Interleukin-6 serum levels in patients with parkinson's disease

Neurochemical Research

Volumn 34, Issue 8, 2009, Pages 1401-1404

  Hofmann, Kerly Wollmeister ^a   Schuh, Artur Francisco Schumacher ^a   Saute, Jonas ^a,b   Townsend, Raquel ^a   Fricke, Daniele ^a   Leke, Renata ^b   Souza, Diogo O ^b   Portela, Luis Valmor ^b   Chaves, Márcia Lorena Fagundes ^a   Rieder, Carlos R M ^a  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b Instituto de Ciencias Biologicas e da Saude Pontifical Catholic University of Minas Gerais   (Brazil)

Author keywords

Cytokines; Interleukin 6; Levodopa; Parkinson's disease

Indexed keywords

INTERLEUKIN 6; LEVODOPA;

AGED; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DISEASE SEVERITY; FEMALE; HUMAN; MALE; NEUROIMMUNOLOGY; NIGRONEOSTRIATAL SYSTEM; PARKINSON DISEASE; PRIORITY JOURNAL;

EID: 67349283932     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-009-9921-z     Document Type: Article

References (27)

1. A Schapira 2006 Etiology of Parkinson's disease Neurology 66 S10 S23
2. O Aktas O Ullrich C Infante-Duarte 2007 Neuronal damage in brain inflammation Arch Neurol 64 185 189 10.1001/archneur.64.2.185
3. C Wersinger A Sidhu 2006 An inflammatory pathomechanism for Parkinson's disease? Curr Med Chem 13 591 602 10.2174/092986706776055760
4. P Teismann K Tieu O Cohen 2003 Pathogenic role of glial cells in Parkinson's disease Mov Disord 18 121 129 10.1002/mds.10332
5. A Czlonkowska IK Jastrzebska A Cztonkowski 2002 Immune processes in the pathogenesis of Parkinson's disease-a potential role for microglia and nitric oxide Med Sci Monit 8 165 177
6. EC Hirsch S Hunot A Hartmann 2005 Neuroinflammatory processes in Parkinson's disease Parkinsonism Relat Disord 11 S9 S15 10.1016/j.parkreldis. 2004.10.013
7. M Sawada K Imamura T Nagatsu 2006 Role of cytokines in inflammatory process in Parkinson's disease J Neural Transm Suppl 70 373 381 10.1007/978-3-211-45295-0-57 (Pubitemid 44622226)
8. DL Gruol TE Nelson 1997 Physiological and pathological roles of interleukin-6 in the central nervous system Mol Neurobiol 15 307 339 10.1007/BF02740665 (Pubitemid 127720200)
9. RA Gadient UH Otten 1997 Interleukin-6 (IL-6)-a molecule with both beneficial and destructive potentials Prog Neurobiol 52 379 390 10.1016/S0301-0082(97)00021-X
10. M Mogi M Harada T Kondo 1994 Interleukin-1β, interleukin-6, epidermal growth factor and transforming growth factor-α are elevated in the brain from parkinsonian patients Neurosci Lett 180 147 150 10.1016/0304-3940(94)90508-8
11. T Nagatsu 2002 Parkinson's disease: changes in apoptosis-related factors suggesting possible gene therapy J Neural Transm 109 731 745 10.1007/s007020200061
12. D Blum-Degen T Muller W Kuhn 1995 Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients Neurosci Lett 202 17 20 10.1016/0304-3940(95)12192-7
13. T Muller D Blum-Degen H Przuntek 1998 Interleukin-6 levels in cerebrospinal fluid inversely correlates to severity of Parkinson's disease Acta Neurol Scand 98 142 144 (Pubitemid 28351288)
14. G Stypula J Kunert-Radek H Stephen 1996 Evaluation of interleukins, ACTH, cortisol and prolactin concentrations in the blood of patients with Parkinson's disease Neuroimmunomodulation 3 131 134 10.1159/000097237 (Pubitemid 26373868)
15. MV Selikhova NE Kushlinskii NV Lyubimova 2002 Impaired production of plasma interleukin-6 in patients with Parkinson's disease Bull Exp Biol Med 133 81 83 10.1023/A:1015120930920
16. H Bessler R Djaldetti H Salman 1999 IL-1β, IL-2, IL-6 and TNF-α production by peripheral blood mononuclear cells from patients with Parkinson's disease Biomed Pharmacother 53 141 145 10.1016/S0753-3322(99)80079-1
17. AJ Hughes SE Daniel L Kilford 1992 Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinic-pathological study of 100 cases J Neurol Neurosurg Psychiatry 55 181 184
18. MM Hoehn MD Yahr 1967 Parkinsonism: onset, progression, and mortality Neurology 17 427 442 10.1159/000137111 (Pubitemid 33596369)
19. Schwab RS, England AC (1969) Projection technique for evaluating surgery in Parkinson's disease. In: Gillingham FJ, Donaldson MC (eds) Third symposium on Parkinson's disease, Livingstone, pp 152-157
20. EC Hirsch T Breidert E Rousselet 2003 The role of glial reaction and inflammation in Parkinson's disease Ann N Y Acad Sci 991 214 228 (Pubitemid 36793816)
21. G Sébire D Emile C Walton C Héry 1993 In vitro production of IL-6, IL-1β, and tumor necrosis factor-α by human embryonic microglial and neuronal cells J Immunol 150 1517 1523 (Pubitemid 23127443)
22. M Sawada A Suzumura M Marunouchi 1992 TNFα induces IL-6 production by astrocytes but not by microglia Brain Res 583 296 299
23. JG Norris EN Benveniste 1993 Interleukin-6 production by astrocytes: induction by the neurotransmitter norepinephrine J Neuroimmunol 45 137 146 10.1016/0165-5728(93)90174-W (Pubitemid 23224392)
24. JG Norris L Tang SM Sparacio 1994 Signal transduction pathways mediating astrocytes IL-6 induction by IL-1β and tumor necrosis fator-α J Immunol 152 841 850 (Pubitemid 24072989)
25. ED Cadman DG Witte C Lee 1994 Regulation of the release of interleukin-6 from human astrocytoma cells J Neurochem 63 980 987 (Pubitemid 24266611)
26. BD Gritter D Regoli JJ Howbert 1994 Interleukin-6 secretion from human astrocytoma cells induced by substance P J Neuroimmunol 51 101 108 10.1016/0165-5728(94)90134-1
27. H Braak K Del Tredici U Rub 2003 Staging of brain pathology related to sporadic Parkinsons disease Neurobiol Aging 24 197 211 10.1016/S0197-4580(02) 00065-9