Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

DMM Disease Models and Mechanisms

Volumn 7, Issue 2, 2014, Pages 215-224

  Ng, Shengyong ^a   March, Sandra ^a,b   Galstian, Ani ^a,b   Hanson, Kirsten ^c   Carvalho, Tânia ^c   Mota, Maria M ^c   Bhatia, Sangeeta N ^a,b,d,e  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c UNIVERSITY OF LISBON   (Portugal)

^d Massachusetts Institute of Technology Cambridge   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Hypoxia; Liver stage malaria; Primary hepatocytes

Indexed keywords

COBALT CHLORIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN;

ANIMAL CELL; ARTICLE; CELL DENSITY; CELL GROWTH; CELL HYPOXIA; CELL MATURATION; CELL SURFACE; CELL SURVIVAL; COCULTURE; CORRELATION ANALYSIS; ERYTHROCYTOSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CULTURE; LIVER SINUSOID; MALARIA FALCIPARUM; MATHEMATICAL MODEL; NONHUMAN; OXYGEN CONCENTRATION; OXYGEN TENSION; PARASITE DEVELOPMENT; PLASMODIUM BERGHEI; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PLASMODIUM YOELII INFECTION; PRIORITY JOURNAL; RAT; TRANSCRIPTION INITIATION; ANIMAL; ANOXIA; CELL CULTURE; CELL MEMBRANE; COMPLICATION; DRUG EFFECTS; ERYTHROCYTE; GROWTH, DEVELOPMENT AND AGING; KINETICS; LIFE CYCLE STAGE; LIVER; LIVER CELL; MALARIA; METABOLISM; MOUSE; PARASITOLOGY; PATHOLOGY; PHYSIOLOGY; PLASMODIUM; PRESSURE; SPOROZOITE; SURVIVAL;

ANIMALS; ANOXIA; CELL MEMBRANE; CELLS, CULTURED; COCULTURE TECHNIQUES; ERYTHROCYTES; HEPATOCYTES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KINETICS; LIFE CYCLE STAGES; LIVER; MALARIA; MICE; OXYGEN; PARTIAL PRESSURE; PLASMODIUM; SPOROZOITES; SURVIVAL ANALYSIS;

EID: 84894305879     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.013490     Document Type: Article

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