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Volumn 22, Issue 2, 2014, Pages 91-96

Sortilin: The mechanistic link between genes, cholesterol, and coronary artery disease

Author keywords

genome wide association studies; hyperlipidemia; low density lipoprotein cholesterol; SORT1; sortilin

Indexed keywords

ADAPTOR PROTEINS, VESICULAR TRANSPORT; CHOLESTEROL, LDL; CORONARY ARTERY DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; HYPERLIPIDEMIAS; LIPID METABOLISM; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84894215692     PISSN: 10615377     EISSN: 15384683     Source Type: Journal    
DOI: 10.1097/CRD.0000000000000008     Document Type: Review
Times cited : (11)

References (35)
  • 1
  • 2
    • 77956327982 scopus 로고    scopus 로고
    • Sortl, encoded by the cardiovascular risk locus lpl 3.3, is a regulator of hepatic lipoprotein export
    • Kjolby M, Andersen OM, Rreiderhoff T, et al. Sortl, encoded by the cardiovascular risk locus lpl 3.3, is a regulator of hepatic lipoprotein export. Cell Metab. 2010;12:213-223.
    • (2010) Cell Metab , vol.12 , pp. 213-223
    • Kjolby, M.1    Andersen, O.M.2    Rreiderhoff, T.3
  • 3
    • 84894215418 scopus 로고    scopus 로고
    • Accessed March 15, 2012
    • Centers for Disease Control and Prevention. High Cholesterol: Understand Your Risks. 2012. Available at: http://www.cdc.gov/cholesterol. Accessed March 15, 2012.
    • (2012) High Cholesterol: Understand Your Risks
  • 4
    • 67651111687 scopus 로고    scopus 로고
    • Lipid Treatment Assessment Project 2 Investigators. Lipid treatment assessment project 2: A multinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol goals
    • Waters DD, Rrotons C, Chiang CW, et al; Lipid Treatment Assessment Project 2 Investigators. Lipid treatment assessment project 2: a multinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol goals. Circulation. 2009;120:28-34.
    • (2009) Circulation , vol.120 , pp. 28-34
    • Waters, D.D.1    Rrotons, C.2    Chiang, C.W.3
  • 5
    • 34547623750 scopus 로고    scopus 로고
    • WTCCC and the Cardiogenics Consortium. Genomewide association analysis of coronary artery disease
    • Samani NJ, Erdmann J, Hall AS, et al; WTCCC and the Cardiogenics Consortium. Genomewide association analysis of coronary artery disease. N Engl JMed. 2007;357:443-453.
    • (2007) N Engl JMed , vol.357 , pp. 443-453
    • Samani, N.J.1    Erdmann, J.2    Hall, A.S.3
  • 6
    • 84856073667 scopus 로고    scopus 로고
    • Genomewide association studies in cardiovascular disease-an update 2011
    • Zeller T, Rlankenberg S, Diemert P. Genomewide association studies in cardiovascular disease-an update 2011. Clin Chem. 2012;58:92-103.
    • (2012) Clin Chem , vol.58 , pp. 92-103
    • Zeller, T.1    Rlankenberg, S.2    Diemert, P.3
  • 7
    • 38649132270 scopus 로고    scopus 로고
    • Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    • Kathiresan S, Melander O, Guiducci C, et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet. 2008;40:189-197.
    • (2008) Nat Genet , vol.40 , pp. 189-197
    • Kathiresan, S.1    Melander, O.2    Guiducci, C.3
  • 8
    • 38649125868 scopus 로고    scopus 로고
    • Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    • Wilier CJ, Sanna S, Jackson AU, et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet. 2008;40:161-169.
    • (2008) Nat Genet , vol.40 , pp. 161-169
    • Wilier, C.J.1    Sanna, S.2    Jackson, A.U.3
  • 9
    • 38849166666 scopus 로고    scopus 로고
    • Wellcome Trust Case Control Consortium. LDL-cholesterol concentrations: A genome-wide association study
    • Sandhu MS, Waterworth DM, Debenham SL, et al; Wellcome Trust Case Control Consortium. LDL-cholesterol concentrations: a genome-wide association study. Lancet. 2008;371:483-491.
    • (2008) Lancet , vol.371 , pp. 483-491
    • Sandhu, M.S.1    Waterworth, D.M.2    Debenham, S.L.3
  • 10
    • 38749149611 scopus 로고    scopus 로고
    • Genome-wide association study identifies genes for biomarkers of cardiovascular disease: Serum urate and dyslipidemia
    • Wallace C, Newhouse SJ, Braund P, et al. Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet. 2008;82:139-149.
    • (2008) Am J Hum Genet , vol.82 , pp. 139-149
    • Wallace, C.1    Newhouse, S.J.2    Braund, P.3
  • 11
    • 58149161560 scopus 로고    scopus 로고
    • ENGAGE Consortium. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
    • Aulchenko YS, Ripatti S, Lindqvist I, et al; ENGAGE Consortium. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet. 2009;41:47-55.
    • (2009) Nat Genet , vol.41 , pp. 47-55
    • Aulchenko, Y.S.1    Ripatti, S.2    Lindqvist, I.3
  • 12
    • 58149163149 scopus 로고    scopus 로고
    • Common variants at 30 loci contribute to polygenic dyslipidemia
    • Kathiresan S, Wilier CJ, Peloso GM, et al. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 2009;41:56-65.
    • (2009) Nat Genet , vol.41 , pp. 56-65
    • Kathiresan, S.1    Wilier, C.J.2    Peloso, G.M.3
  • 13
    • 58149159573 scopus 로고    scopus 로고
    • Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
    • Sabatti C, Service SK, Hartikainen AL, et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet. 2009;41:35-46.
    • (2009) Nat Genet , vol.41 , pp. 35-46
    • Sabatti, C.1    Service, S.K.2    Hartikainen, A.L.3
  • 14
    • 54249106249 scopus 로고    scopus 로고
    • The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol
    • Samani NJ, Braund PS, Erdmann J, et al. The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. J Mol Med (Berl). 2008;86:1233-1241.
    • (2008) J Mol Med (Berl) , vol.86 , pp. 1233-1241
    • Samani, N.J.1    Braund, P.S.2    Erdmann, J.3
  • 15
    • 77955499945 scopus 로고    scopus 로고
    • From noncoding variant to phenotype via SORT1 at the lpl3 cholesterol locus
    • Musunuru K, Strong A, Frank-Kamenetsky M, et al. From noncoding variant to phenotype via SORT1 at the lpl3 cholesterol locus. Nature. 2010;466:714-719.
    • (2010) Nature , vol.466 , pp. 714-719
    • Musunuru, K.1    Strong, A.2    Frank-Kamenetsky, M.3
  • 16
    • 79956122722 scopus 로고    scopus 로고
    • Sortilin: An unusual suspect in cholesterol metabolism: From GWAS identification to in vivo biochemical analyses, sortilin has been identified as a novel mediator of human lipoprotein metabolism
    • Dube JB, Johansen CT, Hegele RA. Sortilin: an unusual suspect in cholesterol metabolism: from GWAS identification to in vivo biochemical analyses, sortilin has been identified as a novel mediator of human lipoprotein metabolism. Bioessays. 2011;33:430-437.
    • (2011) Bioessays , vol.33 , pp. 430-437
    • Dube, J.B.1    Johansen, C.T.2    Hegele, R.A.3
  • 17
    • 0033605593 scopus 로고    scopus 로고
    • Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase
    • Nielsen MS, Jacobsen C, Olivecrona G, et al. Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J Biol Chem. 1999;274:8832-8836.
    • (1999) J Biol Chem , vol.274 , pp. 8832-8836
    • Nielsen, M.S.1    Jacobsen, C.2    Olivecrona, G.3
  • 18
    • 84862703993 scopus 로고    scopus 로고
    • Sortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins
    • Pallesen LT, Vaegter CB. Sortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins. Mol Neurobiol. 2012;45:379-387.
    • (2012) Mol Neurobiol , vol.45 , pp. 379-387
    • Pallesen, L.T.1    Vaegter, C.B.2
  • 19
    • 14444281750 scopus 로고    scopus 로고
    • Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography
    • Petersen CM, Nielsen MS, Nykjaer A, et al. Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. J Biol Chem. 1997;272:3599-3605.
    • (1997) J Biol Chem , vol.272 , pp. 3599-3605
    • Petersen, C.M.1    Nielsen, M.S.2    Nykjaer, A.3
  • 20
    • 10744219632 scopus 로고    scopus 로고
    • Sortilin is essential for proNGF-induced neuronal cell death
    • Nykjaer A, Lee R, Teng KK, et al. Sortilin is essential for proNGF-induced neuronal cell death. Nature. 2004;427:843-848.
    • (2004) Nature , vol.427 , pp. 843-848
    • Nykjaer, A.1    Lee, R.2    Teng, K.K.3
  • 21
    • 79551474326 scopus 로고    scopus 로고
    • SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk
    • Reitz C, Tokuhiro S, Clark LN, et al. SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk. Ann Neurol. 2011;69:47-64.
    • (2011) Ann Neurol , vol.69 , pp. 47-64
    • Reitz, C.1    Tokuhiro, S.2    Clark, L.N.3
  • 22
    • 84871839229 scopus 로고    scopus 로고
    • Sortilin-related VPS 10 domain containing receptor 1 and Alzheimer's disease-associated allelic variations preferentially exist in female or type 2 diabetes mellitus patients in southern Han Chinese
    • He Y, Fang Z, Yu G. Sortilin-related VPS 10 domain containing receptor 1 and Alzheimer's disease-associated allelic variations preferentially exist in female or type 2 diabetes mellitus patients in southern Han Chinese. Psychogeriatrics. 2012;12:215-225.
    • (2012) Psychogeriatrics , vol.12 , pp. 215-225
    • He, Y.1    Fang, Z.2    Yu, G.3
  • 23
    • 84871815475 scopus 로고    scopus 로고
    • Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein
    • Gustafsen C, Glerup S, Pallesen LT, et al. Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein. J Neurosci. 2013;33:64-71.
    • (2013) J Neurosci , vol.33 , pp. 64-71
    • Gustafsen, C.1    Glerup, S.2    Pallesen, L.T.3
  • 24
    • 78449286213 scopus 로고    scopus 로고
    • Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin
    • Hu F, Padukkavidana T, Vsegter CB, et al. Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron. 2010;68:654-667.
    • (2010) Neuron , vol.68 , pp. 654-667
    • Hu, F.1    Padukkavidana, T.2    Vsegter, C.B.3
  • 25
    • 79953134227 scopus 로고    scopus 로고
    • SorLA regulates the activity of lipoprotein lipase by intracellular trafficking
    • Klinger SC, Glerup S, Raarup MK, et al. SorLA regulates the activity of lipoprotein lipase by intracellular trafficking. J Cell Sci. 2011;124(pt 7):1095-1105.
    • (2011) J Cell Sci , vol.124 , Issue.PART 7 , pp. 1095-1105
    • Klinger, S.C.1    Glerup, S.2    Raarup, M.K.3
  • 26
    • 0026694431 scopus 로고
    • Apolipoprotein B gene mutations affecting cholesterol levels
    • Farese RV Jr, Linton MF, Young SG. Apolipoprotein B gene mutations affecting cholesterol levels. J Intern Med. 1992;231:643-652.
    • (1992) J Intern Med , vol.231 , pp. 643-652
    • Farese Jr., R.V.1    Linton, M.F.2    Young, S.G.3
  • 27
    • 54449087031 scopus 로고    scopus 로고
    • Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS 1 Op domain receptor families
    • Nilsson SK, Christensen S, Raarup MK, et al. Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS 1 Op domain receptor families. JBiol Chem. 2008;283:25920-25927.
    • (2008) JBiol Chem , vol.283 , pp. 25920-25927
    • Nilsson, S.K.1    Christensen, S.2    Raarup, M.K.3
  • 28
    • 77955505564 scopus 로고    scopus 로고
    • Biological, clinical and population relevance of 95 loci for blood lipids
    • Teslovich TM, Musunuru K, Smith AV, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010;466:707-713.
    • (2010) Nature , vol.466 , pp. 707-713
    • Teslovich, T.M.1    Musunuru, K.2    Smith, A.V.3
  • 29
    • 84858783318 scopus 로고    scopus 로고
    • Finding genes and variants for lipid levels after genome-wide association analysis
    • Wilier CJ, Mohlke KL. Finding genes and variants for lipid levels after genome-wide association analysis. Curr Opin Lipidol. 2012;23:98-103.
    • (2012) Curr Opin Lipidol , vol.23 , pp. 98-103
    • Wilier, C.J.1    Mohlke, K.L.2
  • 30
    • 84868689211 scopus 로고    scopus 로고
    • Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia
    • Roth EM, Me Kenney JM, Hanotin C, et al. Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia. NEngl JMed. 2012;367:1891-1900.
    • (2012) NEngl JMed , vol.367 , pp. 1891-1900
    • Roth, E.M.1    Me Kenney, J.M.2    Hanotin, C.3
  • 31
    • 84874760989 scopus 로고    scopus 로고
    • RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function
    • Blattmann P, Schuberth C, Pepperkok R, et al. RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function. PLoS Genet. 2013;9:el003338.
    • (2013) PLoS Genet
    • Blattmann, P.1    Schuberth, C.2    Pepperkok, R.3
  • 32
    • 73649141739 scopus 로고    scopus 로고
    • Genetic variation at chromosome lpl3.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease
    • Linsel-Nitschke P, Heeren J, Aherrahrou Z, et al. Genetic variation at chromosome lpl3.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease. Atherosclerosis. 2010;208:183-189.
    • (2010) Atherosclerosis , vol.208 , pp. 183-189
    • Linsel-Nitschke, P.1    Heeren, J.2    Aherrahrou, Z.3
  • 33
    • 56549111118 scopus 로고    scopus 로고
    • VPS 1 OP-domain receptors-regulators of neuronal viability and function
    • Willnow TE, Petersen CM, Nykjaer A. VPS 1 OP-domain receptors-regulators of neuronal viability and function. Nat Rev Neurosci. 2008;9:899-909.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 899-909
    • Willnow, T.E.1    Petersen, C.M.2    Nykjaer, A.3
  • 34
    • 84873744036 scopus 로고    scopus 로고
    • Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation
    • Capsoni S, Amato G, Vignone D, et al. Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation. Biochem Biophys Res Commun. 2013;431:579-585.
    • (2013) Biochem Biophys Res Commun , vol.431 , pp. 579-585
    • Capsoni, S.1    Amato, G.2    Vignone, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.