A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses

PLoS ONE

Volumn 2, Issue 10, 2007, Pages

  Swirski, Filip K ^a   Berger, Cedric R ^a   Figueiredo, Jose Luiz ^a   Mempel, Thorsten R ^a   von Andrian, Ulrich H ^b   Pittet, Mikael J ^a   Weissleder, Ralph ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; N HYDROXYSUCCINIMIDE; FLUORESCENT DYE; INDOLE DERIVATIVE; N-HYDROXYSUCCINIMIDE; PHOTOPROTEIN; RED FLUORESCENT PROTEIN; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER IMMUNOTHERAPY; CELL FUNCTION; CELL LABELING; CELL TRANSFER; CELLULAR IMMUNITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; COVALENT BOND; CYTOTOXIC T LYMPHOCYTE; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; IMAGING SYSTEM; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LEUKOCYTE; MAMMAL CELL; MOLECULAR IMAGING; MOLECULAR PROBE; MOUSE; MULTIPHOTON MICROSCOPY; NONHUMAN; TUMOR MODEL; ANIMAL; BAGG ALBINO MOUSE; BIOLOGICAL MODEL; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; FLUORESCENCE MICROSCOPY; IMMUNE SYSTEM; IMMUNOLOGY; INSTRUMENTATION; METABOLISM; METHODOLOGY; NEAR INFRARED SPECTROSCOPY; SPLEEN;

MAMMALIA;

ANIMALS; CELL SURVIVAL; FLUORESCENT DYES; IMMUNE SYSTEM; INDOLES; LEUKOCYTES; LUMINESCENT PROTEINS; MICE; MICE, INBRED BALB C; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; SPECTROSCOPY, NEAR-INFRARED; SPLEEN; SUCCINIMIDES;

EID: 41649093964     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001075     Document Type: Article

References (18)

1. Weissleder R, Ntziachristos V (2003) Shedding light onto five molecular targets. Nat Med 9: 123-128.
2. Ntziachristos V, Ripoll J, Wang LV, Weissleder R (2005) Looking and listening to light: the evolution of whole-body photonic imaging. Nat Biotechnol 23: 313-320.
3. Mempel TR, Henricksen SE, Von Andrian UH (2004) T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427: 154-159.
4. Miller MJ, Wei SH, Cahalan MD, Parker I (2003) Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc Natl Acad Sci U S A 100: 2604-2609.
5. Sumen C, Mempel TR, Mazo IB, von Andrian UH (2004) Intravital microscopy: visualizing immunity in context. Immunity 21: 315-329.
6. Bhakta NR, Oh DY, Lewis RS (2005) Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment. Nat Immunol 6: 143-151.
7. Bousso P, Bhakta NR, Lewis RS, Robey E (2002) Dynamics of thymocyte-stromal cell interactions visualized by two-photon inicroscopy. Science 296: 1876-1880.
8. Bousso P, Robey E (2003) Dynamics of CD8+ T oell priming by dendritic cells in intact lymph nodes. Nat Immunol 4: 579-585.
9. Huang AL, Chen X, Hoon MA, Chandrashekar J, Guo W, et al. (2006) The cells and logic for mammalian sour taste detection. Nature 442: 934-938.
10. Mempel TR, Pittet MJ, Khazaie K, Weninger W, Weissleder R, et al. (2006) Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity 25: 129-141.
11. Miller MJ, Safrina O, Parker I, Cahalan MD (2004) Imaging the single cell dynamics of CD4+ T cell activacton by dendritic cells in lymph nodes. J Exp Med 200: 847-856.
12. Lyons AB, Parish CR (1994) Determination of lymphocyte division by flow cytometry. J Immunol Methods 171; 131-137.
13. Chen MI, Pittet MJ, Gorelik I, Flavell RA, Weissleder R, et al. (2005) Regulatory T cells suppress tumor-spccific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A 102: 419-424.
14. Pittet MJ, Grimm J, Berger CR, Tamura T, Wojtkiewicz G, et al. (2007) In vivo imaging of T cell delivery to tumors after adoptive transfer therapy. Proc Natl Acad Sci U S A 104: 12457-12461.
15. Boissonnas A, Fetler L, Zeelenberg IS, Hugues S, Amigorena S (2007) In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor. J Exp Med 204: 345-356.
16. Mrass P, Takano H, Ng LG, Daxini S, Lasaro MO, et al. (2006) Random migration precedes stable target cell interactions of tumor-infiltrating T cells. J Exp Med 203: 2749-2761.
17. Hanson HL, Donermeyer DL, Ikeda H, White JM, Shankaran V, etal. (2000) Eradication of established tumors by CD8+ T cell adoptive immunotherapy. Immunity 13: 265-276.
18. Lehr HA, Krober M, Hubner C, Vajkoczy P, Menger MD, et al. (1993) Stimulation of leukocyte/endothelium interaction by oxidized low-density lipoprotein in hairless mice. Involvement of CD11b/CD18 adhesion receptor complex. Lab Invest 68: 388-395.