메뉴 건너뛰기




Volumn 23, Issue 2, 2014, Pages 143-148

The epithelial Na+ channel: A new player in the vasculature

Author keywords

Aldosterone; ENaC; Endothelial cells; Nitric oxide; Shear stress

Indexed keywords

ANIMALS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; EPITHELIAL SODIUM CHANNELS; HUMANS; HYPERTENSION; MECHANOTRANSDUCTION, CELLULAR; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; SODIUM; STRESS, MECHANICAL;

EID: 84894107277     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/01.mnh.0000441054.88962.2c     Document Type: Review
Times cited : (27)

References (43)
  • 1
    • 0033858350 scopus 로고    scopus 로고
    • Structure and regulation of amiloride sensitive sodium channels
    • Alvarez de la Rosa D, Canessa CM, Fyfe GK, et al. Structure and regulation of amiloride sensitive sodium channels. Annu Rev Physiol 2000; 62:573-594.
    • (2000) Annu Rev Physiol , vol.62 , pp. 573-594
    • De La Rosa Alvarez, D.1    Canessa, C.M.2    Fyfe, G.K.3
  • 2
    • 0030945484 scopus 로고    scopus 로고
    • Epithelial sodium channels: Function, structure, and regulation
    • Garty H, Palmer LG. Epithelial sodium channels: function, structure, and regulation. Phys Rev 1997; 77:359-396.
    • (1997) Phys Rev , vol.77 , pp. 359-396
    • Garty, H.1    Palmer, L.G.2
  • 3
    • 84901938271 scopus 로고    scopus 로고
    • The role of ENaC in vascular endothelium
    • doi: 10.1007/s0042-013-1356-3. [Epub ahead of print]
    • Kusche-Vihrog K, Jeggle P, Oberleithner H. The role of ENaC in vascular endothelium. Pflugers Arch 2013. doi: 10.1007/s0042-013-1356-3. [Epub ahead of print]
    • (2013) Pflugers Arch
    • Kusche-Vihrog, K.1    Jeggle, P.2    Oberleithner, H.3
  • 4
    • 0032702619 scopus 로고    scopus 로고
    • Genetic variants in the epithelial sodium channel in relation to aldosterone and potassium excretion and risk for hypertension
    • Ambrosius WT, Bloem LJ, Zhou L, et al. Genetic variants in the epithelial sodium channel in relation to aldosterone and potassium excretion and risk for hypertension. Hypertension 1999; 34:631-637.
    • (1999) Hypertension , vol.34 , pp. 631-637
    • Ambrosius, W.T.1    Bloem, L.J.2    Zhou, L.3
  • 5
    • 0027946089 scopus 로고
    • Liddle's syndrome: Heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel
    • Shimkets RA, Warnock DG, Bositis CM, et al. Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 1994; 79:407-414.
    • (1994) Cell , vol.79 , pp. 407-414
    • Shimkets, R.A.1    Warnock, D.G.2    Bositis, C.M.3
  • 6
    • 0031594450 scopus 로고    scopus 로고
    • Liddle syndrome: An autosomal dominant form of human hypertension
    • Warnock DG. Liddle syndrome: an autosomal dominant form of human hypertension. Kidney Intern 1998; 53:18-24.
    • (1998) Kidney Intern , vol.53 , pp. 18-24
    • Warnock, D.G.1
  • 7
    • 84876670590 scopus 로고    scopus 로고
    • Epithelial sodium channel stiffens the vascular endothelium in vitro and in Liddle mice
    • Jeggle P, Callies C, Tarjus A, et al. Epithelial sodium channel stiffens the vascular endothelium in vitro and in Liddle mice. Hypertension 2013; 61:1053-1059.
    • (2013) Hypertension , vol.61 , pp. 1053-1059
    • Jeggle, P.1    Callies, C.2    Tarjus, A.3
  • 8
    • 84876691199 scopus 로고    scopus 로고
    • The amiloride-sensitive endothelial sodium channel and vascular tone
    • Warnock DG. The amiloride-sensitive endothelial sodium channel and vascular tone. Hypertension 2013; 61:952-954.
    • (2013) Hypertension , vol.61 , pp. 952-954
    • Warnock, D.G.1
  • 10
    • 33846829686 scopus 로고    scopus 로고
    • Dose-dependent endothelial cell growth and stiffening by aldosterone: Endothelial protection by eplerenone
    • Hillebrand U, Schillers H, Riethmuller C, et al. Dose-dependent endothelial cell growth and stiffening by aldosterone: endothelial protection by eplerenone. J Hypertens 2007; 25:639-647.
    • (2007) J Hypertens , vol.25 , pp. 639-647
    • Hillebrand, U.1    Schillers, H.2    Riethmuller, C.3
  • 11
    • 33744533444 scopus 로고    scopus 로고
    • Differential action of steroid hormones on human endothelium
    • Oberleithner H, Riethmuller C, Ludwig T, et al. Differential action of steroid hormones on human endothelium. J Cell Sci 2006; 119:1926-1932.
    • (2006) J Cell Sci , vol.119 , pp. 1926-1932
    • Oberleithner, H.1    Riethmuller, C.2    Ludwig, T.3
  • 13
    • 0034811390 scopus 로고    scopus 로고
    • Mineralocorticoid receptormediated signaling regulates the ion gated sodium channel in vascular endothelial cells and requires an intact cytoskeleton
    • Golestaneh N, Klein C, Valamanesh F, et al. Mineralocorticoid receptormediated signaling regulates the ion gated sodium channel in vascular endothelial cells and requires an intact cytoskeleton. Biochem Biophys Res Commun 2001; 280:1300-1306.
    • (2001) Biochem Biophys Res Commun , vol.280 , pp. 1300-1306
    • Golestaneh, N.1    Klein, C.2    Valamanesh, F.3
  • 14
    • 0032806149 scopus 로고    scopus 로고
    • Immunochemical analysis of the sodium channel in rodent and human eye
    • Mirshahi M, Nicolas C, Mirshahi S, et al. Immunochemical analysis of the sodium channel in rodent and human eye. Exp Eye Res 1999; 69:21-32.
    • (1999) Exp Eye Res , vol.69 , pp. 21-32
    • Mirshahi, M.1    Nicolas, C.2    Mirshahi, S.3
  • 15
    • 1842477357 scopus 로고    scopus 로고
    • Aldosterone signaling modifies capillary formation by human bone marrow endothelial cells
    • Chen W, Valamanesh F, Mirshahi T, et al. Aldosterone signaling modifies capillary formation by human bone marrow endothelial cells. Vascul Pharmacol 2004; 40:269-277.
    • (2004) Vascul Pharmacol , vol.40 , pp. 269-277
    • Chen, W.1    Valamanesh, F.2    Mirshahi, T.3
  • 16
    • 62149087087 scopus 로고    scopus 로고
    • Functional ENaC channels expressed in endothelial cells: A new candidate for mediating shear force
    • Wang S, Meng F, Mohan S, et al. Functional ENaC channels expressed in endothelial cells: a new candidate for mediating shear force. Microcirculation 2009; 16:276-287.
    • (2009) Microcirculation , vol.16 , pp. 276-287
    • Wang, S.1    Meng, F.2    Mohan, S.3
  • 17
    • 84856736864 scopus 로고    scopus 로고
    • Firewall function of the endothelial glycocalyx in the regulation of sodium homeostasis
    • Korte S, Wiesinger A, Straeter AS, et al. Firewall function of the endothelial glycocalyx in the regulation of sodium homeostasis. Pflugers Arch 2012; 463:269-278.
    • (2012) Pflugers Arch , vol.463 , pp. 269-278
    • Korte, S.1    Wiesinger, A.2    Straeter, A.S.3
  • 18
    • 77954242394 scopus 로고    scopus 로고
    • The epithelial sodium channel (ENaC): Mediator of the aldosterone response in the vascular endothelium?
    • Kusche-Vihrog K, Callies C, Fels J, et al. The epithelial sodium channel (ENaC): mediator of the aldosterone response in the vascular endothelium? Steroids 2009; 75:544-549.
    • (2009) Steroids , vol.75 , pp. 544-549
    • Kusche-Vihrog, K.1    Callies, C.2    Fels, J.3
  • 19
    • 67049155914 scopus 로고    scopus 로고
    • Endothelial epithelial sodium channel inhibition activates endothelial nitric oxide synthase via phosphoinositide 3-kinase/Akt in small-diameter mesenteric arteries
    • Perez FR, Venegas F, Gonzalez M, et al. Endothelial epithelial sodium channel inhibition activates endothelial nitric oxide synthase via phosphoinositide 3-kinase/Akt in small-diameter mesenteric arteries. Hypertension 2009; 53:1000-1007.
    • (2009) Hypertension , vol.53 , pp. 1000-1007
    • Perez, F.R.1    Venegas, F.2    Gonzalez, M.3
  • 20
    • 37249005847 scopus 로고    scopus 로고
    • Aldosterone and amiloride alter ENaC abundance in vascular endothelium
    • Kusche-Vihrog K, Sobczak K, Bangel N, et al. Aldosterone and amiloride alter ENaC abundance in vascular endothelium. Pflugers Arch 2008; 455:849-857.
    • (2008) Pflugers Arch , vol.455 , pp. 849-857
    • Kusche-Vihrog, K.1    Sobczak, K.2    Bangel, N.3
  • 21
    • 67349097368 scopus 로고    scopus 로고
    • Aldosterone receptor sites on plasma membrane of human vascular endothelium detected by a mechanical nanosensor
    • Wildling L, Hinterdorfer P, Kusche-Vihrog K, et al. Aldosterone receptor sites on plasma membrane of human vascular endothelium detected by a mechanical nanosensor. Pflugers Arch 2009; 458:223-230.
    • (2009) Pflugers Arch , vol.458 , pp. 223-230
    • Wildling, L.1    Hinterdorfer, P.2    Kusche-Vihrog, K.3
  • 22
    • 44949169677 scopus 로고    scopus 로고
    • Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion
    • Caprio M, Newfell BG, la Sala A, et al. Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion. Circ Res 2008; 102:1359-1367.
    • (2008) Circ Res , vol.102 , pp. 1359-1367
    • Caprio, M.1    Newfell, B.G.2    La Sala, A.3
  • 23
    • 36048995394 scopus 로고    scopus 로고
    • Plasma sodium stiffens vascular endothelium and reduces nitric oxide release
    • Oberleithner H, Riethmuller C, Schillers H, et al. Plasma sodium stiffens vascular endothelium and reduces nitric oxide release. Proc Natl Acad Sci USA 2007; 104:16281-16286.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 16281-16286
    • Oberleithner, H.1    Riethmuller, C.2    Schillers, H.3
  • 24
    • 84872375509 scopus 로고    scopus 로고
    • Feedback inhibition of ENaC during acute sodium loading in vivo
    • Patel AB, Frindt G, Palmer LG. Feedback inhibition of ENaC during acute sodium loading in vivo. Am J Physiol Renal Physiol 2013; 304:F222-F232.
    • (2013) Am J Physiol Renal Physiol , vol.304
    • Patel, A.B.1    Frindt, G.2    Palmer, L.G.3
  • 25
    • 0033118702 scopus 로고    scopus 로고
    • Feedback inhibition of rat amiloride-sensitive epithelial sodium channels expressed in Xenopus laevis oocytes
    • Abriel H, Horisberger J-D. Feedback inhibition of rat amiloride-sensitive epithelial sodium channels expressed in Xenopus laevis oocytes. J Physiol (Lond) 1999; 516:31-43.
    • (1999) J Physiol (Lond) , vol.516 , pp. 31-43
    • Abriel, H.1    Horisberger, J.-D.2
  • 26
    • 24944578474 scopus 로고    scopus 로고
    • Vascular ENaC proteins are required for renal myogenic constriction
    • Jernigan NL, Drummond HA. Vascular ENaC proteins are required for renal myogenic constriction. Am J Physiol Renal Physiol 2005; 289:F891-F901.
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Jernigan, N.L.1    Drummond, H.A.2
  • 27
    • 42349100626 scopus 로고    scopus 로고
    • Sensing tension: Epithelial sodium channel/acid-sensing ion channel proteins in cardiovascular homeostasis
    • Drummond HA, Jernigan NL, Grifoni SC. Sensing tension: epithelial sodium channel/acid-sensing ion channel proteins in cardiovascular homeostasis. Hypertension 2008; 51:1265-1271.
    • (2008) Hypertension , vol.51 , pp. 1265-1271
    • Drummond, H.A.1    Jernigan, N.L.2    Grifoni, S.C.3
  • 28
    • 7244260316 scopus 로고    scopus 로고
    • Degenerin/epithelial Na channel proteins: Components of a vascular mechanosensor
    • Drummond HA, Gebremedhin D, Harder DR. Degenerin/epithelial Na channel proteins: components of a vascular mechanosensor. Hypertension 2004; 44:643-648.
    • (2004) Hypertension , vol.44 , pp. 643-648
    • Drummond, H.A.1    Gebremedhin, D.2    Harder, D.R.3
  • 30
    • 38149102275 scopus 로고    scopus 로고
    • Dietary salt enhances benzamilsensitive component of myogenic constriction in mesenteric arteries
    • Jernigan NL, LaMarca B, Speed J, et al. Dietary salt enhances benzamilsensitive component of myogenic constriction in mesenteric arteries. Am J Physiol Heart Circ Physiol 2008; 294:H409-H420.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Jernigan, N.L.1    Lamarca, B.2    Speed, J.3
  • 31
    • 77957921063 scopus 로고    scopus 로고
    • Nitric oxide release follows endothelial nanomechanics and not vice versa
    • Fels J, Callies C, Kusche-Vihrog K, et al. Nitric oxide release follows endothelial nanomechanics and not vice versa. Pflugers Arch 2010; 460:915-923.
    • (2010) Pflugers Arch , vol.460 , pp. 915-923
    • Fels, J.1    Callies, C.2    Kusche-Vihrog, K.3
  • 32
    • 62449128088 scopus 로고    scopus 로고
    • Potassium softens vascular endothelium and increases nitric oxide release
    • Oberleithner H, Callies C, Kusche-Vihrog K, et al. Potassium softens vascular endothelium and increases nitric oxide release. Proc Natl Acad Sci USA 2009; 106:2829-2834.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2829-2834
    • Oberleithner, H.1    Callies, C.2    Kusche-Vihrog, K.3
  • 33
    • 3042730959 scopus 로고    scopus 로고
    • ENOS at a glance
    • Sessa WC. eNOS at a glance. J Cell Sci 2004; 117:2427-2429.
    • (2004) J Cell Sci , vol.117 , pp. 2427-2429
    • Sessa, W.C.1
  • 34
    • 79551469279 scopus 로고    scopus 로고
    • Stiff endothelial cell syndrome in vascular inflammation and mineralocorticoid excess
    • Lang F. Stiff endothelial cell syndrome in vascular inflammation and mineralocorticoid excess. Hypertension 2011; 57:146-147.
    • (2011) Hypertension , vol.57 , pp. 146-147
    • Lang, F.1
  • 35
    • 84864189077 scopus 로고    scopus 로고
    • Cortical actin nanodynamics determines nitric oxide release in vascular endothelium
    • Fels J, Jeggle P, Kusche-Vihrog K, et al. Cortical actin nanodynamics determines nitric oxide release in vascular endothelium. PLoS One 2012; 7:e41520.
    • (2012) PLoS One , vol.7
    • Fels, J.1    Jeggle, P.2    Kusche-Vihrog, K.3
  • 36
    • 33646580380 scopus 로고    scopus 로고
    • The carboxyl terminus of the alphasubunit of the amiloride-sensitive epithelial sodium channel binds to F-actin
    • Mazzochi C, Bubien JK, Smith PR, et al. The carboxyl terminus of the alphasubunit of the amiloride-sensitive epithelial sodium channel binds to F-actin. J Biol Chem 2006; 281:6528-6538.
    • (2006) J Biol Chem , vol.281 , pp. 6528-6538
    • Mazzochi, C.1    Bubien, J.K.2    Smith, P.R.3
  • 37
    • 33845355027 scopus 로고    scopus 로고
    • Interaction of epithelial ion channels with the actin-based cytoskeleton
    • Mazzochi C, Benos DJ, Smitg PR. Interaction of epithelial ion channels with the actin-based cytoskeleton. Am J Physiol Renal Physiol 2006; 291:F1113-F1122.
    • (2006) Am J Physiol Renal Physiol , vol.291
    • Mazzochi, C.1    Benos, D.J.2    Smitg, P.R.3
  • 38
    • 0029072762 scopus 로고
    • Flow-mediated endothelial mechanotransduction
    • Davies PF. Flow-mediated endothelial mechanotransduction. Physiol Rev 1995; 75:519-560.
    • (1995) Physiol Rev , vol.75 , pp. 519-560
    • Davies, P.F.1
  • 39
    • 84879927279 scopus 로고    scopus 로고
    • Flow detection and calcium signalling in vascular endothelial cells
    • Ando J, Yamamoto K. Flow detection and calcium signalling in vascular endothelial cells. Cardiovasc Res 2013; 99:260-268.
    • (2013) Cardiovasc Res , vol.99 , pp. 260-268
    • Ando, J.1    Yamamoto, K.2
  • 40
    • 35348904935 scopus 로고    scopus 로고
    • The structure and function of the endothelial glycocalyx layer
    • Weinbaum S, Tarbell JM, Damiano ER. The structure and function of the endothelial glycocalyx layer. Annu Rev Biomed Eng 2007; 9:121-167.
    • (2007) Annu Rev Biomed Eng , vol.9 , pp. 121-167
    • Weinbaum, S.1    Tarbell, J.M.2    Damiano, E.R.3
  • 41
    • 58149192157 scopus 로고    scopus 로고
    • The endothelial glycocalyx: A mechano-sensor andtransducer
    • Tarbell JM, Ebong EE. The endothelial glycocalyx: a mechano-sensor andtransducer. Sci Signal 2008; 1:Pt8.
    • (2008) Sci Signal , vol.1
    • Tarbell, J.M.1    Ebong, E.E.2
  • 42
    • 75149186586 scopus 로고    scopus 로고
    • Altered whole kidney blood flow autoregulation in a mouse model of reduced beta-ENaC
    • Grifoni SC, Chiposi R, McKey SE, et al. Altered whole kidney blood flow autoregulation in a mouse model of reduced beta-ENaC. Am J Physiol Renal Physiol 2010; 298:F285-F292.
    • (2010) Am J Physiol Renal Physiol , vol.298
    • Grifoni, S.C.1    Chiposi, R.2    McKey, S.E.3
  • 43
    • 84861883786 scopus 로고    scopus 로고
    • Impaired myogenic constriction of the renal afferent arteriole in a mouse model of reduced betaENaC expression
    • Ge Y, Gannon K, Gousset M, et al. Impaired myogenic constriction of the renal afferent arteriole in a mouse model of reduced betaENaC expression. Am J Physiol Renal Physiol 2012; 302:F1486-F1493.
    • (2012) Am J Physiol Renal Physiol , vol.302
    • Ge, Y.1    Gannon, K.2    Gousset, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.