Modulation by oxygen of zonal gene expression in liver studied in primary rat hepatocyte cultures

Cell Biology and Toxicology

Volumn 13, Issue 4-5, 1997, Pages 243-255

  Kietzmann, T ^a,b   Jungermann, K ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Inst F Biochem Molec Z   (Germany)

Author keywords

Glucagon; Glucokinase; Insulin; Metabolic zonation; Oxygen; Periportal zone; Perivenous zone; Phosphoenolpyruvate carboxykinase

Indexed keywords

CARBON MONOXIDE; GLUCAGON; GLUCOKINASE; HYDROGEN PEROXIDE; INSULIN; OXYGEN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

ANIMAL CELL; BINDING AFFINITY; CARBOHYDRATE METABOLISM; CONFERENCE PAPER; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVATION; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL CULTURE; LIVER METABOLISM; METABOLIC CAPACITY; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CARBOHYDRATE METABOLISM; CELLS, CULTURED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCAGON; GLUCOKINASE; HYDROGEN PEROXIDE; INSULIN; LIVER; OXYGEN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROMOTER REGIONS (GENETICS); RATS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0030808425     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007427206391     Document Type: Conference Paper

References (54)

1. Balks HJ, Jungermann K. Regulation of peripheral insulin/ glucagon levels by rat liver. Eur J Biochem 1984;141:645-50.
2. Bartels H, Vogt B, Jungermann K. Glycogen synthesis from pyruvate in the periportal and from glucose in the perivenous zone in perfused livers from fasted rats. FEBS Lett. 1987;221:277-83.
3. Bartels H, Vogt B, Jungermann K. Glycogen synthesis via the indirect gluconeogenic pathway in the periportal and via the direct glucose utilizing pathway in the perivenous zone of perfused rat liver. Histochemistry. 1988;89:253-60.
4. Bartels H, Linnemann H, Jungermann K. Predominant localization of phosphoenolpyruvate carboxykinase mRNA in the periportal zone of rat liver parenchyma demonstrated by in situ hybridization. FEBS Lett. 1989;248:188-94.
5. Bartels H, Herbort H, Jungermann K. Predominant periportal expression of the phosphoenolpyruvate carboxykinase and tyrosine aminotransferase gene in rat liver demonstrated by in situ hybridization: Dynamics during the daily feeding rhythm and starvation-refeeding cycle. Histochemistry. 1990;95:637-44.
6. Beck I, Weinmann R, Caro J. Characterization of hypoxia-responsive enhancer in the human erythropoietin gene shows presence of hypoxia-inducible 120kD nuclear DNA-binding protein in erythropoietin-producing and non-producing cells. Blood. 1993;82:704-11.
7. Blanchard KL, Acquaviva AM, Galson DL, Bunn HF. Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements. Mol Cell Biol. 1992;12:5373-85.
8. Christ B, Nath A, Bastian H, Jungermann K. Regulation of the expression of the phosphoenolpyruvate carboxykinase gene in cultured rat hepatocytes by glucagon and insulin. Eur J Biochem. 1988;178:373-9.
9. Christ B, Nath A, Jungermann K. Mechanism of the inhibition by insulin of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures: action on gene transcription, mRNA level and stability as well as hysteresis effect. Biol Chem Hoppe-Seyler. 1990;371:397-402.
10. Christ B, Nath A, Jungermann K. Interactions of nuclear protein from cultured rat hepatocytes with the cyclic AMP responsive elements and the NF1-CTF site in the promoter of the rat phosphoenolpyruvate carboxykinase gene. Biochem Biophys Res Commun. 1991;181:367-74.
11. Eilers F, Bartels H, Jungermann K. Zonal expression of the glucokinase gene in rat liver: Dynamics during the daily feeding rhythm and starvation-refeeding cycle demonstrated by in situ hybridization. Histochemistry. 1993;99: 133-40.
12. Eilers F, Modaressi S, Jungermann K. Predominant periportal expression of the fructose 1,6-bisphosphatase gene in rat liver: dynamics during the daily feeding-rhythm and starvation-refeeding cycle. Histochem Cell Biol. 1995;103:293-300.
13. Fandrey J, Frede S, Jelkmann W. Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem J. 1994;303:507-10.
14. Feldmann G, Scoazec JY, Racine L, Bernuau D. Functional hepatocellular heterogeneity for the production of plasma proteins. Enzyme. 1992;46:139-54
15. Gardemann A, Püschel GP, Jungermann K. Nervous control of liver metabolism and hemodynamics. Eur J Biochem. 1992;207:399-401.
16. Gebhardt R. Metabolic zonation of the liver: Regulation and implications for liver function. Pharmacol Ther. 1992;53: 275-354.
17. Goldberg MA, Dunning SB, Bunn HF. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science. 1988;242:1412-15.
18. Gumucio JJ. Hepatocyte heterogeneity. The coming of age from the description of a biological curiosity to a partial understanding of its physiological meaning in regulation. Hepatology. 1989;9:154-60.
19. Häussinger D, Lamers WH, Moorman AF. Hepatocyte heterogeneity in the metabolism of amino acids and ammonia. Enzyme. 1992;46:72-93.
20. Hellkamp J, Christ B, Bastian H, Jungermann K. Modulation by oxygen of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures. Eur J Biochem. 1991;198:635-9.
21. Jungermann K, ed. Zonal liver cell heterogeneity. Enzyme. 1992;46:5-168. [Special volume].
22. Jungermann K. Zonation of metabolism and gene expression in liver. Histochem Cell Biol. 1995;103:81-91.
23. Jungermann K, Barth C. Energy metabolism and nutrition. In: Gregor R, Windhorst U, eds. Comprehensive human physiology. Vol. 2. Berlin: Springer-Verlag; 1996:1425-57.
24. Jungermann K, Katz N. Functional specialization of different hepatocyte populations. Physiol Rev. 1989;69:708-64.
25. Jungermann K, Kietzmann T. Zonation of parenchymal and nonparenchymal metabolism in liver. Annu Rev Nutr. 1996; 16:179-203.
26. Jungermann K, Thurman RG. Hepatocyte heterogeneity in the metabolism of carbohydrates. Enzyme. 1992;46:33-58.
27. Jungermann K, Heilbronn R, Katz N, Sasse D. The glucose/glucose-6-phosphate cycle in the periportal and perivenous zone of rat liver. Eur J Biochem. 1982;123:429-36.
28. Katz J, Kuwajima M, Foster DW, McGarry JD. The glucose-paradox: new perspectives on hepatic carbohydrate metabolism. Trends Biochem Sci. 1986;11:136-40.
29. Katz N, Jungermann K. Autoregulatory switch from glycolysis to gluconeogenesis in rat hepatocytes suspensions. The problem of metabolic zonation of liver parenchyma. Z Physiol Chem. 1976;357:359-75.
30. Kietzmann T, Jungermann K. Metabolic zonation of liver parenchyma and its short-term and long-term regulation. In: Vidal-Vanaclocha F, ed. Functional heterogeneity of liver tissue. Austin: RG Landes Biomedical Publishers; 1996:1-42.
31. Kietzmann T, Schmidt H, Probst I, Jungermann K. Modulation of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene by oxygen in rat hepatocyte cultures. Evidence for a heme protein as oxygen sensor. FEBS Lett. 1992;1:251-5.
32. Kietzmann T, Schmidt H, Unthan-Fechner K, Probst I, Jungermann K. A ferro-heme protein senses oxygen levels, which modulate the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene in rat hepatocyte cultures. Biochem Biophys Res Commun. 1993;5:792-8.
33. Kietzmann T, Bratke J, Jungermann K. Oxygen modulates the glucagon-dependent expression of the phosphoenolpyruvate carboxykinase (PCK) gene in the first 277 bp of its 5′ region. Pflügers Archiv Eur J Physiol. 1995;R146:A533.
34. Kietzmann T, Freimann S, Bratke J, Jungermann K. Regulation of the gluconeogenic phosphoenolpyruvate carboxykinase and the glycolytic aldolase A gene expression by oxygen in rat hepatocyte cultures. Involvement of hydrogen peroxide as mediator in the response to oxygen. FEBS Lett. 1996;388:228-32.
35. 2 tensions in rat hepatocytes. Kidney Int. 1997a;51:542-7.
36. 2. Biochem J. 1997b;321:17-20.
37. Koury ST, Bondourant MC, Koury MJ, Semenza GL. Localization of cells producing erythropoietin in murine liver by in situ hybridization. Blood. 1991;77:2497-503.
38. Lamas E, Kahn A, Guillouzo A. Detection of mRNAs present at low concentrations in rat liver by in situ hybridization: application to the study of metabolic regulation and azo dye hepatocarcinogenesis. J Histochem Cytochem. 1987;35: 559-63.
39. Miethke H, Wittig B, Nath A, Jungermann K. Gluconeogenic-glycolytic capacities and metabolic zonation in liver of rats with streptozotocin, non-ketotic as compared to alloxan, ketotic diabetes. Histochemistry. 1986;85:483-9.
40. Nauck M, Wölfle D, Katz N, Jungermann K. Modulation of the glucagon-dependent induction of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase by arterial and venous oxygen concentrations in hepatocyte cultures. Eur J Biochem. 1981;119:657-61.
41. Pilkis SJ, Granner DK. Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Physiol. 1992;54:885-909.
42. Probst I, Schwartz P, Jungermann K. Induction in primary culture of "gluconeogenic" and "glycolytic" hepatocytes resembling periportal and perivenous cells. Eur J Biochem. 1982;126:271-8.
43. Püschel GP, Jungermann K. Integration of function in the hepatic acinus: Intercellular communication in neural and humoral control of liver metabolism. Prog Liver Dis. 1994;12:19-46.
44. Quistorff B. Gluconeogenesis in periportal and perivenous hepatocytes of rat liver isolated by a new high-yield digitonin-collagenase perfusion technique. Biochem J. 1985;226: 289-91.
45. Quistorff B, Dich J, Grunnet N. Periportal and perivenous hepatocytes retain their zonal characteristics in primary culture. Biochem Biphys Res Commun. 1986;139:1055-61.
46. Quistorff B, Katz N, Witters LA. Hepatocyte heterogeneity in the metabolism of fatty acids: discrepancies on zonation of acetyl-CoA carboxylase. Enzyme. 1992;46:59-71.
47. Sasse D. Dynamics of liver glycogen. Histochemistry. 1975;45: 237-54.
48. Sasse D, Spormitz UM, Maly IP. Liver architecture. Enzyme. 1992;46:8-32.
49. Semenza GL, Nejfelt MK, Chi SM, Antonorakis SE. Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene. Proc Natl Acad Sci USA. 1991;88:5680-4.
50. Thurman RG, Kauffman FC. Sublobular compartmentation of pharmacologic events (SCOPE): metabolic fluxes in periportal and pericentral regions of the liver lobule. Hepatology. 1985;5:144-51.
51. Traber PG. Acinar localization of enzymes involved in biotransformation: analysis of the cytochrome P450 gene superfamily. Cell Biol Rev. 1989;19:87-116.
52. Vidal-Vanaclocha F, ed. Functional heterogeneity of liver tissue. Austin: RG Landes Biomedical Publishers; 1996:1-242.
53. 2 tension. Proc Natl Acad Sci USA. 1995;92:5510-14.
54. Wölfle D, Jungermann K. Long-term effects of physiological oxygen concentrations on glycolysis and gluconeogenesis in hepatocyte cultures. Eur J Biochem. 1985;151:299-303.