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Volumn 19, Issue 2, 2014, Pages 135-150

Human epidermal growth factor receptor family-targeted therapies in the treatment of HER2-overexpressing breast cancer

Author keywords

Breast cancer; Epidermal growth factor receptor; Human epidermal growth factor receptor tyrosine kinase receptor family; Tyrosine kinase inhibitor

Indexed keywords

1 [4 [(5 CYCLOPROPYL 1H PYRAZOL 3 YL)AMINO]PYRROLO[2,1 F][1,2,4]TRIAZIN 2 YL] N (6 FLUORO 3 PYRIDINYL) 2 METHYL 2 PYRROLIDINECARBOXAMIDE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; AFATINIB; ANASTROZOLE; ANTHRACYCLINE; AROMATASE INHIBITOR; BEVACIZUMAB; BUPARLISIB; CAPECITABINE; CARBOPLATIN; CIXUTUMUMAB; CYCLOPHOSPHAMIDE; DACTOLISIB; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; ERLOTINIB; ESTROGEN RECEPTOR; EVEROLIMUS; FLUOROURACIL; GANITUMAB; GEFITINIB; IMETELSTAT; INK 128; LAPATINIB; LAPATINIB PLUS PAZOPANIB; LETROZOLE; LUMINESPIB; MM 111; NAVELBINE; NERATINIB; PACLITAXEL; PAZOPANIB; PB 272; PERTUZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PICTILISIB; PROTEIN KINASE B; SUNITINIB; TEMSIROLIMUS; TRASTUZUMAB; TRASTUZUMAB EMTANSINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XL 147; ANTINEOPLASTIC AGENT; ERBB2 PROTEIN, HUMAN; MONOCLONAL ANTIBODY; QUINAZOLINE DERIVATIVE;

EID: 84894107205     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2013-0283     Document Type: Article
Times cited : (54)

References (126)
  • 1
    • 65449119185 scopus 로고    scopus 로고
    • Anti-EGFR therapy: Mechanism and advances in clinical efficacy in breast cancer
    • Flynn JF, Wong C, Wu JM. Anti-EGFR therapy: Mechanism and advances in clinical efficacy in breast cancer. J Oncol 2009;2009:526963.
    • (2009) J Oncol , vol.2009 , pp. 526963
    • Flynn, J.F.1    Wong, C.2    Wu, J.M.3
  • 2
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG et al. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235:177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 3
    • 44149098849 scopus 로고    scopus 로고
    • Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients
    • Sassen A, Rochon J, Wild P et al. Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients. Breast Cancer Res 2008;10: R2.
    • (2008) Breast Cancer Res , vol.10
    • Sassen, A.1    Rochon, J.2    Wild, P.3
  • 4
    • 0038575385 scopus 로고    scopus 로고
    • Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer
    • WittonCJ, Reeves JR, Going JJ et al. Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer. J Pathol 2003;200:290-297.
    • (2003) J Pathol , vol.200 , pp. 290-297
    • Witton, C.J.1    Reeves, J.R.2    Going, J.J.3
  • 5
    • 77149162377 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes
    • Rimawi MF, Shetty PB, Weiss HL et al. Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes. Cancer 2010;116:1234-1242.
    • (2010) Cancer , vol.116 , pp. 1234-1242
    • Rimawi, M.F.1    Shetty, P.B.2    Weiss, H.L.3
  • 6
    • 73349119689 scopus 로고    scopus 로고
    • High risk of recurrence for patients with breast cancer who have human epidermal growth factor receptor 2-positive, node-negative tumors 1 cm or smaller
    • Gonzalez-Angulo AM, Litton JK, Broglio KR et al. High risk of recurrence for patients with breast cancer who have human epidermal growth factor receptor 2-positive, node-negative tumors 1 cm or smaller. J Clin Oncol 2009;27:5700-5706.
    • (2009) J Clin Oncol , vol.27 , pp. 5700-5706
    • Gonzalez-Angulo, A.M.1    Litton, J.K.2    Broglio, K.R.3
  • 8
    • 73349085919 scopus 로고    scopus 로고
    • Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer
    • Spector NL, Blackwell KL. Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol 2009;27:5838-5847.
    • (2009) J Clin Oncol , vol.27 , pp. 5838-5847
    • Spector, N.L.1    Blackwell, K.L.2
  • 9
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl JMed 2001;344:783-792.
    • (2001) N Engl JMed , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 10
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in firstline treatment of HER2-overexpressing metastatic breast cancer
    • Vogel CL, Cobleigh MA, TripathyDet al. Efficacy and safety of trastuzumab as a single agent in firstline treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002;20:719-726.
    • (2002) J Clin Oncol , vol.20 , pp. 719-726
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3
  • 11
    • 17144371333 scopus 로고    scopus 로고
    • Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule
    • Baselga J, Carbonell X, Castañeda-Soto NJ et al. Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule. J Clin Oncol 2005;23: 2162-2171.
    • (2005) J Clin Oncol , vol.23 , pp. 2162-2171
    • Baselga, J.1    Carbonell, X.2    Castañeda-Soto, N.J.3
  • 12
    • 73949105921 scopus 로고    scopus 로고
    • Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: Results from the randomized phase III TAnDEM study
    • Kaufman B, Mackey JR, Clemens MR et al. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study. J Clin Oncol 2009;27:5529-5537.
    • (2009) J Clin Oncol , vol.27 , pp. 5529-5537
    • Kaufman, B.1    McKey, J.R.2    Clemens, M.R.3
  • 13
    • 84856319982 scopus 로고    scopus 로고
    • Higher efficacy of letrozole in combination with trastuzumab compared to letrozole monotherapy as firstline treatment in patients with HER2-positive, hormone-receptor-positive metastatic breast cancer-results of the eLEcTRA trial
    • Huober J, Fasching PA, BarsoumMet al. Higher efficacy of letrozole in combination with trastuzumab compared to letrozole monotherapy as firstline treatment in patients with HER2-positive, hormone-receptor-positive metastatic breast cancer-results of the eLEcTRA trial. Breast 2012;21:27-33.
    • (2012) Breast , vol.21 , pp. 27-33
    • Huober, J.1    Fasching, P.A.2    Barsoum, M.3
  • 14
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
    • Piccart-Gebhart MJ, Procter M, Leyland-Jones B et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. NEngl JMed 2005;353: 1659-1672.
    • (2005) NEngl JMed , vol.353 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 15
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005; 353:1673-1684.
    • (2005) N Engl J Med , vol.353 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 16
    • 80053539103 scopus 로고    scopus 로고
    • Adjuvant trastuzumab in HER2-positive breast cancer
    • Slamon D, Eiermann W, Robert N et al. Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med 2011;365:1273-1283.
    • (2011) N Engl J Med , vol.365 , pp. 1273-1283
    • Slamon, D.1    Eiermann, W.2    Robert, N.3
  • 17
    • 73349115249 scopus 로고    scopus 로고
    • Fluorouracil, epirubicin, and cyclophosphamide with either docetaxelor vinorelbine, withorwithouttrastuzumab, as adjuvant treatments of breast cancer: Final results of the FinHer Trial
    • Joensuu H, Bono P, Kataja V et al. Fluorouracil, epirubicin, and cyclophosphamide with either docetaxelor vinorelbine, withorwithouttrastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer Trial. J Clin Oncol 2009;27: 5685-5692.
    • (2009) J Clin Oncol , vol.27 , pp. 5685-5692
    • Joensuu, H.1    Bono, P.2    Kataja, V.3
  • 18
    • 84872350882 scopus 로고    scopus 로고
    • HERA TRIAL: 2 years versus 1 year of trastuzumab after adjuvant chemotherapy in women with HER2-positive early breast cancer at 8 years of median follow up
    • [Abstract LBA6]. ixe2a
    • Goldhirsch A, Piccart M, ProcterMet al. HERA TRIAL: 2 years versus 1 year of trastuzumab after adjuvant chemotherapy in women with HER2-positive early breast cancer at 8 years of median follow up[Abstract LBA6]. AnnOncol 2012;23 (suppl 9):ixe2a.
    • (2012) AnnOncol , vol.23 , Issue.SUPPL. 9
    • Goldhirsch, A.1    Piccart, M.2    Procter, M.3
  • 19
    • 33344478381 scopus 로고    scopus 로고
    • Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer
    • Joensuu H, Kellokumpu-Lehtinen PL, Bono P et al. Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. NEngl JMed 2006;354:809-820.
    • (2006) NEngl JMed , vol.354 , pp. 809-820
    • Joensuu, H.1    Kellokumpu-Lehtinen, P.L.2    Bono, P.3
  • 20
    • 84872292477 scopus 로고    scopus 로고
    • PHARE trial results comparing 6 to 12months of trastuzumab in adjuvant early breast cancer
    • [Abstract LBA5]. ixe2a
    • Pivot X, RomieuG, BonnefoiHet al. PHARE trial results comparing 6 to 12months of trastuzumab in adjuvant early breast cancer [Abstract LBA5]. Ann Oncol 2012;23(suppl 9):ixe2a.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9
    • Pivot, X.1    Romieu, G.2    Bonnefoi, H.3
  • 21
    • 33846297680 scopus 로고    scopus 로고
    • Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: An update of the initial randomized study population and data of additional patients treated with the same regimen
    • Buzdar AU, Valero V, Ibrahim NK et al. Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: an update of the initial randomized study population and data of additional patients treated with the same regimen. Clin Cancer Res 2007;13:228-233.
    • (2007) Clin Cancer Res , vol.13 , pp. 228-233
    • Buzdar, A.U.1    Valero, V.2    Ibrahim, N.K.3
  • 22
    • 85190567755 scopus 로고    scopus 로고
    • ACOSOG Z1041 (Alliance): Definitive analysis of randomized neoadjuvant trial comparing FEC followed by paclitaxel plus trastuzumab (FEC? P1T) with paclitaxel plus trastuzumab followed by FEC plus trastuzumab (P1T? FEC1T) in HER21 operable breast cancer
    • [Abstract 502]
    • Buzdar A, Suman VJ, Meric-Bernstam F et al. ACOSOG Z1041 (Alliance): Definitive analysis of randomized neoadjuvant trial comparing FEC followed by paclitaxel plus trastuzumab (FEC? P1T) with paclitaxel plus trastuzumab followed by FEC plus trastuzumab (P1T? FEC1T) in HER21 operable breast cancer [Abstract 502]. J Clin Oncol 2013;31 (suppl).
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Buzdar, A.1    Suman, V.J.2    Meric-Bernstam, F.3
  • 23
    • 77951624086 scopus 로고    scopus 로고
    • Neoadjuvant treatmentwith trastuzumab in HER2-positive breast cancer: Results from the GeparQuattro study
    • Untch M, Rezai M, Loibl S et al. Neoadjuvant treatmentwith trastuzumab in HER2-positive breast cancer: results from the GeparQuattro study. J Clin Oncol 2010;28:2024-2031.
    • (2010) J Clin Oncol , vol.28 , pp. 2024-2031
    • Untch, M.1    Rezai, M.2    Loibl, S.3
  • 24
    • 75149145066 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): A randomised controlled superiority trial with a parallel HER2-negative cohort
    • Gianni L, Eiermann W, Semiglazov V et al. Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2-negative cohort. Lancet 2010;375: 377-384.
    • (2010) Lancet , vol.375 , pp. 377-384
    • Gianni, L.1    Eiermann, W.2    Semiglazov, V.3
  • 25
    • 84885672724 scopus 로고    scopus 로고
    • Follow-up results of NOAH, a randomized phase III trial evaluating neoadjuvant chemotherapy with trastuzumab (CT1H) followed by adjuvant H versus CT alone, in patients with HER2-positive locally advanced breast cancer
    • [Abstract 503]
    • Gianni L, Eiermann W, Semiglazov V et al. Follow-up results of NOAH, a randomized phase III trial evaluating neoadjuvant chemotherapy with trastuzumab (CT1H) followed by adjuvant H versus CT alone, in patients with HER2-positive locally advanced breast cancer [Abstract 503]. J Clin Oncol 2013;31(suppl).
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Gianni, L.1    Eiermann, W.2    Semiglazov, V.3
  • 27
    • 21144439000 scopus 로고    scopus 로고
    • Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
    • Kwak EL, Sordella R, Bell DW et al. Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proc Natl Acad Sci USA 2005;102:7665-7670.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 7665-7670
    • Kwak, E.L.1    Sordella, R.2    Bell, D.W.3
  • 28
    • 67349087409 scopus 로고    scopus 로고
    • Efficacy and safety of erlotinib in patients with locally advanced or metastatic breast cancer
    • Dickler MN, Cobleigh MA, Miller KD et al. Efficacy and safety of erlotinib in patients with locally advanced or metastatic breast cancer. Breast Cancer Res Treat 2009;115:115-121.
    • (2009) Breast Cancer Res Treat , vol.115 , pp. 115-121
    • Dickler, M.N.1    Cobleigh, M.A.2    Miller, K.D.3
  • 29
    • 65649115021 scopus 로고    scopus 로고
    • A phase I/II trial of trastuzumab plus erlotinib in metastatic HER2-positive breast cancer: A dual ErbB targeted approach
    • Britten CD, Finn RS, Bosserman LD et al. A phase I/II trial of trastuzumab plus erlotinib in metastatic HER2-positive breast cancer: a dual ErbB targeted approach. Clin Breast Cancer 2009; 9:16-22.
    • (2009) Clin Breast Cancer , vol.9 , pp. 16-22
    • Britten, C.D.1    Finn, R.S.2    Bosserman, L.D.3
  • 31
    • 58149153020 scopus 로고    scopus 로고
    • A phase I-II study of combined blockade of the ErbB receptor network with trastuzumab and gefitinib in patients with HER2 (ErbB2)-overexpressing metastatic breast cancer
    • Arteaga CL, O'Neill A, Moulder SL et al. A phase I-II study of combined blockade of the ErbB receptor network with trastuzumab and gefitinib in patients with HER2 (ErbB2)-overexpressing metastatic breast cancer. Clin Cancer Res 2008;14:6277-6283.
    • (2008) Clin Cancer Res , vol.14 , pp. 6277-6283
    • Arteaga, C.L.1    O'Neill, A.2    Moulder, S.L.3
  • 32
    • 84856234624 scopus 로고    scopus 로고
    • A phase I/II prospective, single arm trial of gefitinib, trastuzumab, and docetaxel in patients with stage IV HER-2 positive metastatic breast cancer
    • Somlo G, Martel CL, Lau SK et al. A phase I/II prospective, single arm trial of gefitinib, trastuzumab, and docetaxel in patients with stage IV HER-2 positive metastatic breast cancer. Breast Cancer Res Treat 2012;131:899-906.
    • (2012) Breast Cancer Res Treat , vol.131 , pp. 899-906
    • Somlo, G.1    Martel, C.L.2    Lau, S.K.3
  • 33
    • 23944476155 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas
    • Burris HA 3rd, Hurwitz HI, Dees EC et al. Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J Clin Oncol 2005;23:5305-5313.
    • (2005) J Clin Oncol , vol.23 , pp. 5305-5313
    • Burris III, H.A.1    Hurwitz, H.I.2    Dees, E.C.3
  • 34
    • 85066971284 scopus 로고    scopus 로고
    • FDA drug approval summary: Lapatinib in combination with capecitabine for previously treated metastatic breast cancer thatoverexpressesHER-2
    • Ryan Q, Ibrahim A, Cohen MH et al. FDA drug approval summary: lapatinib in combination with capecitabine for previously treated metastatic breast cancer thatoverexpressesHER-2. TheOncologist 2008;13:1114-1119.
    • (2008) TheOncologist , vol.13 , pp. 1114-1119
    • Ryan, Q.1    Ibrahim, A.2    Cohen, M.H.3
  • 36
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006;355:2733-2743.
    • (2006) N Engl J Med , vol.355 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 37
    • 73149115341 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
    • Johnston S, Pippen J Jr, Pivot X et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol 2009;27:5538-5546.
    • (2009) J Clin Oncol , vol.27 , pp. 5538-5546
    • Johnston, S.1    Pippen Jr., J.2    Pivot, X.3
  • 38
    • 84866536687 scopus 로고    scopus 로고
    • Openlabel phase III randomized controlled trial comparing taxane-based chemotherapy (Tax) with lapatinib (L) or trastuzumab (T) as first-line therapy for women with HER2+ metastatic breast cancer: Interim analysis (IA) of NCIC CTG MA.31/GSK EGF 108919
    • [Abstract LBA671]
    • Gelmon KA, Boyle F, Kaufman B et al. Openlabel phase III randomized controlled trial comparing taxane-based chemotherapy (Tax) with lapatinib (L) or trastuzumab (T) as first-line therapy for women with HER2+ metastatic breast cancer: Interim analysis (IA) of NCIC CTG MA.31/GSK EGF 108919 [Abstract LBA671]. J Clin Oncol 2012;30 (suppl).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Gelmon, K.A.1    Boyle, F.2    Kaufman, B.3
  • 39
    • 84856444501 scopus 로고    scopus 로고
    • Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy (GeparQuinto, GBG 44): A randomised phase 3 trial
    • Untch M, Loibl S, Bischoff J et al. Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy (GeparQuinto, GBG 44): A randomised phase 3 trial. Lancet Oncol 2012;13:135-144.
    • (2012) Lancet Oncol , vol.13 , pp. 135-144
    • Untch, M.1    Loibl, S.2    Bischoff, J.3
  • 40
    • 84871712684 scopus 로고    scopus 로고
    • Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: A randomised, controlled, phase 3 trial
    • Goss PE, Smith IE, O'Shaughnessy J et al. Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: A randomised, controlled, phase 3 trial. Lancet Oncol 2013;14:88-96.
    • (2013) Lancet Oncol , vol.14 , pp. 88-96
    • Goss, P.E.1    Smith, I.E.2    O'Shaughnessy, J.3
  • 41
    • 77949884661 scopus 로고    scopus 로고
    • Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
    • Blackwell KL, Burstein HJ, Storniolo AM et al. Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol 2010;28:1124-1130.
    • (2010) J Clin Oncol , vol.28 , pp. 1124-1130
    • Blackwell, K.L.1    Burstein, H.J.2    Storniolo, A.M.3
  • 42
    • 84879923789 scopus 로고    scopus 로고
    • A phase III randomized study of paclitaxel and trastuzumab versus paclitaxel, trastuzumab and lapatinib in first line treatment of HER2 positive metastatic breast cancer
    • [Abstract OT1-1-06]. Paper presented at: San Antonio Breast Cancer Symposium (CTRC-AACR); December 4-8, 2012; San Antonio, TX
    • Crown JP, Moulton B, O'DonovanN. A phase III randomized study of paclitaxel and trastuzumab versus paclitaxel, trastuzumab and lapatinib in first line treatment of HER2 positive metastatic breast cancer [Abstract OT1-1-06]. Cancer Res 2012;72 (suppl 3). Paper presented at: San Antonio Breast Cancer Symposium (CTRC-AACR); December 4-8, 2012; San Antonio, TX.
    • (2012) Cancer Res , vol.72 , Issue.SUPPL. 3
    • Crown, J.P.1    Moulton, B.2    O'Donovan, N.3
  • 43
    • 84879925487 scopus 로고    scopus 로고
    • ALTERNATIVE: Safety and efficacy of lapatinib (L), trastuzumab (T), or both in combination with an aromatase inhibitor (AI) for the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2 positive (HER2+) metastatic breast cancer
    • [Abstract OT1-1-04]. Paper presented at: San Antonio Breast Cancer Symposium (CTRCAACR); December 4-8, 2012; San Antonio, TX
    • Johnston S, Wroblewski S, Huang Y et al. ALTERNATIVE: Safety and efficacy of lapatinib (L), trastuzumab (T), or both in combination with an aromatase inhibitor (AI) for the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2 positive (HER2+) metastatic breast cancer [Abstract OT1-1-04]. Cancer Res 2012;72(suppl 3). Paper presented at: San Antonio Breast Cancer Symposium (CTRCAACR); December 4-8, 2012; San Antonio, TX.
    • (2012) Cancer Res , vol.72 , Issue.SUPPL. 3
    • Johnston, S.1    Wroblewski, S.2    Huang, Y.3
  • 44
    • 84857236823 scopus 로고    scopus 로고
    • Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): A randomised, openlabel, multicentre, phase 3 trial
    • Baselga J, Bradbury I, Eidtmann H et al. Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, openlabel, multicentre, phase 3 trial. Lancet 2012;379: 633-640.
    • (2012) Lancet , vol.379 , pp. 633-640
    • Baselga, J.1    Bradbury, I.2    Eidtmann, H.3
  • 45
    • 84878336498 scopus 로고    scopus 로고
    • Evaluation of lapatinib as a component of neoadjuvant therapy for HER21operable breast cancer: NSABP protocol B-41
    • [Abstract LBA506]
    • Robidoux A, Tang G, Rastogi P et al. Evaluation of lapatinib as a component of neoadjuvant therapy for HER21operable breast cancer: NSABP protocol B-41 [Abstract LBA506]. J Clin Oncol 2012;30(suppl).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Robidoux, A.1    Tang, G.2    Rastogi, P.3
  • 46
    • 84885416696 scopus 로고    scopus 로고
    • Clinical and translational results ofCALGB40601:Aneoadjuvant phase III trial of weekly paclitaxel and trastuzumab with or without lapatinib for HER2-positive breast cancer
    • [Abstract 500]
    • Carey LA, Berry DA, Ollila D et al. Clinical and translational results ofCALGB40601:Aneoadjuvant phase III trial of weekly paclitaxel and trastuzumab with or without lapatinib for HER2-positive breast cancer [Abstract 500]. J Clin Oncol 2013;31(suppl).
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Carey, L.A.1    Berry, D.A.2    Ollila, D.3
  • 47
    • 84866552915 scopus 로고    scopus 로고
    • Lapatinib, trastuzumab or the combination added to preoperative chemotherapy for breast cancer: A metaanalysis of randomized evidence
    • Valachis A, Nearchou A, Lind P et al. Lapatinib, trastuzumab or the combination added to preoperative chemotherapy for breast cancer: a metaanalysis of randomized evidence. Breast Cancer Res Treat 2012;135:655-662.
    • (2012) Breast Cancer Res Treat , vol.135 , pp. 655-662
    • Valachis, A.1    Nearchou, A.2    Lind, P.3
  • 48
    • 84879473563 scopus 로고    scopus 로고
    • Multicenter phase II study of neoadjuvant lapatinib and trastuzumab with hormonal therapy and without chemotherapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer: TBCRC 006
    • Rimawi MF, Mayer IA, Forero A et al. Multicenter phase II study of neoadjuvant lapatinib and trastuzumab with hormonal therapy and without chemotherapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer: TBCRC 006. J Clin Oncol 2013;31:1726-1731.
    • (2013) J Clin Oncol , vol.31 , pp. 1726-1731
    • Rimawi, M.F.1    Mayer, I.A.2    Forero, A.3
  • 49
    • 85190568131 scopus 로고    scopus 로고
    • Puma Biotechnology Inc. an investigational PanHER inhibitor; closes $55 million private placement and completes merger. Available at Accessed February 16, 2012
    • Puma Biotechnology Inc. Puma Biotechnology announces licensing agreement with Pfizer for the development and commercialization of neratinib, an investigational PanHER inhibitor; closes $55 million private placement and completes merger. Available at http://www.pumabiotechnology.com/ pr20111005.html. Accessed February 16, 2012.
    • Puma Biotechnology announces licensing agreement with Pfizer for the development and commercialization of neratinib
  • 50
    • 2542582261 scopus 로고    scopus 로고
    • Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase
    • Rabindran SK, Discafani CM, Rosfjord EC et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res 2004;64:3958-3965.
    • (2004) Cancer Res , vol.64 , pp. 3958-3965
    • Rabindran, S.K.1    Discafani, C.M.2    Rosfjord, E.C.3
  • 51
    • 13944262091 scopus 로고    scopus 로고
    • Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity
    • Tsou HR, Overbeek-Klumpers EG, Hallett WA et al. Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity. J Med Chem 2005;48:1107-1131.
    • (2005) J Med Chem , vol.48 , pp. 1107-1131
    • Tsou, H.R.1    Overbeek-Klumpers, E.G.2    Hallett, W.A.3
  • 52
    • 77950497981 scopus 로고    scopus 로고
    • Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer
    • Burstein HJ, Sun Y, Dirix LY et al. Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer. J Clin Oncol 2010;28:1301-1307.
    • (2010) J Clin Oncol , vol.28 , pp. 1301-1307
    • Burstein, H.J.1    Sun, Y.2    Dirix, L.Y.3
  • 53
    • 84871595073 scopus 로고    scopus 로고
    • Safety and efficacy of neratinib (HKI-272) plus vinorelbine in the treatment of patients with ErbB2-positive metastatic breast cancer pretreated with anti-HER2 therapy
    • Awada A, Dirix L, Manso Sanchez L et al. Safety and efficacy of neratinib (HKI-272) plus vinorelbine in the treatment of patients with ErbB2-positive metastatic breast cancer pretreated with anti-HER2 therapy. Ann Oncol 2013;24:109-116.
    • (2013) Ann Oncol , vol.24 , pp. 109-116
    • Awada, A.1    Dirix, L.2    Manso Sanchez, L.3
  • 54
    • 84878551145 scopus 로고    scopus 로고
    • Combination neratinib (HKI-272) and paclitaxel therapy in patients with HER2-positive metastatic breast cancer
    • Chow LW, Xu B, Gupta S et al. Combination neratinib (HKI-272) and paclitaxel therapy in patients with HER2-positive metastatic breast cancer. Br J Cancer 2013;108:1985-1993.
    • (2013) Br J Cancer , vol.108 , pp. 1985-1993
    • Chow, L.W.1    Xu, B.2    Gupta, S.3
  • 55
    • 84866109630 scopus 로고    scopus 로고
    • A phase 2, randomized, open-label, study of neratinib (HKI-272) vs. lapatinib plus capecitabine for 2nd/ 3rd-line treatment of HER21 locally advanced or metastatic breast cancer
    • [Abstract S5-7]
    • Martin M, Bonneterre J, Geyer CE, Jr. et al. A phase 2, randomized, open-label, study of neratinib (HKI-272) vs. lapatinib plus capecitabine for 2nd/ 3rd-line treatment of HER21 locally advanced or metastatic breast cancer [Abstract S5-7]. Cancer Res 2011;71(suppl):113sa.
    • (2011) Cancer Res , vol.71 , Issue.SUPPL. , pp. 113
    • Martin, M.1    Bonneterre, J.2    Geyer Jr., C.E.3
  • 56
    • 84879965682 scopus 로고    scopus 로고
    • Aphase I dose-escalation study evaluating weekly paclitaxel with neratinib and trastuzumab in women with metastatic HER2-positive breast cancer, NSABP FB-8
    • [Abstract 611]
    • Jankowitz RC, Abraham J, TanARet al. Aphase I dose-escalation study evaluating weekly paclitaxel with neratinib and trastuzumab in women with metastatic HER2-positive breast cancer, NSABP FB-8 [Abstract 611]. J Clin Oncol 2012;30(suppl).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Jankowitz, R.C.1    Abraham, J.2    Tan, A.R.3
  • 57
    • 49149118719 scopus 로고    scopus 로고
    • BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
    • Li D, Ambrogio L, Shimamura T et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 2008;27:4702-4711.
    • (2008) Oncogene , vol.27 , pp. 4702-4711
    • Li, D.1    Ambrogio, L.2    Shimamura, T.3
  • 58
    • 84867621201 scopus 로고    scopus 로고
    • Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker
    • Solca F, Dahl G, Zoephel A et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther 2012;343:342-350.
    • (2012) J Pharmacol Exp Ther , vol.343 , pp. 342-350
    • Solca, F.1    Dahl, G.2    Zoephel, A.3
  • 59
    • 84863715765 scopus 로고    scopus 로고
    • A phase II study of afatinib (BIBW 2992), an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab
    • Lin NU, Winer EP, Wheatley D et al. A phase II study of afatinib (BIBW 2992), an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab. Breast Cancer Res Treat 2012;133:1057-1065.
    • (2012) Breast Cancer Res Treat , vol.133 , pp. 1057-1065
    • Lin, N.U.1    Winer, E.P.2    Wheatley, D.3
  • 60
    • 84870635223 scopus 로고    scopus 로고
    • A neoadjuvant, randomized, open-label phase II trial of afatinib (A) versus trastuzumab (T) versus lapatinib (L) in patients (pts) with locally advanced HER2-positive breast cancer (BC)
    • [Abstract 606]
    • Rimawi MF, Aleixo SB, Rozas AA et al. A neoadjuvant, randomized, open-label phase II trial of afatinib (A) versus trastuzumab (T) versus lapatinib (L) in patients (pts) with locally advanced HER2-positive breast cancer (BC) [Abstract 606]. J Clin Oncol 2012;30(suppl).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Rimawi, M.F.1    Aleixo, S.B.2    Rozas, A.A.3
  • 61
    • 84870640206 scopus 로고    scopus 로고
    • LUXbreast 2: Phase II, open-label study of oral afatinib in HER2-overexpressing metastatic breast cancer (MBC) patients (pts) who progressed on prior trastuzumab (T) and/or lapatanib (L)
    • [Abstract TPS651]
    • Hickish T, Tseng L-M, Mehta AO et al. LUXbreast 2: Phase II, open-label study of oral afatinib in HER2-overexpressing metastatic breast cancer (MBC) patients (pts) who progressed on prior trastuzumab (T) and/or lapatanib (L) [Abstract TPS651]. J Clin Oncol 2012;30(suppl).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Hickish, T.1    Tseng, L.-M.2    Mehta, A.O.3
  • 62
    • 84867880323 scopus 로고    scopus 로고
    • LUX-breast 3: Randomized phase II study of afatinib alone or with vinorelbine versus investigator's choice of treatment in patients (pts) with HER2-positive breast cancer (BC) with progressive brain metastases (BM) after trastuzumab or lapatinib-based therapy
    • [Abstract TPS647]
    • Joensuu H, Kaci MO. LUX-breast 3: Randomized phase II study of afatinib alone or with vinorelbine versus investigator's choice of treatment in patients (pts) with HER2-positive breast cancer (BC) with progressive brain metastases (BM) after trastuzumab or lapatinib-based therapy [Abstract TPS647]. J Clin Oncol 2012;30(suppl).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Joensuu, H.1    Kaci, M.O.2
  • 63
    • 1842605531 scopus 로고    scopus 로고
    • Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
    • Franklin MC, Carey KD, Vajdos FF et al. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell 2004;5:317-328.
    • (2004) Cancer Cell , vol.5 , pp. 317-328
    • Franklin, M.C.1    Carey, K.D.2    Vajdos, F.F.3
  • 65
    • 84862914692 scopus 로고    scopus 로고
    • Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
    • Baselga J, Cortés J, Kim SB et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med 2012;366:109-119.
    • (2012) N Engl J Med , vol.366 , pp. 109-119
    • Baselga, J.1    Cortés, J.2    Kim, S.B.3
  • 66
    • 84876970810 scopus 로고    scopus 로고
    • Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): Overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study
    • Swain SM, Kim SB, Cortés J et al. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol 2013;14:461-471.
    • (2013) Lancet Oncol , vol.14 , pp. 461-471
    • Swain, S.M.1    Kim, S.B.2    Cortés, J.3
  • 67
    • 84855297353 scopus 로고    scopus 로고
    • Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): A randomised multicentre, open-label, phase 2 trial
    • Gianni L, Pienkowski T, Im YH et al. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. Lancet Oncol 2012;13:25-32.
    • (2012) Lancet Oncol , vol.13 , pp. 25-32
    • Gianni, L.1    Pienkowski, T.2    Im, Y.H.3
  • 68
    • 84883359410 scopus 로고    scopus 로고
    • Pertuzumab plus trastuzumab in combination with standard neoadjuvant anthracycline-containing and anthracycline-freechemotherapyregimensinpatients with HER2-positive early breast cancer: A randomized phase II cardiac safety study (TRYPHAENA)
    • Schneeweiss A, Chia S, Hickish T et al. Pertuzumab plus trastuzumab in combination with standard neoadjuvant anthracycline-containing and anthracycline-freechemotherapyregimensinpatients with HER2-positive early breast cancer: a randomized phase II cardiac safety study (TRYPHAENA). Ann Oncol 2013;24:2278-2284.
    • (2013) Ann Oncol , vol.24 , pp. 2278-2284
    • Schneeweiss, A.1    Chia, S.2    Hickish, T.3
  • 69
    • 84859409756 scopus 로고    scopus 로고
    • Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3
    • McDonagh CF, Huhalov A, Harms BD et al. Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3. Mol Cancer Ther 2012;11:582-593.
    • (2012) Mol Cancer Ther , vol.11 , pp. 582-593
    • McDonagh, C.F.1    Huhalov, A.2    Harms, B.D.3
  • 70
    • 56449129810 scopus 로고    scopus 로고
    • Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
    • LewisPhillipsGD, Li G, DuggerDLet al. Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res 2008;68:9280-9290.
    • (2008) Cancer Res , vol.68 , pp. 9280-9290
    • LewisPhillips, G.D.1    Li, G.2    Dugger, D.L.3
  • 72
    • 79551585669 scopus 로고    scopus 로고
    • Quantitative assessment of diagnostic markers and correlations with efficacy in two phase II studies of trastuzumab-DM1 (T-DM1) for patients (pts) with metastatic breast cancer (MBC)whohadprogressed on prior HER2-directed therapy
    • [Abstract 1016]
    • LoRusso P, Krop IE, Burris HA III et al. Quantitative assessment of diagnostic markers and correlations with efficacy in two phase II studies of trastuzumab-DM1 (T-DM1) for patients (pts) with metastatic breast cancer (MBC)whohadprogressed on prior HER2-directed therapy [Abstract 1016]. J Clin Oncol 2010;28(suppl).
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • LoRusso, P.1    Krop, I.E.2    Burris III, H.A.3
  • 73
    • 84868520609 scopus 로고    scopus 로고
    • Trastuzumab emtansine for HER2-positive advanced breast cancer
    • Verma S, Miles D, Gianni L et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med 2012;367:1783-1791.
    • (2012) N Engl J Med , vol.367 , pp. 1783-1791
    • Verma, S.1    Miles, D.2    Gianni, L.3
  • 74
    • 84876011018 scopus 로고    scopus 로고
    • Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
    • Hurvitz SA, Dirix L, Kocsis J et al. Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol 2013;31:1157-1163.
    • (2013) J Clin Oncol , vol.31 , pp. 1157-1163
    • Hurvitz, S.A.1    Dirix, L.2    Kocsis, J.3
  • 75
    • 84867821797 scopus 로고    scopus 로고
    • Cardiac safety in a phase II study of trastuzumab emtansine (T-DM1) following anthracycline-based chemotherapy as adjuvant or neoadjuvant therapy for earlystage HER2-positive breast cancer
    • [Abstract 532J]
    • Dang CT, Gianni L, Romieu G et al. Cardiac safety in a phase II study of trastuzumab emtansine (T-DM1) following anthracycline-based chemotherapy as adjuvant or neoadjuvant therapy for earlystage HER2-positive breast cancer [Abstract 532J]. J Clin Oncol 2012;30(suppl).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Dang, C.T.1    Gianni, L.2    Romieu, G.3
  • 76
    • 80051869605 scopus 로고    scopus 로고
    • Modular anti-EGFR and anti-Her2 targeting of SK-BR-3 and BT474 breast cancer cell lines in the presence of ErbB receptor-specific growth factors
    • Diermeier-Daucher S, Breindl S, Buchholz S et al. Modular anti-EGFR and anti-Her2 targeting of SK-BR-3 and BT474 breast cancer cell lines in the presence of ErbB receptor-specific growth factors. Cytometry A 2011;79:684-693.
    • (2011) Cytometry A , vol.79 , pp. 684-693
    • Diermeier-Daucher, S.1    Breindl, S.2    Buchholz, S.3
  • 77
    • 0141725532 scopus 로고    scopus 로고
    • Novel therapeutic strategies targeting the epidermal growth factor receptor (EGFR) family and its downstream effectors in breast cancer
    • Atalay G, Cardoso F, Awada A et al. Novel therapeutic strategies targeting the epidermal growth factor receptor (EGFR) family and its downstream effectors in breast cancer. Ann Oncol 2003;14:1346-1363.
    • (2003) Ann Oncol , vol.14 , pp. 1346-1363
    • Atalay, G.1    Cardoso, F.2    Awada, A.3
  • 78
    • 77955559443 scopus 로고    scopus 로고
    • EGFR overexpression and activation in high HER2, ER negative breast cancer cell line induces trastuzumab resistance
    • Dua R, Zhang J, Nhonthachit P et al. EGFR overexpression and activation in high HER2, ER negative breast cancer cell line induces trastuzumab resistance. Breast Cancer Res Treat 2010;122:685-697.
    • (2010) Breast Cancer Res Treat , vol.122 , pp. 685-697
    • Dua, R.1    Zhang, J.2    Nhonthachit, P.3
  • 79
    • 0035949699 scopus 로고    scopus 로고
    • AKTplays a central role in tumorigenesis
    • Testa JR, Bellacosa A. AKTplays a central role in tumorigenesis. Proc Natl Acad Sci USA 2001;98: 10983-10985.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10983-10985
    • Testa, J.R.1    Bellacosa, A.2
  • 80
    • 59449088408 scopus 로고    scopus 로고
    • Phosphorylated EGFR and PI3K/Akt signaling kinases are expressed in circulating tumor cells of breast cancer patients
    • Kallergi G, Agelaki S, Kalykaki A et al. Phosphorylated EGFR and PI3K/Akt signaling kinases are expressed in circulating tumor cells of breast cancer patients. Breast Cancer Res 2008;10:R80.
    • (2008) Breast Cancer Res , vol.10
    • Kallergi, G.1    Agelaki, S.2    Kalykaki, A.3
  • 81
    • 28844433950 scopus 로고    scopus 로고
    • Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients
    • Tokunaga E, Kimura Y, Oki E et al. Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients. Int J Cancer 2006;118: 284-289.
    • (2006) Int J Cancer , vol.118 , pp. 284-289
    • Tokunaga, E.1    Kimura, Y.2    Oki, E.3
  • 82
    • 84882962589 scopus 로고    scopus 로고
    • Biomarker analyses in CLEOPATRA: A phase III, placebocontrolled study of pertuzumab in HER2-positive, first-line metastatic breast cancer (MBC) [Abstract S5-1]
    • Paper presented at: San Antonio Breast Cancer Symposium (CTRCAACR); December 4-8, 2012 San Antonio, TX
    • Baselga J, Cortes J, Im S-A et al. Biomarker analyses in CLEOPATRA: A phase III, placebocontrolled study of pertuzumab in HER2-positive, first-line metastatic breast cancer (MBC) [Abstract S5-1]. CancerRes2012;72(suppl 3). Paper presented at: San Antonio Breast Cancer Symposium (CTRCAACR); December 4-8, 2012; San Antonio, TX.
    • (2012) CancerRes , vol.72 , Issue.SUPPL. 3
    • Baselga, J.1    Cortes, J.2    Im, S.-A.3
  • 83
    • 77956572401 scopus 로고    scopus 로고
    • A first-inhuman phase I study to evaluate the pan-PI3K inhibitor GDC-0941 administered QD or BID in patients with advanced solid tumors
    • [Abstract 2541]
    • Von Hoff DD, Lo RP, Tibes R et al. A first-inhuman phase I study to evaluate the pan-PI3K inhibitor GDC-0941 administered QD or BID in patients with advanced solid tumors [Abstract 2541]. J Clin Oncol 2010;28:7sa.
    • (2010) J Clin Oncol , vol.28
    • Von Hoff, D.D.1    Lo, R.P.2    Tibes, R.3
  • 84
    • 84894104510 scopus 로고    scopus 로고
    • Ph IB/II study of BKM120 plus trastuzumab (T) in patients with T-resistant HER21 advanced breast cancer (BC)
    • [Abstract 3180]
    • Pistilli B, Urruticoechea A, Chan S et al. Ph IB/II study of BKM120 plus trastuzumab (T) in patients with T-resistant HER21 advanced breast cancer (BC) [Abstract 3180]. Ann Oncol 2012;23(suppl 9): ix116a.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9
    • Pistilli, B.1    Urruticoechea, A.2    Chan, S.3
  • 85
    • 76049123027 scopus 로고    scopus 로고
    • Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells
    • Brachmann SM, Hofmann I, Schnell C et al. Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells. Proc Natl Acad Sci USA 2009;106:22299-22304.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 22299-22304
    • Brachmann, S.M.1    Hofmann, I.2    Schnell, C.3
  • 86
    • 84894058532 scopus 로고    scopus 로고
    • PIKHER2: A phase Ib/II study evaluating safety and efficacy of oral BKM120 in combination with lapatinib inHER2-positive, PI3K-activated, trastuzumabresistant advanced breast cancer
    • [Abstract TPS663]
    • Goncalves A, Isambert N, Campone M et al. PIKHER2: A phase Ib/II study evaluating safety and efficacy of oral BKM120 in combination with lapatinib inHER2-positive, PI3K-activated, trastuzumabresistant advanced breast cancer [Abstract TPS663]. J Clin Oncol 2013;31(suppl).
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Goncalves, A.1    Isambert, N.2    Campone, M.3
  • 87
    • 85190570434 scopus 로고    scopus 로고
    • Aphase I/ IB dose-escalation study of BEZ235 in combination with trastuzumab in patients with PI3-kinase or PTEN altered HER21 metastatic breast cancer
    • [Abstract 508]
    • KropIE, SauraC, RodonAhnert J et al. Aphase I/ IB dose-escalation study of BEZ235 in combination with trastuzumab in patients with PI3-kinase or PTEN altered HER21 metastatic breast cancer [Abstract 508]. J Clin Oncol 2012;30(suppl).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Krop, I.E.1    Saura, C.2    RodonAhnert, J.3
  • 88
    • 84874659112 scopus 로고    scopus 로고
    • A phase I study of the AKT inhibitor (MK-2206) with concurrent trastuzumab and lapatinib in patients with HER2-positive solid tumors
    • [Abstract 3028]
    • Han HS, Swanton C, Janjigian YY et al. A phase I study of the AKT inhibitor (MK-2206) with concurrent trastuzumab and lapatinib in patients with HER2-positive solid tumors [Abstract 3028]. J Clin Oncol 2011;29(suppl).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Han, H.S.1    Swanton, C.2    Janjigian, Y.Y.3
  • 89
    • 85190567482 scopus 로고    scopus 로고
    • Phase Ib dose-escalation trial of the AKT inhibitor (AKTi) MK2206 in combination with paclitaxel (P) and trastuzumab (H) in patients (pts) with HER2-overexpressing (HER21) cancer
    • [Abstract 2605]
    • Chien AJ, Truong TG, MeliskoME et al. Phase Ib dose-escalation trial of the AKT inhibitor (AKTi) MK2206 in combination with paclitaxel (P) and trastuzumab (H) in patients (pts) with HER2-overexpressing (HER21) cancer [Abstract 2605]. J Clin Oncol 2013;31(suppl).
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Chien, A.J.1    Truong, T.G.2    Melisko, M.E.3
  • 91
    • 80051751593 scopus 로고    scopus 로고
    • Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy
    • Morrow PK, Wulf GM, Ensor J et al. Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy. J Clin Oncol 2011; 29:3126-3132.
    • (2011) J Clin Oncol , vol.29 , pp. 3126-3132
    • Morrow, P.K.1    Wulf, G.M.2    Ensor, J.3
  • 92
    • 78650967232 scopus 로고    scopus 로고
    • Phase I trial of oral mTOR inhibitor everolimus in combination with trastuzumab and vinorelbine in pretreated patients with HER2-overexpressing metastatic breast cancer
    • Jerusalem G, Fasolo A, Dieras V et al. Phase I trial of oral mTOR inhibitor everolimus in combination with trastuzumab and vinorelbine in pretreated patients with HER2-overexpressing metastatic breast cancer. Breast Cancer Res Treat 2011; 125:447-455.
    • (2011) Breast Cancer Res Treat , vol.125 , pp. 447-455
    • Jerusalem, G.1    Fasolo, A.2    Dieras, V.3
  • 93
    • 78650984926 scopus 로고    scopus 로고
    • Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab
    • Andre F, Campone M, O'Regan R et al. Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab. J Clin Oncol 2010;28:5110-5115.
    • (2010) J Clin Oncol , vol.28 , pp. 5110-5115
    • Andre, F.1    Campone, M.2    O'Regan, R.3
  • 94
    • 84885420714 scopus 로고    scopus 로고
    • Phase III, randomized, double-blind, placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant, advanced breast cancer (BOLERO-3)
    • [Abstract 505]
    • O'Regan R, Ozguroglu M, Andre F et al. Phase III, randomized, double-blind, placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant, advanced breast cancer (BOLERO-3) [Abstract 505]. J Clin Oncol 2013;31(suppl).
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • O'Regan, R.1    Ozguroglu, M.2    Andre, F.3
  • 95
    • 23944439945 scopus 로고    scopus 로고
    • Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
    • Chan S, Scheulen ME, Johnston S et al. Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J Clin Oncol 2005;23:5314-5322.
    • (2005) J Clin Oncol , vol.23 , pp. 5314-5322
    • Chan, S.1    Scheulen, M.E.2    Johnston, S.3
  • 96
    • 84655175180 scopus 로고    scopus 로고
    • Ridaforolimus (AP23573; MK-8669) in combination with trastuzumab for patients with HER2-positive trastuzumab-refractory metastatic breast cancer: A multicenter phase 2 clinical trial
    • [Abstract 3091]
    • Yardley DA, Seiler M, Ray-Coquard I et al. Ridaforolimus (AP23573; MK-8669) in combination with trastuzumab for patients with HER2-positive trastuzumab-refractory metastatic breast cancer: a multicenter phase 2 clinical trial [Abstract 3091]. Cancer Res 2009;69(suppl).
    • (2009) Cancer Res , vol.69 , Issue.SUPPL.
    • Yardley, D.A.1    Seiler, M.2    Ray-Coquard, I.3
  • 97
    • 0035915421 scopus 로고    scopus 로고
    • Insulin-likegrowthfactor-I receptor signaling and resistance to trastuzumab (Herceptin)
    • LuY, Zi X, ZhaoY et al. Insulin-likegrowthfactor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 2001;93:1852-1857.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1852-1857
    • Lu, Y.1    Zi, X.2    Zhao, Y.3
  • 98
    • 79960985354 scopus 로고    scopus 로고
    • HSP90 inhibition is effective in breast cancer: A phase 2 trial of tanespimycin (17aag) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab
    • Modi S, Stopeck AT, Linden HM et al. HSP90 inhibition is effective in breast cancer: a phase 2 trial of tanespimycin (17aag) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab. Clin Cancer Res 2011;;17::5132-5139.
    • (2011) Clin Cancer Res , vol.17 , pp. 5132-5139
    • Modi, S.1    Stopeck, A.T.2    Linden, H.M.3
  • 99
    • 85190571904 scopus 로고    scopus 로고
    • Phase IB/II study of the HSP90 inhibitor AUY922, in combinationwith trastuzumab, in patients with HER21 advanced breast cancer
    • [Abstract 530]
    • Kong A, Rea D, Ahmed S et al. Phase IB/II study of the HSP90 inhibitor AUY922, in combinationwith trastuzumab, in patients with HER21 advanced breast cancer [Abstract 530]. J Clin Oncol 2012;30 (suppl).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Kong, A.1    Rea, D.2    Ahmed, S.3
  • 100
    • 70349918608 scopus 로고    scopus 로고
    • Lipid-conjugated telomerase template antagonists sensitize resistant HER2-positive breast cancer cells to trastuzumab
    • Goldblatt EM, Erickson PA, Gentry ER et al. Lipid-conjugated telomerase template antagonists sensitize resistant HER2-positive breast cancer cells to trastuzumab. Breast Cancer Res Treat 2009;118: 21-32.
    • (2009) Breast Cancer Res Treat , vol.118 , pp. 21-32
    • Goldblatt, E.M.1    Erickson, P.A.2    Gentry, E.R.3
  • 101
    • 85190567584 scopus 로고    scopus 로고
    • Inhibiting telomerase to reverse trastuzumab (T) resistance in HER21 breast cancer
    • [Abstract P5-18-13]. Paper presented at: San Antonio Breast Cancer Symposium (CTRC-AACR); December 4-8, 2012; San Antonio, TX
    • Miller KD, Stedin CE, PrasadN et al. Inhibiting telomerase to reverse trastuzumab (T) resistance in HER21 breast cancer [Abstract P5-18-13]. Cancer Res 2012;72(suppl 3). Paper presented at: San Antonio Breast Cancer Symposium (CTRC-AACR); December 4-8, 2012; San Antonio, TX.
    • (2012) Cancer Res , vol.72 , Issue.SUPPL. 3
    • Miller, K.D.1    Stedin, C.E.2    Prasad, N.3
  • 102
    • 12144291334 scopus 로고    scopus 로고
    • Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients
    • Konecny GE, Meng YG, Untch M et al. Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients. Clin Cancer Res 2004;10:1706-1716.
    • (2004) Clin Cancer Res , vol.10 , pp. 1706-1716
    • Konecny, G.E.1    Meng, Y.G.2    Untch, M.3
  • 103
    • 34447322566 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic correlation frommousetohumanwithpazopanib, amultikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
    • Kumar R, Knick VB, Rudolph SK et al. Pharmacokinetic-pharmacodynamic correlation frommousetohumanwithpazopanib, amultikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol Cancer Ther 2007;6: 2012-2021.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2012-2021
    • Kumar, R.1    Knick, V.B.2    Rudolph, S.K.3
  • 104
    • 84879338637 scopus 로고    scopus 로고
    • A randomized and open-label trial evaluating the addition of pazopanib to lapatinib as first-line therapy in patients with HER2-positive advanced breast cancer
    • Johnston SR, Gomez H, Stemmer SM et al. A randomized and open-label trial evaluating the addition of pazopanib to lapatinib as first-line therapy in patients with HER2-positive advanced breast cancer. Breast Cancer Res Treat 2013;137: 755-766.
    • (2013) Breast Cancer Res Treat , vol.137 , pp. 755-766
    • Johnston, S.R.1    Gomez, H.2    Stemmer, S.M.3
  • 105
    • 84880603356 scopus 로고    scopus 로고
    • A randomized phase II study of lapatinib 1 pazopanib versus lapatinib in patients with HER21 inflammatory breast cancer
    • Cristofanilli M, Johnston SR, Manikhas A et al. A randomized phase II study of lapatinib 1 pazopanib versus lapatinib in patients with HER21 inflammatory breast cancer. Breast Cancer Res Treat 2013;137:471-482.
    • (2013) Breast Cancer Res Treat , vol.137 , pp. 471-482
    • Cristofanilli, M.1    Johnston, S.R.2    Manikhas, A.3
  • 106
    • 84856455116 scopus 로고    scopus 로고
    • oral [package insert]. New York, NY: Pfizer Inc
    • SUTENT (sunitinib malate) capsules, oral [package insert]. New York, NY: Pfizer Inc.; 2011.
    • (2011) SUTENT (sunitinib malate) capsules
  • 107
    • 84869205333 scopus 로고    scopus 로고
    • An exploratory study of sunitinib in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive metastatic breast cancer
    • Cardoso F, Canon JL, Amadori D et al. An exploratory study of sunitinib in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive metastatic breast cancer. Breast 2012;21:716-723.
    • (2012) Breast , vol.21 , pp. 716-723
    • Cardoso, F.1    Canon, J.L.2    Amadori, D.3
  • 108
    • 84894093299 scopus 로고    scopus 로고
    • Final results of neoadjuvant trial of bevacizumab (B) and trastuzumab (T) in combination with weekly paclitaxel (P) as neoadjuvant treatment in HER2-positive breast cancer: A phase II trial (AVANTHER)
    • [Abstract P1-14-10]. Paper presented at: San Antonio Breast Cancer Symposium (CTRC-AACR); December 4-8, 2012; San Antonio, TX
    • Fernandez M, Calvo I, Martinez N et al. Final results of neoadjuvant trial of bevacizumab (B) and trastuzumab (T) in combination with weekly paclitaxel (P) as neoadjuvant treatment in HER2-positive breast cancer: A phase II trial (AVANTHER) [Abstract P1-14-10]. Cancer Res 2012;72(suppl 3). Paper presented at: San Antonio Breast Cancer Symposium (CTRC-AACR); December 4-8, 2012; San Antonio, TX.
    • (2012) Cancer Res , vol.72 , Issue.SUPPL. 3
    • Fernandez, M.1    Calvo, I.2    Martinez, N.3
  • 109
    • 84860148054 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in combination with trastuzumab and capecitabine as first-line treatment for HER-2-positive locally recurrent or metastatic breast cancer
    • MartínM, Makhson A, Gligorov J et al. Phase II study of bevacizumab in combination with trastuzumab and capecitabine as first-line treatment for HER-2-positive locally recurrent or metastatic breast cancer. The Oncologist 2012;17: 469-475.
    • (2012) The Oncologist , vol.17 , pp. 469-475
    • Martín, M.1    Makhson, A.2    Gligorov, J.3
  • 110
    • 84878757223 scopus 로고    scopus 로고
    • A phase II study of bevacizumab in combination with vinorelbine and trastuzumab in HER2-positive metastatic breast cancer
    • Lin NU, Seah DS, Gelman R et al. A phase II study of bevacizumab in combination with vinorelbine and trastuzumab in HER2-positive metastatic breast cancer. Breast Cancer Res Treat 2013;139: 403-410.
    • (2013) Breast Cancer Res Treat , vol.139 , pp. 403-410
    • Lin, N.U.1    Seah, D.S.2    Gelman, R.3
  • 111
    • 84879477431 scopus 로고    scopus 로고
    • AVEREL: A randomized phase III Trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer
    • Gianni L, Romieu GH, Lichinitser M et al. AVEREL: a randomized phase III Trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer. J Clin Oncol 2013;31:1719-1725.
    • (2013) J Clin Oncol , vol.31 , pp. 1719-1725
    • Gianni, L.1    Romieu, G.H.2    Lichinitser, M.3
  • 112
    • 85190572111 scopus 로고    scopus 로고
    • A randomized phase III double-blinded placebocontrolled trial of first-line chemotherapy and trastuzumab with or without bevacizumab for patients with HER2/neu-overexpressing metastatic breast cancer (HER21 MBC): A trial of the Eastern Cooperative Oncology Group (E1105)
    • Arteaga CL, Mayer IA, O'Neill AM et al. A randomized phase III double-blinded placebocontrolled trial of first-line chemotherapy and trastuzumab with or without bevacizumab for patients with HER2/neu-overexpressing metastatic breast cancer (HER21 MBC): A trial of the Eastern Cooperative Oncology Group (E1105). J Clin Oncol 2012;30:605a.
    • (2012) J Clin Oncol , vol.30
    • Arteaga, C.L.1    Mayer, I.A.2    O'Neill, A.M.3
  • 113
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 2012;490:61-70.
    • (2012) Nature , vol.490 , pp. 61-70
  • 114
    • 84865191389 scopus 로고    scopus 로고
    • Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: Results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657)
    • Esserman LJ, Berry DA, Cheang MC et al. Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657). Breast Cancer Res Treat 2012;132:1049-1062.
    • (2012) Breast Cancer Res Treat , vol.132 , pp. 1049-1062
    • Esserman, L.J.1    Berry, D.A.2    Cheang, M.C.3
  • 115
    • 33646746413 scopus 로고    scopus 로고
    • A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer
    • Xia W, Bacus S, Hegde P et al. A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer. Proc Natl Acad Sci USA 2006;103:7795-7800.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7795-7800
    • Xia, W.1    Bacus, S.2    Hegde, P.3
  • 116
    • 84865127032 scopus 로고    scopus 로고
    • Therapeutic implications of estrogen receptor signaling in HER2-positive breast cancers
    • Nahta R, O'Regan RM. Therapeutic implications of estrogen receptor signaling in HER2-positive breast cancers. Breast Cancer Res Treat 2012;135: 39-48.
    • (2012) Breast Cancer Res Treat , vol.135 , pp. 39-48
    • Nahta, R.1    O'Regan, R.M.2
  • 117
    • 84894061059 scopus 로고    scopus 로고
    • Impact of hormone receptor (HR) status on clinicopathological features, patterns of recurrence, and clinical outcomes among patients (pts) with human epidermal growth factor receptor-2 positive (HER2) breast cancer (BC) in the National Comprehensive Cancer Network (NCCN)
    • [Abstract 599]
    • Vaz Duarte Luis IM, Ottesen RA, Hughes ME et al. Impact of hormone receptor (HR) status on clinicopathological features, patterns of recurrence, and clinical outcomes among patients (pts) with human epidermal growth factor receptor-2 positive (HER2) breast cancer (BC) in the National Comprehensive Cancer Network (NCCN) [Abstract 599]. J Clin Oncol 2012;30(suupl).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Vaz Duarte Luis, I.M.1    Ottesen, R.A.2    Hughes, M.E.3
  • 118
    • 41449105551 scopus 로고    scopus 로고
    • HER2 status and benefit fromadjuvant trastuzumab in breast cancer
    • Paik S, Kim C, Wolmark N. HER2 status and benefit fromadjuvant trastuzumab in breast cancer. N Engl J Med 2008;358:1409-1411.
    • (2008) N Engl J Med , vol.358 , pp. 1409-1411
    • Paik, S.1    Kim, C.2    Wolmark, N.3
  • 119
    • 70449561613 scopus 로고    scopus 로고
    • Correlation of HER2 status between primary tumors and corresponding circulating tumor cells in advanced breast cancer patients
    • Pestrin M, Bessi S, Galardi F et al. Correlation of HER2 status between primary tumors and corresponding circulating tumor cells in advanced breast cancer patients. Breast Cancer Res Treat 2009;118:523-530.
    • (2009) Breast Cancer Res Treat , vol.118 , pp. 523-530
    • Pestrin, M.1    Bessi, S.2    Galardi, F.3
  • 120
    • 79959228670 scopus 로고    scopus 로고
    • Multiple biomarker expression on circulating tumor cells in comparison to tumor tissues from primary and metastatic sites in patients with locally advanced/ inflammatory, and stage IV breast cancer, using a novel detection technology
    • Somlo G, Lau SK, Frankel P et al. Multiple biomarker expression on circulating tumor cells in comparison to tumor tissues from primary and metastatic sites in patients with locally advanced/ inflammatory, and stage IV breast cancer, using a novel detection technology. Breast Cancer Res Treat 2011;128:155-163.
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 155-163
    • Somlo, G.1    Lau, S.K.2    Frankel, P.3
  • 121
    • 84864085607 scopus 로고    scopus 로고
    • Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughouttumor progression
    • Lindström LS, Karlsson E, Wilking UM et al. Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughouttumor progression. J Clin Oncol 2012;30:2601-2608.
    • (2012) J Clin Oncol , vol.30 , pp. 2601-2608
    • Lindström, L.S.1    Karlsson, E.2    Wilking, U.M.3
  • 122
    • 84894083981 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2 (HER2) suppression with the addition of lapatinib to trastuzumab in HER2-positive metastatic breast cancer (HALT: LPT112515)
    • [Abstract TPS664599]
    • Lin NU, Danso MA, David AK et al. Human epidermal growth factor receptor 2 (HER2) suppression with the addition of lapatinib to trastuzumab in HER2-positive metastatic breast cancer (HALT: LPT112515) [Abstract TPS664599]. J Clin Oncol 2013;31(suppl).
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Lin, N.U.1    Danso, M.A.2    David, A.K.3
  • 123
    • 84884639882 scopus 로고    scopus 로고
    • Open-label, phase II trial of afatinib, with or without vinorelbine (V), for the treatment of HER2-overexpressing inflammatory breast cancer (IBC)
    • [Abstract TPS650]
    • Swanton C, Cromer J. Open-label, phase II trial of afatinib, with or without vinorelbine (V), for the treatment of HER2-overexpressing inflammatory breast cancer (IBC) [Abstract TPS650]. J Clin Oncol 2012;30(suppl).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Swanton, C.1    Cromer, J.2
  • 124
    • 79952092706 scopus 로고    scopus 로고
    • Phase II studyof the antibodydrug conjugatetrastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy
    • Burris HA 3rd, Rugo HS, Vukelja SJ et al. Phase II studyof the antibodydrug conjugatetrastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy. J Clin Oncol 2011;29: 398-405.
    • (2011) J Clin Oncol , vol.29 , pp. 398-405
    • Burris III, H.A.1    Rugo, H.S.2    Vukelja, S.J.3
  • 125
    • 84867842898 scopus 로고    scopus 로고
    • MARIANNE: A phase III, randomized study of trastuzumab-DM1 (T-DM1) with or without pertuzumab (P) compared with trastuzumab (H) plus taxane for firstline treatment of HER2-positive, progressive, or recurrent locally advanced or metastatic breast cancer (MBC)
    • [Abstract TPS102]
    • Ellis PA, Barrios CH, ImY et al. MARIANNE: A phase III, randomized study of trastuzumab-DM1 (T-DM1) with or without pertuzumab (P) compared with trastuzumab (H) plus taxane for firstline treatment of HER2-positive, progressive, or recurrent locally advanced or metastatic breast cancer (MBC) [Abstract TPS102]. J Clin Oncol 2011; 29(suppl).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Ellis, P.A.1    Barrios, C.H.2    Im, Y.3
  • 126
    • 84867780233 scopus 로고    scopus 로고
    • BOLERO-1: A randomized, phase III, double-blind, placebocontrolled multicenter trial of everolimus in combination with trastuzumab and paclitaxel as first-line therapy in women with HER2-positive (HER2+), locally advanced or metastatic breast cancer (BC)
    • [Abstract TPS648]
    • Hurvitz SA, Andre F, BurrisHA et al. BOLERO-1: A randomized, phase III, double-blind, placebocontrolled multicenter trial of everolimus in combination with trastuzumab and paclitaxel as first-line therapy in women with HER2-positive (HER2+), locally advanced or metastatic breast cancer (BC) [Abstract TPS648]. J ClinOncol 2012;30 (suppl).
    • (2012) J ClinOncol , vol.30 , Issue.SUPPL.
    • Hurvitz, S.A.1    Andre, F.2    Burris, H.A.3


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