A nonadaptive origin of a beneficial trait: In silico selection for free energy of folding leads to the neutral emergence of mutational robustness in single domain proteins

Journal of Molecular Evolution

Volumn 78, Issue 2, 2014, Pages 130-139

  Pagan, Rafael F ^a   Massey, Steven E ^a  

^a UNIVERSITY OF PUERTO RICO RIO PIEDRAS   (Puerto Rico)

Author keywords

G; Emergence; Free energy of folding; Mutational robustness; Neutral network; Pseudaptation

Indexed keywords

PROTEIN;

ADAPTATION; ARTICLE; CHEMISTRY; GENETIC SELECTION; GENETICS; MOLECULAR EVOLUTION; MUTATION; PROTEIN FOLDING; PROTEIN STABILITY; QUANTITATIVE TRAIT; THEORETICAL MODEL;

ADAPTATION, BIOLOGICAL; EVOLUTION, MOLECULAR; MODELS, THEORETICAL; MUTATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEINS; QUANTITATIVE TRAIT, HERITABLE; SELECTION, GENETIC;

EID: 84894385712     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00239-013-9606-8     Document Type: Article

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