Physiological expression of the PI3K-activating mutation Pik3ca H1047R combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice

Biochemical Journal

Volumn 458, Issue 2, 2014, Pages 251-258

  Hare, Lauren M ^a,b   Phesse, Toby J ^c,d   Waring, Paul M ^d   Montgomery, Karen G ^a   Kinross, Kathryn M ^a,d   Mills, Kevin ^a   Roh, Vincent ^a   Heath, Joan K ^c,d   Ramsay, Robert G ^a,d   Ernst, Matthias ^c,d   Phillips, Wayne A ^a,b,d  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

polypeptide (Pik3ca); Adenomatous polyposis coli (Apc); Catalytic; Colorectal cancer; Mouse model; Phosphoinositide 3 kinase; Phosphoinositide 3 kinase (PI3K)

Indexed keywords

ADENOCARCINOMA; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCK-IN TECHNIQUES; INTESTINAL NEOPLASMS; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NEOPLASM INVASIVENESS; PHOSPHATIDYLINOSITOL 3-KINASES;

EID: 84894263520     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131412     Document Type: Article

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