, 157:115-117.
20. Covington H.E., Vialou V., Nestler E.J. From synapse to nucleus: novel targets for treating depression. Neuropharmacology 2010, 58:683-693.
21. Duman R.S., Monteggia L.M. A neurotrophic model for stress-related mood disorders. Biol Psychiatry 2006, 59:1116-1127.
22. Nestler E.J., Barrot M., DiLeone R.J., Eisch A.J., Gold S.J., Monteggia L.M. Neurobiology of depression. Neuron 2002, 34:13-25.
23. Karege F., Vaudan G., Schwald M., Perroud N., La Harpe R. Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs. Brain Res Mol Brain Res 2005, 136:29-37.
24. Smith M.A., Makino S., Kvetnansky R., Post R.M. Stress and glucocorticoids affect the expressing of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci 1995, 15:1768-1777.
25. Nibuya M., Morinobu S., Duman R.S. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 1995, 15:7539-7547.
26. Shirayama Y., Chen A.C., Nakagawa S., Russell D.S., Duman R.S. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 2002, 22:3251-3261.
27. Siuciak J.A., Lewis D.R., Wiegand S.J., Lindsay R.M. Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Behav 1997, 56:131-137.
28. Pittaluga A., Raiteri L., Longordo F., Luccini E., Barbiero V.S., Racagni G., et al. Antidepressant treatments and function of glutamate ionotropic receptors mediating amine release in hippocampus. Neuropharmacology 2007, 53:27-36.
29. Lonze B.E., Ginty D.D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 2002, 35:605-623.
30. Hatalski C.G., Baram T.Z. Stress-induced transcriptional regulation in the developing rat brain involves increased cyclic adenosine 3',5'-monophosphate-regulatory element binding activity. Mol Endocrinol 1997, 11:2016-2024.
31. Boer V., Alejel T., Beimesche S., Cierny I., Krause D., Knepel W., et al. CRE/CREB-driven up-regulation of gene expression by chronic social stress in CRE-luciferase transgenic mice: reversal by antidepressant treatment. PLoS One 2007, 2:431.
32. Conti A.C., Cryan J.F., Dalvi A., Lucki I., Blendy J.A. cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioural or endocrine responses to antidepressant drugs. J Neurosci 2002, 22:3236-3268.
33. Qi X., Lin W., Li J., Li H., Wang D., Sun M. Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress. Neurobiol Dis 2008, 31:278-285.
34. Nair A., Vaidya V.A. Cyclic AMP response element binding protein and brain-derived neurotrophic factor: molecules that modulate our mood?. J Biosci 2006, 31:423-434.
35. Cesare D.D., Fimia G.M., Sassone-Corsi P. Signalling routes to CREM and CREB: plasticity in transcriptional activation. Trends Biochem Sci 1999, 24:281-285.
36. Montminy M. Transcriptional regulation by cyclic AMP. Annu Rev Biochem 1997, 66:807-822.
37. Hagiwara M., Brindle P., Harootunian A., Armstrong R., Rivier J., Vale W., et al. Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Mol Cell Biol 1993, 13:4852-4859.
38. Shelton R.C. The molecular neurobiology of depression. Psych Clin North Am 2007, 30:1-11.
39. Shelton R.C., Hal Manier D., Lewis D.A. Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls. Int J Neuropsychopharmacol 2009, 12:1223-1232.
40. Shelton R.C., Sanders-Bush E., Manier D.H., Lewis D.A. Elevated 5-HT 2a receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A. Neuroscience 2009, 158:1406-1415.
41. Huang K.P., Huang F.L., Li J., Schuck P., McPhie P. Calcium-sensitive interaction between calmodulin and modified forms of rat brain neurogranin/RC3. Biochemistry 2000, 39:7291-7299.
42. McDonald B.J., Chung H.J., Huganir R.L. Identification of protein kinase C phosphorylation sites within the AMPA receptor GluR2 subunit. Neuropharmacology 2001, 41:672-679.
43. Nogues X. Protein kinase, C learning and memory: a circular determinism between physiology and behaviour. Prog Neuropsychopharmacol Biol Psychiatry 1997, 21:507-529.
44. Ramakers G.M., Pasinelli P., Hens J.J., Gispen W.H., De Graan P.N. Protein kinase C in synaptic plasticity: changes in the in situ phosphorylation state of identified pre- and postsynaptic substrates. Prog Neuropsychopharmacol Biol Psychiatry 1997, 21:455-486.
45. Szabo S.T., Machado-Vieira R., Yuan P., Wang Y., Wei Y., Falke C., et al. Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of Mania. Neuropharmacology 2009, 56:47-55.
46. Ananth J. Treatment-resistant depression. Psychother Psychosom 1998, 67:61-70.
47. Detke M.J., Rickels M., Lucki I. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology 1995, 121:66-72.
48. Porsolt R.D., Le Pichon M., Jalfre M. Animal model of depression. Nature 1977, 266:730-732.
49. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
50. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
51. De Souza C.T., Gasparetti A.L., Pereira-da-Silva M., Araújo E.P., Carvalheira J.B., Saas M.J., et al. Peroxisome proliferator-activated receptor gamma coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion. Diabetologia 2003, 11:1522-1531.
52. Fortunato J.J., Réus G.Z., Kirsch T.R., Stringari R.B., Stertz L., Kapczinski F., et al. Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry 2009, 13:1425-1430.
53. aan het Rot M., Collins K.A., Murrough J.W., Perez A.M., Reich D.L., Charney D.S., et al. Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression. Biol Psychiatry 2010, 67:139-145.
54. Castren E., Vooikar V., Rantamaki T. Role of neurotrophic factors in depression. Curr Opin Pharmacol 2007, 7:18-21.
55. Rogóz Z., Skuza G., Legutko B. Repeated co-treatment with fluoxetine and amantadine induces brain-derived neurotrophic factor gene expression in rats. Pharmacol Rep 2008, 60:817-826.
56. Roceri M., Hendriks W., Racagni G., Ellenbroek B.A., Riva M.A. Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus. Mol Psychiatry 2002, 7:609-616.
57. Blendy J.A. The role of CREB in depression and antidepressant treatment. Biol Psychiatry 2006, 59:1144-1150.