메뉴 건너뛰기




Volumn 10, Issue 3, 2014, Pages 459-468

Lacosamide for the treatment of epilepsy

Author keywords

Absorption; Distribution; Elimination; Lacosamide; Partial onset seizures; Pharmacokinetic; Status epilepticus; Toxicology

Indexed keywords

ACETAMIDE DERIVATIVE; ANTICONVULSIVE AGENT; HARKOSERIDE;

EID: 84894164143     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2014.883378     Document Type: Article
Times cited : (26)

References (65)
  • 2
    • 40849123949 scopus 로고    scopus 로고
    • The global burden and stigma of epilepsy
    • de Boer HM, Mula M, Sander JW. The global burden and stigma of epilepsy. Epilepsy Behav 2008;12(4):540-6
    • (2008) Epilepsy Behav , vol.12 , Issue.4 , pp. 540-6
    • De Boer, H.M.1    Mula, M.2    Sander, J.W.3
  • 3
    • 54349115897 scopus 로고    scopus 로고
    • Epilepsy: Epidemiology, classification and natural history
    • Angus-Leppan H, Parsons LM. Epilepsy: Epidemiology, classification and natural history. Medicine 2008;36(11):571-8
    • (2008) Medicine , vol.36 , Issue.11 , pp. 571-8
    • Angus-Leppan, H.1    Parsons, L.M.2
  • 4
    • 67349192949 scopus 로고    scopus 로고
    • The descriptive epidemiology of epilepsya review
    • Banerjee PN, Filippi D, Allen Hauser W. The descriptive epidemiology of epilepsya review. Epilepsy Res 2009;85(1):31-45
    • (2009) Epilepsy Res , vol.85 , Issue.1 , pp. 31-45
    • Banerjee, P.N.1    Filippi, D.2    Allen Hauser, W.3
  • 6
    • 0034598762 scopus 로고    scopus 로고
    • Early identification of refractory epilepsy
    • Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342(5):314-19
    • (2000) N Engl J Med , vol.342 , Issue.5 , pp. 314-19
    • Kwan, P.1    Brodie, M.J.2
  • 7
    • 0037869179 scopus 로고    scopus 로고
    • SPM-927
    • Hovinga CA. SPM-927. IDrugs 2003;6(5):479-85
    • (2003) IDrugs , vol.6 , Issue.5 , pp. 479-85
    • Hovinga, C.A.1
  • 8
    • 84891673132 scopus 로고    scopus 로고
    • Development of new treatment approaches for epilepsy: Unmet needs and opportunities
    • French JA, White HS, Klitgaard H, et al. Development of new treatment approaches for epilepsy: Unmet needs and opportunities. Epilepsia 2013;54(Suppl 4):3-12
    • (2013) Epilepsia , vol.54 , Issue.SUPPL. 4 , pp. 3-12
    • French, J.A.1    White, H.S.2    Klitgaard, H.3
  • 9
    • 84880469215 scopus 로고    scopus 로고
    • Pharmacoresistant epilepsy: Unmet needs in solving the puzzle(s)
    • Weaver DF, Pohlmann-Eden B. Pharmacoresistant epilepsy: Unmet needs in solving the puzzle(s). Epilepsia 2013;54(Suppl 2):80-5
    • (2013) Epilepsia , vol.54 , Issue.SUPPL. 2 , pp. 80-5
    • Weaver, D.F.1    Pohlmann-Eden, B.2
  • 10
    • 84894157229 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence. CG137 epilepsy: NICE guideline 2012. Available from: [Last accessed 22 December 2013]
    • National Institute for Health and Clinical Excellence. CG137 epilepsy: NICE guideline 2012. Available from: Http://guidance.nice.org.uk/CG137/ NICEGuidance/pdf/English [Last accessed 22 December 2013]
  • 11
    • 11144353969 scopus 로고    scopus 로고
    • Efficacy and tolerability of the new antiepileptic drugs II: Treatment of refractory epilepsy: Report of the therapeutics and technology assessment subcommittee and quality standards subcommittee of the american academy of neurology and the american epilepsy society
    • French JA, Kanner AM, Bautista J, et al. Efficacy and tolerability of the new antiepileptic drugs II: Treatment of refractory epilepsy: Report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004;62(8):1261-73
    • (2004) Neurology , vol.62 , Issue.8 , pp. 1261-73
    • French, J.A.1    Kanner, A.M.2    Bautista, J.3
  • 12
    • 84894213760 scopus 로고    scopus 로고
    • European Medicines Agency. Lacosamide: Summary of product characteristics. Available from: [Last accessed 22 December 2013]
    • European Medicines Agency. Lacosamide: Summary of product characteristics. Available from: Www.ema. europa.eu/docs/en-GB/document-library/ EPAR-Product-Information/human/000863/WC500050338.pdf [Last accessed 22 December 2013]
  • 13
    • 84894146142 scopus 로고    scopus 로고
    • US FDA. Vimpat (lacosamide): Highlights of prescribing information. Available from: [Last accessed 22 December 2013]
    • US FDA. Vimpat (lacosamide): Highlights of prescribing information. Available from: Www.accessdata.fda.gov/drugsatfda-docs/label/2013/022253s010, 022254s005,022255s002lbl. pdf [Last accessed 22 December 2013]
  • 14
    • 0036146487 scopus 로고    scopus 로고
    • New antiepileptic drugs currently in clinical trials: Is there a strategy in their development?
    • Bialer M. New antiepileptic drugs currently in clinical trials: Is there a strategy in their development? Ther Drug Monit 2002;24(1):85-90
    • (2002) Ther Drug Monit , vol.24 , Issue.1 , pp. 85-90
    • Bialer, M.1
  • 15
    • 34247855780 scopus 로고    scopus 로고
    • Lacosamide: A review of preclinical properties
    • Review that describes properties and features of LCM
    • Beyreuther BK, Freitag J, Heers C, et al. Lacosamide: A review of preclinical properties. CNS Drug Rev 2007;13(1):21-42 . Review that describes properties and features of LCM.
    • (2007) CNS Drug Rev , vol.13 , Issue.1 , pp. 21-42
    • Beyreuther, B.K.1    Freitag, J.2    Heers, C.3
  • 16
    • 34247550257 scopus 로고    scopus 로고
    • Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy
    • Stöhr T, Kupferberg HJ, Stables JP, et al. Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. Epilepsy Res 2007;74(2-3):147-54
    • (2007) Epilepsy Res , vol.74 , Issue.2-3 , pp. 147-54
    • Stöhr, T.1    Kupferberg, H.J.2    Stables, J.P.3
  • 17
    • 11144232600 scopus 로고    scopus 로고
    • Basic clinical pharmacological investigations of the new antiepileptic drug SPM 927
    • Horstmann R, Bonn R, Cawello W, et al. Basic clinical pharmacological investigations of the new antiepileptic drug SPM 927. Epilepsia 2002;43(Suppl 7):188
    • (2002) Epilepsia , vol.43 , Issue.SUPPL. 7 , pp. 188
    • Horstmann, R.1    Bonn, R.2    Cawello, W.3
  • 18
    • 77949469954 scopus 로고    scopus 로고
    • Lacosamide as treatment for partial epilepsy: Mechanisms of action, pharmacology, effects, and safety
    • Article that describes properties and features of LCM
    • Kellinghaus C. Lacosamide as treatment for partial epilepsy: Mechanisms of action, pharmacology, effects, and safety. Ther Clin Risk Manag 2009;5:757-66 . Article that describes properties and features of LCM.
    • (2009) Ther Clin Risk Manag , vol.5 , pp. 757-66
    • Kellinghaus, C.1
  • 19
    • 84861913387 scopus 로고    scopus 로고
    • Drug binding assays do not reveal specific binding of lacosamide to collapsing response mediator protein 2 (CRMP-2)
    • Wolff C, Carrington B, Varrin-Doyer M, et al. Drug binding assays do not reveal specific binding of lacosamide to collapsing response mediator protein 2 (CRMP-2). CNS Neurosci Ther 2012;18(6):493-500
    • (2012) CNS Neurosci Ther , vol.18 , Issue.6 , pp. 493-500
    • Wolff, C.1    Carrington, B.2    Varrin-Doyer, M.3
  • 20
    • 11844297771 scopus 로고    scopus 로고
    • GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity
    • Yoshimura T, Kawano Y, Arimura N, et al. GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell 2005;120(1):137-49
    • (2005) Cell , vol.120 , Issue.1 , pp. 137-49
    • Yoshimura, T.1    Kawano, Y.2    Arimura, N.3
  • 21
    • 11144259374 scopus 로고    scopus 로고
    • Reduction of hippocampal collapsing response mediated protein-2 in patients with mesial temporal lobe epilepsy
    • Czech T, Yang JW, Csaszar E, et al. Reduction of hippocampal collapsing response mediated protein-2 in patients with mesial temporal lobe epilepsy. Neurochem Res 2004;29(12):2189-96
    • (2004) Neurochem Res , vol.29 , Issue.12 , pp. 2189-96
    • Czech, T.1    Yang, J.W.2    Csaszar, E.3
  • 22
    • 33846193132 scopus 로고    scopus 로고
    • Bioequivalence of short-time infusions compared to oral administration of SPM 927
    • Kropeit D, Schiltmeyer B, Cawello W, et al. Bioequivalence of short-time infusions compared to oral administration of SPM 927. Epilepsia 2004;45(Suppl 7):123-4
    • (2004) Epilepsia , vol.45 , Issue.SUPPL. 7 , pp. 123-4
    • Kropeit, D.1    Schiltmeyer, B.2    Cawello, W.3
  • 23
    • 39749167069 scopus 로고    scopus 로고
    • Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures
    • Trial that demonstrates safety and tolerability of intravenous LCM as replacement for oral LCM
    • Biton V, Rosenfeld WE, Whitesides J, et al. Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures. Epilepsia 2008;49(3):418-24. Trial that demonstrates safety and tolerability of intravenous LCM as replacement for oral LCM.
    • (2008) Epilepsia , vol.49 , Issue.3 , pp. 418-24
    • Biton, V.1    Rosenfeld, W.E.2    Whitesides, J.3
  • 24
    • 57849141134 scopus 로고    scopus 로고
    • Progress report on new antiepileptic drugs: A Summary of the Ninth Eilat Conference (EILAT IX)
    • Bialer M, Johannessenb SI, Levyc RH, et al. Progress report on new antiepileptic drugs: A Summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res 2009;83(1):1-43
    • (2009) Epilepsy Res , vol.83 , Issue.1 , pp. 1-43
    • Bialer, M.1    Johannessenb, S.I.2    Levyc, R.H.3
  • 25
    • 84872086635 scopus 로고    scopus 로고
    • Tolerability pharmacokinetics and bioequivalence of the tablet and syrup formulations of lacosamide in plasma saliva and urine: Saliva as a surrogate of pharmacokinetics in the central compartment
    • Trial that demonstrates bioequivalence of 200 mg LCM oral tablet and syrup formulation
    • Cawello W, Bökens H, Nickel B, et al. Tolerability, pharmacokinetics, and bioequivalence of the tablet and syrup formulations of lacosamide in plasma, saliva, and urine: Saliva as a surrogate of pharmacokinetics in the central compartment. Epilepsia 2013;54(1):81-8 . Trial that demonstrates bioequivalence of 200 mg LCM oral tablet and syrup formulation.
    • (2013) Epilepsia , vol.54 , Issue.1 , pp. 81-8
    • Cawello, W.1    Bökens, H.2    Nickel, B.3
  • 27
    • 33846242456 scopus 로고    scopus 로고
    • Food does not affect the pharmacokinetics of SPM 927
    • Cawello W, Kropeit D, Schiltmeyer B, et al. Food does not affect the pharmacokinetics of SPM 927. Epilepsia 2004;45(Suppl 7):307
    • (2004) Epilepsia , vol.45 , Issue.SUPPL. 7 , pp. 307
    • Cawello, W.1    Kropeit, D.2    Schiltmeyer, B.3
  • 28
    • 84863120232 scopus 로고    scopus 로고
    • Pharmacokinetics brain distribution and plasma protein binding of the antiepileptic drug lacosamide in rats
    • Koo TS, Kim SJ, Ha DJ, et al. Pharmacokinetics, brain distribution, and plasma protein binding of the antiepileptic drug lacosamide in rats. Arch Pharm Res 2011;34(12):2059-64
    • (2011) Arch Pharm Res , vol.34 , Issue.12 , pp. 2059-64
    • Koo, T.S.1    Kim, S.J.2    Ha, D.J.3
  • 29
    • 33846244930 scopus 로고    scopus 로고
    • Pharmacokinetics of the new antiepileptic drug SPM 927 in human subjects with different age and gender
    • Schiltmeyer B, Cawello W, Kropeit D, et al. Pharmacokinetics of the new antiepileptic drug SPM 927 in human subjects with different age and gender. Epilepsia 2004;45(Suppl 7):313
    • (2004) Epilepsia , vol.45 , Issue.SUPPL. 7 , pp. 313
    • Schiltmeyer, B.1    Cawello, W.2    Kropeit, D.3
  • 30
    • 63449105974 scopus 로고    scopus 로고
    • Lacosamide: In partial-onset seizures
    • Cross SA, Curran MP. Lacosamide: In partial-onset seizures. Drugs 2009;69(4):449-59
    • (2009) Drugs , vol.69 , Issue.4 , pp. 449-59
    • Cross, S.A.1    Curran, M.P.2
  • 31
    • 79951659549 scopus 로고    scopus 로고
    • Saliva and serum lacosamide concentrations in patients with epilepsy
    • Greenaway C, Ratnaraj N, Sander JW, Patsalos PN. Saliva and serum lacosamide concentrations in patients with epilepsy. Epilepsia 2011;52(2):258-63
    • (2011) Epilepsia , vol.52 , Issue.2 , pp. 258-63
    • Greenaway, C.1    Ratnaraj, N.2    Sander, J.W.3    Patsalos, P.N.4
  • 32
    • 84872063167 scopus 로고    scopus 로고
    • Low lacosamide plasma protein binding in lacosamide-naive patients
    • Fountain N, Staelens L, Tytgat D, et al. Low lacosamide plasma protein binding in lacosamide-naive patients. Neurology 2012;78:P01.077
    • (2012) Neurology , vol.78
    • Fountain, N.1    Staelens, L.2    Tytgat, D.3
  • 33
    • 40849114132 scopus 로고    scopus 로고
    • Low potential for drug-drug interaction of lacosamide
    • Thomas D, Scharfenecker U, Nickel B, et al. Low potential for drug-drug interaction of lacosamide. Epilepsia 2006;47(Suppl 4):200
    • (2006) Epilepsia , vol.47 , Issue.SUPPL. 4 , pp. 200
    • Thomas, D.1    Scharfenecker, U.2    Nickel, B.3
  • 34
    • 77955504218 scopus 로고    scopus 로고
    • Emerging roles of collapsing response mediator proteins (CRMPs) as regulators of voltage-gated calcium channels and synaptic transmission
    • Wang Y, Brittain JM, Wilson SM, et al. Emerging roles of collapsing response mediator proteins (CRMPs) as regulators of voltage-gated calcium channels and synaptic transmission. Commun Integr Biol 2010;3(2):172-5
    • (2010) Commun Integr Biol , vol.3 , Issue.2 , pp. 172-5
    • Wang, Y.1    Brittain, J.M.2    Wilson, S.M.3
  • 35
    • 40849086321 scopus 로고    scopus 로고
    • Lacosamide: An investigational drug for adjunctive treatment of partial-onset seizures
    • Ben-Menachem E. Lacosamide: An investigational drug for adjunctive treatment of partial-onset seizures. Drugs Today (Barc) 2008;44(1):35-40
    • (2008) Drugs Today (Barc) , vol.44 , Issue.1 , pp. 35-40
    • Ben-Menachem, E.1
  • 36
    • 34447344551 scopus 로고    scopus 로고
    • Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures
    • Phase IIb trial that demonstrates efficacy and tolerability of LCM in the treatment of adults with uncontrolled partial-onset seizures
    • Ben-Menachem E, Biton V, Jatuzis D, et al. Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures. Epilepsia 2007;48(7):1308-17. Phase IIb trial that demonstrates efficacy and tolerability of LCM in the treatment of adults with uncontrolled partial-onset seizures.
    • (2007) Epilepsia , vol.48 , Issue.7 , pp. 1308-17
    • Ben-Menachem, E.1    Biton, V.2    Jatuzis, D.3
  • 37
    • 61849088333 scopus 로고    scopus 로고
    • Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial
    • Phase III trial that demonstrates efficacy and tolerability of LCM in the treatment of adults with uncontrolled partial-onset seizures
    • Halasz P, Kalviainen R, Mazurkiewicz-Beldzinska M, et al. Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial. Epilepsia 2009;50(3):443-53. Phase III trial that demonstrates efficacy and tolerability of LCM in the treatment of adults with uncontrolled partial-onset seizures.
    • (2009) Epilepsia , vol.50 , Issue.3 , pp. 443-53
    • Halasz, P.1    Kalviainen, R.2    Mazurkiewicz-Beldzinska, M.3
  • 38
    • 77953033494 scopus 로고    scopus 로고
    • Lacosamide as adjunctive therapy for partial-onset seizures: A randomized controlled trial
    • Phase III trial that demonstrates efficacy and safety of LCM (400 and 600mg/day) as a adjunctive treatment in patients with uncontrolled partialonset seizures
    • Chung S, Sperling MR, Biton V, et al. Lacosamide as adjunctive therapy for partial-onset seizures: A randomized controlled trial. Epilepsia 2010;51(6):958-67. Phase III trial that demonstrates efficacy and safety of LCM (400 and 600mg/day) as a adjunctive treatment in patients with uncontrolled partialonset seizures.
    • (2010) Epilepsia , vol.51 , Issue.6 , pp. 958-67
    • Chung, S.1    Sperling, M.R.2    Biton, V.3
  • 39
    • 84894136708 scopus 로고    scopus 로고
    • Lacosamide has no potential for interaction with metformin
    • Schiltmeyer B, Thomas D, Horstmann R, et al. Lacosamide has no potential for interaction with metformin. Diabet Med 2006;23(Suppl 4):315-16
    • (2006) Diabet Med , vol.23 , Issue.SUPPL. 4 , pp. 315-16
    • Schiltmeyer, B.1    Thomas, D.2    Horstmann, R.3
  • 40
    • 84879759369 scopus 로고    scopus 로고
    • Lack of effect of lacosamide in the pharmacokinetic and pharmacodynamic profiles of warfarin
    • Stockis A, van Lier JJ, Cawello W, et al. Lack of effect of lacosamide in the pharmacokinetic and pharmacodynamic profiles of warfarin. Epilepsia 2013;54(7):1161-6
    • (2013) Epilepsia , vol.54 , Issue.7 , pp. 1161-6
    • Stockis, A.1    Van Lier, J.J.2    Cawello, W.3
  • 41
    • 84874745080 scopus 로고    scopus 로고
    • Pharmacodynamic and pharmacokinetic evaluation of coadministration of lacosamide and oral contraceptive
    • Cawello W, Rosenkranz B, Schmid B, et al. Pharmacodynamic and pharmacokinetic evaluation of coadministration of lacosamide and oral contraceptive. Epilepsia 2013;54(3):530-6
    • (2013) Epilepsia , vol.54 , Issue.3 , pp. 530-6
    • Cawello, W.1    Rosenkranz, B.2    Schmid, B.3
  • 42
    • 84857551225 scopus 로고    scopus 로고
    • Long-term and efficacy in patients with uncontrolled partial-onset seizures treated with adjunctive lacosamide: Results from a Phase III open-label extension trial
    • Trial that describes long-term efficacy and safety of LCM
    • Husain A, Chung S, Faught E, et al. Long-term and efficacy in patients with uncontrolled partial-onset seizures treated with adjunctive lacosamide: Results from a Phase III open-label extension trial. Epilepsia 2012;53(3):521-8 . Trial that describes long-term efficacy and safety of LCM.
    • (2012) Epilepsia , vol.53 , Issue.3 , pp. 521-8
    • Husain, A.1    Chung, S.2    Faught, E.3
  • 43
    • 84885121938 scopus 로고    scopus 로고
    • Long-term adjunctive lacosamide in patients with uncontrolled partial-onset seizures: Results from the SP774 Phase III open-label extension trial
    • 28th August - 1st September; Rome, Italy
    • Rosenow F, Kelemen A, Ben-Menachem E, et al. Long-term adjunctive lacosamide in patients with uncontrolled partial-onset seizures: Results from the SP774 Phase III open-label extension trial. 29th International Epilepsy Congress; 28th August - 1st September 2011; Rome, Italy
    • (2011) 29th International Epilepsy Congress
    • Rosenow, F.1    Kelemen, A.2    Ben-Menachem, E.3
  • 44
    • 84885110814 scopus 로고    scopus 로고
    • Lacosamide: Long-term safety and efficacy in partial-onset seizures
    • 28th August - 1st September; Rome, Italy
    • Rosenfeld W, Fountain NB, Kaubrys G, et al. Lacosamide: Long-term safety and efficacy in partial-onset seizures. 29th International Epilepsy Congress; 28th August - 1st September 2011; Rome, Italy
    • (2011) 29th International Epilepsy Congress
    • Rosenfeld, W.1    Fountain, N.B.2    Kaubrys, G.3
  • 45
    • 70449533094 scopus 로고    scopus 로고
    • Six months of postmarketing experience with adjunctive lacosamide in patients with pharmacoresistant focal epilepsy at a tertiary epilepsy center in Germany
    • Wehner T, Bauer S, Hamer HM, et al. Six months of postmarketing experience with adjunctive lacosamide in patients with pharmacoresistant focal epilepsy at a tertiary epilepsy center in Germany. Epilepsy Behav 2009;16(3):423-5
    • (2009) Epilepsy Behav , vol.16 , Issue.3 , pp. 423-5
    • Wehner, T.1    Bauer, S.2    Hamer, H.M.3
  • 46
    • 81255150028 scopus 로고    scopus 로고
    • Early clinical experience with lacosamide as adjunctive therapy in patients with refractory focal epilepsy and nocturnal seizures
    • Garcia-Morales I, Delgado RT, Falip M, et al. Early clinical experience with lacosamide as adjunctive therapy in patients with refractory focal epilepsy and nocturnal seizures. Seizure 2011;20(10):801-4
    • (2011) Seizure , vol.20 , Issue.10 , pp. 801-4
    • Garcia-Morales, I.1    Delgado, R.T.2    Falip, M.3
  • 47
    • 84856448512 scopus 로고    scopus 로고
    • Initial post marketing experience with lacosamide in adult patients with epilepsy
    • Harden CL, Cohn A, Lowe M, et al. Initial post marketing experience with lacosamide in adult patients with epilepsy. Epilepsy Res 2012;98(2-3):260-3
    • (2012) Epilepsy Res , vol.98 , Issue.2-3 , pp. 260-3
    • Harden, C.L.1    Cohn, A.2    Lowe, M.3
  • 48
    • 84894209483 scopus 로고    scopus 로고
    • EP2462990A1. European patent application. Available from: [Last accessed 22 December 2013]
    • EP2462990A1. European patent application. Available from: Http://patentimages.storage.googleapis.com/pdfs/43d1839757e9fdc60f9d/ EP2462990A1. pdf [Last accessed 22 December 2013]
  • 49
    • 84894214271 scopus 로고    scopus 로고
    • Registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. Available from:[Last accessed 22 December 2013]
    • Registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. Available from: Http://clinicaltrials.gov/[Last accessed 22 December 2013]
  • 50
    • 59749093137 scopus 로고    scopus 로고
    • Intravenous lacosamide as successful treatment for nonconvulsive status epilepticus after failure of first-line therapy
    • Kellinghaus C, Berning S, Besselmann M. Intravenous lacosamide as successful treatment for nonconvulsive status epilepticus after failure of first-line therapy. Epilepsy Behav 2009;14:429-31
    • (2009) Epilepsy Behav , vol.14 , pp. 429-31
    • Kellinghaus, C.1    Berning, S.2    Besselmann, M.3
  • 51
    • 79955827689 scopus 로고    scopus 로고
    • The use of lacosamide in refractory status epilepticus
    • Goodwin H, Hinson HE, Shermock KM, et al. The use of lacosamide in refractory status epilepticus. Neurocrit Care 2011;14(3):348-53
    • (2011) Neurocrit Care , vol.14 , Issue.3 , pp. 348-53
    • Goodwin, H.1    Hinson, H.E.2    Shermock, K.M.3
  • 52
    • 78650789188 scopus 로고    scopus 로고
    • Intravenous lacosamide for treatment of status epilepticus
    • Article that describes LCM as a treatment option for the treatment of SE after failure of standard therapy or when standard agents are unsuitable
    • Kellinghaus C, Berning S, Immisch I, et al. Intravenous lacosamide for treatment of status epilepticus. Acta Neurol Scand 2011;123(2):137-41 . Article that describes LCM as a treatment option for the treatment of SE after failure of standard therapy or when standard agents are unsuitable.
    • (2011) Acta Neurol Scand , vol.123 , Issue.2 , pp. 137-41
    • Kellinghaus, C.1    Berning, S.2    Immisch, I.3
  • 53
    • 84874745972 scopus 로고    scopus 로고
    • Lacosamide as a new tratment option in status epilepticus
    • Review that describes the efficacy and safety of LCM in the treatment of SE
    • Höfler J, Trinka E. Lacosamide as a new tratment option in status epilepticus. Epilepsia 2013;54(3):393-404. Review that describes the efficacy and safety of LCM in the treatment of SE.
    • (2013) Epilepsia , vol.54 , Issue.3 , pp. 393-404
    • Höfler, J.1    Trinka, E.2
  • 54
    • 79952446608 scopus 로고    scopus 로고
    • The acute and chronic effects of the novel anticonvulsant lacosamide in an experimental model of status epilepticus
    • Wasterlain C, Stçhr T, Mantagne A. The acute and chronic effects of the novel anticonvulsant lacosamide in an experimental model of status epilepticus. Epilepsy Res 2011;94(1-2):10-17
    • (2011) Epilepsy Res , vol.94 , Issue.1-2 , pp. 10-17
    • Wasterlain, C.1    Stçhr, T.2    Mantagne, A.3
  • 55
    • 84887998690 scopus 로고    scopus 로고
    • Intravenous lacosamide as treatment option in post-stroke non convulsive status epilepticus in the elderly: A proofof- concept observational study
    • Article that exhibits safety and efficacy of LCM as a first-choice drug against post-stroke nonconvulsive SE
    • Belcastro V, Vidale S, Pierguidi L, et al. Intravenous lacosamide as treatment option in post-stroke non convulsive status epilepticus in the elderly: A proofof- concept, observational study. Seizure 2013;22(10):905-7 . Article that exhibits safety and efficacy of LCM as a first-choice drug against post-stroke nonconvulsive SE.
    • (2013) Seizure , vol.22 , Issue.10 , pp. 905-7
    • Belcastro, V.1    Vidale, S.2    Pierguidi, L.3
  • 56
    • 84872085935 scopus 로고    scopus 로고
    • Safety and tolerability of adjunctive lacosamide intravenous loading dose in lacosamide-naive patients with partialonset seizures
    • Article that demonstrates the efficacy and tolerability of rapidly initiating adjunctive LCM via a single intravenous loading dose
    • Fountain NB, Krauss G, Isojarvi J, et al. Safety and tolerability of adjunctive lacosamide intravenous loading dose in lacosamide-naive patients with partialonset seizures. Epilepsia 2013;54(1):58-65. Article that demonstrates the efficacy and tolerability of rapidly initiating adjunctive LCM via a single intravenous loading dose.
    • (2013) Epilepsia , vol.54 , Issue.1 , pp. 58-65
    • Fountain, N.B.1    Krauss, G.2    Isojarvi, J.3
  • 57
    • 79955833087 scopus 로고    scopus 로고
    • Experience with lacosamide in a series of children with drug-resistant focal epilepsy
    • Guilhoto LMFF, Loddenkemper T, Gooty VD, et al. Experience with lacosamide in a series of children with drug-resistant focal epilepsy. Pediatr Neurol 2011;44(6):414-19
    • (2011) Pediatr Neurol , vol.44 , Issue.6 , pp. 414-19
    • Lmff, G.1    Loddenkemper, T.2    Gooty, V.D.3
  • 58
    • 84655167165 scopus 로고    scopus 로고
    • Preliminary efficacy and safety of lacosamide in children with refractory epilepsy
    • Heyman E, Lahat E, Levin N, et al. Preliminary efficacy and safety of lacosamide in children with refractory epilepsy. Eur J Paediatr Neurol 2012;16(1):15-19
    • (2012) Eur J Paediatr Neurol , vol.16 , Issue.1 , pp. 15-19
    • Heyman, E.1    Lahat, E.2    Levin, N.3
  • 59
    • 84859342333 scopus 로고    scopus 로고
    • Lacosamide in refractory mixed pediatric epilepsy: A prospective add-on study
    • Rastogi RG, Ng Y. Lacosamide in refractory mixed pediatric epilepsy: A prospective add-on study. J Child Neurol 2012;27(4):492-5
    • (2012) J Child Neurol , vol.27 , Issue.4 , pp. 492-5
    • Rastogi, R.G.1    Ng, Y.2
  • 60
    • 78649357007 scopus 로고    scopus 로고
    • A pooled analysis of lacosamide clinical trial data grouped by mechanism of action of concomitant antiepileptic drugs
    • Sake J, Herbert D, Isojarvi J, et al. A pooled analysis of lacosamide clinical trial data grouped by mechanism of action of concomitant antiepileptic drugs. CNS Drugs 2010;24(12):1055-68
    • (2010) CNS Drugs , vol.24 , Issue.12 , pp. 1055-68
    • Sake, J.1    Herbert, D.2    Isojarvi, J.3
  • 61
    • 84858284935 scopus 로고    scopus 로고
    • Rational polytherapy with lacosamide in clinical practice results of a Spanish cohort analysis RELACOVA
    • Villanueva V, Lopez-Gomariz E, Lopez-Trigo J, et al. Rational polytherapy with lacosamide in clinical practice results of a Spanish cohort analysis RELACOVA. Epilepsy Behav 2012;23(3):298-304
    • (2012) Epilepsy Behav , vol.23 , Issue.3 , pp. 298-304
    • Villanueva, V.1    Lopez-Gomariz, E.2    Lopez-Trigo, J.3
  • 62
    • 84872072110 scopus 로고    scopus 로고
    • The adverse event profile of lacosamide: A systematic review and meta-analysis of randomized controlled trials
    • A review and meta-analysis that describes the side effects of LCM
    • Zaccara G, Perucca P, Loiacono G, et al. The adverse event profile of lacosamide: A systematic review and meta-analysis of randomized controlled trials. Epilepsia 2013;54(1):66-74. A review and meta-analysis that describes the side effects of LCM.
    • (2013) Epilepsia , vol.54 , Issue.1 , pp. 66-74
    • Zaccara, G.1    Perucca, P.2    Loiacono, G.3
  • 63
    • 78651251889 scopus 로고    scopus 로고
    • Lacosamide neurotoxicity associated with concomitant use of sodium channelblocking antiepileptic drugs: A pharmacodynamic interaction?
    • Novy J, Patsalos PN, Sander JW, et al. Lacosamide neurotoxicity associated with concomitant use of sodium channelblocking antiepileptic drugs: A pharmacodynamic interaction? Epilepsy Behav 2011;20(1):20-3
    • (2011) Epilepsy Behav , vol.20 , Issue.1 , pp. 20-3
    • Novy, J.1    Patsalos, P.N.2    Sander, J.W.3
  • 64
    • 84858293570 scopus 로고    scopus 로고
    • Minimizing pharmacodynamic interactions of high doses of lacosamide
    • Edwards HB, Cole AG, Griffiths AS, et al. Minimizing pharmacodynamic interactions of high doses of lacosamide. Acta Neurol Scand 2012;125(4):228-33
    • (2012) Acta Neurol Scand , vol.125 , Issue.4 , pp. 228-33
    • Edwards, H.B.1    Cole, A.G.2    Griffiths, A.S.3
  • 65
    • 77952781301 scopus 로고    scopus 로고
    • Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures
    • Krauss G, Ben-Menachem E, Mameniskiene R, et al. Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures. Epilepsia 2010;51(6):951-7
    • (2010) Epilepsia , vol.51 , Issue.6 , pp. 951-7
    • Krauss, G.1    Ben-Menachem, E.2    Mameniskiene, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.