Potassium softens vascular endothelium and increases nitric oxide release

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 8, 2009, Pages 2829-2834

  Oberleithner, H ^a   Callies, C ^a   Kusche Vihrog, K ^a   Schillers, H ^a   Shahin, V ^a   Riethmuller, C ^a   MacGregor, G A ^b   De Wardener, H E ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Aldosterone; Blood pressure; Cortical actin; Epithelial sodium channel; Stiffness

Indexed keywords

ACTIN; ALDOSTERONE; CYTOCHALASIN D; NITRIC OXIDE; POTASSIUM; SODIUM; SODIUM CHANNEL; TRYPSIN;

AORTA; ARTICLE; ATOMIC FORCE MICROSCOPE; BLOOD PRESSURE; BRAIN CORTEX; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSKELETON; DEPOLYMERIZATION; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; FLUIDIZATION; GELATION; HUMAN; HUMAN CELL; MICROSCOPE; NANOSENSOR; PRIORITY JOURNAL; SODIUM BLOOD LEVEL; SODIUM TRANSPORT; VASCULAR ENDOTHELIUM;

ACTINS; AMILORIDE; ANIMALS; CATTLE; CYTOCHALASIN D; ENDOTHELIUM, VASCULAR; EPITHELIAL SODIUM CHANNEL; MICROSCOPY, ATOMIC FORCE; NITRIC OXIDE; POTASSIUM; TRYPSIN;

BOVINAE;

EID: 62449128088     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0813069106     Document Type: Article

References (47)

1. Roson Ml, et al. (2006) Acute sodium overload produces renal tubulointerstitial inflammation in normal rats. Kidney lnt 70:1439-1446.
2. Ni Z, Vaziri ND (2001) Effect of salt loading on nitric oxide synthase expression in normotensive rats. Am J Hypertens 14:155-163.
3. Mercier N, et al. (2007) Sodium, arterial stiffness, and cardiovascular mortality in hypertensive rats. Am J Hypertens 20:319-325.
4. Frohlich ED, Varagic J (2005) Sodium directly impairs target organ function in hypertension. Curr Opin Cardiol 20:424-429.
5. Adrogue HJ, Madias NE (2007) Sodium and potassium in the pathogenesis of hypertension. N Engl J Med 356:1966-1978.
6. Kido M, et al. (2008) Protective effect of dietary potassium against vascular injury in salt-sensitive hypertension. Hypertension 51:225-231.
7. He FJ, MacGregor GA (2001) Fortnightly review: beneficial effects of potassium. BMJ 323:497-501
8. Khaw KT, Barrett-Connor E (1987) Dietary potassium and stroke-associated mortality.A 12-year prospective population study. N Engl J Med 316:235-240.
9. Tobian L, MacNeill D, Johnson MA, Ganguli MC, Iwai J (1984) Potassium protection against lesions of the renal tubules, arteries, and glomeruli and nephron loss in salt-loaded hypertensive Dahl S rats. Hypertension 6:1170-1176.
10. Rader DJ, Daugherty A (2008) Translating molecular discoveries into new therapies for atherosclerosis. Nature 451:904-913.
11. Hillebrand U, et al. (2006) 17beta-estradiol increases volume, apical surface and elasticity of human endothelium mediated by Na+/H + exchange. Cardiovasc Res 69:916-924.
12. Gorelik J, et al. (2005) Aldosterone acts via an ATP autocrine/paracrine system: the Edelman ATP hypothesis revisited. Proc Natl Acad 5ci USA 102:15000-15005.
13. Hillebrand U, et al. (2007) Dose-dependent endothelial cell growth and stiffening by aldosterone: endothelial protection by eplerenone. J Hypertens 25:639-647.
14. Kusche-Vihrog K, et al. (2008) Aldosterone and amiloride alter ENaC abundance in vascular endothelium. Pflugers Arch 455:849-857.
15. Oberleithner H, et al. (2006) Differential action of steroid hormones on human endothelium. J Cell Sci 119:1926-1932.
16. Oberleithner H, et al. (2007) Plasma sodium stiffens vascular endothelium and reduces nitric oxide release. Proc Natl Acad Sci USA 104:16281-16286.
17. He FJ, et al. (2005) Effect of short-term supplementation of potassium chloride and potassium citrate on blood pressure in hypertensives. Hypertension 45:571-574.
18. Fang Y, Mu JJ, He LC, Wang 5C, Liu ZQ (2006) Salt loading on plasma asymmetrical dimethylarginine and the protective role of potassium supplement in normotensive salt-sensitive Asians. Hypertension 48:724-729.
19. Morris RC Jr, Sebastian A, Forman A, Tanaka M, Schmidlin O (1999) Normotensive salt sensitivity: effects of race and dietary potassium. Hypertension 33:18-23.
20. Haddy FJ, Vanhoutte PM, Feletou M (2006) Role of potassium in regulating blood flow and blood pressure. Am J Physiol Regul Integr Comp Physiol 290:R546-R552.
21. Kasas S, et al. (2005) Superficial and deep changes of cellular mechanical properties following cytoskeleton disassembly. Cell Motil Cytoskeleton 62:124-132.
22. Caldwell RA, Boucher RC, Stutts MJ (2004) Serine protease activation of near-silent epithelial Na+ channels. Am J Physiol Cell Physioi 286:C190-C194.
23. Ju H, Zou R, Venema VJ, Venema RC (1997) Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity. J Biol Chem 272:18522-18525.
24. Kondrikov D, Han HR, Block ER, Su Y (2006) Growth and density-dependent regulation of NO synthase by the actin cytoskeleton in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 290:L41-L50.
25. Su Y, Edwards-Bennett S, Bubb MR, Block ER (2003) Regulation of endothelial nitric oxide synthase by the actin cytoskeleton. Am J Physiol Cell Physiol 284:C1542-C1549.
26. Searles CD, IdeL, Davis ME, Cai H, Weber M (2004) Actin cytoskeleton organization and posttranscriptional regulation of endothelial nitric oxide synthase during cell growth.Circ Res 95:488-495.
27. Ezzati M, Lopez AD, Rodgers A, Vander H5, Murray CJ (2002) Selected major risk factors and global and regional burden of disease. Lancet 360:1347-1360.
28. Mohr M, et al. (2004) Potassium kinetics in human muscle interstitium during repeated intense exercise in relation to fatigue. Pflugers Arch 448:452-456.
29. Nordsborg N, et al, (2003) Muscle interstitial potassium kineticsduring intense exhaustive exercise: effect of previous arm exercise. Am J Physiol Regul integr Comp Physiol 285:R143-R148.
30. Kofuji P, Newman EA (2004) Potassium buffering in the central nervous system. Neuroscience 129:1045-1056.
31. Hillebrand U, et al. (2009) Nebivolol decreases endothelial cell stiffness via the estrogen receptor beta: a nano-imaging study. J Hypertens, in press.
32. Trepat X, et al. (2007) Universal physical responses to stretch in the living cell. Nature 447:592-595.
33. Sanchez D, et al. (2008) Non-contact measurement of the local mechanical properties of living cells using pressure applied via a pipette. BiophysJ 95:3017-3027.
34. Pesen D, Hoh JH (2005) Modes of remodeling in the cortical cytoskeleton of vascular endothelial cells. FEBS Lett 579:473-476.
35. Pesen D, Hoh JH (2005) Micromechanical architecture of the endothelial cell cortex.Biophys J 88:670-679.
36. Joseph NR, Engel MB, Catchpole HR (1961) Distribution of sodium and potassium in certain cells and tissues. Nature 191:1175-1178.
37. Nilius B, Droogmans G (2001) Ion channels and their functional role in vascular endothelium. Physiol Rev 81:1415-1459.
38. Edwards G, Dora KA, Gardener MJ, Garland CJ, Weston AH (1998) K+ is an endothe-lium-derived hyperpolarizing factor in rat arteries. Nature 396:269-272.
39. Sheng JZ, Braun AP (2007) Small- and intermediate-conductance Ca2+-activated K+ channels directly control agonist-evoked nitric oxide synthesis in human vascular endothelial cells. Am J Physiol Cell Physiol 293:C458-C467.
40. Amberg GC, Bonev AD, Rossow CF, Nelson MT, Santana LF (2003) Modulation of the molecular composition of large conductance, Ca(2+) activated K(+) channels in vascular smooth muscle during hypertension. J Clin Invest 112:717-724.
41. Sandow SL, Tare M (2007) C-type natriuretic peptide: a new endothelium-derived hyperpolarizing factor? Trends Pharmacol Sci 28:61-67.
42. Griffith TM, Chaytor AT, Edwards DH (2004) The obligatory link: role of gap junctional communication in endothelium-dependent smooth muscle hyperpolarization. Pharmacol Res 49:551-564.
43. Chaytor AT, Edwards DH, Bakker LM, Griffith TM (2003) Distinct hyperpolarizing and relaxant roles for gap junctions and endothelium-derived H202 in NO-independent relaxations of rabbit arteries. Proc Natl Acad Sci USA 100:15212-15217.
44. Griffith TM, Chaytor AT, Taylor HJ, Giddings BD, Edwards DH (2002) cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions. Proc Natl Acad Sci USA 99:6392-6397.
45. Grinspan JB, Mueller SN, Levine EM (1983) Bovine endothelial cells transformed in vitro by benzo (a) pyrene. J Cell Physiol 114:328-338.
46. Jovov B, Berdiev BK, Fuller CM, Ji HL, Benos DJ (2002) The serine protease trypsin cleaves C termini of beta- and gamma-subunits of epithelial Na+ channels. J Biol Chem 277:4134-4140.
47. Carl P, Schillers H (2008) Elasticity measurement of living cells with an atomic force microscope: data acquisition and processing. Pflugers Arch 457:551-559.