메뉴 건너뛰기




Volumn 27, Issue 3, 2014, Pages 460-470

L-carnitine attenuates the development of kidney fibrosis in hypertensive rats by upregulating PPAR-γ

Author keywords

blood pressure; fibrosis; hypertension; kidney; L carnitine; L NAME; PPAR

Indexed keywords

BLOOD PRESSURE; FIBROSIS; HYPERTENSION; KIDNEY; L-CARNITINE; L-NAME; PPAR.;

EID: 84894232191     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1093/ajh/hpt268     Document Type: Article
Times cited : (46)

References (39)
  • 1
    • 0034056789 scopus 로고    scopus 로고
    • Is microalbuminuria a predictor of cardiovascular and renal disease in patients with essential hypertension?
    • Campese VM, Bianchi S, Bigazzi R. Is microalbuminuria a predictor of cardiovascular and renal disease in patients with essential hypertension? Curr Opin Nephrol Hypertens 2000; 9:143-147.
    • (2000) Curr Opin Nephrol Hypertens , vol.9 , pp. 143-147
    • Campese, V.M.1    Bianchi, S.2    Bigazzi, R.3
  • 2
    • 79954469664 scopus 로고    scopus 로고
    • Renal injury in angiotensin IINAME-induced hypertensive rats is independent of elevated blood pressure
    • Polichnowski AJ, Lu L, Cowley AW, Jr. Renal injury in angiotensin IINAME-induced hypertensive rats is independent of elevated blood pressure. Am J Physiol Renal Physiol 2011; 300:F1008-F1016.
    • (2011) Am J Physiol Renal Physiol , vol.300
    • Polichnowski, A.J.1    Lu, L.2    Cowley Jr., A.W.3
  • 3
    • 79952278420 scopus 로고    scopus 로고
    • Hypertension and kidney disease
    • Ritz E. Hypertension and kidney disease. Clin Nephrol 2010; 74:S39-S43.
    • (2010) Clin Nephrol , vol.74
    • Ritz, E.1
  • 4
    • 70349659185 scopus 로고    scopus 로고
    • Angiotensin II induces connective tissue growth factor and collagen i expression via transforming growth factor-beta-dependent and-independent Smad pathways: The role of Smad3
    • Yang F, Chung AC, Huang XR, Lan HY. Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and-independent Smad pathways: the role of Smad3. Hypertension 2009; 54:877-884.
    • (2009) Hypertension , vol.54 , pp. 877-884
    • Yang, F.1    Chung, A.C.2    Huang, X.R.3    Lan, H.Y.4
  • 5
    • 45149121685 scopus 로고    scopus 로고
    • Kidney fibrosis in hypertensive rats: Role of oxidative stress
    • Zhao W, Chen SS, Chen Y, Ahokas RA, Sun Y. Kidney fibrosis in hypertensive rats: role of oxidative stress. Am J Nephrol 2008; 28:548-554.
    • (2008) Am J Nephrol , vol.28 , pp. 548-554
    • Zhao, W.1    Chen, S.S.2    Chen, Y.3    Ahokas, R.A.4    Sun, Y.5
  • 6
    • 69549110735 scopus 로고    scopus 로고
    • Fluorofenidone attenuates collagen i and transforming growth factor-beta1 expression through a nicotinamide adenine dinucleotide phosphate oxidase-dependent way in NRK-52E cells
    • Peng ZZ, Hu GY, Shen H, Wang L, Ning WB, Xie YY, Wang NS, Li BX, Tang YT, Tao LJ. Fluorofenidone attenuates collagen I and transforming growth factor-beta1 expression through a nicotinamide adenine dinucleotide phosphate oxidase-dependent way in NRK-52E cells. Nephrology (Carlton) 2009; 14:565-572.
    • (2009) Nephrology (Carlton) , vol.14 , pp. 565-572
    • Peng, Z.Z.1    Hu, G.Y.2    Shen, H.3    Wang, L.4    Ning, W.B.5    Xie, Y.Y.6    Wang, N.S.7    Li, B.X.8    Tang, Y.T.9    Tao, L.J.10
  • 7
    • 62949101948 scopus 로고    scopus 로고
    • NADPH oxidases and angiotensin II receptor signaling
    • Garrido AM, Griendling KK. NADPH oxidases and angiotensin II receptor signaling. Mol Cell Endocrinol 2009; 302:148-158.
    • (2009) Mol Cell Endocrinol , vol.302 , pp. 148-158
    • Garrido, A.M.1    Griendling, K.K.2
  • 8
    • 77953808712 scopus 로고    scopus 로고
    • Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation
    • Leask A. Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation. Circ Res 2010; 106:1675-1680.
    • (2010) Circ Res , vol.106 , pp. 1675-1680
    • Leask, A.1
  • 9
    • 58149127646 scopus 로고    scopus 로고
    • PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta
    • Kawai T, Masaki T, Doi S, Arakawa T, Yokoyama Y, Doi T, Kohno N, Yorioka N. PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta. Lab Invest 2009; 89:47-58.
    • (2009) Lab Invest , vol.89 , pp. 47-58
    • Kawai, T.1    Masaki, T.2    Doi, S.3    Arakawa, T.4    Yokoyama, Y.5    Doi, T.6    Kohno, N.7    Yorioka, N.8
  • 10
    • 54249163313 scopus 로고    scopus 로고
    • The role of inflammatory markers in the cardioprotective effect of L-carnitine in L-NAME-induced hypertension
    • Miguel-Carrasco JL, Mate A, Monserrat MT, Arias JL, Aramburu O, Vazquez CM. The role of inflammatory markers in the cardioprotective effect of L-carnitine in L-NAME-induced hypertension. Am J Hypertens 2008; 21:1231-1237.
    • (2008) Am J Hypertens , vol.21 , pp. 1231-1237
    • Miguel-Carrasco, J.L.1    Mate, A.2    Monserrat, M.T.3    Arias, J.L.4    Aramburu, O.5    Vazquez, C.M.6
  • 14
    • 84866017810 scopus 로고    scopus 로고
    • Telmisartan counteracts TGF-beta1 induced epithelial-to-mesenchymal transition via PPAR-gamma in human proximal tubule epithelial cells
    • Chen Y, Luo Q, Xiong Z, Liang W, Chen L, Xiong Z. Telmisartan counteracts TGF-beta1 induced epithelial-to-mesenchymal transition via PPAR-gamma in human proximal tubule epithelial cells. Int J Clin Exp Pathol 2012; 5:522-529.
    • (2012) Int J Clin Exp Pathol , vol.5 , pp. 522-529
    • Chen, Y.1    Luo, Q.2    Xiong, Z.3    Liang, W.4    Chen, L.5    Xiong, Z.6
  • 15
    • 77955251736 scopus 로고    scopus 로고
    • Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components
    • Martin H. Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components. Mutat Res 2010; 690:57-63.
    • (2010) Mutat Res , vol.690 , pp. 57-63
    • Martin, H.1
  • 16
    • 0032189158 scopus 로고    scopus 로고
    • Effect of l-carnitine on the status of lipid peroxidation and antioxidants in aging rats
    • Kalaiselvi T, Panneerselvam C. Effect of l-carnitine on the status of lipid peroxidation and antioxidants in aging rats. J Nutr Biochem 1998; 9:575-581.
    • (1998) J Nutr Biochem , vol.9 , pp. 575-581
    • Kalaiselvi, T.1    Panneerselvam, C.2
  • 17
    • 0034994973 scopus 로고    scopus 로고
    • Protective role of L-carnitine on liver and heart lipid peroxidation in atherosclerotic rats
    • Dayanandan A, Kumar P, Panneerselvam C. Protective role of L-carnitine on liver and heart lipid peroxidation in atherosclerotic rats. J Nutr Biochem 2001; 12:254-257.
    • (2001) J Nutr Biochem , vol.12 , pp. 254-257
    • Dayanandan, A.1    Kumar, P.2    Panneerselvam, C.3
  • 18
    • 0034834828 scopus 로고    scopus 로고
    • L-carnitine prevents the progression of atherosclerotic lesions in hypercholesterolaemic rabbits
    • Sayed-Ahmed MM, Khattab MM, Gad MZ, Mostafa N. L-carnitine prevents the progression of atherosclerotic lesions in hypercholesterolaemic rabbits. Pharmacol Res 2001; 44:235-242.
    • (2001) Pharmacol Res , vol.44 , pp. 235-242
    • Sayed-Ahmed, M.M.1    Khattab, M.M.2    Gad, M.Z.3    Mostafa, N.4
  • 20
    • 77349090650 scopus 로고    scopus 로고
    • Comparative effects of captopril and l-carnitine on blood pressure and antioxidant enzyme gene expression in the heart of spontaneously hypertensive rats
    • Miguel-Carrasco JL, Monserrat MT, Mate A, Vazquez CM. Comparative effects of captopril and l-carnitine on blood pressure and antioxidant enzyme gene expression in the heart of spontaneously hypertensive rats. Eur J Pharmacol 2010; 632:65-72.
    • (2010) Eur J Pharmacol , vol.632 , pp. 65-72
    • Miguel-Carrasco, J.L.1    Monserrat, M.T.2    Mate, A.3    Vazquez, C.M.4
  • 21
    • 77954818479 scopus 로고    scopus 로고
    • The therapeutic prospects of using L-carnitine to manage hypertension-related organ damage
    • Mate A, Miguel-Carrasco JL, Vazquez CM. The therapeutic prospects of using L-carnitine to manage hypertension-related organ damage. Drug Discov Today 2010; 15:484-492.
    • (2010) Drug Discov Today , vol.15 , pp. 484-492
    • Mate, A.1    Miguel-Carrasco, J.L.2    Vazquez, C.M.3
  • 24
    • 84857470016 scopus 로고    scopus 로고
    • The mouse gene encoding the carnitine biosynthetic enzyme 4-N-trimethylaminobutyraldehyde dehydrogenase is regulated by peroxisome proliferator-activated receptor alpha
    • Wen G, Ringseis R, Rauer C, Eder K. The mouse gene encoding the carnitine biosynthetic enzyme 4-N-trimethylaminobutyraldehyde dehydrogenase is regulated by peroxisome proliferator-activated receptor alpha. Biochim Biophys Acta 2012; 1819:357-365.
    • (2012) Biochim Biophys Acta , vol.1819 , pp. 357-365
    • Wen, G.1    Ringseis, R.2    Rauer, C.3    Eder, K.4
  • 26
    • 0031742105 scopus 로고    scopus 로고
    • Glomerular cell proliferation and apoptosis in uninephrectomized spontaneously hypertensive rats
    • Rodriguez-Lopez AM, Flores O, Arevalo MA, Lopez-Novoa JM. Glomerular cell proliferation and apoptosis in uninephrectomized spontaneously hypertensive rats. Kidney Int Suppl 1998; 68:S36-S40.
    • (1998) Kidney Int Suppl , vol.68
    • Rodriguez-Lopez, A.M.1    Flores, O.2    Arevalo, M.A.3    Lopez-Novoa, J.M.4
  • 27
    • 77954562244 scopus 로고    scopus 로고
    • L-carnitine treatment in patients with mild diastolic heart failure is associated with improvement in diastolic function and symptoms
    • Serati AR, Motamedi MR, Emami S, Varedi P, Movahed MR. L-carnitine treatment in patients with mild diastolic heart failure is associated with improvement in diastolic function and symptoms. Cardiology 2010; 116:178-182.
    • (2010) Cardiology , vol.116 , pp. 178-182
    • Serati, A.R.1    Motamedi, M.R.2    Emami, S.3    Varedi, P.4    Movahed, M.R.5
  • 28
    • 3042716265 scopus 로고    scopus 로고
    • Imidapril improves L-NAME-exacerbated nephrosclerosis with TGF-beta 1 inhibition in spontaneously hypertensive rats
    • Ono H, Saitoh M, Ono Y, Ishimitu T, Matsuoka H. Imidapril improves L-NAME-exacerbated nephrosclerosis with TGF-beta 1 inhibition in spontaneously hypertensive rats. J Hypertens 2004; 22:1389-1395.
    • (2004) J Hypertens , vol.22 , pp. 1389-1395
    • Ono, H.1    Saitoh, M.2    Ono, Y.3    Ishimitu, T.4    Matsuoka, H.5
  • 34
    • 77949471906 scopus 로고    scopus 로고
    • L-carnitine attenuates cardiac remodelling rather than vascular remodelling in deoxycorticosterone acetate-salt hypertensive rats
    • O'Brien D, Chunduri P, Iyer A, Brown L. L-carnitine attenuates cardiac remodelling rather than vascular remodelling in deoxycorticosterone acetate-salt hypertensive rats. Basic Clin Pharmacol Toxicol 2010; 106:296-301.
    • (2010) Basic Clin Pharmacol Toxicol , vol.106 , pp. 296-301
    • O'Brien, D.1    Chunduri, P.2    Iyer, A.3    Brown, L.4
  • 36
    • 0042626565 scopus 로고    scopus 로고
    • L-carnitine transport in kidney of normotensive, Wistar-Kyoto rats: Effect of chronic L-carnitine administration
    • Gomez-Amores L, Mate A, Vazquez CM. L-carnitine transport in kidney of normotensive, Wistar-Kyoto rats: effect of chronic L-carnitine administration. Pharm Res 2003; 20:1133-1140.
    • (2003) Pharm Res , vol.20 , pp. 1133-1140
    • Gomez-Amores, L.1    Mate, A.2    Vazquez, C.M.3
  • 37
    • 73649124171 scopus 로고    scopus 로고
    • The role of peroxisome proliferator-activated receptor alpha in transcriptional regulation of novel organic cation transporters
    • Eder K, Ringseis R. The role of peroxisome proliferator-activated receptor alpha in transcriptional regulation of novel organic cation transporters. Eur J Pharmacol 2010; 628:1-5.
    • (2010) Eur J Pharmacol , Issue.628 , pp. 1-5
    • Eder, K.1    Ringseis, R.2
  • 38
    • 67349232471 scopus 로고    scopus 로고
    • Tei index: The earliest detectable cardiac structural and functional abnormality detectable in Hb Bart's foetal edema
    • Chao G, Zheng C, Meng D, Su J, Xie X, Li W, Henein M. Tei index: the earliest detectable cardiac structural and functional abnormality detectable in Hb Bart's foetal edema. Int J Cardiol 2009; 134:e150-e154.
    • (2009) Int J Cardiol , vol.134
    • Chao, G.1    Zheng, C.2    Meng, D.3    Su, J.4    Xie, X.5    Li, W.6    Henein, M.7
  • 39
    • 0027361036 scopus 로고
    • Effects of carnitine and its congeners on eicosanoid discharge from rat cells: Implications for release of TNFalpha
    • Garrelds IM, Elliott GR, Pruimboom WM, Zijlstra FJ, Bonta IL. Effects of carnitine and its congeners on eicosanoid discharge from rat cells: implications for release of TNFalpha. Mediators Inflamm 1993; 2:S57-S62.
    • (1993) Mediators Inflamm , vol.2
    • Garrelds, I.M.1    Elliott, G.R.2    Pruimboom, W.M.3    Zijlstra, F.J.4    Bonta, I.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.