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Volumn 118, Issue 5, 2012, Pages 1181-1191

Suboptimal responses in chronic myeloid leukemia: Implications and management strategies

Author keywords

chronic myeloid leukemia; dasatinib; imatinib mesylate; nilotinib; tyrosine kinase inhibitor

Indexed keywords

BOSUTINIB; DANUSERTIB; DASATINIB; IMATINIB; NILOTINIB; PONATINIB;

EID: 84857359667     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.26391     Document Type: Article
Times cited : (18)

References (72)
  • 1
    • 79951575730 scopus 로고    scopus 로고
    • American Cancer Society Accessed on September 1, 2010
    • American Cancer Society. Cancer Facts and Figures 2010. Available at: Accessed on September 1, 2010.
    • (2010) Cancer Facts and Figures
  • 3
    • 0018630746 scopus 로고
    • Transposition of 9q34 and 22(q11qter) regions has a specific role in chronic myelocytic leukemia
    • Pasquali F, Casalone R, Francesconi D, et al. Transposition of 9q34 and 22 (q11toqter) regions has a specific role in chronic myelocytic leukemia. Hum Genet. 1979; 52: 55-67. (Pubitemid 10194799)
    • (1979) Human Genetics , vol.52 , Issue.1 , pp. 55-67
    • Pasquali, F.1    Casalone, R.2    Francesconi, D.3
  • 4
    • 0021811764 scopus 로고
    • Structural organization of the bcr gene and its role in the Ph' translocation
    • DOI 10.1038/315758a0
    • Heisterkamp N, Stam K, Groffen J, de Klein A, Grosveld G,. Structural organization of the bcr gene and its role in the Ph'translocation. Nature. 1985; 315: 758-761. (Pubitemid 15022931)
    • (1985) Nature , vol.315 , Issue.6022 , pp. 758-761
    • Heisterkamp, N.1    Stam, K.2    Groffen, J.3
  • 5
    • 67349233062 scopus 로고    scopus 로고
    • Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia
    • Hochhaus A, O'Brien SG, Guilhot F, et al. Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia. Leukemia. 2009; 23: 1054-1061.
    • (2009) Leukemia , vol.23 , pp. 1054-1061
    • Hochhaus, A.1    O'Brien, S.G.2    Guilhot, F.3
  • 6
    • 77949767505 scopus 로고    scopus 로고
    • International randomized study of interferon vs STI571 (IRIS) 8-year follow up: Sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib [abstract]
    • Deininger M, O'Brien SG, Guilhot F, et al. International randomized study of interferon vs STI571 (IRIS) 8-year follow up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib [abstract]. Blood (ASH Annual Meeting Abstracts). 2009; 114: 1126.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 1126
    • Deininger, M.1    O'Brien, S.G.2    Guilhot, F.3
  • 7
    • 79952726094 scopus 로고    scopus 로고
    • Princeton, NJ: Bristol-Myers Squibb Co
    • Sprycel [package insert]. Princeton, NJ: Bristol-Myers Squibb Co; 2010.
    • (2010) Sprycel [Package Insert]
  • 8
    • 79952725158 scopus 로고    scopus 로고
    • East Hanover, NJ: Novartis Pharmaceuticals
    • Tasigna [package insert]. East Hanover, NJ: Novartis Pharmaceuticals; 2010.
    • (2010) Tasigna [Package Insert]
  • 9
    • 73349122639 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: An update of concepts and management recommendations of European LeukemiaNet
    • Baccarani M, Cortes J, Pane F, et al. Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol. 2009; 27: 6041-6051.
    • (2009) J Clin Oncol , vol.27 , pp. 6041-6051
    • Baccarani, M.1    Cortes, J.2    Pane, F.3
  • 14
    • 43049104149 scopus 로고    scopus 로고
    • Molecular monitoring in chronic myeloid leukemia: Response to tyrosine kinase inhibitors and prognostic implications
    • DOI 10.1002/cncr.23427
    • Jabbour E, Cortes JE, Kantarjian HM,. Molecular monitoring in chronic myeloid leukemia: response to tyrosine kinase inhibitors and prognostic implications. Cancer. 2008; 112: 2112-2118. (Pubitemid 351628619)
    • (2008) Cancer , vol.112 , Issue.10 , pp. 2112-2118
    • Jabbour, E.1    Cortes, J.E.2    Kantarjian, H.M.3
  • 15
    • 66549115119 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia: ESMO clinical recommendations for diagnosis, treatment and follow-up
    • Baccarani M, Dreyling M,. Chronic myelogenous leukemia: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 2009; 20 (suppl 4): 105-107.
    • (2009) Ann Oncol , vol.20 , Issue.SUPPL. 4 , pp. 105-107
    • Baccarani, M.1    Dreyling, M.2
  • 16
    • 67651184109 scopus 로고    scopus 로고
    • Milestones and monitoring in patients with CML treated with imatinib
    • Deininger MW,. Milestones and monitoring in patients with CML treated with imatinib. Hematology Am Soc Hematol Educ Program. 2008: 419-426.
    • (2008) Hematology Am Soc Hematol Educ Program , pp. 419-426
    • Deininger, M.W.1
  • 21
    • 76549114789 scopus 로고    scopus 로고
    • Early prediction of success or failure of treatment with second-generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia
    • Milojkovic D, Nicholson E, Apperley JF, et al. Early prediction of success or failure of treatment with second-generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia. Haematologica. 2010; 95: 224-231.
    • (2010) Haematologica , vol.95 , pp. 224-231
    • Milojkovic, D.1    Nicholson, E.2    Apperley, J.F.3
  • 22
    • 50949119729 scopus 로고    scopus 로고
    • Failure to achieve a major cytogenetic response by 12 months defines inadequate response in patients receiving nilotinib or dasatinib as second or subsequent line therapy for chronic myeloid leukemia
    • Tam CS, Kantarjian H, Garcia-Manero G, et al. Failure to achieve a major cytogenetic response by 12 months defines inadequate response in patients receiving nilotinib or dasatinib as second or subsequent line therapy for chronic myeloid leukemia. Blood. 2008; 112: 516-518.
    • (2008) Blood , vol.112 , pp. 516-518
    • Tam, C.S.1    Kantarjian, H.2    Garcia-Manero, G.3
  • 24
    • 0348015863 scopus 로고    scopus 로고
    • The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia
    • DOI 10.1046/j.1365-2141.2003.04200.x
    • Wang L, Pearson K, Ferguson JE, Clark RE,. The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia. Br J Haematol. 2003; 120: 990-999. (Pubitemid 36411558)
    • (2003) British Journal of Haematology , vol.120 , Issue.6 , pp. 990-999
    • Wang, L.1    Pearson, K.2    Ferguson, J.E.3    Clark, R.E.4
  • 25
    • 68549098145 scopus 로고    scopus 로고
    • Significance of suboptimal response to imatinib, as defined by the European LeukemiaNet, in the long-term outcome of patients with early chronic myeloid leukemia in chronic phase
    • Alvarado Y, Kantarjian H, O'Brien S, et al. Significance of suboptimal response to imatinib, as defined by the European LeukemiaNet, in the long-term outcome of patients with early chronic myeloid leukemia in chronic phase. Cancer. 2009; 115: 3709-3718.
    • (2009) Cancer , vol.115 , pp. 3709-3718
    • Alvarado, Y.1    Kantarjian, H.2    O'Brien, S.3
  • 26
    • 58149396984 scopus 로고    scopus 로고
    • European LeukemiaNet criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor
    • Marin D, Milojkovic D, Olavarria E, et al. European LeukemiaNet criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor. Blood. 2008; 112: 4437-4444.
    • (2008) Blood , vol.112 , pp. 4437-4444
    • Marin, D.1    Milojkovic, D.2    Olavarria, E.3
  • 31
    • 79952782403 scopus 로고    scopus 로고
    • Chronic myeloid leukemia (CML) patients with "suboptimal" response to imatinib (IM) according to European LeukemiaNet criteria have a poorer outcome with respect to "optimal" responders: A GIMEMA CMLWorking Party analysis [abstract]
    • Castagnetti F, Gugliotta G, Palandri F, et al. Chronic myeloid leukemia (CML) patients with "suboptimal" response to imatinib (IM) according to European LeukemiaNet criteria have a poorer outcome with respect to "optimal" responders: a GIMEMA CMLWorking Party analysis [abstract]. Blood (ASH Annual Meeting Abstracts). 2009; 114: 2196.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 2196
    • Castagnetti, F.1    Gugliotta, G.2    Palandri, F.3
  • 32
    • 67650587143 scopus 로고    scopus 로고
    • Delayed achievement of cytogenetic and molecular response is associated with increased risk of progression among patients with chronic myeloid leukemia in early chronic phase receiving high-dose or standard-dose imatinib therapy
    • Quintas-Cardama A, Kantarjian H, Jones D, et al. Delayed achievement of cytogenetic and molecular response is associated with increased risk of progression among patients with chronic myeloid leukemia in early chronic phase receiving high-dose or standard-dose imatinib therapy. Blood. 2009; 113: 6315-6321.
    • (2009) Blood , vol.113 , pp. 6315-6321
    • Quintas-Cardama, A.1    Kantarjian, H.2    Jones, D.3
  • 33
    • 77958595179 scopus 로고    scopus 로고
    • Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: An analysis from the International Randomized Study of Interferon versus STI571 (IRIS)
    • Hughes TP, Hochhaus A, Branford S, et al. Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon versus STI571 (IRIS). Blood. 2010; 116: 3758-3765.
    • (2010) Blood , vol.116 , pp. 3758-3765
    • Hughes, T.P.1    Hochhaus, A.2    Branford, S.3
  • 34
    • 77953691179 scopus 로고    scopus 로고
    • Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia
    • Saglio G, Kim DW, Issaragrisil S, et al. Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med. 2010; 362: 2251-2259.
    • (2010) N Engl J Med , vol.362 , pp. 2251-2259
    • Saglio, G.1    Kim, D.W.2    Issaragrisil, S.3
  • 35
    • 77952467377 scopus 로고    scopus 로고
    • Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib
    • Marin D, Bazeos A, Mahon FX, et al. Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib. J Clin Oncol. 2010; 28: 2381-2388.
    • (2010) J Clin Oncol , vol.28 , pp. 2381-2388
    • Marin, D.1    Bazeos, A.2    Mahon, F.X.3
  • 37
    • 67049087117 scopus 로고    scopus 로고
    • Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: The ADAGIO study
    • Noens L, van Lierde MA, De Bock R, et al. Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: the ADAGIO study. Blood. 2009; 113: 5401-5411.
    • (2009) Blood , vol.113 , pp. 5401-5411
    • Noens, L.1    Van Lierde, M.A.2    De Bock, R.3
  • 39
    • 77950396947 scopus 로고    scopus 로고
    • Significant higher rates of undetectable molecular residual disease and molecular responses with pegylated form of interferon a2a in combination with imatinib (IM) for the treatment of newly diagnosed chronic phase (CP) chronic myeloid leukaemia (CML) patients (pts): Confirmatory results at 18 months of part 1 of the SPIRIT phase III randomized trial of the French CML group (FI LMC) [abstract]
    • Guilhot F, Preudhomme C, Guilhot J, et al. Significant higher rates of undetectable molecular residual disease and molecular responses with pegylated form of interferon a2a in combination with imatinib (IM) for the treatment of newly diagnosed chronic phase (CP) chronic myeloid leukaemia (CML) patients (pts): confirmatory results at 18 months of part 1 of the SPIRIT phase III randomized trial of the French CML group (FI LMC) [abstract]. Blood (ASH Annual Meeting Abstracts). 2009; 114: 340.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 340
    • Guilhot, F.1    Preudhomme, C.2    Guilhot, J.3
  • 40
    • 77953241114 scopus 로고    scopus 로고
    • Randomized comparison of imatinib 800 mg vs. imatinib 400 mg +/- IFN in newly diagnosed BCR/ABL positive chronic phase CML: Analysis of molecular remission at 12 months. The German CML-Study IV [abstract]
    • Hehlmann R, Jung-Munkwitz S, Lauseker M, et al. Randomized comparison of imatinib 800 mg vs. imatinib 400 mg +/- IFN in newly diagnosed BCR/ABL positive chronic phase CML: analysis of molecular remission at 12 months. The German CML-Study IV [abstract]. Blood (ASH Annual Meeting Abstracts). 2009; 114: 339.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 339
    • Hehlmann, R.1    Jung-Munkwitz, S.2    Lauseker, M.3
  • 42
    • 64049099666 scopus 로고    scopus 로고
    • Imatinib mesylate dose escalation is associated with durable responses in patients with chronic myeloid leukemia after cytogenetic failure on standard-dose imatinib therapy
    • Jabbour E, Kantarjian HM, Jones D, et al. Imatinib mesylate dose escalation is associated with durable responses in patients with chronic myeloid leukemia after cytogenetic failure on standard-dose imatinib therapy. Blood. 2009; 113: 2154-2160.
    • (2009) Blood , vol.113 , pp. 2154-2160
    • Jabbour, E.1    Kantarjian, H.M.2    Jones, D.3
  • 43
    • 60049092698 scopus 로고    scopus 로고
    • Efficacy of imatinib dose escalation in patients with chronic myeloid leukemia in chronic phase
    • Kantarjian HM, Larson RA, Guilhot F, et al. Efficacy of imatinib dose escalation in patients with chronic myeloid leukemia in chronic phase. Cancer. 2009; 115: 551-560.
    • (2009) Cancer , vol.115 , pp. 551-560
    • Kantarjian, H.M.1    Larson, R.A.2    Guilhot, F.3
  • 44
    • 77953072695 scopus 로고    scopus 로고
    • Phase IV study evaluating efficacy of escalated dose of imatinib in chronic myeloid leukemia patients showing suboptimal response to standard dose imatinib
    • Koh Y, Kim I, Yoon SS, et al. Phase IV study evaluating efficacy of escalated dose of imatinib in chronic myeloid leukemia patients showing suboptimal response to standard dose imatinib. Ann Hematol. 2010; 89: 725-731.
    • (2010) Ann Hematol , vol.89 , pp. 725-731
    • Koh, Y.1    Kim, I.2    Yoon, S.S.3
  • 45
    • 0038176390 scopus 로고    scopus 로고
    • The effect of dose increase of imatinib mesylate in patients with chronic or accelerated phase chronic myelogenous leukemia with inadequate hematologic or cytogenetic response to initial treatment
    • Zonder JA, Pemberton P, Brandt H, Mohamed AN, Schiffer CA,. The effect of dose increase of imatinib mesylate in patients with chronic or accelerated phase chronic myelogenous leukemia with inadequate hematologic or cytogenetic response to initial treatment. Clin Cancer Res. 2003; 9: 2092-2097. (Pubitemid 36687630)
    • (2003) Clinical Cancer Research , vol.9 , Issue.6 , pp. 2092-2097
    • Zonder, J.A.1    Pemberton, P.2    Brandt, H.3    Mohamed, A.N.4    Schiffer, C.A.5
  • 47
    • 77955450607 scopus 로고    scopus 로고
    • Impact of prior therapy and suboptimal response to imatinib on the efficacy and safety of nilotinib among 1,422 patients with imatinib-resistant or -intolerant chronic myeloid leukemia (CML) in chronic phase (CP): Sub-analyses of the ENACT (Expanding Nilotinib Access in Clinical Trials) study [abstract]
    • Nicolini FE, Kim D-W, Ceglarek B, et al. Impact of prior therapy and suboptimal response to imatinib on the efficacy and safety of nilotinib among 1,422 patients with imatinib-resistant or -intolerant chronic myeloid leukemia (CML) in chronic phase (CP): sub-analyses of the ENACT (Expanding Nilotinib Access In Clinical Trials) study [abstract]. Blood (ASH Annual Meeting Abstracts). 2009; 114: 2201.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 2201
    • Nicolini, F.E.1    Kim, D.-W.2    Ceglarek, B.3
  • 48
    • 84857644148 scopus 로고    scopus 로고
    • Nilotinib responses and tolerability confirmed in North American patients with chronic myeloid leukemia (CML) from ENACT (Expanding Nilotinib Access in Clinical Trials) [abstract]
    • Powell BL, Khoury HJ, Lipton JH, Rizzieri DA, Williams D, Turner AR,. Nilotinib responses and tolerability confirmed in North American patients with chronic myeloid leukemia (CML) from ENACT (Expanding Nilotinib Access in Clinical Trials) [abstract]. Blood (ASH Annual Meeting Abstracts). 2009; 114: 3295.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 3295
    • Powell, B.L.1    Khoury, H.J.2    Lipton, J.H.3    Rizzieri, D.A.4    Williams, D.5    Turner, A.R.6
  • 49
    • 79551708576 scopus 로고    scopus 로고
    • Patterns and management of selected adverse events of adult patients with imatinib-resistant or -intolerant chronic myeloid leukemia (CML) from the ENACT (Expanding Nilotinib Access in Clinical Trials) study [abstract]
    • le Coutre PD, Ceglarek B, Turkina A, et al. Patterns and management of selected adverse events of adult patients with imatinib-resistant or -intolerant chronic myeloid leukemia (CML) from the ENACT (Expanding Nilotinib Access In Clinical Trials) study [abstract]. Blood (ASH Annual Meeting Abstracts). 2009; 114: 1115.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 1115
    • Le Coutre, P.D.1    Ceglarek, B.2    Turkina, A.3
  • 50
    • 78649662408 scopus 로고    scopus 로고
    • Nilotinib-associated molecular responses achieved in chronic myeloid leukemia in chronic phase (CML-CP) patients with a suboptimal molecular response to imatinib [abstract]
    • Yang AS, Jillella A, Miller CB, et al. Nilotinib-associated molecular responses achieved in chronic myeloid leukemia in chronic phase (CML-CP) patients with a suboptimal molecular response to imatinib [abstract]. Blood (ASH Annual Meeting Abstracts). 2009; 114: 2206.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 2206
    • Yang, A.S.1    Jillella, A.2    Miller, C.B.3
  • 51
    • 84857372063 scopus 로고    scopus 로고
    • Patients (Pts) with Ph+ chronic myeloid leukemia in chronic phase (CML-CP) with a suboptimal molecular response to imatinib (IM) can achieve deeper responses when switched to nilotinib [abstract]
    • Miller C, Ailawadhi S, Jillella AP, et al. Patients (Pts) with Ph+ chronic myeloid leukemia in chronic phase (CML-CP) with a suboptimal molecular response to imatinib (IM) can achieve deeper responses when switched to nilotinib [abstract]. Blood (ASH Annual Meeting Abstracts). 2010; 116: 2301.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 2301
    • Miller, C.1    Ailawadhi, S.2    Jillella, A.P.3
  • 52
    • 79952037284 scopus 로고    scopus 로고
    • Selective escalation of imatinib therapy and early switching to nilotinib in de novo chronic phase CML patients: Interim results from the TIDEL-II trial [abstract]
    • Yeung DT, Osborn M, White DL, et al. Selective escalation of imatinib therapy and early switching to nilotinib in de novo chronic phase CML patients: interim results from the TIDEL-II trial [abstract]. Blood (ASH Annual Meeting Abstracts). 2010; 116: 209.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 209
    • Yeung, D.T.1    Osborn, M.2    White, D.L.3
  • 55
    • 49249121723 scopus 로고    scopus 로고
    • Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia
    • Shah NP, Kantarjian HM, Kim DW, et al. Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia. J Clin Oncol. 2008; 26: 3204-3212.
    • (2008) J Clin Oncol , vol.26 , pp. 3204-3212
    • Shah, N.P.1    Kantarjian, H.M.2    Kim, D.W.3
  • 56
    • 79956130861 scopus 로고    scopus 로고
    • Four-year follow-up of patients with chronic-phase chronic myeloid leukemia (CP-CML) receiving 100 mg of dasatinib once daily [abstract]
    • Shah NP, Cortes JE, Schiffer CA, et al. Four-year follow-up of patients with chronic-phase chronic myeloid leukemia (CP-CML) receiving 100 mg of dasatinib once daily [abstract]. J Clin Oncol. 2010; 28 (15 suppl): 6512.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL. , pp. 6512
    • Shah, N.P.1    Cortes, J.E.2    Schiffer, C.A.3
  • 57
    • 79952038063 scopus 로고    scopus 로고
    • ENESTnd update: Continued superiority of nilotinib versus imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) [abstract]
    • Hughes TP, Hochhaus A, Saglio G, et al. ENESTnd update: continued superiority of nilotinib versus imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) [abstract]. Blood (ASH Annual Meeting Abstracts). 2010; 116: 207.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 207
    • Hughes, T.P.1    Hochhaus, A.2    Saglio, G.3
  • 58
    • 79952038795 scopus 로고    scopus 로고
    • Dasatinib versus imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) in the DASISION trial: 18-month follow-up [abstract]
    • Shah N, Kantarjian H, Hochhaus A, et al. Dasatinib versus imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) in the DASISION trial: 18-month follow-up [abstract]. Blood (ASH Annual Meeting Abstracts). 2010; 116: 206.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 206
    • Shah, N.1    Kantarjian, H.2    Hochhaus, A.3
  • 59
    • 77954659561 scopus 로고    scopus 로고
    • Nilotinib is active in chronic and accelerated phase chronic myeloid leukemia following failure of imatinib and dasatinib therapy
    • Giles FJ, Abruzzese E, Rosti G, et al. Nilotinib is active in chronic and accelerated phase chronic myeloid leukemia following failure of imatinib and dasatinib therapy. Leukemia. 2010; 24: 1299-1301.
    • (2010) Leukemia , vol.24 , pp. 1299-1301
    • Giles, F.J.1    Abruzzese, E.2    Rosti, G.3
  • 60
    • 33846200681 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) is active in Philadelphia chromosome-positive chronic myelogenous leukemia after imatinib and nilotinib (AMN107) therapy failure
    • DOI 10.1182/blood-2006-07-035493
    • Quintas-Cardama A, Kantarjian H, Jones D, et al. Dasatinib (BMS-354825) is active in Philadelphia chromosome-positive chronic myelogenous leukemia after imatinib and nilotinib (AMN107) therapy failure. Blood. 2007; 109: 497-499. (Pubitemid 46105944)
    • (2007) Blood , vol.109 , Issue.2 , pp. 497-499
    • Quintas-Cardama, A.1    Kantarjian, H.2    Jones, D.3    Nicaise, C.4    O'Brien, S.5    Giles, F.6    Talpaz, M.7    Cortes, J.8
  • 61
    • 77949674913 scopus 로고    scopus 로고
    • A phase 1 trial of oral AP24534 in patients with refractory chronic myeloid leukemia and other hematologic malignancies: First results of safety and clinical activity against T315I and resistant mutations [abstract]
    • Cortes J, Talpaz M, Deininger M, et al. A phase 1 trial of oral AP24534 in patients with refractory chronic myeloid leukemia and other hematologic malignancies: first results of safety and clinical activity against T315I and resistant mutations [abstract]. Blood (ASH Annual Meeting Abstracts). 2009; 114: 643.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 643
    • Cortes, J.1    Talpaz, M.2    Deininger, M.3
  • 62
    • 77950919574 scopus 로고    scopus 로고
    • Danusertib hydrochloride (PHA-739358), a multi-kinase aurora inhibitor, elicits clinical benefit in advanced chronic myeloid leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia [abstract]
    • Cortes-Franco J, Dombret H, Schafhausen P, et al. Danusertib hydrochloride (PHA-739358), a multi-kinase aurora inhibitor, elicits clinical benefit in advanced chronic myeloid leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia [abstract]. Blood (ASH Annual Meeting Abstracts). 2009; 114: 864.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 864
    • Cortes-Franco, J.1    Dombret, H.2    Schafhausen, P.3
  • 63
    • 65649108082 scopus 로고    scopus 로고
    • Efficacy and safety of bosutinib (SKI-606) in patients with chronic phase (CP) Ph+ chronic myelogenous leukemia (CML) with resistance or intolerance to imatinib [abstract]
    • Cortes J, Kantarjian HM, Kim D-W, et al. Efficacy and safety of bosutinib (SKI-606) in patients with chronic phase (CP) Ph+ chronic myelogenous leukemia (CML) with resistance or intolerance to imatinib [abstract]. Blood (ASH Annual Meeting Abstracts). 2008; 112: 1098.
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112 , pp. 1098
    • Cortes, J.1    Kantarjian, H.M.2    Kim, D.-W.3
  • 64
    • 80051724345 scopus 로고    scopus 로고
    • Bosutinib as third-line treatment for chronic phase chronic myeloid leukemia following failure of second-line therapy with dasatinib or nilotinib [abstract]
    • Khoury HJ, Kim D-W, Zaritskey A, et al. Bosutinib as third-line treatment for chronic phase chronic myeloid leukemia following failure of second-line therapy with dasatinib or nilotinib [abstract]. Blood (ASH Annual Meeting Abstracts). 2010; 116: 892.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 892
    • Khoury, H.J.1    Kim, D.-W.2    Zaritskey, A.3
  • 65
    • 72849159485 scopus 로고
    • Chromosome studies on normal and leukemic human leukocytes
    • Nowell PC, Hungerford DA,. Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst. 1960; 25: 85-109.
    • (1960) J Natl Cancer Inst , vol.25 , pp. 85-109
    • Nowell, P.C.1    Hungerford, D.A.2
  • 66
    • 33947496833 scopus 로고    scopus 로고
    • Diagnosis and management of chronic myeloid leukemia: A survey of American and European practice patterns
    • DOI 10.1002/cncr.22523
    • Kantarjian HM, Cortes J, Guilhot F, Hochhaus A, Baccarani M, Lokey L,. Diagnosis and management of chronic myeloid leukemia: a survey of American and European practice patterns. Cancer. 2007; 109: 1365-1375. (Pubitemid 46466564)
    • (2007) Cancer , vol.109 , Issue.7 , pp. 1365-1375
    • Kantarjian, H.M.1    Cortes, J.2    Guilhot, F.3    Hochhaus, A.4    Baccarani, M.5    Lokey, L.6
  • 71
    • 34948829146 scopus 로고    scopus 로고
    • Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: Interim results of a phase 2 study
    • DOI 10.1182/blood-2007-02-073528
    • Ottmann O, Dombret H, Martinelli G, et al. Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study. Blood. 2007; 110: 2309-2315. (Pubitemid 47523149)
    • (2007) Blood , vol.110 , Issue.7 , pp. 2309-2315
    • Ottmann, O.1    Dombret, H.2    Martinelli, G.3    Simonsson, B.4    Guilhot, F.5    Larson, R.A.6    Rege-Cambrin, G.7    Radich, J.8    Hochhaus, A.9    Apanovitch, A.M.10    Gollerkeri, A.11    Coutre, S.12


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