The mouse gene encoding the carnitine biosynthetic enzyme 4-N-trimethylaminobutyraldehyde dehydrogenase is regulated by peroxisome proliferator-activated receptor α

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1819, Issue 5, 2012, Pages 357-365

  Wen, Gaiping ^a   Ringseis, Robert ^a   Rauer, Christine ^a   Eder, Klaus ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Carnitine synthesis; Functional PPRE; PPAR ; Target gene

Indexed keywords

4 N TRIMETHYLAMINOBUTYRALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; CARNITINE; HORMONE RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR RESPONSE ELEMENT; TRIMETHYLLYSINE DIOXYGENASE; UNCLASSIFIED DRUG;

AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; COMPUTER MODEL; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE TARGETING; HOMEOSTASIS; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; INTRON; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR BINDING; REPORTER GENE; SITE DIRECTED MUTAGENESIS;

ALDEHYDE OXIDOREDUCTASES; ANIMALS; CARNITINE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; MICE; MIXED FUNCTION OXYGENASES; NUCLEOTIDE MOTIFS; PPAR ALPHA; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RESPONSE ELEMENTS;

EID: 84857470016     PISSN: 18749399     EISSN: 18764320     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2012.01.004     Document Type: Article

References (28)

1. Rebouche C.J., Seim H. Carnitine metabolism and its regulation in microorganisms and mammals. Annu. Rev. Nutr. 1998, 18:39-61.
2. Vaz F.M., Wanders R.J. Carnitine biosynthesis in mammals. Biochem. J. 2002, 361:417-429.
3. Tamai I., Ohashi R., Nezu J., Yabuuchi H., Oku A., Shimane M., Sai Y., Tsuji A. Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J. Biol. Chem. 1998, 273:20378-20382.
4. Tamai I., Ohashi R., Nezu J.I., Sai Y., Kobayashi D., Oku A., Shimane M., Tsuji A. Molecular and functional characterization of organic cation/carnitine transporter family in mice. J. Biol. Chem. 2000, 275:40064-40072.
5. Ringseis R., Eder K. Influence of pharmacological PPARα activators on carnitine homeostasis in proliferating and non-proliferating species. Pharmacol. Res. 2009, 60:179-184.
6. Desvergne B., Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 1999, 20:649-688.
7. Mandard S., Müller M., Kersten S. Peroxisome proliferator receptor α target genes. Cell. Mol. Life Sci. 2004, 61:393-416.
8. Helledie T., Grøntved L., Jensen S.S., Kiilerich P., Rietveld L., Albrektsen T., Boysen M.S., Nøhr J., Larsen L.K., Fleckner J., Stunnenberg H.G., Kristiansen K., Mandrup S. The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents. J. Biol. Chem. 2002, 277:26821-26830.
9. Hansmannel F., Clémencet M.C., Le Jossic-Corcos C., Osumi T., Latruffe N., Nicolas-Francés V. Functional characterization of a peroxisome proliferator response-element located in the intron 3 of rat peroxisomal thiolase B gene. Biochem. Biophys. Res. Commun. 2003, 311:149-155.
10. Gutgesell A., Wen G., König B., Koch A., Spielmann J., Stangl G.I., Eder K., Ringseis R. Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARα and PPARδ in liver cells. Biochim. Biophys. Acta 2009, 1790:1206-1216.
11. Wen G., Ringseis R., Eder K. Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor α via a PPRE located in the first intron. Biochem. Pharmacol. 2010, 79:768-776.
12. Forman B.M., Chen J., Evans R.M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:4312-4317.
13. Krey G., Braissant O., L'Horset F., Kalkhoven E., Perroud M., Parker M.G., Wahli W. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol. Endocrinol. 1997, 11:779-791.
14. Luci S., Geissler S., König B., Koch A., Stangl G.I., Hirche F., Eder K. PPARα agonists up-regulate organic cation transporters in rat liver cells. Biochem. Biophys. Res. Commun. 2006, 350:704-708.
15. Ringseis R., Pösel S., Hirche F., Eder K. Treatment with pharmacological peroxisome proliferator-activated receptor α agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats. Pharmacol. Res. 2007, 56:175-183.
16. Ringseis R., Wege N., Wen G., Rauer C., Hirche F., Kluge H., Eder K. Carnitine synthesis and uptake into cells are stimulated by fasting in pigs as a model of nonproliferating species. J. Nutr. Biochem. 2009, 20:840-847.
17. van Vlies N., Ferdinandusse S., Turkenburg M., Wanders R.J., Vaz F.M. PPARα-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation. Biochim. Biophys. Acta 2007, 1767:1134-1142.
18. Koch A., König B., Stangl G.I., Eder K. PPARα mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis. Exp. Biol. Med. 2008, 233:356-365.
19. Gutgesell A., Ringseis R., Brandsch C., Stangl G.I., Hirche F., Eder K. Peroxisome proliferator-activated receptor α and enzymes of carnitine biosynthesis in the liver are down-regulated during lactation in rats. Metabolism 2009, 58:226-232.
20. Wen G., Kühne H., Rauer C., Ringseis R., Eder K. Mouse γ-butyrobetaine dioxygenase is regulated by peroxisome proliferator-activated receptor α through a PPRE located in the proximal promoter. Biochem. Pharmacol. 2011, 82:175-183.
21. Podvinec M., Kaufmann M.R., Handschin C., Meyer U.A. NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Mol. Endocrinol. 2002, 16:1269-1279.
22. Mandard S., Zandbergen F., Tan N.S., Escher P., Patsouris D., Koenig W., Kleemann R., Bakker A., Veenman F., Wahli W., Müller M., Kersten S. The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment. J. Biol. Chem. 2004, 279:34411-34420.
23. Napal L., Marrero P.F., Haro D. An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A. J. Mol. Biol. 2005, 354:751-759.
24. Kersten S., Seydoux J., Peters J.M., Gonzalez F.J., Desvergne B., Wahli W. Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting. J. Clin. Invest. 1999, 103:1489-1498.
25. Owen O.E., Morgan A.P., Kemp H.G., Sullivan J.M., Herrera M.G., Cahill G.F. Brain metabolism during fasting. J. Clin. Invest. 1967, 46:1589-1595.
26. Brandt J.M., Djouadi F., Kelly D. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor α. J. Biol. Chem. 1998, 273:23786-23792.
27. Mascaro C., Acosta E., Ortiz J.A., Marrero P.F., Hegardt F.G., Haro D. Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor. J. Biol. Chem. 1998, 273:8560-8563.
28. Makowski L., Noland R.C., Koves T.R., Xing W., Ilkayeva O.R., Muehlbauer M.J., Stevens R.D., Muoio D.M. Metabolic profiling of PPARα-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. FASEB J. 2009, 23:586-604.