Transcriptomic effects-based monitoring for endocrine active chemicals: Assessing relative contribution of treated wastewater to downstream pollution

Environmental Science and Technology

Volumn 48, Issue 4, 2014, Pages 2385-2394

  Martinović Weigelt, Dalma ^a   Mehinto, Alvine C ^b   Ankley, Gerald T ^c   Denslow, Nancy D ^d   Barber, Larry B ^e   Lee, Kathy E ^e   King, Ryan J ^a   Schoenfuss, Heiko L ^f   Schroeder, Anthony L ^c   Villeneuve, Daniel L ^c  

^a UNIVERSITY OF ST THOMAS   (United States)

^b SOUTHERN CALIFORNIA COASTAL WATER RESEARCH PROJECT   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d UNIVERSITY OF FLORIDA   (United States)

^e U S GEOLOGICAL SURVEY   (United States)

^f ST CLOUD STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; CYPRINIDAE; ENDOCRINE DISRUPTORS; ENVIRONMENTAL MONITORING; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIVER; MALE; PRINCIPAL COMPONENT ANALYSIS; SEASONS; TRANSCRIPTOME; WASTE WATER; WATER POLLUTANTS, CHEMICAL; WATER POLLUTION; WATER PURIFICATION;

EID: 84894266683     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es404027n     Document Type: Article

References (40)

1. Hutchinson, T. H.; Ankley, G. T.; Segner, H.; Tyler, C. R. Screening and testing for endocrine disruption in fish-biomarkers as "signposts," not "traffic lights," in risk assessment Environ. Health Perspect. 2006, 114 (Suppl 1) 106-114
2. Connon, R. E.; Geist, J.; Werner, I. Effect-based tools for monitoring and predicting the ecotoxicological effects of chemicals in the aquatic environment Sensors (Basel) 2012, 12 (9) 12741-12771
3. Van Aggelen, G.; Ankley, G. T.; Baldwin, W. S.; Bearden, D. W.; Benson, W. H.; Chipman, J. K.; Collette, T. W.; Craft, J. A.; Denslow, N. D.; Embry, M. R.; Falciani, F.; George, S. G.; Helbing, C. C.; Hoekstra, P. F.; Iguchi, T.; Kagami, Y.; Katsiadaki, I.; Kille, P.; Liu, L.; Lord, P. G.; McIntyre, T.; O'Neill, A.; Osachoff, H.; Perkins, E. J.; Santos, E. M.; Skirrow, R. C.; Snape, J. R.; Tyler, C. R.; Versteeg, D.; Viant, M. R.; Volz, D. C.; Williams, T. D.; Yu, L. Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: Hurdles, achievements, and future outlook Environ. Health Perspect. 2010, 118 (1) 1-5
4. Spurgeon, D. J.; Jones, O. A. H.; Dorne, J. L. C. M.; Svendsen, C.; Swain, A.; Stürzenbaum, S. R. System toxicology approaches for understanding the joint effects of environmental chemical mixtures Sci. Total Environ. 2010, 408 (18) 3725-3734
5. Altenburger, R.; Scholz, S.; Schmitt-Jansen, M.; Busch, W.; Escher, B. I. Mixture toxicity revisited from a toxicogenomic perspective Environ. Sci. Technol. 2012, 46 (5) 2508-2522
6. Falciani, F.; Diab, A. M.; Sabine, V.; Williams, T. D.; Ortega, F.; George, S. G.; Chipman, J. K. Hepatic transcriptomic profiles of European flounder (Platichthys flesus) from field sites and computational approaches to predict site from stress gene responses following exposure to model toxicants Aquat. Toxicol. 2008, 90 (2) 92-101
7. Garcia-Reyero, N.; Adelman, I. R.; Martinovic, D.; Liu, L.; Denslow, N. D. Site-specific impacts on gene expression and behavior in fathead minnows (Pimephales promelas) exposed in situ to streams adjacent to sewage treatment plants BMC Bioinf. 2009, 10 (Suppl 11) S11-2105-10-S11-S11
8. Sellin Jeffries, M. K.; Mehinto, A. C.; Carter, B. J.; Denslow, N. D.; Kolok, A. S. Taking microarrays to the field: Differential hepatic gene expression of caged fathead minnows from Nebraska watersheds Environ. Sci. Technol. 2012, 46 (3) 1877-1885
9. Poynton, H. C.; Zuzow, R.; Loguinov, A. V.; Perkins, E. J.; Vulpe, C. D. Gene expression profiling in Daphnia magna, part II: Validation of a copper specific gene expression signature with effluent from two copper mines in California Environ. Sci. Technol. 2008, 42 (16) 6257-6263
10. Williams, T. D.; Turan, N.; Diab, A. M.; Wu, H.; Mackenzie, C.; Bartie, K. L.; Hrydziuszko, O.; Lyons, B. P.; Stentiford, G. D.; Herbert, J. M.; Abraham, J. K.; Katsiadaki, I.; Leaver, M. J.; Taggart, J. B.; George, S. G.; Viant, M. R.; Chipman, K. J.; Falciani, F. Towards a system level understanding of non-model organisms sampled from the environment: A network biology approach PLoS Comput. Biol. 2011, 7 (8 e1002126
11. Garcia-Reyero, N.; Lavelle, C. M.; Escalon, B. L.; Martinovic, D.; Kroll, K. J.; Sorensen, P. W.; Denslow, N. D. Behavioral and genomic impacts of a wastewater effluent on the fathead minnow Aquat. Toxicol. 2011, 101 (1) 38-48
12. Lee, K. E.; Langer, S. K.; Barber, L. B.; Writer, J. H.; Ferrey, M. L.; Schoenfuss, H. L.; Furlong, E. T.; Foreman, W. T.; Gray, J. L.; ReVello, R. C.; Martinovic, D.; Woodruff, O. P.; Keefe, S. H.; Brown, G. K.; Taylor, H. E.; Ferrer, I.; Thurman, E. M. Endocrine active chemicals, pharmaceuticals, and other chemicals of concern in surface water, wastewater-treatment plant effluent, and bed sediment, and biological characteristics in selected streams, Minnesota-design, methods, and data, 2009; USGS Data Series 575; U.S. Geological Survey, Reston, VA, 2011.
13. Ankley, G. T.; Bencic, D. C.; Breen, M. S.; Collette, T. W.; Conolly, R. B.; Denslow, N. D.; Edwards, S. W.; Ekman, D. R.; Garcia-Reyero, N.; Jensen, K. M.; Lazorchak, J. M.; Martinovic, D.; Miller, D. H.; Perkins, E. J.; Orlando, E. F.; Villeneuve, D. L.; Wang, R. L.; Watanabe, K. H. Endocrine disrupting chemicals in fish: Developing exposure indicators and predictive models of effects based on mechanism of action Aquat. Toxicol. 2009, 92 (3) 168-178
14. Villeneuve, D. L.; Garcia-Reyero, N.; Martinovic-Weigelt, D.; Li, Z.; Watanabe, K. H.; Orlando, E. F.; Lalone, C. A.; Edwards, S. W.; Burgoon, L. D.; Denslow, N. D.; Perkins, E. J.; Ankley, G. T. A graphical systems model and tissue-specific functional gene sets to aid transcriptomic analysis of chemical impacts on the female teleost reproductive axis Mutat. Res. 2012, 746 (2) 151-162
15. Skelton, D.; Ekman, D. R.; Martinović-Weigelt, D.; Ankley, G. T.; Villeneuve, D. L.; Teng, Q.; Collette, T. W. Metabolomics for in situ environmental monitoring of surface waters impacted by contaminants from both point and nonpoint sources. Environ. Sci. Technol. DOI: 10.1021/es404021f.
16. Berninger, J. P.; Martinović-Weigelt, D.; Garcia-Reyero, N.; Escalon, L.; Perkins, E. J.; Ankley, G. T.; Villeneuve, D. L. Using transcriptomic tools to evaluate biological effects across effluent gradients at a diverse set of study sites in Minnesota, USA. Environ. Sci. Technol. DOI: 10.1021/es4040254.
17. Davis, A. P.; Murphy, C. G.; Johnson, R.; Lay, J. M.; Lennon-Hopkins, K.; Saraceni-Richards, C.; Sciaky, D.; King, B. L.; Rosenstein, M. C.; Wiegers, T. C.; Mattingly, C. J. The comparative toxicogenomics database: Update 2013 Nucleic Acids Res. 2013, 41 (D1) D1104-1114
18. Kolok, A. S.; Miller, J. T.; Schoenfuss, H. L. The mini mobile environmental monitoring unit: A novel bio-assessment tool J. Environ. Monit. 2012, 14 (1) 202-208
19. Huang, D. W.; Sherman, B. T.; Zheng, X.; Yang, J.; Imamichi, T.; Stephens, R.; Lempicki, R. A. Extracting biological meaning from large gene lists with DAVID. Current Protocols in Bioinformatics; John Wiley and Sons, Inc: New York, 2009; Chapter 13, Unit 13.11.
20. Kanehisa, M.; Goto, S.; Sato, Y.; Furumichi, M.; Tanabe, M. KEGG for integration and interpretation of large-scale molecular datasets Nucleic Acids Res. 2012, 40 (D1) D109-D114
21. Caldwell, D. J.; Mastrocco, F.; Anderson, P. D.; Länge, R.; Sumpter, J. P. Predicted-no-effect concentrations for the steroid estrogens estrone, 17β-estradiol, estriol, and 17α-ethinylestradiol Environ. Toxicol. Chem. 2012, 31 (6) 1396-1406
22. Nelson, E. D.; Do, H.; Lewis, R. S.; Carr, S. A. Diurnal variability of pharmaceutical, personal care product, estrogen and alkylphenol concentrations in effluent from a tertiary wastewater treatment facility Environ. Sci. Technol. 2010, 45 (4) 1228-1234
23. Murphy, K. A.; Quadro, L.; White, L. A. The intersection between the aryl hydrocarbon receptor (AhR)-and retinoic acid-signaling pathways Vitam. Horm. 2007, 75, 33-67
24. Strauss, L.; Kallio, J.; Desai, N.; Pakarinen, P.; Miettinen, T.; Gylling, H.; Albrecht, M.; Makela, S.; Mayerhofer, A.; Poutanen, M. Increased exposure to estrogens disturbs maturation, steroidogenesis, and cholesterol homeostasis via estrogen receptor alpha in adult mouse Leydig cells Endocrinology 2009, 150 (6) 2865-2872
25. Jeong, S.; Yoon, M. Inhibition of the actions of peroxisome proliferator-activated receptor alpha on obesity by estrogen Obesity 2007, 15 (6) 1430-1440
26. Zhang, Y. X.; Yan, J. F.; Fan, L.; Zhang, W. Y.; Zhou, Z. W.; Chen, X.; Su, X. Y.; Tang, X. M.; Yang, D. C. Synthesis and preliminary evaluation of antidiabetic activity of 4-(3-(4-bromophenyl)-3-oxo-l-arylpropylamino)- N -(5-methylisoxazol-3-yl) benzenesulfonamide Acta Pharm. Sin. 2009, 44 (11) 1244-1251
27. Gressner, O. A.; Lahme, B.; Rehbein, K.; Siluschek, M.; Weiskirchen, R.; Gressner, A. M. Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways J. Hepatol. 2008, 49 (5) 758-767
28. Casals-Casas, C.; Feige, J. N.; Desvergne, B. Interference of pollutants with PPARs: Endocrine disruption meets metabolism Int. J. Obes. (London) 2008, 32 (Suppl 6) S53-61
29. Moens, L. N.; Smolders, R.; van der Ven, K.; van Remortel, P.; Del-Favero, J.; De Coen, W. M. Effluent impact assessment using microarray-based analysis in common carp: A systems toxicology approach Chemosphere 2007, 67 (11) 2293-2304
30. Dubik, D.; Shiu, R. P. Mechanism of estrogen activation of c-myc oncogene expression Oncogene 1992, 7 (8) 1587-1594
31. Liu, Y.; Lin, L.; Zarnegar, R. Modulation of hepatocyte growth factor gene expression by estrogen in mouse ovary Mol. Cell. Endocrinol. 1994, 104 (2) 173-181
32. Ghosh, S.; Karin, M. Missing pieces in the NF-kappaB puzzle Cell 2002, 109 (Suppl) S81-96
33. Biswas, D. K.; Singh, S.; Shi, Q.; Pardee, A. B.; Iglehart, J. D. Crossroads of estrogen receptor and NF-kappaB signaling Sci. STKE 2005, 2005 (288) pe27
34. Kazi, A. A.; Jones, J. M.; Koos, R. D. Chromatin immunoprecipitation analysis of gene expression in the rat uterus in vivo: Estrogen-induced recruitment of both estrogen receptor alpha and hypoxia-inducible factor 1 to the vascular endothelial growth factor promoter Mol. Endocrinol. 2005, 19 (8) 2006-2019
35. Kang, K. W.; Lee, S. J.; Kim, S. G. Molecular mechanism of nrf2 activation by oxidative stress Antioxid. Redox Signaling 2005, 7 (11-12) 1664-1673
36. Stehr, C. M.; Myers, M. S.; Burrows, D. G.; Krahn, M. M.; Meador, J. P.; McCain, B. B.; Varanasi, U. S. H. A. Chemical contamination and associated liver diseases in two species of fish from San Francisco Bay and Bodega Bay Ecotoxicology 1997, 6 (1) 35-65
37. Koza, R. A.; Moore, M. J.; Stegeman, J. J. Elevated ornithine decarboxylase activity, polyamines and cell proliferation in neoplastic and vacuolated liver cells of winter flounder (Pleuronectes americanus) Carcinogenesis 1993, 14 (3) 399-405
38. Cameron, C. Effects of peroxisome proliferator-activated receptor ligands on the hypothalamic-pituitary-gonadal axis of the male goldfish. Ph.D. Thesis, University of Ottawa, Canada, 2011.
39. King-Heiden, T. C.; Mehta, V.; Xiong, K. M.; Lanham, K. A.; Antkiewicz, D. S.; Ganser, A.; Heideman, W.; Peterson, R. E. Reproductive and developmental toxicity of dioxin in fish Mol. Cell. Endocrinol. 2012, 354 (1) 121-138
40. Hernández-Ochoa, I.; Karman, B. N.; Flaws, J. A. The role of the aryl hydrocarbon receptor in the female reproductive system Biochem. Pharmacol. 2009, 77 (4) 547-559