Differential effects of the catechol-O-methyltransferase Val158Met genotype on the cognitive function of schizophrenia patients and healthy Japanese individuals

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Tsuchimine, Shoko ^a   Yasui Furukori, Norio ^a   Kaneda, Ayako ^a   Kaneko, Sunao ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE;

ADULT; ANALYSIS OF VARIANCE; ATTENTION; COGNITION; EXECUTIVE FUNCTION; FEMALE; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; MALE; MEMORY; METABOLISM; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; REGRESSION ANALYSIS; SCHIZOPHRENIA;

ADULT; ANALYSIS OF VARIANCE; ATTENTION; CATECHOL O-METHYLTRANSFERASE; COGNITION; DOPAMINE; EXECUTIVE FUNCTION; FEMALE; GENOTYPE; HUMANS; MALE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC; REGRESSION ANALYSIS; SCHIZOPHRENIA;

EID: 84894287292     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076763     Document Type: Article

References (36)

1. Badner JA, Gershon ES (2002) Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 7: 405-411. doi:10.1038/sj.mp.4001012. PubMed: 11986984.
2. Morón JA, Brockington A, Wise R, Rocha BA, Hope BT (2001) Dopamine up- take through the Norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. J Neuroscience 22: 389-395.
3. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL et al. (1996) Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6: 243-250. doi: 10.1097/00008571-199606000-00007. PubMed: 8807664.
4. Saito S, Iida A, Sekine A, Miura Y, Sakamoto T et al. (2001) Identification of 197 genetic variations in six human methyltranferase genes in the Japanese population. J Hum Genet 46: 529-537. doi: 10.1007/s100380170035. PubMed: 11558902.
5. Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M et al. (2004) Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet 75: 807-821. doi:10.1086/425589. PubMed: 15457404.
6. Brozoski TJ, Brown RM, Rosvold HE, Goldman PS (1979) Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science 205: 929-932. doi:10.1126/science.112679. PubMed: 112679.
7. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM et al. (2001) Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A 986: 917-922. PubMed: 11381111.
8. Joober R, Gauthier J, Lal S, Bloom D, Lalonde P et al. (2002) Catechol-O-methyltransferase Val-108/158-Met gene variants associated with performance on the Wisconsin Card Sorting. Test - Arch Gen Psychiatry 59: 662-663. doi:10.1001/archpsyc.59.7.662.
9. Goldberg TE, Egan MF, Gscheidle T, Coppola R, Weickert T et al. (2003) Executive subprocesses in working memory: relationship to catechol-O- methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry 60: 889-896. doi:10.1001/archpsyc.60.9.889.
10. Galderisi S, Maj M, Kirkpatrick B, Piccardi P, Mucci A et al. (2005) Catechol-O-methyltransferase Val158Met polymorphism in schizophrenia: associations with cognitive and motor impairment. Neuropsychobiology 52: 83-89. doi:10.1159/000087096. PubMed: 16037677.
11. Barnett JH, Jones PB, Robbins TW, Müller U (2007) Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. Mol Psychiatry 12: 502-509. PubMed: 17325717.
12. Leung WW, McClure MM, Siever LJ, Barch DM, Harvey PD (2007) Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions. Neuropsychiatr Dis Treat 3: 925-934. PubMed: 19300629.
13. Ho BC, Wassink TH, O'Leary DS, Sheffield VC, Andreasen NC (2005) Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow. Mol Psychiatry 10: 229: 287-298. PubMed: 15668720.
14. Szöke A, Schürhoff F, Méary A, Mathieu F, Chevalier F et al. (2006) Lack of influence of COMT and NET genes variants on executive functions in schizophrenic and bipolar patients, their first-degree relatives and controls. Am J Med Genet B Neuropsychiatr Genet 141B: 504-512. doi:10.1002/ajmg.b.30352. PubMed: 16741933.
15. Dickerson FB, Boronow JJ, Stallings C, Origoni AE, Sullens A et al. (2007) The catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia. Schizophr Res 96: 87-92. doi:10.1016/j.schres.2007.05.021. PubMed: 17601704.
16. Malhotra AK, Kestler LJ, Mazzanti C, Bates JA, Goldberg T et al. (2002) A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry 159: 652-654. doi: 10.1176/appi.ajp.159.4. 652. PubMed: 11925305.
17. Stefanis NC, van Os J, Avramopoulos D, Smyrnis N, Evdokimidis I et al. (2005) Effect of COMT Val158Met polymorphism on the Continuous Performance Test, Identical Pairs Version: tuning rather than improving performance. Am J Psychiatry 162: 1752-1754. doi:10.1176/appi.ajp.162.9.1752. PubMed: 16135641.
18. Sheldrick AJ, Krug A, Markov V, Leube D, Michel TM et al. (2008) Effect of COMT val158met genotype on cognition and personality. Eur Psychiatry 23: 385-389. doi:10.1016/j.eurpsy.2008.01.1331. PubMed: 18755576.
19. Tsai SJ, Yu YW, Chen TJ, Chen JY, Liou YJ et al. (2003) Association study of a functional catechol-O-methyltransferase-gene polymorphism and cognitive function in healthy females. Neurosci Lett 338: 123-126. PubMed: 12566168.
20. Stefanis NC, Van Os J, Avramopoulos D, Smyrnis N, Evdokimidis I et al. (2004) Variation in catechol-o-methyltransferase val158 met genotype associated with schizotypy but not cognition: a population study in 543 young men. Biol Psychiatry 56: 510-515. doi:10.1016/j.biopsych.2004.06.038. PubMed: 15450787.
21. Kaneda Y, Sumiyoshi T, Keefe R, Ishimoto Y, Numata S et al. (2007) Brief assessment of cognition in schizophrenia: validation of the Japanese version. Psychiatry Clin Neurosci 61: 602-609. doi:10.1111/j.1440-1819.2007.01725.x. PubMed: 18081619.
22. Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9: 97-113. doi:10.1016/0028-3932(71)90067- 4. PubMed: 5146491.
23. First MB, Gibbon M, Spitzer RL, Williams JBW, Benjamin LS (1997) Structured Clinical Interview for DSM-IV Axis II Personality Disorders, (SCID-II). Washington, D.C.: American Psychiatric Press, Inc.
24. Matsuoka K, Uno M, Kasai K, Koyama K, Kim Y (2006) Estimation of premorbid IQ in individuals with Alzheimer's disease using Japanese ideographic script (Kanji) compound words: Japanese version of National Adult Reading. Test - Psychiatry Clin Neurosci 60: 332-339. doi:10.1111/j.1440-1819.2006.01510.x.
25. Crocker AD (1994) Dopamine-mechanisms of action. Aust. Prescr17: 17-21.
26. O'Carroll R (2000) Cognitive impairment in schizophrenia. APT 6: 161-168.
27. Prata DP, Mechelli A, Fu CH, Picchioni M, Kane F et al. (2009) Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia. Biol Psychiatry 65: 473-480. doi:10.1016/j.biopsych.2008.09.027. PubMed: 19054502.
28. Diamond A, Briand L, Fossella J, Gehlbach L (2004) Genetic and neurochemical modulation of prefrontal cognitive functions in children. Am J Psychiatry 161: 125-132. doi:10.1176/appi.ajp.161.1.125. PubMed: 14702260.
29. O'Hara R, Miller E, Liao CP, Way N, Lin X et al. (2006) COMT genotype, gender and cognition in community-dwelling, older adults. Neurosci Lett 409: 205-209. doi:10.1016/j.neulet.2006.09.047. PubMed: 17029783.
30. Nolan KA, Bilder RM, Lachman HM, Volavka J (2004) Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibility. Am J Psychiatry 161: 359-361. doi:10.1176/appi.ajp.161.2.359. PubMed: 14754787.
31. Bilder RM, Volavka J, Czobor P, Malhotra AK, Kennedy JL et al. (2002) Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biol Psychiatry 52: 701-707. doi:10.1016/S0006-3223(02)01416-6. PubMed: 12372660.
32. Weinberger DR (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 44: 660-669. doi:10.1001/archpsyc.1987.01800190080012. PubMed: 3606332.
33. Akil M, Kolachana BS, Rothmond DA, Hyde TM, Weinberger DR et al. (2003) Catechol-O-methyltransferase genotype and dopamine regulation in the human brain. J Neurosci 23: 2008-2013. PubMed: 12657658.
34. Winterer G, Goldman D (2003) Genetics of human prefrontal function. Brain Res Brain. Res Rev 43: 134-163. Review. doi:10.1016/S0165-0173(03)00205-4.
35. Nackley AG, Shabalina SA, Tchivileva IE, Satterfield K, Korchynskyi O et al. (2006) Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. Science 314: 1930-1933. doi:10.1126/science.1131262. PubMed: 17185601.
36. Bruder GE, Keilp JG, Xu H, Shikhman M, Schori E et al. (2005) Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations. Biol Psychiatry 58: 901-907. doi:10.1016/j.biopsych.2005.05.010. PubMed: 16043133.