α6-integrin is required for the adhesion and vasculogenic potential of hemangioma stem cells

Stem Cells

Volumn 32, Issue 3, 2014, Pages 684-693

  Smadja, David M ^a,b,c   Guerin, Coralie L ^b   Boscolo, Elisa ^a   Bieche, Ivan ^b   Mulliken, John B ^a   Bischoff, Joyce ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

6 Integrin; Adhesion; Fluorescence molecular tomography; Hemangioma stem cells; Vasculogenesis

Indexed keywords

ADHESION; FLUORESCENCE MOLECULAR TOMOGRAPHY; HEMANGIOMA STEM CELLS; VASCULOGENESIS; Α6-INTEGRIN;

ANIMALS; CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; CHILD, PRESCHOOL; FEMALE; GENE KNOCKDOWN TECHNIQUES; HEMANGIOMA; HUMANS; INFANT; INTEGRIN ALPHA6; LAMININ; LIVER; MALE; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; STEM CELLS;

EID: 84894283456     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1539     Document Type: Article

References (38)

1. Hynes RO,. Integrins: Bidirectional, allosteric signaling machines. Cell 2002; 110: 673-687.
2. Hierck BP, Thorsteinsdottir S, Niessen CM, et al. Variants of the alpha 6 beta 1 laminin receptor in early murine development: Distribution, molecular cloning and chromosomal localization of the mouse integrin alpha 6 subunit. Cell Adhes Commun 1993; 1: 33-53.
3. Smadja DM, Bieche I, Helley D, et al. Increased VEGFR2 expression during human late endothelial progenitor cells expansion enhances in vitro angiogenesis with up-regulation of integrin alpha(6). J Cell Mol Med 2007; 11: 1149-1161.
4. Bouvard C, Gafsou B, Dizier B, et al. alpha6-integrin subunit plays a major role in the proangiogenic properties of endothelial progenitor cells. Arterioscler Thromb Vasc Biol 2010; 30: 1569-1575.
5. Georges-Labouesse E, Messaddeq N, Yehia G, et al. Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Nat Genet 1996; 13: 370-373.
6. Pulkkinen L, Kimonis VE, Xu Y, et al. Homozygous alpha6 integrin mutation in junctional epidermolysis bullosa with congenital duodenal atresia. Hum Mol Genet 1997; 6: 669-674.
7. Allegra M, Gagnoux-Palacios L, Gache Y, et al. Rapid decay of alpha6 integrin caused by a mis-sense mutation in the propeller domain results in severe junctional epidermolysis bullosa with pyloric atresia. J Invest Dermatol 2003; 121: 1336-1343.
8. Lee TH, Seng S, Li H, et al. Integrin regulation by vascular endothelial growth factor in human brain microvascular endothelial cells: Role of alpha6beta1 integrin in angiogenesis. J Biol Chem 2006; 281: 40450-40460.
9. Lathia JD, Gallagher J, Heddleston JM, et al. Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell 2010; 6: 421-432.
10. Wilschut KJ, van Tol HT, Arkesteijn GJ, et al. Alpha 6 integrin is important for myogenic stem cell differentiation. Stem Cell Res 2011; 7: 112-123.
11. Castaldo C, Di Meglio F, Nurzynska D, et al. CD117-positive cells in adult human heart are localized in the subepicardium, and their activation is associated with laminin-1 and alpha6 integrin expression. Stem Cells 2008; 26: 1723-1731.
12. Qian H, Tryggvason K, Jacobsen SE, et al. Contribution of alpha6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with alpha4 integrins. Blood 2006; 107: 3503-3510.
13. Mulliken JB, Fishman SJ, Burrows PE,. Vascular anomalies. Curr Probl Surg 2000; 37: 517-584.
14. Khan ZA, Boscolo E, Picard A, et al. Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice. J Clin Invest 2008; 118: 2592-2599.
15. Boscolo E, Mulliken JB, Bischoff J,. VEGFR-1 mediates endothelial differentiation and formation of blood vessels in a murine model of infantile hemangioma. Am J Pathol 2011; 179: 2266-2277.
16. Boscolo E, Stewart CL, Greenberger S, et al. JAGGED1 signaling regulates hemangioma stem cell-to-pericyte/vascular smooth muscle cell differentiation. Arterioscler Thromb Vasc Biol 2011; 31: 2181-2192.
17. Martin-Padura I, De Castellarnau C, Uccini S, et al. Expression of VE (vascular endothelial)-cadherin and other endothelial-specific markers in haemangiomas. J Pathol 1995; 175: 51-57.
18. Tan ST, Velickovic M, Ruger BM, et al. Cellular and extracellular markers of hemangioma. Plast Reconstr Surg 2000; 106: 529-538.
19. Chung J, Mercurio AM,. Contributions of the alpha6 integrins to breast carcinoma survival and progression. Mol Cells 2004; 17: 203-209.
20. Rabinovitz I, Nagle RB, Cress AE,. Integrin alpha 6 expression in human prostate carcinoma cells is associated with a migratory and invasive phenotype in vitro and in vivo. Clin Exp Metastasis 1995; 13: 481-491.
21. Primo L, Seano G, Roca C, et al. Increased expression of alpha6 integrin in endothelial cells unveils a proangiogenic role for basement membrane. Cancer Res 2010; 70: 5759-5769.
22. Greenberger S, Adini I, Boscolo E, et al. Targeting NF-kappaB in infantile hemangioma-derived stem cells reduces VEGF-A expression. Angiogenesis 2010; 13: 327-335.
23. Greenberger S, Boscolo E, Adini I, et al. Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells. N Engl J Med 2010; 362: 1005-1013.
24. Smadja DM, Mulliken JB, Bischoff J,. E-selectin mediates stem cell adhesion and formation of blood vessels in a murine model of infantile hemangioma. Am J Pathol 2012; 181: 2239-2247.
25. Smadja D, Gaussem P, Roncal C, et al. Arterial and venous thrombosis is associated with different angiogenic cytokine patterns in patients with antiphospholipid syndrome. Lupus 2010; 19: 837-843.
26. Swirski FK, Berger CR, Figueiredo JL, et al. A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses. Plos One 2007; 2: e1075.
27. Lee RH, Seo MJ, Pulin AA, et al. The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice. Blood 2009; 113: 816-826.
28. Kulungowski AM, Alomari AI, Chawla A, et al. Lessons from a liver hemangioma registry: Subtype classification. J Pediatr Surg 2012; 47: 165-170.
29. Caseiro-Alves F, Brito J, Araujo AE, et al. Liver haemangioma: Common and uncommon findings and how to improve the differential diagnosis. Eur Radiol 2007; 17: 1544-1554.
30. Huang SA, Tu HM, Harney JW, et al. Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med 2000; 343: 185-189.
31. Horii KA, Drolet BA, Frieden IJ, et al. Prospective study of the frequency of hepatic hemangiomas in infants with multiple cutaneous infantile hemangiomas. Pediatr Dermatol 2011; 28: 245-253.
32. Chen MS, Tung KS, Coonrod SA, et al. Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: Implications for murine fertilization. Proc Natl Acad Sci USA 1999; 96: 11830-11835.
33. Nath D, Slocombe PM, Webster A, et al. Meltrin gamma(ADAM-9) mediates cellular adhesion through alpha(6)beta(1)integrin, leading to a marked induction of fibroblast cell motility. J Cell Sci 2000; 113 (pt 12): 2319-2328.
34. Yoder MC, Mead LE, Prater D, et al. Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 2007; 109: 1801-1809.
35. Moser M, Bauer M, Schmid S, et al. Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med 2009; 15: 300-305.
36. Carloni V, Romanelli RG, Mercurio AM, et al. Knockout of alpha6 beta1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells. Gastroenterology 1998; 115: 433-442.
37. Cariati M, Naderi A, Brown JP, et al. Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line. Int J Cancer 2008; 122: 298-304.
38. Chung J, Kim TH,. Integrin-dependent translational control: Implication in cancer progression. Microsc Res Tech 2008; 71: 380-386.