Pharmacodynamic and pharmacokinetic evaluation of coadministration of lacosamide and an oral contraceptive (levonorgestrel plus ethinylestradiol) in healthy female volunteers

Epilepsia

Volumn 54, Issue 3, 2013, Pages 530-536

  Cawello, Willi ^a   Rosenkranz, Bernd ^b   Schmid, Bernhard ^c   Wierich, Werner ^d  

^a UCB PHARMA   (Belgium)

^b STELLENBOSCH UNIVERSITY   (South Africa)

^c Nuvisan GmbH   (Germany)

^d NONE

Author keywords

Drug drug interaction; Epilepsy; Lacosamide; Oral contraceptive; Pharmacodynamics; Pharmacokinetics

Indexed keywords

ETHINYLESTRADIOL PLUS LEVONORGESTREL; HARKOSERIDE; PROGESTERONE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; BRONCHITIS; CLINICAL TRIAL; DIZZINESS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ERUPTION; DRUG FEVER; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DRY SKIN; ELECTROCARDIOGRAM; EOSINOPHIL COUNT; EOSINOPHILIA; ERYTHEMA; EVENING DOSAGE; FATIGUE; FEMALE; HEMATOMA; HUMAN; HUMAN EXPERIMENT; INFECTION; MAXIMUM PLASMA CONCENTRATION; MENSTRUAL CYCLE; NORMAL HUMAN; OTALGIA; OVULATION INHIBITION; PARESTHESIA; PHYSICAL EXAMINATION; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; PRURITUS; RASH; ROSACEA; SIDE EFFECT; TIME TO MAXIMUM PLASMA CONCENTRATION; TINNITUS; VITAL SIGN;

ACETAMIDES; ADOLESCENT; ADULT; ANTICONVULSANTS; CONTRACEPTIVES, ORAL, COMBINED; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; ETHINYL ESTRADIOL; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEVONORGESTREL; PROGESTERONE; YOUNG ADULT;

EID: 84874745080     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/epi.12085     Document Type: Article

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